7R3B

S-adenosylmethionine synthetase from Lactobacillus plantarum complexed with AMPPNP, methionine and SAM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004478	molecular_function	methionine adenosyltransferase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006556	biological_process	S-adenosylmethionine biosynthetic process
A	0006730	biological_process	one-carbon metabolic process
A	0016740	molecular_function	transferase activity
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0004478	molecular_function	methionine adenosyltransferase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006556	biological_process	S-adenosylmethionine biosynthetic process
B	0006730	biological_process	one-carbon metabolic process
B	0016740	molecular_function	transferase activity
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0004478	molecular_function	methionine adenosyltransferase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006556	biological_process	S-adenosylmethionine biosynthetic process
C	0006730	biological_process	one-carbon metabolic process
C	0016740	molecular_function	transferase activity
C	0046872	molecular_function	metal ion binding
D	0000287	molecular_function	magnesium ion binding
D	0004478	molecular_function	methionine adenosyltransferase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0006556	biological_process	S-adenosylmethionine biosynthetic process
D	0006730	biological_process	one-carbon metabolic process
D	0016740	molecular_function	transferase activity
D	0046872	molecular_function	metal ion binding
E	0000287	molecular_function	magnesium ion binding
E	0004478	molecular_function	methionine adenosyltransferase activity
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0006556	biological_process	S-adenosylmethionine biosynthetic process
E	0006730	biological_process	one-carbon metabolic process
E	0016740	molecular_function	transferase activity
E	0046872	molecular_function	metal ion binding
F	0000287	molecular_function	magnesium ion binding
F	0004478	molecular_function	methionine adenosyltransferase activity
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0006556	biological_process	S-adenosylmethionine biosynthetic process
F	0006730	biological_process	one-carbon metabolic process
F	0016740	molecular_function	transferase activity
F	0046872	molecular_function	metal ion binding
G	0000287	molecular_function	magnesium ion binding
G	0004478	molecular_function	methionine adenosyltransferase activity
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0006556	biological_process	S-adenosylmethionine biosynthetic process
G	0006730	biological_process	one-carbon metabolic process
G	0016740	molecular_function	transferase activity
G	0046872	molecular_function	metal ion binding
H	0000287	molecular_function	magnesium ion binding
H	0004478	molecular_function	methionine adenosyltransferase activity
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0006556	biological_process	S-adenosylmethionine biosynthetic process
H	0006730	biological_process	one-carbon metabolic process
H	0016740	molecular_function	transferase activity
H	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00376
Number of Residues	11
Details	ADOMET_SYNTHASE_1 S-adenosylmethionine synthase signature 1. GAGDQGmmfGY

Chain	Residue	Details
A	GLY126-TYR136

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site_id	PS00377
Number of Residues	9
Details	ADOMET_SYNTHASE_2 S-adenosylmethionine synthase signature 2. GGGAFSgKD

Chain	Residue	Details
A	GLY270-ASP278

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	56
Details	BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_00086

Chain	Residue	Details
A	HIS16
B	GLN100
B	ASP174
B	ARG241
B	ARG256
B	LYS281
C	HIS16
C	GLU57
C	GLN100
C	ASP174
C	ARG241
A	GLU57
C	ARG256
C	LYS281
D	HIS16
D	GLU57
D	GLN100
D	ASP174
D	ARG241
D	ARG256
D	LYS281
E	HIS16
A	GLN100
E	GLU57
E	GLN100
E	ASP174
E	ARG241
E	ARG256
E	LYS281
F	HIS16
F	GLU57
F	GLN100
F	ASP174
A	ASP174
F	ARG241
F	ARG256
F	LYS281
G	HIS16
G	GLU57
G	GLN100
G	ASP174
G	ARG241
G	ARG256
G	LYS281
A	ARG241
H	HIS16
H	GLU57
H	GLN100
H	ASP174
H	ARG241
H	ARG256
H	LYS281
A	ARG256
A	LYS281
B	HIS16
B	GLU57

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site_id	SWS_FT_FI2
Number of Residues	40
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00086

Chain	Residue	Details
A	ASP18
B	LYS277
C	ASP18
C	GLU44
C	ASP250
C	ALA273
C	LYS277
D	ASP18
D	GLU44
D	ASP250
D	ALA273
A	GLU44
D	LYS277
E	ASP18
E	GLU44
E	ASP250
E	ALA273
E	LYS277
F	ASP18
F	GLU44
F	ASP250
F	ALA273
A	ASP250
F	LYS277
G	ASP18
G	GLU44
G	ASP250
G	ALA273
G	LYS277
H	ASP18
H	GLU44
H	ASP250
H	ALA273
A	ALA273
H	LYS277
A	LYS277
B	ASP18
B	GLU44
B	ASP250
B	ALA273

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