7R3E
Fusion construct of PqsE and RhlR in complex with the synthetic antagonist mBTL
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0001216 | molecular_function | DNA-binding transcription activator activity |
| A | 0001217 | molecular_function | DNA-binding transcription repressor activity |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0010467 | biological_process | gene expression |
| A | 0016289 | molecular_function | acyl-CoA hydrolase activity |
| A | 0032993 | cellular_component | protein-DNA complex |
| A | 0038023 | molecular_function | signaling receptor activity |
| A | 0044550 | biological_process | secondary metabolite biosynthetic process |
| A | 0045862 | biological_process | positive regulation of proteolysis |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| A | 0046889 | biological_process | positive regulation of lipid biosynthetic process |
| A | 0062162 | biological_process | positive regulation of pyocyanine biosynthetic process |
| A | 1900378 | biological_process | positive regulation of secondary metabolite biosynthetic process |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0001216 | molecular_function | DNA-binding transcription activator activity |
| B | 0001217 | molecular_function | DNA-binding transcription repressor activity |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0010467 | biological_process | gene expression |
| B | 0016289 | molecular_function | acyl-CoA hydrolase activity |
| B | 0032993 | cellular_component | protein-DNA complex |
| B | 0038023 | molecular_function | signaling receptor activity |
| B | 0044550 | biological_process | secondary metabolite biosynthetic process |
| B | 0045862 | biological_process | positive regulation of proteolysis |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| B | 0046889 | biological_process | positive regulation of lipid biosynthetic process |
| B | 0062162 | biological_process | positive regulation of pyocyanine biosynthetic process |
| B | 1900378 | biological_process | positive regulation of secondary metabolite biosynthetic process |
Functional Information from PROSITE/UniProt
| site_id | PS00622 |
| Number of Residues | 28 |
| Details | HTH_LUXR_1 LuxR-type HTH domain signature. GksSgeIAiiLsIsesTVnfHhkNIqkK |
| Chain | Residue | Details |
| A | GLY526-LYS553 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19788310","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20419351","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27082157","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36456567","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Q0I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Q0J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DH8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HIO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HIQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HIS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KGX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7R3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7R3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7R3J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B4A","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19788310","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20419351","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27082157","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36456567","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7R3J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 130 |
| Details | Domain: {"description":"HTH luxR-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00411","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 38 |
| Details | DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00411","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"36456567","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B4A","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
