7QV5

Amyloid fibril from the antimicrobial peptide uperin 3.5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0006952	biological_process	defense response
A	0016020	cellular_component	membrane
A	0042742	biological_process	defense response to bacterium
A	0042803	molecular_function	protein homodimerization activity
A	0044218	cellular_component	other organism cell membrane
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0051715	biological_process	cytolysis in another organism
B	0005576	cellular_component	extracellular region
B	0006952	biological_process	defense response
B	0016020	cellular_component	membrane
B	0042742	biological_process	defense response to bacterium
B	0042803	molecular_function	protein homodimerization activity
B	0044218	cellular_component	other organism cell membrane
B	0050830	biological_process	defense response to Gram-positive bacterium
B	0051715	biological_process	cytolysis in another organism
C	0005576	cellular_component	extracellular region
C	0006952	biological_process	defense response
C	0016020	cellular_component	membrane
C	0042742	biological_process	defense response to bacterium
C	0042803	molecular_function	protein homodimerization activity
C	0044218	cellular_component	other organism cell membrane
C	0050830	biological_process	defense response to Gram-positive bacterium
C	0051715	biological_process	cytolysis in another organism
D	0005576	cellular_component	extracellular region
D	0006952	biological_process	defense response
D	0016020	cellular_component	membrane
D	0042742	biological_process	defense response to bacterium
D	0042803	molecular_function	protein homodimerization activity
D	0044218	cellular_component	other organism cell membrane
D	0050830	biological_process	defense response to Gram-positive bacterium
D	0051715	biological_process	cytolysis in another organism
E	0005576	cellular_component	extracellular region
E	0006952	biological_process	defense response
E	0016020	cellular_component	membrane
E	0042742	biological_process	defense response to bacterium
E	0042803	molecular_function	protein homodimerization activity
E	0044218	cellular_component	other organism cell membrane
E	0050830	biological_process	defense response to Gram-positive bacterium
E	0051715	biological_process	cytolysis in another organism
F	0005576	cellular_component	extracellular region
F	0006952	biological_process	defense response
F	0016020	cellular_component	membrane
F	0042742	biological_process	defense response to bacterium
F	0042803	molecular_function	protein homodimerization activity
F	0044218	cellular_component	other organism cell membrane
F	0050830	biological_process	defense response to Gram-positive bacterium
F	0051715	biological_process	cytolysis in another organism
G	0005576	cellular_component	extracellular region
G	0006952	biological_process	defense response
G	0016020	cellular_component	membrane
G	0042742	biological_process	defense response to bacterium
G	0042803	molecular_function	protein homodimerization activity
G	0044218	cellular_component	other organism cell membrane
G	0050830	biological_process	defense response to Gram-positive bacterium
G	0051715	biological_process	cytolysis in another organism
H	0005576	cellular_component	extracellular region
H	0006952	biological_process	defense response
H	0016020	cellular_component	membrane
H	0042742	biological_process	defense response to bacterium
H	0042803	molecular_function	protein homodimerization activity
H	0044218	cellular_component	other organism cell membrane
H	0050830	biological_process	defense response to Gram-positive bacterium
H	0051715	biological_process	cytolysis in another organism
I	0005576	cellular_component	extracellular region
I	0006952	biological_process	defense response
I	0016020	cellular_component	membrane
I	0042742	biological_process	defense response to bacterium
I	0042803	molecular_function	protein homodimerization activity
I	0044218	cellular_component	other organism cell membrane
I	0050830	biological_process	defense response to Gram-positive bacterium
I	0051715	biological_process	cytolysis in another organism
J	0005576	cellular_component	extracellular region
J	0006952	biological_process	defense response
J	0016020	cellular_component	membrane
J	0042742	biological_process	defense response to bacterium
J	0042803	molecular_function	protein homodimerization activity
J	0044218	cellular_component	other organism cell membrane
J	0050830	biological_process	defense response to Gram-positive bacterium
J	0051715	biological_process	cytolysis in another organism
K	0005576	cellular_component	extracellular region
K	0006952	biological_process	defense response
K	0016020	cellular_component	membrane
K	0042742	biological_process	defense response to bacterium
K	0042803	molecular_function	protein homodimerization activity
K	0044218	cellular_component	other organism cell membrane
K	0050830	biological_process	defense response to Gram-positive bacterium
K	0051715	biological_process	cytolysis in another organism
L	0005576	cellular_component	extracellular region
L	0006952	biological_process	defense response
L	0016020	cellular_component	membrane
L	0042742	biological_process	defense response to bacterium
L	0042803	molecular_function	protein homodimerization activity
L	0044218	cellular_component	other organism cell membrane
L	0050830	biological_process	defense response to Gram-positive bacterium
L	0051715	biological_process	cytolysis in another organism
M	0005576	cellular_component	extracellular region
M	0006952	biological_process	defense response
M	0016020	cellular_component	membrane
M	0042742	biological_process	defense response to bacterium
M	0042803	molecular_function	protein homodimerization activity
M	0044218	cellular_component	other organism cell membrane
M	0050830	biological_process	defense response to Gram-positive bacterium
M	0051715	biological_process	cytolysis in another organism
N	0005576	cellular_component	extracellular region
N	0006952	biological_process	defense response
N	0016020	cellular_component	membrane
N	0042742	biological_process	defense response to bacterium
N	0042803	molecular_function	protein homodimerization activity
N	0044218	cellular_component	other organism cell membrane
N	0050830	biological_process	defense response to Gram-positive bacterium
N	0051715	biological_process	cytolysis in another organism
O	0005576	cellular_component	extracellular region
O	0006952	biological_process	defense response
O	0016020	cellular_component	membrane
O	0042742	biological_process	defense response to bacterium
O	0042803	molecular_function	protein homodimerization activity
O	0044218	cellular_component	other organism cell membrane
O	0050830	biological_process	defense response to Gram-positive bacterium
O	0051715	biological_process	cytolysis in another organism
P	0005576	cellular_component	extracellular region
P	0006952	biological_process	defense response
P	0016020	cellular_component	membrane
P	0042742	biological_process	defense response to bacterium
P	0042803	molecular_function	protein homodimerization activity
P	0044218	cellular_component	other organism cell membrane
P	0050830	biological_process	defense response to Gram-positive bacterium
P	0051715	biological_process	cytolysis in another organism
Q	0005576	cellular_component	extracellular region
Q	0006952	biological_process	defense response
Q	0016020	cellular_component	membrane
Q	0042742	biological_process	defense response to bacterium
Q	0042803	molecular_function	protein homodimerization activity
Q	0044218	cellular_component	other organism cell membrane
Q	0050830	biological_process	defense response to Gram-positive bacterium
Q	0051715	biological_process	cytolysis in another organism
R	0005576	cellular_component	extracellular region
R	0006952	biological_process	defense response
R	0016020	cellular_component	membrane
R	0042742	biological_process	defense response to bacterium
R	0042803	molecular_function	protein homodimerization activity
R	0044218	cellular_component	other organism cell membrane
R	0050830	biological_process	defense response to Gram-positive bacterium
R	0051715	biological_process	cytolysis in another organism
S	0005576	cellular_component	extracellular region
S	0006952	biological_process	defense response
S	0016020	cellular_component	membrane
S	0042742	biological_process	defense response to bacterium
S	0042803	molecular_function	protein homodimerization activity
S	0044218	cellular_component	other organism cell membrane
S	0050830	biological_process	defense response to Gram-positive bacterium
S	0051715	biological_process	cytolysis in another organism
T	0005576	cellular_component	extracellular region
T	0006952	biological_process	defense response
T	0016020	cellular_component	membrane
T	0042742	biological_process	defense response to bacterium
T	0042803	molecular_function	protein homodimerization activity
T	0044218	cellular_component	other organism cell membrane
T	0050830	biological_process	defense response to Gram-positive bacterium
T	0051715	biological_process	cytolysis in another organism
U	0005576	cellular_component	extracellular region
U	0006952	biological_process	defense response
U	0016020	cellular_component	membrane
U	0042742	biological_process	defense response to bacterium
U	0042803	molecular_function	protein homodimerization activity
U	0044218	cellular_component	other organism cell membrane
U	0050830	biological_process	defense response to Gram-positive bacterium
U	0051715	biological_process	cytolysis in another organism
V	0005576	cellular_component	extracellular region
V	0006952	biological_process	defense response
V	0016020	cellular_component	membrane
V	0042742	biological_process	defense response to bacterium
V	0042803	molecular_function	protein homodimerization activity
V	0044218	cellular_component	other organism cell membrane
V	0050830	biological_process	defense response to Gram-positive bacterium
V	0051715	biological_process	cytolysis in another organism
W	0005576	cellular_component	extracellular region
W	0006952	biological_process	defense response
W	0016020	cellular_component	membrane
W	0042742	biological_process	defense response to bacterium
W	0042803	molecular_function	protein homodimerization activity
W	0044218	cellular_component	other organism cell membrane
W	0050830	biological_process	defense response to Gram-positive bacterium
W	0051715	biological_process	cytolysis in another organism
X	0005576	cellular_component	extracellular region
X	0006952	biological_process	defense response
X	0016020	cellular_component	membrane
X	0042742	biological_process	defense response to bacterium
X	0042803	molecular_function	protein homodimerization activity
X	0044218	cellular_component	other organism cell membrane
X	0050830	biological_process	defense response to Gram-positive bacterium
X	0051715	biological_process	cytolysis in another organism
Y	0005576	cellular_component	extracellular region
Y	0006952	biological_process	defense response
Y	0016020	cellular_component	membrane
Y	0042742	biological_process	defense response to bacterium
Y	0042803	molecular_function	protein homodimerization activity
Y	0044218	cellular_component	other organism cell membrane
Y	0050830	biological_process	defense response to Gram-positive bacterium
Y	0051715	biological_process	cytolysis in another organism
Z	0005576	cellular_component	extracellular region
Z	0006952	biological_process	defense response
Z	0016020	cellular_component	membrane
Z	0042742	biological_process	defense response to bacterium
Z	0042803	molecular_function	protein homodimerization activity
Z	0044218	cellular_component	other organism cell membrane
Z	0050830	biological_process	defense response to Gram-positive bacterium
Z	0051715	biological_process	cytolysis in another organism
a	0005576	cellular_component	extracellular region
a	0006952	biological_process	defense response
a	0016020	cellular_component	membrane
a	0042742	biological_process	defense response to bacterium
a	0042803	molecular_function	protein homodimerization activity
a	0044218	cellular_component	other organism cell membrane
a	0050830	biological_process	defense response to Gram-positive bacterium
a	0051715	biological_process	cytolysis in another organism

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	144
Details	Peptide: {"description":"Uperin-3.5","featureId":"PRO_0000043858"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	27
Details	Site: {"description":"Involved in inter-helical interactions along the fibril","evidences":[{"source":"PubMed","id":"33431675","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Modified residue: {"description":"Valine amide","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"1996","firstPage":"1325","lastPage":"1331","volume":"49","journal":"Aust. J. Chem.","title":"New antibiotic uperin peptides from the dorsal glands of the australian toadlet Uperoleia mjobergii.","authors":["Bradford A.M.","Bowie J.H.","Tyler M.J.","Wallace J.C."]}}]}

Chain

Residue

Details

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