Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7QO4

26S proteasome WT-Ubp6-UbVS complex in the si state (ATPases, Rpn1, Ubp6, and UbVS)

Functional Information from GO Data

Chain	GOid	namespace	contents
8	0000502	cellular_component	proteasome complex
8	0004843	molecular_function	cysteine-type deubiquitinase activity
8	0005838	cellular_component	proteasome regulatory particle
8	0006508	biological_process	proteolysis
8	0008234	molecular_function	cysteine-type peptidase activity
8	0016579	biological_process	protein deubiquitination
8	0032434	biological_process	regulation of proteasomal ubiquitin-dependent protein catabolic process
8	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
8	0061136	biological_process	regulation of proteasomal protein catabolic process
8	0070628	molecular_function	proteasome binding
8	0072671	biological_process	mitochondria-associated ubiquitin-dependent protein catabolic process
8	1901799	biological_process	negative regulation of proteasomal protein catabolic process
H	0000502	cellular_component	proteasome complex
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0008540	cellular_component	proteasome regulatory particle, base subcomplex
H	0010604	biological_process	positive regulation of macromolecule metabolic process
H	0016887	molecular_function	ATP hydrolysis activity
H	0031625	molecular_function	ubiquitin protein ligase binding
H	0036402	molecular_function	proteasome-activating activity
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0045732	biological_process	positive regulation of protein catabolic process
H	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
H	0070682	biological_process	proteasome regulatory particle assembly
H	1901800	biological_process	positive regulation of proteasomal protein catabolic process
I	0000502	cellular_component	proteasome complex
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0006511	biological_process	ubiquitin-dependent protein catabolic process
I	0008540	cellular_component	proteasome regulatory particle, base subcomplex
I	0010604	biological_process	positive regulation of macromolecule metabolic process
I	0016887	molecular_function	ATP hydrolysis activity
I	0031503	biological_process	protein-containing complex localization
I	0036402	molecular_function	proteasome-activating activity
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0043171	biological_process	peptide catabolic process
I	0045732	biological_process	positive regulation of protein catabolic process
I	0070651	biological_process	nonfunctional rRNA decay
I	0070682	biological_process	proteasome regulatory particle assembly
I	1901800	biological_process	positive regulation of proteasomal protein catabolic process
J	0000502	cellular_component	proteasome complex
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0006289	biological_process	nucleotide-excision repair
J	0006338	biological_process	chromatin remodeling
J	0008540	cellular_component	proteasome regulatory particle, base subcomplex
J	0010604	biological_process	positive regulation of macromolecule metabolic process
J	0016887	molecular_function	ATP hydrolysis activity
J	0019904	molecular_function	protein domain specific binding
J	0031625	molecular_function	ubiquitin protein ligase binding
J	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
J	0034515	cellular_component	proteasome storage granule
J	0036402	molecular_function	proteasome-activating activity
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
J	0070651	biological_process	nonfunctional rRNA decay
J	0070682	biological_process	proteasome regulatory particle assembly
J	1901800	biological_process	positive regulation of proteasomal protein catabolic process
K	0000502	cellular_component	proteasome complex
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
K	0008540	cellular_component	proteasome regulatory particle, base subcomplex
K	0010604	biological_process	positive regulation of macromolecule metabolic process
K	0016887	molecular_function	ATP hydrolysis activity
K	0036402	molecular_function	proteasome-activating activity
K	0042802	molecular_function	identical protein binding
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
K	0070682	biological_process	proteasome regulatory particle assembly
K	1901800	biological_process	positive regulation of proteasomal protein catabolic process
L	0000502	cellular_component	proteasome complex
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005634	cellular_component	nucleus
L	0006289	biological_process	nucleotide-excision repair
L	0008540	cellular_component	proteasome regulatory particle, base subcomplex
L	0010604	biological_process	positive regulation of macromolecule metabolic process
L	0016887	molecular_function	ATP hydrolysis activity
L	0019904	molecular_function	protein domain specific binding
L	0031597	cellular_component	cytosolic proteasome complex
L	0031625	molecular_function	ubiquitin protein ligase binding
L	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
L	0036402	molecular_function	proteasome-activating activity
L	0036503	biological_process	ERAD pathway
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
L	0070682	biological_process	proteasome regulatory particle assembly
L	1901800	biological_process	positive regulation of proteasomal protein catabolic process
M	0000502	cellular_component	proteasome complex
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0006511	biological_process	ubiquitin-dependent protein catabolic process
M	0008540	cellular_component	proteasome regulatory particle, base subcomplex
M	0010604	biological_process	positive regulation of macromolecule metabolic process
M	0016887	molecular_function	ATP hydrolysis activity
M	0036402	molecular_function	proteasome-activating activity
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
M	0070682	biological_process	proteasome regulatory particle assembly
M	1901800	biological_process	positive regulation of proteasomal protein catabolic process
Z	0000502	cellular_component	proteasome complex
Z	0004175	molecular_function	endopeptidase activity
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005737	cellular_component	cytoplasm
Z	0005783	cellular_component	endoplasmic reticulum
Z	0006511	biological_process	ubiquitin-dependent protein catabolic process
Z	0008540	cellular_component	proteasome regulatory particle, base subcomplex
Z	0030234	molecular_function	enzyme regulator activity
Z	0030674	molecular_function	protein-macromolecule adaptor activity
Z	0034515	cellular_component	proteasome storage granule
Z	0042176	biological_process	regulation of protein catabolic process
Z	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
9	LYS27-ASP52

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. TkIImATNrpdtLDpALl.R

Chain	Residue	Details
L	THR321-ARG339
K	VAL312-ARG330
J	ILE288-ARG306
M	VAL321-ARG339
I	VAL322-ARG340
H	ILE349-ARG367

site_id	PS00972
Number of Residues	16
Details	USP_1 Ubiquitin specific protease (USP) domain signature 1. GFknmGNtCYLNAtLQ

Chain	Residue	Details
8	GLY110-GLN125

site_id	PS00973
Number of Residues	19
Details	USP_2 Ubiquitin specific protease (USP) domain signature 2. YnLiGVitHqGanses.GHY

Chain	Residue	Details
8	TYR430-TYR448

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
M	GLY222
Z	SER178

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0000269\|PubMed:12504901, ECO:0007744\|PubMed:22814378

Chain	Residue	Details
M	ALA2
H	SER231

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:19779198

Chain	Residue	Details
M	TYR180
I	LYS255
I	LYS290

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18407956

Chain	Residue	Details
8	SER470
Z	SER695

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)