7R0J

Structure of the V2 receptor Cter-arrestin2-ScFv30 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000139	cellular_component	Golgi membrane
C	0000785	cellular_component	chromatin
C	0001664	molecular_function	G protein-coupled receptor binding
C	0001678	biological_process	intracellular glucose homeostasis
C	0001934	biological_process	positive regulation of protein phosphorylation
C	0002029	biological_process	desensitization of G protein-coupled receptor signaling pathway
C	0002031	biological_process	G protein-coupled receptor internalization
C	0002092	biological_process	positive regulation of receptor internalization
C	0003713	molecular_function	transcription coactivator activity
C	0004402	molecular_function	histone acetyltransferase activity
C	0004857	molecular_function	enzyme inhibitor activity
C	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
C	0005096	molecular_function	GTPase activator activity
C	0005159	molecular_function	insulin-like growth factor receptor binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005765	cellular_component	lysosomal membrane
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005905	cellular_component	clathrin-coated pit
C	0005929	cellular_component	cilium
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0007165	biological_process	signal transduction
C	0007166	biological_process	cell surface receptor signaling pathway
C	0007600	biological_process	sensory perception
C	0016567	biological_process	protein ubiquitination
C	0019899	molecular_function	enzyme binding
C	0030659	cellular_component	cytoplasmic vesicle membrane
C	0030666	cellular_component	endocytic vesicle membrane
C	0030674	molecular_function	protein-macromolecule adaptor activity
C	0031143	cellular_component	pseudopodium
C	0031397	biological_process	negative regulation of protein ubiquitination
C	0031410	cellular_component	cytoplasmic vesicle
C	0031434	molecular_function	mitogen-activated protein kinase kinase binding
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0031701	molecular_function	angiotensin receptor binding
C	0032715	biological_process	negative regulation of interleukin-6 production
C	0032717	biological_process	negative regulation of interleukin-8 production
C	0035025	biological_process	positive regulation of Rho protein signal transduction
C	0035721	biological_process	intraciliary retrograde transport
C	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
C	0042981	biological_process	regulation of apoptotic process
C	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
C	0043149	biological_process	stress fiber assembly
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0045746	biological_process	negative regulation of Notch signaling pathway
C	0045880	biological_process	positive regulation of smoothened signaling pathway
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0060090	molecular_function	molecular adaptor activity
C	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
C	0097499	biological_process	protein localization to non-motile cilium
C	1902533	biological_process	positive regulation of intracellular signal transduction
C	1903568	biological_process	negative regulation of protein localization to ciliary membrane
C	1990763	molecular_function	arrestin family protein binding

Functional Information from PROSITE/UniProt

site_id	PS00295
Number of Residues	19
Details	ARRESTINS Arrestins signature. FRYGrEDlDVLGLtFrKDL

Chain	Residue	Details
C	PHE61-LEU79

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	41
Details	Region: {"description":"Interaction with CHRM2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	11
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q8BWG8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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