7QJ6

Structure of recombinant human gamma-Tubulin Ring Complex 10-spoked assembly intermediate (spokes 3-12, substoichiometric spokes 13-14)

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000278	biological_process	mitotic cell cycle
C	0000922	cellular_component	spindle pole
C	0000930	cellular_component	gamma-tubulin complex
C	0001764	biological_process	neuron migration
C	0005515	molecular_function	protein binding
C	0005654	cellular_component	nucleoplasm
C	0005813	cellular_component	centrosome
C	0005815	cellular_component	microtubule organizing center
C	0005829	cellular_component	cytosol
C	0005874	cellular_component	microtubule
C	0005881	cellular_component	cytoplasmic microtubule
C	0007020	biological_process	microtubule nucleation
C	0007420	biological_process	brain development
C	0016020	cellular_component	membrane
C	0031122	biological_process	cytoplasmic microtubule organization
C	0036064	cellular_component	ciliary basal body
C	0043015	molecular_function	gamma-tubulin binding
C	0051011	molecular_function	microtubule minus-end binding
C	0051225	biological_process	spindle assembly
C	0051321	biological_process	meiotic cell cycle
C	0065003	biological_process	protein-containing complex assembly
D	0000226	biological_process	microtubule cytoskeleton organization
D	0000278	biological_process	mitotic cell cycle
D	0000922	cellular_component	spindle pole
D	0000930	cellular_component	gamma-tubulin complex
D	0005198	molecular_function	structural molecule activity
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005813	cellular_component	centrosome
D	0005814	cellular_component	centriole
D	0005815	cellular_component	microtubule organizing center
D	0005819	cellular_component	spindle
D	0005827	cellular_component	polar microtubule
D	0005829	cellular_component	cytosol
D	0005874	cellular_component	microtubule
D	0007020	biological_process	microtubule nucleation
D	0007338	biological_process	single fertilization
D	0016020	cellular_component	membrane
D	0031122	biological_process	cytoplasmic microtubule organization
D	0043015	molecular_function	gamma-tubulin binding
D	0051011	molecular_function	microtubule minus-end binding
D	0051225	biological_process	spindle assembly
D	0051321	biological_process	meiotic cell cycle
E	0000226	biological_process	microtubule cytoskeleton organization
E	0000278	biological_process	mitotic cell cycle
E	0000922	cellular_component	spindle pole
E	0000930	cellular_component	gamma-tubulin complex
E	0001764	biological_process	neuron migration
E	0005515	molecular_function	protein binding
E	0005654	cellular_component	nucleoplasm
E	0005813	cellular_component	centrosome
E	0005815	cellular_component	microtubule organizing center
E	0005829	cellular_component	cytosol
E	0005874	cellular_component	microtubule
E	0005881	cellular_component	cytoplasmic microtubule
E	0007020	biological_process	microtubule nucleation
E	0007420	biological_process	brain development
E	0016020	cellular_component	membrane
E	0031122	biological_process	cytoplasmic microtubule organization
E	0036064	cellular_component	ciliary basal body
E	0043015	molecular_function	gamma-tubulin binding
E	0051011	molecular_function	microtubule minus-end binding
E	0051225	biological_process	spindle assembly
E	0051321	biological_process	meiotic cell cycle
E	0065003	biological_process	protein-containing complex assembly
F	0000226	biological_process	microtubule cytoskeleton organization
F	0000278	biological_process	mitotic cell cycle
F	0000922	cellular_component	spindle pole
F	0000930	cellular_component	gamma-tubulin complex
F	0005198	molecular_function	structural molecule activity
F	0005200	molecular_function	structural constituent of cytoskeleton
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005813	cellular_component	centrosome
F	0005814	cellular_component	centriole
F	0005815	cellular_component	microtubule organizing center
F	0005819	cellular_component	spindle
F	0005827	cellular_component	polar microtubule
F	0005829	cellular_component	cytosol
F	0005874	cellular_component	microtubule
F	0007020	biological_process	microtubule nucleation
F	0007338	biological_process	single fertilization
F	0016020	cellular_component	membrane
F	0031122	biological_process	cytoplasmic microtubule organization
F	0043015	molecular_function	gamma-tubulin binding
F	0051011	molecular_function	microtubule minus-end binding
F	0051225	biological_process	spindle assembly
F	0051321	biological_process	meiotic cell cycle
G	0000226	biological_process	microtubule cytoskeleton organization
G	0000278	biological_process	mitotic cell cycle
G	0000922	cellular_component	spindle pole
G	0000930	cellular_component	gamma-tubulin complex
G	0001764	biological_process	neuron migration
G	0005515	molecular_function	protein binding
G	0005654	cellular_component	nucleoplasm
G	0005813	cellular_component	centrosome
G	0005815	cellular_component	microtubule organizing center
G	0005829	cellular_component	cytosol
G	0005874	cellular_component	microtubule
G	0005881	cellular_component	cytoplasmic microtubule
G	0007020	biological_process	microtubule nucleation
G	0007420	biological_process	brain development
G	0016020	cellular_component	membrane
G	0031122	biological_process	cytoplasmic microtubule organization
G	0036064	cellular_component	ciliary basal body
G	0043015	molecular_function	gamma-tubulin binding
G	0051011	molecular_function	microtubule minus-end binding
G	0051225	biological_process	spindle assembly
G	0051321	biological_process	meiotic cell cycle
G	0065003	biological_process	protein-containing complex assembly
H	0000226	biological_process	microtubule cytoskeleton organization
H	0000278	biological_process	mitotic cell cycle
H	0000922	cellular_component	spindle pole
H	0000930	cellular_component	gamma-tubulin complex
H	0005198	molecular_function	structural molecule activity
H	0005200	molecular_function	structural constituent of cytoskeleton
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005813	cellular_component	centrosome
H	0005814	cellular_component	centriole
H	0005815	cellular_component	microtubule organizing center
H	0005819	cellular_component	spindle
H	0005827	cellular_component	polar microtubule
H	0005829	cellular_component	cytosol
H	0005874	cellular_component	microtubule
H	0007020	biological_process	microtubule nucleation
H	0007338	biological_process	single fertilization
H	0016020	cellular_component	membrane
H	0031122	biological_process	cytoplasmic microtubule organization
H	0043015	molecular_function	gamma-tubulin binding
H	0051011	molecular_function	microtubule minus-end binding
H	0051225	biological_process	spindle assembly
H	0051321	biological_process	meiotic cell cycle
I	0000226	biological_process	microtubule cytoskeleton organization
I	0000278	biological_process	mitotic cell cycle
I	0000922	cellular_component	spindle pole
I	0000930	cellular_component	gamma-tubulin complex
I	0000931	cellular_component	gamma-tubulin ring complex
I	0005200	molecular_function	structural constituent of cytoskeleton
I	0005515	molecular_function	protein binding
I	0005813	cellular_component	centrosome
I	0005815	cellular_component	microtubule organizing center
I	0005829	cellular_component	cytosol
I	0005874	cellular_component	microtubule
I	0007020	biological_process	microtubule nucleation
I	0015630	cellular_component	microtubule cytoskeleton
I	0016020	cellular_component	membrane
I	0031122	biological_process	cytoplasmic microtubule organization
I	0043015	molecular_function	gamma-tubulin binding
I	0051011	molecular_function	microtubule minus-end binding
I	0051225	biological_process	spindle assembly
I	0051321	biological_process	meiotic cell cycle
I	0055037	cellular_component	recycling endosome
I	0065003	biological_process	protein-containing complex assembly
J	0000226	biological_process	microtubule cytoskeleton organization
J	0000278	biological_process	mitotic cell cycle
J	0000922	cellular_component	spindle pole
J	0000930	cellular_component	gamma-tubulin complex
J	0000931	cellular_component	gamma-tubulin ring complex
J	0005515	molecular_function	protein binding
J	0005813	cellular_component	centrosome
J	0005815	cellular_component	microtubule organizing center
J	0005829	cellular_component	cytosol
J	0005874	cellular_component	microtubule
J	0005929	cellular_component	cilium
J	0007020	biological_process	microtubule nucleation
J	0008017	molecular_function	microtubule binding
J	0031122	biological_process	cytoplasmic microtubule organization
J	0035869	cellular_component	ciliary transition zone
J	0036064	cellular_component	ciliary basal body
J	0043015	molecular_function	gamma-tubulin binding
J	0051011	molecular_function	microtubule minus-end binding
J	0051225	biological_process	spindle assembly
J	0051321	biological_process	meiotic cell cycle
K	0000226	biological_process	microtubule cytoskeleton organization
K	0000278	biological_process	mitotic cell cycle
K	0000922	cellular_component	spindle pole
K	0000930	cellular_component	gamma-tubulin complex
K	0000931	cellular_component	gamma-tubulin ring complex
K	0005200	molecular_function	structural constituent of cytoskeleton
K	0005515	molecular_function	protein binding
K	0005813	cellular_component	centrosome
K	0005815	cellular_component	microtubule organizing center
K	0005829	cellular_component	cytosol
K	0005874	cellular_component	microtubule
K	0007020	biological_process	microtubule nucleation
K	0015630	cellular_component	microtubule cytoskeleton
K	0016020	cellular_component	membrane
K	0031122	biological_process	cytoplasmic microtubule organization
K	0043015	molecular_function	gamma-tubulin binding
K	0051011	molecular_function	microtubule minus-end binding
K	0051225	biological_process	spindle assembly
K	0051321	biological_process	meiotic cell cycle
K	0055037	cellular_component	recycling endosome
K	0065003	biological_process	protein-containing complex assembly
L	0000226	biological_process	microtubule cytoskeleton organization
L	0000278	biological_process	mitotic cell cycle
L	0000922	cellular_component	spindle pole
L	0000930	cellular_component	gamma-tubulin complex
L	0000931	cellular_component	gamma-tubulin ring complex
L	0005813	cellular_component	centrosome
L	0005815	cellular_component	microtubule organizing center
L	0005829	cellular_component	cytosol
L	0005874	cellular_component	microtubule
L	0007020	biological_process	microtubule nucleation
L	0008017	molecular_function	microtubule binding
L	0016020	cellular_component	membrane
L	0031122	biological_process	cytoplasmic microtubule organization
L	0043015	molecular_function	gamma-tubulin binding
L	0051011	molecular_function	microtubule minus-end binding
L	0051225	biological_process	spindle assembly
L	0051321	biological_process	meiotic cell cycle
Q	0000070	biological_process	mitotic sister chromatid segregation
Q	0000166	molecular_function	nucleotide binding
Q	0000212	biological_process	meiotic spindle organization
Q	0000226	biological_process	microtubule cytoskeleton organization
Q	0000242	cellular_component	pericentriolar material
Q	0000278	biological_process	mitotic cell cycle
Q	0000794	cellular_component	condensed nuclear chromosome
Q	0000930	cellular_component	gamma-tubulin complex
Q	0000931	cellular_component	gamma-tubulin ring complex
Q	0005200	molecular_function	structural constituent of cytoskeleton
Q	0005515	molecular_function	protein binding
Q	0005525	molecular_function	GTP binding
Q	0005634	cellular_component	nucleus
Q	0005737	cellular_component	cytoplasm
Q	0005813	cellular_component	centrosome
Q	0005814	cellular_component	centriole
Q	0005819	cellular_component	spindle
Q	0005827	cellular_component	polar microtubule
Q	0005829	cellular_component	cytosol
Q	0005874	cellular_component	microtubule
Q	0005876	cellular_component	spindle microtubule
Q	0005881	cellular_component	cytoplasmic microtubule
Q	0005929	cellular_component	cilium
Q	0007017	biological_process	microtubule-based process
Q	0007020	biological_process	microtubule nucleation
Q	0007052	biological_process	mitotic spindle organization
Q	0015630	cellular_component	microtubule cytoskeleton
Q	0031122	biological_process	cytoplasmic microtubule organization
Q	0031252	cellular_component	cell leading edge
Q	0036064	cellular_component	ciliary basal body
Q	0042802	molecular_function	identical protein binding
Q	0043005	cellular_component	neuron projection
Q	0045177	cellular_component	apical part of cell
Q	0055037	cellular_component	recycling endosome
Q	0097730	cellular_component	non-motile cilium
Q	0140490	molecular_function	microtubule nucleator activity
Q	1990498	cellular_component	mitotic spindle microtubule
R	0000070	biological_process	mitotic sister chromatid segregation
R	0000166	molecular_function	nucleotide binding
R	0000212	biological_process	meiotic spindle organization
R	0000226	biological_process	microtubule cytoskeleton organization
R	0000242	cellular_component	pericentriolar material
R	0000278	biological_process	mitotic cell cycle
R	0000794	cellular_component	condensed nuclear chromosome
R	0000930	cellular_component	gamma-tubulin complex
R	0000931	cellular_component	gamma-tubulin ring complex
R	0005200	molecular_function	structural constituent of cytoskeleton
R	0005515	molecular_function	protein binding
R	0005525	molecular_function	GTP binding
R	0005634	cellular_component	nucleus
R	0005737	cellular_component	cytoplasm
R	0005813	cellular_component	centrosome
R	0005814	cellular_component	centriole
R	0005819	cellular_component	spindle
R	0005827	cellular_component	polar microtubule
R	0005829	cellular_component	cytosol
R	0005874	cellular_component	microtubule
R	0005876	cellular_component	spindle microtubule
R	0005881	cellular_component	cytoplasmic microtubule
R	0005929	cellular_component	cilium
R	0007017	biological_process	microtubule-based process
R	0007020	biological_process	microtubule nucleation
R	0007052	biological_process	mitotic spindle organization
R	0015630	cellular_component	microtubule cytoskeleton
R	0031122	biological_process	cytoplasmic microtubule organization
R	0031252	cellular_component	cell leading edge
R	0036064	cellular_component	ciliary basal body
R	0042802	molecular_function	identical protein binding
R	0043005	cellular_component	neuron projection
R	0045177	cellular_component	apical part of cell
R	0055037	cellular_component	recycling endosome
R	0097730	cellular_component	non-motile cilium
R	0140490	molecular_function	microtubule nucleator activity
R	1990498	cellular_component	mitotic spindle microtubule
S	0000070	biological_process	mitotic sister chromatid segregation
S	0000166	molecular_function	nucleotide binding
S	0000212	biological_process	meiotic spindle organization
S	0000226	biological_process	microtubule cytoskeleton organization
S	0000242	cellular_component	pericentriolar material
S	0000278	biological_process	mitotic cell cycle
S	0000794	cellular_component	condensed nuclear chromosome
S	0000930	cellular_component	gamma-tubulin complex
S	0000931	cellular_component	gamma-tubulin ring complex
S	0005200	molecular_function	structural constituent of cytoskeleton
S	0005515	molecular_function	protein binding
S	0005525	molecular_function	GTP binding
S	0005634	cellular_component	nucleus
S	0005737	cellular_component	cytoplasm
S	0005813	cellular_component	centrosome
S	0005814	cellular_component	centriole
S	0005819	cellular_component	spindle
S	0005827	cellular_component	polar microtubule
S	0005829	cellular_component	cytosol
S	0005874	cellular_component	microtubule
S	0005876	cellular_component	spindle microtubule
S	0005881	cellular_component	cytoplasmic microtubule
S	0005929	cellular_component	cilium
S	0007017	biological_process	microtubule-based process
S	0007020	biological_process	microtubule nucleation
S	0007052	biological_process	mitotic spindle organization
S	0015630	cellular_component	microtubule cytoskeleton
S	0031122	biological_process	cytoplasmic microtubule organization
S	0031252	cellular_component	cell leading edge
S	0036064	cellular_component	ciliary basal body
S	0042802	molecular_function	identical protein binding
S	0043005	cellular_component	neuron projection
S	0045177	cellular_component	apical part of cell
S	0055037	cellular_component	recycling endosome
S	0097730	cellular_component	non-motile cilium
S	0140490	molecular_function	microtubule nucleator activity
S	1990498	cellular_component	mitotic spindle microtubule
T	0000070	biological_process	mitotic sister chromatid segregation
T	0000166	molecular_function	nucleotide binding
T	0000212	biological_process	meiotic spindle organization
T	0000226	biological_process	microtubule cytoskeleton organization
T	0000242	cellular_component	pericentriolar material
T	0000278	biological_process	mitotic cell cycle
T	0000794	cellular_component	condensed nuclear chromosome
T	0000930	cellular_component	gamma-tubulin complex
T	0000931	cellular_component	gamma-tubulin ring complex
T	0005200	molecular_function	structural constituent of cytoskeleton
T	0005515	molecular_function	protein binding
T	0005525	molecular_function	GTP binding
T	0005634	cellular_component	nucleus
T	0005737	cellular_component	cytoplasm
T	0005813	cellular_component	centrosome
T	0005814	cellular_component	centriole
T	0005819	cellular_component	spindle
T	0005827	cellular_component	polar microtubule
T	0005829	cellular_component	cytosol
T	0005874	cellular_component	microtubule
T	0005876	cellular_component	spindle microtubule
T	0005881	cellular_component	cytoplasmic microtubule
T	0005929	cellular_component	cilium
T	0007017	biological_process	microtubule-based process
T	0007020	biological_process	microtubule nucleation
T	0007052	biological_process	mitotic spindle organization
T	0015630	cellular_component	microtubule cytoskeleton
T	0031122	biological_process	cytoplasmic microtubule organization
T	0031252	cellular_component	cell leading edge
T	0036064	cellular_component	ciliary basal body
T	0042802	molecular_function	identical protein binding
T	0043005	cellular_component	neuron projection
T	0045177	cellular_component	apical part of cell
T	0055037	cellular_component	recycling endosome
T	0097730	cellular_component	non-motile cilium
T	0140490	molecular_function	microtubule nucleator activity
T	1990498	cellular_component	mitotic spindle microtubule
U	0000070	biological_process	mitotic sister chromatid segregation
U	0000166	molecular_function	nucleotide binding
U	0000212	biological_process	meiotic spindle organization
U	0000226	biological_process	microtubule cytoskeleton organization
U	0000242	cellular_component	pericentriolar material
U	0000278	biological_process	mitotic cell cycle
U	0000794	cellular_component	condensed nuclear chromosome
U	0000930	cellular_component	gamma-tubulin complex
U	0000931	cellular_component	gamma-tubulin ring complex
U	0005200	molecular_function	structural constituent of cytoskeleton
U	0005515	molecular_function	protein binding
U	0005525	molecular_function	GTP binding
U	0005634	cellular_component	nucleus
U	0005737	cellular_component	cytoplasm
U	0005813	cellular_component	centrosome
U	0005814	cellular_component	centriole
U	0005819	cellular_component	spindle
U	0005827	cellular_component	polar microtubule
U	0005829	cellular_component	cytosol
U	0005874	cellular_component	microtubule
U	0005876	cellular_component	spindle microtubule
U	0005881	cellular_component	cytoplasmic microtubule
U	0005929	cellular_component	cilium
U	0007017	biological_process	microtubule-based process
U	0007020	biological_process	microtubule nucleation
U	0007052	biological_process	mitotic spindle organization
U	0015630	cellular_component	microtubule cytoskeleton
U	0031122	biological_process	cytoplasmic microtubule organization
U	0031252	cellular_component	cell leading edge
U	0036064	cellular_component	ciliary basal body
U	0042802	molecular_function	identical protein binding
U	0043005	cellular_component	neuron projection
U	0045177	cellular_component	apical part of cell
U	0055037	cellular_component	recycling endosome
U	0097730	cellular_component	non-motile cilium
U	0140490	molecular_function	microtubule nucleator activity
U	1990498	cellular_component	mitotic spindle microtubule
V	0000070	biological_process	mitotic sister chromatid segregation
V	0000166	molecular_function	nucleotide binding
V	0000212	biological_process	meiotic spindle organization
V	0000226	biological_process	microtubule cytoskeleton organization
V	0000242	cellular_component	pericentriolar material
V	0000278	biological_process	mitotic cell cycle
V	0000794	cellular_component	condensed nuclear chromosome
V	0000930	cellular_component	gamma-tubulin complex
V	0000931	cellular_component	gamma-tubulin ring complex
V	0005200	molecular_function	structural constituent of cytoskeleton
V	0005515	molecular_function	protein binding
V	0005525	molecular_function	GTP binding
V	0005634	cellular_component	nucleus
V	0005737	cellular_component	cytoplasm
V	0005813	cellular_component	centrosome
V	0005814	cellular_component	centriole
V	0005819	cellular_component	spindle
V	0005827	cellular_component	polar microtubule
V	0005829	cellular_component	cytosol
V	0005874	cellular_component	microtubule
V	0005876	cellular_component	spindle microtubule
V	0005881	cellular_component	cytoplasmic microtubule
V	0005929	cellular_component	cilium
V	0007017	biological_process	microtubule-based process
V	0007020	biological_process	microtubule nucleation
V	0007052	biological_process	mitotic spindle organization
V	0015630	cellular_component	microtubule cytoskeleton
V	0031122	biological_process	cytoplasmic microtubule organization
V	0031252	cellular_component	cell leading edge
V	0036064	cellular_component	ciliary basal body
V	0042802	molecular_function	identical protein binding
V	0043005	cellular_component	neuron projection
V	0045177	cellular_component	apical part of cell
V	0055037	cellular_component	recycling endosome
V	0097730	cellular_component	non-motile cilium
V	0140490	molecular_function	microtubule nucleator activity
V	1990498	cellular_component	mitotic spindle microtubule
W	0000070	biological_process	mitotic sister chromatid segregation
W	0000166	molecular_function	nucleotide binding
W	0000212	biological_process	meiotic spindle organization
W	0000226	biological_process	microtubule cytoskeleton organization
W	0000242	cellular_component	pericentriolar material
W	0000278	biological_process	mitotic cell cycle
W	0000794	cellular_component	condensed nuclear chromosome
W	0000930	cellular_component	gamma-tubulin complex
W	0000931	cellular_component	gamma-tubulin ring complex
W	0005200	molecular_function	structural constituent of cytoskeleton
W	0005515	molecular_function	protein binding
W	0005525	molecular_function	GTP binding
W	0005634	cellular_component	nucleus
W	0005737	cellular_component	cytoplasm
W	0005813	cellular_component	centrosome
W	0005814	cellular_component	centriole
W	0005819	cellular_component	spindle
W	0005827	cellular_component	polar microtubule
W	0005829	cellular_component	cytosol
W	0005874	cellular_component	microtubule
W	0005876	cellular_component	spindle microtubule
W	0005881	cellular_component	cytoplasmic microtubule
W	0005929	cellular_component	cilium
W	0007017	biological_process	microtubule-based process
W	0007020	biological_process	microtubule nucleation
W	0007052	biological_process	mitotic spindle organization
W	0015630	cellular_component	microtubule cytoskeleton
W	0031122	biological_process	cytoplasmic microtubule organization
W	0031252	cellular_component	cell leading edge
W	0036064	cellular_component	ciliary basal body
W	0042802	molecular_function	identical protein binding
W	0043005	cellular_component	neuron projection
W	0045177	cellular_component	apical part of cell
W	0055037	cellular_component	recycling endosome
W	0097730	cellular_component	non-motile cilium
W	0140490	molecular_function	microtubule nucleator activity
W	1990498	cellular_component	mitotic spindle microtubule
X	0000070	biological_process	mitotic sister chromatid segregation
X	0000166	molecular_function	nucleotide binding
X	0000212	biological_process	meiotic spindle organization
X	0000226	biological_process	microtubule cytoskeleton organization
X	0000242	cellular_component	pericentriolar material
X	0000278	biological_process	mitotic cell cycle
X	0000794	cellular_component	condensed nuclear chromosome
X	0000930	cellular_component	gamma-tubulin complex
X	0000931	cellular_component	gamma-tubulin ring complex
X	0005200	molecular_function	structural constituent of cytoskeleton
X	0005515	molecular_function	protein binding
X	0005525	molecular_function	GTP binding
X	0005634	cellular_component	nucleus
X	0005737	cellular_component	cytoplasm
X	0005813	cellular_component	centrosome
X	0005814	cellular_component	centriole
X	0005819	cellular_component	spindle
X	0005827	cellular_component	polar microtubule
X	0005829	cellular_component	cytosol
X	0005874	cellular_component	microtubule
X	0005876	cellular_component	spindle microtubule
X	0005881	cellular_component	cytoplasmic microtubule
X	0005929	cellular_component	cilium
X	0007017	biological_process	microtubule-based process
X	0007020	biological_process	microtubule nucleation
X	0007052	biological_process	mitotic spindle organization
X	0015630	cellular_component	microtubule cytoskeleton
X	0031122	biological_process	cytoplasmic microtubule organization
X	0031252	cellular_component	cell leading edge
X	0036064	cellular_component	ciliary basal body
X	0042802	molecular_function	identical protein binding
X	0043005	cellular_component	neuron projection
X	0045177	cellular_component	apical part of cell
X	0055037	cellular_component	recycling endosome
X	0097730	cellular_component	non-motile cilium
X	0140490	molecular_function	microtubule nucleator activity
X	1990498	cellular_component	mitotic spindle microtubule
Y	0000070	biological_process	mitotic sister chromatid segregation
Y	0000166	molecular_function	nucleotide binding
Y	0000212	biological_process	meiotic spindle organization
Y	0000226	biological_process	microtubule cytoskeleton organization
Y	0000242	cellular_component	pericentriolar material
Y	0000278	biological_process	mitotic cell cycle
Y	0000794	cellular_component	condensed nuclear chromosome
Y	0000930	cellular_component	gamma-tubulin complex
Y	0000931	cellular_component	gamma-tubulin ring complex
Y	0005200	molecular_function	structural constituent of cytoskeleton
Y	0005515	molecular_function	protein binding
Y	0005525	molecular_function	GTP binding
Y	0005634	cellular_component	nucleus
Y	0005737	cellular_component	cytoplasm
Y	0005813	cellular_component	centrosome
Y	0005814	cellular_component	centriole
Y	0005819	cellular_component	spindle
Y	0005827	cellular_component	polar microtubule
Y	0005829	cellular_component	cytosol
Y	0005874	cellular_component	microtubule
Y	0005876	cellular_component	spindle microtubule
Y	0005881	cellular_component	cytoplasmic microtubule
Y	0005929	cellular_component	cilium
Y	0007017	biological_process	microtubule-based process
Y	0007020	biological_process	microtubule nucleation
Y	0007052	biological_process	mitotic spindle organization
Y	0015630	cellular_component	microtubule cytoskeleton
Y	0031122	biological_process	cytoplasmic microtubule organization
Y	0031252	cellular_component	cell leading edge
Y	0036064	cellular_component	ciliary basal body
Y	0042802	molecular_function	identical protein binding
Y	0043005	cellular_component	neuron projection
Y	0045177	cellular_component	apical part of cell
Y	0055037	cellular_component	recycling endosome
Y	0097730	cellular_component	non-motile cilium
Y	0140490	molecular_function	microtubule nucleator activity
Y	1990498	cellular_component	mitotic spindle microtubule
Z	0000070	biological_process	mitotic sister chromatid segregation
Z	0000166	molecular_function	nucleotide binding
Z	0000212	biological_process	meiotic spindle organization
Z	0000226	biological_process	microtubule cytoskeleton organization
Z	0000242	cellular_component	pericentriolar material
Z	0000278	biological_process	mitotic cell cycle
Z	0000794	cellular_component	condensed nuclear chromosome
Z	0000930	cellular_component	gamma-tubulin complex
Z	0000931	cellular_component	gamma-tubulin ring complex
Z	0005200	molecular_function	structural constituent of cytoskeleton
Z	0005515	molecular_function	protein binding
Z	0005525	molecular_function	GTP binding
Z	0005634	cellular_component	nucleus
Z	0005737	cellular_component	cytoplasm
Z	0005813	cellular_component	centrosome
Z	0005814	cellular_component	centriole
Z	0005819	cellular_component	spindle
Z	0005827	cellular_component	polar microtubule
Z	0005829	cellular_component	cytosol
Z	0005874	cellular_component	microtubule
Z	0005876	cellular_component	spindle microtubule
Z	0005881	cellular_component	cytoplasmic microtubule
Z	0005929	cellular_component	cilium
Z	0007017	biological_process	microtubule-based process
Z	0007020	biological_process	microtubule nucleation
Z	0007052	biological_process	mitotic spindle organization
Z	0015630	cellular_component	microtubule cytoskeleton
Z	0031122	biological_process	cytoplasmic microtubule organization
Z	0031252	cellular_component	cell leading edge
Z	0036064	cellular_component	ciliary basal body
Z	0042802	molecular_function	identical protein binding
Z	0043005	cellular_component	neuron projection
Z	0045177	cellular_component	apical part of cell
Z	0055037	cellular_component	recycling endosome
Z	0097730	cellular_component	non-motile cilium
Z	0140490	molecular_function	microtubule nucleator activity
Z	1990498	cellular_component	mitotic spindle microtubule
a	0000226	biological_process	microtubule cytoskeleton organization
a	0000278	biological_process	mitotic cell cycle
a	0000922	cellular_component	spindle pole
a	0000930	cellular_component	gamma-tubulin complex
a	0005198	molecular_function	structural molecule activity
a	0005200	molecular_function	structural constituent of cytoskeleton
a	0005515	molecular_function	protein binding
a	0005737	cellular_component	cytoplasm
a	0005813	cellular_component	centrosome
a	0005814	cellular_component	centriole
a	0005815	cellular_component	microtubule organizing center
a	0005819	cellular_component	spindle
a	0005827	cellular_component	polar microtubule
a	0005829	cellular_component	cytosol
a	0005874	cellular_component	microtubule
a	0007020	biological_process	microtubule nucleation
a	0007338	biological_process	single fertilization
a	0016020	cellular_component	membrane
a	0031122	biological_process	cytoplasmic microtubule organization
a	0043015	molecular_function	gamma-tubulin binding
a	0051011	molecular_function	microtubule minus-end binding
a	0051225	biological_process	spindle assembly
a	0051321	biological_process	meiotic cell cycle
b	0000931	cellular_component	gamma-tubulin ring complex
b	0005515	molecular_function	protein binding
b	0005813	cellular_component	centrosome
b	0005819	cellular_component	spindle
b	0005829	cellular_component	cytosol
b	0031021	cellular_component	interphase microtubule organizing center
b	0033566	biological_process	gamma-tubulin complex localization
b	0051415	biological_process	microtubule nucleation by interphase microtubule organizing center
b	0090307	biological_process	mitotic spindle assembly
c	0000226	biological_process	microtubule cytoskeleton organization
c	0000278	biological_process	mitotic cell cycle
c	0000922	cellular_component	spindle pole
c	0000930	cellular_component	gamma-tubulin complex
c	0000931	cellular_component	gamma-tubulin ring complex
c	0005813	cellular_component	centrosome
c	0005815	cellular_component	microtubule organizing center
c	0005829	cellular_component	cytosol
c	0005874	cellular_component	microtubule
c	0007020	biological_process	microtubule nucleation
c	0008017	molecular_function	microtubule binding
c	0016020	cellular_component	membrane
c	0031122	biological_process	cytoplasmic microtubule organization
c	0043015	molecular_function	gamma-tubulin binding
c	0051011	molecular_function	microtubule minus-end binding
c	0051225	biological_process	spindle assembly
c	0051321	biological_process	meiotic cell cycle
d	0000931	cellular_component	gamma-tubulin ring complex
d	0005515	molecular_function	protein binding
d	0005813	cellular_component	centrosome
d	0005819	cellular_component	spindle
d	0005829	cellular_component	cytosol
d	0031021	cellular_component	interphase microtubule organizing center
d	0033566	biological_process	gamma-tubulin complex localization
d	0051415	biological_process	microtubule nucleation by interphase microtubule organizing center
d	0090307	biological_process	mitotic spindle assembly
e	0000166	molecular_function	nucleotide binding
e	0000776	cellular_component	kinetochore
e	0000785	cellular_component	chromatin
e	0000786	cellular_component	nucleosome
e	0001738	biological_process	morphogenesis of a polarized epithelium
e	0005200	molecular_function	structural constituent of cytoskeleton
e	0005515	molecular_function	protein binding
e	0005524	molecular_function	ATP binding
e	0005615	cellular_component	extracellular space
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005737	cellular_component	cytoplasm
e	0005829	cellular_component	cytosol
e	0005856	cellular_component	cytoskeleton
e	0005884	cellular_component	actin filament
e	0005886	cellular_component	plasma membrane
e	0005903	cellular_component	brush border
e	0005911	cellular_component	cell-cell junction
e	0005912	cellular_component	adherens junction
e	0005925	cellular_component	focal adhesion
e	0006338	biological_process	chromatin remodeling
e	0006357	biological_process	regulation of transcription by RNA polymerase II
e	0007010	biological_process	cytoskeleton organization
e	0007163	biological_process	establishment or maintenance of cell polarity
e	0007409	biological_process	axonogenesis
e	0008284	biological_process	positive regulation of cell population proliferation
e	0015629	cellular_component	actin cytoskeleton
e	0016020	cellular_component	membrane
e	0016363	cellular_component	nuclear matrix
e	0016514	cellular_component	SWI/SNF complex
e	0016586	cellular_component	RSC-type complex
e	0016787	molecular_function	hydrolase activity
e	0016887	molecular_function	ATP hydrolysis activity
e	0019894	molecular_function	kinesin binding
e	0019901	molecular_function	protein kinase binding
e	0021762	biological_process	substantia nigra development
e	0030027	cellular_component	lamellipodium
e	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
e	0030235	molecular_function	nitric-oxide synthase regulator activity
e	0030424	cellular_component	axon
e	0030863	cellular_component	cortical cytoskeleton
e	0030957	molecular_function	Tat protein binding
e	0031492	molecular_function	nucleosomal DNA binding
e	0031982	cellular_component	vesicle
e	0032991	cellular_component	protein-containing complex
e	0034333	biological_process	adherens junction assembly
e	0035060	cellular_component	brahma complex
e	0035267	cellular_component	NuA4 histone acetyltransferase complex
e	0035633	biological_process	maintenance of blood-brain barrier
e	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
e	0042802	molecular_function	identical protein binding
e	0042981	biological_process	regulation of apoptotic process
e	0043296	cellular_component	apical junction complex
e	0044305	cellular_component	calyx of Held
e	0045176	biological_process	apical protein localization
e	0045202	cellular_component	synapse
e	0045582	biological_process	positive regulation of T cell differentiation
e	0045596	biological_process	negative regulation of cell differentiation
e	0045597	biological_process	positive regulation of cell differentiation
e	0045663	biological_process	positive regulation of myoblast differentiation
e	0045893	biological_process	positive regulation of DNA-templated transcription
e	0048156	molecular_function	tau protein binding
e	0048870	biological_process	cell motility
e	0050998	molecular_function	nitric-oxide synthase binding
e	0051621	biological_process	regulation of norepinephrine uptake
e	0051623	biological_process	positive regulation of norepinephrine uptake
e	0051726	biological_process	regulation of cell cycle
e	0070062	cellular_component	extracellular exosome
e	0070160	cellular_component	tight junction
e	0070316	biological_process	regulation of G0 to G1 transition
e	0070527	biological_process	platelet aggregation
e	0071564	cellular_component	npBAF complex
e	0071565	cellular_component	nBAF complex
e	0071896	biological_process	protein localization to adherens junction
e	0072562	cellular_component	blood microparticle
e	0072749	biological_process	cellular response to cytochalasin B
e	0097433	cellular_component	dense body
e	0098685	cellular_component	Schaffer collateral - CA1 synapse
e	0098793	cellular_component	presynapse
e	0098871	cellular_component	postsynaptic actin cytoskeleton
e	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
e	0098974	biological_process	postsynaptic actin cytoskeleton organization
e	0098978	cellular_component	glutamatergic synapse
e	0140092	cellular_component	bBAF complex
e	0140288	cellular_component	GBAF complex
e	0141108	molecular_function	transporter regulator activity
e	0150111	biological_process	regulation of transepithelial transport
e	1900242	biological_process	regulation of synaptic vesicle endocytosis
e	1902459	biological_process	positive regulation of stem cell population maintenance
e	1903076	biological_process	regulation of protein localization to plasma membrane
e	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
e	1990904	cellular_component	ribonucleoprotein complex
e	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
e	2000779	biological_process	regulation of double-strand break repair
e	2000781	biological_process	positive regulation of double-strand break repair
e	2000819	biological_process	regulation of nucleotide-excision repair
h	0000226	biological_process	microtubule cytoskeleton organization
h	0000278	biological_process	mitotic cell cycle
h	0000922	cellular_component	spindle pole
h	0000930	cellular_component	gamma-tubulin complex
h	0005198	molecular_function	structural molecule activity
h	0005200	molecular_function	structural constituent of cytoskeleton
h	0005515	molecular_function	protein binding
h	0005737	cellular_component	cytoplasm
h	0005813	cellular_component	centrosome
h	0005814	cellular_component	centriole
h	0005815	cellular_component	microtubule organizing center
h	0005819	cellular_component	spindle
h	0005827	cellular_component	polar microtubule
h	0005829	cellular_component	cytosol
h	0005874	cellular_component	microtubule
h	0007020	biological_process	microtubule nucleation
h	0007338	biological_process	single fertilization
h	0016020	cellular_component	membrane
h	0031122	biological_process	cytoplasmic microtubule organization
h	0043015	molecular_function	gamma-tubulin binding
h	0051011	molecular_function	microtubule minus-end binding
h	0051225	biological_process	spindle assembly
h	0051321	biological_process	meiotic cell cycle
i	0000931	cellular_component	gamma-tubulin ring complex
i	0005515	molecular_function	protein binding
i	0005813	cellular_component	centrosome
i	0005819	cellular_component	spindle
i	0005829	cellular_component	cytosol
i	0031021	cellular_component	interphase microtubule organizing center
i	0033566	biological_process	gamma-tubulin complex localization
i	0051415	biological_process	microtubule nucleation by interphase microtubule organizing center
i	0090307	biological_process	mitotic spindle assembly
j	0000226	biological_process	microtubule cytoskeleton organization
j	0000278	biological_process	mitotic cell cycle
j	0000922	cellular_component	spindle pole
j	0000930	cellular_component	gamma-tubulin complex
j	0005198	molecular_function	structural molecule activity
j	0005200	molecular_function	structural constituent of cytoskeleton
j	0005515	molecular_function	protein binding
j	0005737	cellular_component	cytoplasm
j	0005813	cellular_component	centrosome
j	0005814	cellular_component	centriole
j	0005815	cellular_component	microtubule organizing center
j	0005819	cellular_component	spindle
j	0005827	cellular_component	polar microtubule
j	0005829	cellular_component	cytosol
j	0005874	cellular_component	microtubule
j	0007020	biological_process	microtubule nucleation
j	0007338	biological_process	single fertilization
j	0016020	cellular_component	membrane
j	0031122	biological_process	cytoplasmic microtubule organization
j	0043015	molecular_function	gamma-tubulin binding
j	0051011	molecular_function	microtubule minus-end binding
j	0051225	biological_process	spindle assembly
j	0051321	biological_process	meiotic cell cycle
k	0000931	cellular_component	gamma-tubulin ring complex
k	0005515	molecular_function	protein binding
k	0005813	cellular_component	centrosome
k	0005819	cellular_component	spindle
k	0005829	cellular_component	cytosol
k	0031021	cellular_component	interphase microtubule organizing center
k	0033566	biological_process	gamma-tubulin complex localization
k	0051415	biological_process	microtubule nucleation by interphase microtubule organizing center
k	0090307	biological_process	mitotic spindle assembly
l	0000226	biological_process	microtubule cytoskeleton organization
l	0000278	biological_process	mitotic cell cycle
l	0000922	cellular_component	spindle pole
l	0000930	cellular_component	gamma-tubulin complex
l	0000931	cellular_component	gamma-tubulin ring complex
l	0005515	molecular_function	protein binding
l	0005813	cellular_component	centrosome
l	0005815	cellular_component	microtubule organizing center
l	0005829	cellular_component	cytosol
l	0005874	cellular_component	microtubule
l	0005929	cellular_component	cilium
l	0007020	biological_process	microtubule nucleation
l	0008017	molecular_function	microtubule binding
l	0031122	biological_process	cytoplasmic microtubule organization
l	0035869	cellular_component	ciliary transition zone
l	0036064	cellular_component	ciliary basal body
l	0043015	molecular_function	gamma-tubulin binding
l	0051011	molecular_function	microtubule minus-end binding
l	0051225	biological_process	spindle assembly
l	0051321	biological_process	meiotic cell cycle
m	0000931	cellular_component	gamma-tubulin ring complex
m	0005515	molecular_function	protein binding
m	0005813	cellular_component	centrosome
m	0005819	cellular_component	spindle
m	0005829	cellular_component	cytosol
m	0031021	cellular_component	interphase microtubule organizing center
m	0033566	biological_process	gamma-tubulin complex localization
m	0051415	biological_process	microtubule nucleation by interphase microtubule organizing center
m	0090307	biological_process	mitotic spindle assembly

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. AGGTGSG

Chain	Residue	Details
Q	ALA142-GLY148

---

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
e	TYR53-GLY63

---

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WISKqEYDE

Chain	Residue	Details
e	TRP356-GLU364

---

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
e	LEU104-ARG116

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"N-acetylaspartate; in Actin, cytoplasmic 1, N-terminally processed","evidences":[{"source":"PubMed","id":"29581253","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30028079","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2005","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"PubMed","id":"30526847","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30626964","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30785395","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31388018","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32503840","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"PubMed","id":"23673617","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Cross-link: {"description":"(Microbial infection) Isoglutamyl lysine isopeptide (Lys-Glu) (interchain with E-270); by Vibrio toxins RtxA and VgrG1","evidences":[{"source":"PubMed","id":"19015515","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Cross-link: {"description":"(Microbial infection) Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-50); by Vibrio toxins RtxA and VgrG1","evidences":[{"source":"PubMed","id":"19015515","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	60
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine; by BRSK1","evidences":[{"source":"UniProtKB","id":"P83887","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---