7QN7

Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with GABA, histamine and nanobody Nb25

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0004890	molecular_function	GABA-A receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0006821	biological_process	chloride transport
A	0007214	biological_process	gamma-aminobutyric acid signaling pathway
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0004890	molecular_function	GABA-A receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0004890	molecular_function	GABA-A receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0004890	molecular_function	GABA-A receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0004890	molecular_function	GABA-A receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00236
Number of Residues	15
Details	NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CmMdLrrYPlDeqnC

Chain	Residue	Details
B	CYS136-CYS150
E	CYS164-CYS178
A	CYS172-CYS186

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	223
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
B	ARG269-LYS279
C	GLN1-TYR220
C	ARG269-LYS279
D	GLN1-TYR220
D	ARG269-LYS279
E	MET25-GLY248

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site_id	SWS_FT_FI2
Number of Residues	88
Details	TRANSMEM: Helical => ECO:0000305

Chain	Residue	Details
E	VAL249-ILE271
D	ALA246-LEU268
D	ALA280-VAL302
D	TRP426-VAL447
E	ALA275-ALA297
E	ALA309-ALA331
E	TYR430-MET452
C	PHE221-ILE242
C	ALA246-LEU268
C	ALA280-VAL302
C	TRP426-VAL447
D	PHE221-ILE242

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site_id	SWS_FT_FI3
Number of Residues	97
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
E	HIS332-ILE429
B	ASN303-ARG425
C	ASN243-ASP245
C	ASN303-ARG425
D	ASN243-ASP245
D	ASN303-ARG425

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P18506

Chain	Residue	Details
E	SER390
C	PHE200
D	ASP95
D	PHE200
B	PHE200
C	ASP95

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site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
E	ASN103
E	ASN106
D	GLU155

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site_id	SWS_FT_FI6
Number of Residues	9
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24909990

Chain	Residue	Details
B	ASN8
B	ASN80
B	ASN149
C	ASN8
C	ASN80
C	ASN149
D	ASN8
D	ASN80
D	ASN149

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