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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7QO4

26S proteasome WT-Ubp6-UbVS complex in the si state (ATPases, Rpn1, Ubp6, and UbVS)

Functional Information from GO Data
ChainGOidnamespacecontents
80000502cellular_componentproteasome complex
80004843molecular_functioncysteine-type deubiquitinase activity
80005838cellular_componentproteasome regulatory particle
80006508biological_processproteolysis
80008233molecular_functionpeptidase activity
80008234molecular_functioncysteine-type peptidase activity
80016579biological_processprotein deubiquitination
80016787molecular_functionhydrolase activity
80032434biological_processregulation of proteasomal ubiquitin-dependent protein catabolic process
80043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
80070628molecular_functionproteasome binding
80072671biological_processmitochondria-associated ubiquitin-dependent protein catabolic process
81901799biological_processnegative regulation of proteasomal protein catabolic process
81904293biological_processnegative regulation of ERAD pathway
H0000166molecular_functionnucleotide binding
H0000502cellular_componentproteasome complex
H0005515molecular_functionprotein binding
H0005524molecular_functionATP binding
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0006511biological_processubiquitin-dependent protein catabolic process
H0008540cellular_componentproteasome regulatory particle, base subcomplex
H0010498biological_processproteasomal protein catabolic process
H0010604biological_processpositive regulation of macromolecule metabolic process
H0016887molecular_functionATP hydrolysis activity
H0031625molecular_functionubiquitin protein ligase binding
H0036402molecular_functionproteasome-activating activity
H0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
H0045732biological_processpositive regulation of protein catabolic process
H0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
H0070682biological_processproteasome regulatory particle assembly
H0080090biological_processregulation of primary metabolic process
I0000166molecular_functionnucleotide binding
I0000502cellular_componentproteasome complex
I0005515molecular_functionprotein binding
I0005524molecular_functionATP binding
I0005634cellular_componentnucleus
I0005737cellular_componentcytoplasm
I0006511biological_processubiquitin-dependent protein catabolic process
I0008540cellular_componentproteasome regulatory particle, base subcomplex
I0010498biological_processproteasomal protein catabolic process
I0010604biological_processpositive regulation of macromolecule metabolic process
I0016887molecular_functionATP hydrolysis activity
I0031503biological_processprotein-containing complex localization
I0036402molecular_functionproteasome-activating activity
I0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
I0043171biological_processpeptide catabolic process
I0045732biological_processpositive regulation of protein catabolic process
I0070651biological_processnonfunctional rRNA decay
I0070682biological_processproteasome regulatory particle assembly
I0080090biological_processregulation of primary metabolic process
J0000166molecular_functionnucleotide binding
J0000502cellular_componentproteasome complex
J0005515molecular_functionprotein binding
J0005524molecular_functionATP binding
J0005634cellular_componentnucleus
J0005737cellular_componentcytoplasm
J0006289biological_processnucleotide-excision repair
J0006338biological_processchromatin remodeling
J0008540cellular_componentproteasome regulatory particle, base subcomplex
J0010498biological_processproteasomal protein catabolic process
J0010604biological_processpositive regulation of macromolecule metabolic process
J0016887molecular_functionATP hydrolysis activity
J0019904molecular_functionprotein domain specific binding
J0031625molecular_functionubiquitin protein ligase binding
J0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
J0034515cellular_componentproteasome storage granule
J0036402molecular_functionproteasome-activating activity
J0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
J0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
J0070651biological_processnonfunctional rRNA decay
J0070682biological_processproteasome regulatory particle assembly
J0080090biological_processregulation of primary metabolic process
K0000166molecular_functionnucleotide binding
K0000502cellular_componentproteasome complex
K0005515molecular_functionprotein binding
K0005524molecular_functionATP binding
K0005634cellular_componentnucleus
K0005737cellular_componentcytoplasm
K0006511biological_processubiquitin-dependent protein catabolic process
K0008540cellular_componentproteasome regulatory particle, base subcomplex
K0010498biological_processproteasomal protein catabolic process
K0010604biological_processpositive regulation of macromolecule metabolic process
K0016887molecular_functionATP hydrolysis activity
K0036402molecular_functionproteasome-activating activity
K0042802molecular_functionidentical protein binding
K0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
K0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
K0070682biological_processproteasome regulatory particle assembly
K0080090biological_processregulation of primary metabolic process
L0000166molecular_functionnucleotide binding
L0000502cellular_componentproteasome complex
L0005515molecular_functionprotein binding
L0005524molecular_functionATP binding
L0005634cellular_componentnucleus
L0006289biological_processnucleotide-excision repair
L0008540cellular_componentproteasome regulatory particle, base subcomplex
L0010498biological_processproteasomal protein catabolic process
L0010604biological_processpositive regulation of macromolecule metabolic process
L0016887molecular_functionATP hydrolysis activity
L0019904molecular_functionprotein domain specific binding
L0031625molecular_functionubiquitin protein ligase binding
L0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
L0036402molecular_functionproteasome-activating activity
L0036503biological_processERAD pathway
L0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
L0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
L0070682biological_processproteasome regulatory particle assembly
L0080090biological_processregulation of primary metabolic process
M0000166molecular_functionnucleotide binding
M0000502cellular_componentproteasome complex
M0005515molecular_functionprotein binding
M0005524molecular_functionATP binding
M0005634cellular_componentnucleus
M0005737cellular_componentcytoplasm
M0006511biological_processubiquitin-dependent protein catabolic process
M0008540cellular_componentproteasome regulatory particle, base subcomplex
M0010498biological_processproteasomal protein catabolic process
M0010604biological_processpositive regulation of macromolecule metabolic process
M0016887molecular_functionATP hydrolysis activity
M0036402molecular_functionproteasome-activating activity
M0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
M0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
M0070682biological_processproteasome regulatory particle assembly
M0080090biological_processregulation of primary metabolic process
Z0000502cellular_componentproteasome complex
Z0004175molecular_functionendopeptidase activity
Z0005515molecular_functionprotein binding
Z0005634cellular_componentnucleus
Z0005737cellular_componentcytoplasm
Z0005783cellular_componentendoplasmic reticulum
Z0006511biological_processubiquitin-dependent protein catabolic process
Z0008540cellular_componentproteasome regulatory particle, base subcomplex
Z0030234molecular_functionenzyme regulator activity
Z0030674molecular_functionprotein-macromolecule adaptor activity
Z0034515cellular_componentproteasome storage granule
Z0042176biological_processregulation of protein catabolic process
Z0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Functional Information from PROSITE/UniProt
site_idPS00299
Number of Residues26
DetailsUBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD
ChainResidueDetails
9LYS27-ASP52
site_idPS00674
Number of Residues19
DetailsAAA AAA-protein family signature. TkIImATNrpdtLDpALl.R
ChainResidueDetails
LTHR321-ARG339
HILE349-ARG367
MVAL321-ARG339
IVAL322-ARG340
JILE288-ARG306
KVAL312-ARG330
site_idPS00972
Number of Residues16
DetailsUSP_1 Ubiquitin specific protease (USP) domain signature 1. GFknmGNtCYLNAtLQ
ChainResidueDetails
8GLY110-GLN125
site_idPS00973
Number of Residues19
DetailsUSP_2 Ubiquitin specific protease (USP) domain signature 2. YnLiGVitHqGanses.GHY
ChainResidueDetails
8TYR430-TYR448
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues32
DetailsRepeat: {"description":"PC 1"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues37
DetailsRepeat: {"description":"PC 2"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues34
DetailsRepeat: {"description":"PC 3"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues40
DetailsRepeat: {"description":"PC 4"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues32
DetailsRepeat: {"description":"PC 5"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues31
DetailsRepeat: {"description":"PC 6"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues34
DetailsRepeat: {"description":"PC 7"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues64
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues29
DetailsCompositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues12
DetailsCompositional bias: {"description":"Low complexity","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues35
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues6
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues7
DetailsBinding site: {}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues1
DetailsModified residue: {"description":"N-acetylthreonine","evidences":[{"source":"PubMed","id":"12504901","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues1
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU10092","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10093","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues1
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10092","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10093","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

243083

PDB entries from 2025-10-15

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