7QJ0

Structure of recombinant human gamma-Tubulin Ring Complex 6-spoked assembly intermediate (spokes 7-12)

Functional Information from GO Data

Chain	GOid	namespace	contents
G	0000226	biological_process	microtubule cytoskeleton organization
G	0000278	biological_process	mitotic cell cycle
G	0000922	cellular_component	spindle pole
G	0000930	cellular_component	gamma-tubulin complex
G	0001764	biological_process	neuron migration
G	0005515	molecular_function	protein binding
G	0005654	cellular_component	nucleoplasm
G	0005813	cellular_component	centrosome
G	0005815	cellular_component	microtubule organizing center
G	0005829	cellular_component	cytosol
G	0005874	cellular_component	microtubule
G	0005881	cellular_component	cytoplasmic microtubule
G	0007020	biological_process	microtubule nucleation
G	0007420	biological_process	brain development
G	0016020	cellular_component	membrane
G	0031122	biological_process	cytoplasmic microtubule organization
G	0036064	cellular_component	ciliary basal body
G	0043015	molecular_function	gamma-tubulin binding
G	0051011	molecular_function	microtubule minus-end binding
G	0051225	biological_process	spindle assembly
G	0051321	biological_process	meiotic cell cycle
G	0065003	biological_process	protein-containing complex assembly
H	0000226	biological_process	microtubule cytoskeleton organization
H	0000278	biological_process	mitotic cell cycle
H	0000922	cellular_component	spindle pole
H	0000930	cellular_component	gamma-tubulin complex
H	0005198	molecular_function	structural molecule activity
H	0005200	molecular_function	structural constituent of cytoskeleton
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005813	cellular_component	centrosome
H	0005814	cellular_component	centriole
H	0005815	cellular_component	microtubule organizing center
H	0005819	cellular_component	spindle
H	0005827	cellular_component	polar microtubule
H	0005829	cellular_component	cytosol
H	0005874	cellular_component	microtubule
H	0007020	biological_process	microtubule nucleation
H	0007338	biological_process	single fertilization
H	0016020	cellular_component	membrane
H	0031122	biological_process	cytoplasmic microtubule organization
H	0043015	molecular_function	gamma-tubulin binding
H	0051011	molecular_function	microtubule minus-end binding
H	0051225	biological_process	spindle assembly
H	0051321	biological_process	meiotic cell cycle
I	0000226	biological_process	microtubule cytoskeleton organization
I	0000278	biological_process	mitotic cell cycle
I	0000922	cellular_component	spindle pole
I	0000930	cellular_component	gamma-tubulin complex
I	0000931	cellular_component	gamma-tubulin ring complex
I	0005200	molecular_function	structural constituent of cytoskeleton
I	0005515	molecular_function	protein binding
I	0005813	cellular_component	centrosome
I	0005815	cellular_component	microtubule organizing center
I	0005829	cellular_component	cytosol
I	0005874	cellular_component	microtubule
I	0007020	biological_process	microtubule nucleation
I	0015630	cellular_component	microtubule cytoskeleton
I	0016020	cellular_component	membrane
I	0031122	biological_process	cytoplasmic microtubule organization
I	0043015	molecular_function	gamma-tubulin binding
I	0051011	molecular_function	microtubule minus-end binding
I	0051225	biological_process	spindle assembly
I	0051321	biological_process	meiotic cell cycle
I	0055037	cellular_component	recycling endosome
I	0065003	biological_process	protein-containing complex assembly
J	0000226	biological_process	microtubule cytoskeleton organization
J	0000278	biological_process	mitotic cell cycle
J	0000922	cellular_component	spindle pole
J	0000930	cellular_component	gamma-tubulin complex
J	0000931	cellular_component	gamma-tubulin ring complex
J	0005515	molecular_function	protein binding
J	0005813	cellular_component	centrosome
J	0005815	cellular_component	microtubule organizing center
J	0005829	cellular_component	cytosol
J	0005874	cellular_component	microtubule
J	0005929	cellular_component	cilium
J	0007020	biological_process	microtubule nucleation
J	0008017	molecular_function	microtubule binding
J	0031122	biological_process	cytoplasmic microtubule organization
J	0035869	cellular_component	ciliary transition zone
J	0036064	cellular_component	ciliary basal body
J	0043015	molecular_function	gamma-tubulin binding
J	0051011	molecular_function	microtubule minus-end binding
J	0051225	biological_process	spindle assembly
J	0051321	biological_process	meiotic cell cycle
K	0000226	biological_process	microtubule cytoskeleton organization
K	0000278	biological_process	mitotic cell cycle
K	0000922	cellular_component	spindle pole
K	0000930	cellular_component	gamma-tubulin complex
K	0000931	cellular_component	gamma-tubulin ring complex
K	0005200	molecular_function	structural constituent of cytoskeleton
K	0005515	molecular_function	protein binding
K	0005813	cellular_component	centrosome
K	0005815	cellular_component	microtubule organizing center
K	0005829	cellular_component	cytosol
K	0005874	cellular_component	microtubule
K	0007020	biological_process	microtubule nucleation
K	0015630	cellular_component	microtubule cytoskeleton
K	0016020	cellular_component	membrane
K	0031122	biological_process	cytoplasmic microtubule organization
K	0043015	molecular_function	gamma-tubulin binding
K	0051011	molecular_function	microtubule minus-end binding
K	0051225	biological_process	spindle assembly
K	0051321	biological_process	meiotic cell cycle
K	0055037	cellular_component	recycling endosome
K	0065003	biological_process	protein-containing complex assembly
L	0000226	biological_process	microtubule cytoskeleton organization
L	0000278	biological_process	mitotic cell cycle
L	0000922	cellular_component	spindle pole
L	0000930	cellular_component	gamma-tubulin complex
L	0000931	cellular_component	gamma-tubulin ring complex
L	0005813	cellular_component	centrosome
L	0005815	cellular_component	microtubule organizing center
L	0005829	cellular_component	cytosol
L	0005874	cellular_component	microtubule
L	0007020	biological_process	microtubule nucleation
L	0008017	molecular_function	microtubule binding
L	0016020	cellular_component	membrane
L	0031122	biological_process	cytoplasmic microtubule organization
L	0043015	molecular_function	gamma-tubulin binding
L	0051011	molecular_function	microtubule minus-end binding
L	0051225	biological_process	spindle assembly
L	0051321	biological_process	meiotic cell cycle
U	0000070	biological_process	mitotic sister chromatid segregation
U	0000166	molecular_function	nucleotide binding
U	0000212	biological_process	meiotic spindle organization
U	0000226	biological_process	microtubule cytoskeleton organization
U	0000242	cellular_component	pericentriolar material
U	0000278	biological_process	mitotic cell cycle
U	0000794	cellular_component	condensed nuclear chromosome
U	0000930	cellular_component	gamma-tubulin complex
U	0000931	cellular_component	gamma-tubulin ring complex
U	0005200	molecular_function	structural constituent of cytoskeleton
U	0005515	molecular_function	protein binding
U	0005525	molecular_function	GTP binding
U	0005634	cellular_component	nucleus
U	0005737	cellular_component	cytoplasm
U	0005813	cellular_component	centrosome
U	0005814	cellular_component	centriole
U	0005819	cellular_component	spindle
U	0005827	cellular_component	polar microtubule
U	0005829	cellular_component	cytosol
U	0005874	cellular_component	microtubule
U	0005876	cellular_component	spindle microtubule
U	0005881	cellular_component	cytoplasmic microtubule
U	0005929	cellular_component	cilium
U	0007017	biological_process	microtubule-based process
U	0007020	biological_process	microtubule nucleation
U	0007052	biological_process	mitotic spindle organization
U	0015630	cellular_component	microtubule cytoskeleton
U	0031122	biological_process	cytoplasmic microtubule organization
U	0031252	cellular_component	cell leading edge
U	0036064	cellular_component	ciliary basal body
U	0042802	molecular_function	identical protein binding
U	0043005	cellular_component	neuron projection
U	0045177	cellular_component	apical part of cell
U	0055037	cellular_component	recycling endosome
U	0097730	cellular_component	non-motile cilium
U	0140490	molecular_function	microtubule nucleator activity
U	1990498	cellular_component	mitotic spindle microtubule
V	0000070	biological_process	mitotic sister chromatid segregation
V	0000166	molecular_function	nucleotide binding
V	0000212	biological_process	meiotic spindle organization
V	0000226	biological_process	microtubule cytoskeleton organization
V	0000242	cellular_component	pericentriolar material
V	0000278	biological_process	mitotic cell cycle
V	0000794	cellular_component	condensed nuclear chromosome
V	0000930	cellular_component	gamma-tubulin complex
V	0000931	cellular_component	gamma-tubulin ring complex
V	0005200	molecular_function	structural constituent of cytoskeleton
V	0005515	molecular_function	protein binding
V	0005525	molecular_function	GTP binding
V	0005634	cellular_component	nucleus
V	0005737	cellular_component	cytoplasm
V	0005813	cellular_component	centrosome
V	0005814	cellular_component	centriole
V	0005819	cellular_component	spindle
V	0005827	cellular_component	polar microtubule
V	0005829	cellular_component	cytosol
V	0005874	cellular_component	microtubule
V	0005876	cellular_component	spindle microtubule
V	0005881	cellular_component	cytoplasmic microtubule
V	0005929	cellular_component	cilium
V	0007017	biological_process	microtubule-based process
V	0007020	biological_process	microtubule nucleation
V	0007052	biological_process	mitotic spindle organization
V	0015630	cellular_component	microtubule cytoskeleton
V	0031122	biological_process	cytoplasmic microtubule organization
V	0031252	cellular_component	cell leading edge
V	0036064	cellular_component	ciliary basal body
V	0042802	molecular_function	identical protein binding
V	0043005	cellular_component	neuron projection
V	0045177	cellular_component	apical part of cell
V	0055037	cellular_component	recycling endosome
V	0097730	cellular_component	non-motile cilium
V	0140490	molecular_function	microtubule nucleator activity
V	1990498	cellular_component	mitotic spindle microtubule
W	0000070	biological_process	mitotic sister chromatid segregation
W	0000166	molecular_function	nucleotide binding
W	0000212	biological_process	meiotic spindle organization
W	0000226	biological_process	microtubule cytoskeleton organization
W	0000242	cellular_component	pericentriolar material
W	0000278	biological_process	mitotic cell cycle
W	0000794	cellular_component	condensed nuclear chromosome
W	0000930	cellular_component	gamma-tubulin complex
W	0000931	cellular_component	gamma-tubulin ring complex
W	0005200	molecular_function	structural constituent of cytoskeleton
W	0005515	molecular_function	protein binding
W	0005525	molecular_function	GTP binding
W	0005634	cellular_component	nucleus
W	0005737	cellular_component	cytoplasm
W	0005813	cellular_component	centrosome
W	0005814	cellular_component	centriole
W	0005819	cellular_component	spindle
W	0005827	cellular_component	polar microtubule
W	0005829	cellular_component	cytosol
W	0005874	cellular_component	microtubule
W	0005876	cellular_component	spindle microtubule
W	0005881	cellular_component	cytoplasmic microtubule
W	0005929	cellular_component	cilium
W	0007017	biological_process	microtubule-based process
W	0007020	biological_process	microtubule nucleation
W	0007052	biological_process	mitotic spindle organization
W	0015630	cellular_component	microtubule cytoskeleton
W	0031122	biological_process	cytoplasmic microtubule organization
W	0031252	cellular_component	cell leading edge
W	0036064	cellular_component	ciliary basal body
W	0042802	molecular_function	identical protein binding
W	0043005	cellular_component	neuron projection
W	0045177	cellular_component	apical part of cell
W	0055037	cellular_component	recycling endosome
W	0097730	cellular_component	non-motile cilium
W	0140490	molecular_function	microtubule nucleator activity
W	1990498	cellular_component	mitotic spindle microtubule
X	0000070	biological_process	mitotic sister chromatid segregation
X	0000166	molecular_function	nucleotide binding
X	0000212	biological_process	meiotic spindle organization
X	0000226	biological_process	microtubule cytoskeleton organization
X	0000242	cellular_component	pericentriolar material
X	0000278	biological_process	mitotic cell cycle
X	0000794	cellular_component	condensed nuclear chromosome
X	0000930	cellular_component	gamma-tubulin complex
X	0000931	cellular_component	gamma-tubulin ring complex
X	0005200	molecular_function	structural constituent of cytoskeleton
X	0005515	molecular_function	protein binding
X	0005525	molecular_function	GTP binding
X	0005634	cellular_component	nucleus
X	0005737	cellular_component	cytoplasm
X	0005813	cellular_component	centrosome
X	0005814	cellular_component	centriole
X	0005819	cellular_component	spindle
X	0005827	cellular_component	polar microtubule
X	0005829	cellular_component	cytosol
X	0005874	cellular_component	microtubule
X	0005876	cellular_component	spindle microtubule
X	0005881	cellular_component	cytoplasmic microtubule
X	0005929	cellular_component	cilium
X	0007017	biological_process	microtubule-based process
X	0007020	biological_process	microtubule nucleation
X	0007052	biological_process	mitotic spindle organization
X	0015630	cellular_component	microtubule cytoskeleton
X	0031122	biological_process	cytoplasmic microtubule organization
X	0031252	cellular_component	cell leading edge
X	0036064	cellular_component	ciliary basal body
X	0042802	molecular_function	identical protein binding
X	0043005	cellular_component	neuron projection
X	0045177	cellular_component	apical part of cell
X	0055037	cellular_component	recycling endosome
X	0097730	cellular_component	non-motile cilium
X	0140490	molecular_function	microtubule nucleator activity
X	1990498	cellular_component	mitotic spindle microtubule
Y	0000070	biological_process	mitotic sister chromatid segregation
Y	0000166	molecular_function	nucleotide binding
Y	0000212	biological_process	meiotic spindle organization
Y	0000226	biological_process	microtubule cytoskeleton organization
Y	0000242	cellular_component	pericentriolar material
Y	0000278	biological_process	mitotic cell cycle
Y	0000794	cellular_component	condensed nuclear chromosome
Y	0000930	cellular_component	gamma-tubulin complex
Y	0000931	cellular_component	gamma-tubulin ring complex
Y	0005200	molecular_function	structural constituent of cytoskeleton
Y	0005515	molecular_function	protein binding
Y	0005525	molecular_function	GTP binding
Y	0005634	cellular_component	nucleus
Y	0005737	cellular_component	cytoplasm
Y	0005813	cellular_component	centrosome
Y	0005814	cellular_component	centriole
Y	0005819	cellular_component	spindle
Y	0005827	cellular_component	polar microtubule
Y	0005829	cellular_component	cytosol
Y	0005874	cellular_component	microtubule
Y	0005876	cellular_component	spindle microtubule
Y	0005881	cellular_component	cytoplasmic microtubule
Y	0005929	cellular_component	cilium
Y	0007017	biological_process	microtubule-based process
Y	0007020	biological_process	microtubule nucleation
Y	0007052	biological_process	mitotic spindle organization
Y	0015630	cellular_component	microtubule cytoskeleton
Y	0031122	biological_process	cytoplasmic microtubule organization
Y	0031252	cellular_component	cell leading edge
Y	0036064	cellular_component	ciliary basal body
Y	0042802	molecular_function	identical protein binding
Y	0043005	cellular_component	neuron projection
Y	0045177	cellular_component	apical part of cell
Y	0055037	cellular_component	recycling endosome
Y	0097730	cellular_component	non-motile cilium
Y	0140490	molecular_function	microtubule nucleator activity
Y	1990498	cellular_component	mitotic spindle microtubule
Z	0000070	biological_process	mitotic sister chromatid segregation
Z	0000166	molecular_function	nucleotide binding
Z	0000212	biological_process	meiotic spindle organization
Z	0000226	biological_process	microtubule cytoskeleton organization
Z	0000242	cellular_component	pericentriolar material
Z	0000278	biological_process	mitotic cell cycle
Z	0000794	cellular_component	condensed nuclear chromosome
Z	0000930	cellular_component	gamma-tubulin complex
Z	0000931	cellular_component	gamma-tubulin ring complex
Z	0005200	molecular_function	structural constituent of cytoskeleton
Z	0005515	molecular_function	protein binding
Z	0005525	molecular_function	GTP binding
Z	0005634	cellular_component	nucleus
Z	0005737	cellular_component	cytoplasm
Z	0005813	cellular_component	centrosome
Z	0005814	cellular_component	centriole
Z	0005819	cellular_component	spindle
Z	0005827	cellular_component	polar microtubule
Z	0005829	cellular_component	cytosol
Z	0005874	cellular_component	microtubule
Z	0005876	cellular_component	spindle microtubule
Z	0005881	cellular_component	cytoplasmic microtubule
Z	0005929	cellular_component	cilium
Z	0007017	biological_process	microtubule-based process
Z	0007020	biological_process	microtubule nucleation
Z	0007052	biological_process	mitotic spindle organization
Z	0015630	cellular_component	microtubule cytoskeleton
Z	0031122	biological_process	cytoplasmic microtubule organization
Z	0031252	cellular_component	cell leading edge
Z	0036064	cellular_component	ciliary basal body
Z	0042802	molecular_function	identical protein binding
Z	0043005	cellular_component	neuron projection
Z	0045177	cellular_component	apical part of cell
Z	0055037	cellular_component	recycling endosome
Z	0097730	cellular_component	non-motile cilium
Z	0140490	molecular_function	microtubule nucleator activity
Z	1990498	cellular_component	mitotic spindle microtubule
a	0000226	biological_process	microtubule cytoskeleton organization
a	0000278	biological_process	mitotic cell cycle
a	0000922	cellular_component	spindle pole
a	0000930	cellular_component	gamma-tubulin complex
a	0005198	molecular_function	structural molecule activity
a	0005200	molecular_function	structural constituent of cytoskeleton
a	0005515	molecular_function	protein binding
a	0005737	cellular_component	cytoplasm
a	0005813	cellular_component	centrosome
a	0005814	cellular_component	centriole
a	0005815	cellular_component	microtubule organizing center
a	0005819	cellular_component	spindle
a	0005827	cellular_component	polar microtubule
a	0005829	cellular_component	cytosol
a	0005874	cellular_component	microtubule
a	0007020	biological_process	microtubule nucleation
a	0007338	biological_process	single fertilization
a	0016020	cellular_component	membrane
a	0031122	biological_process	cytoplasmic microtubule organization
a	0043015	molecular_function	gamma-tubulin binding
a	0051011	molecular_function	microtubule minus-end binding
a	0051225	biological_process	spindle assembly
a	0051321	biological_process	meiotic cell cycle
b	0000931	cellular_component	gamma-tubulin ring complex
b	0005515	molecular_function	protein binding
b	0005813	cellular_component	centrosome
b	0005819	cellular_component	spindle
b	0005829	cellular_component	cytosol
b	0031021	cellular_component	interphase microtubule organizing center
b	0033566	biological_process	gamma-tubulin complex localization
b	0051415	biological_process	microtubule nucleation by interphase microtubule organizing center
b	0090307	biological_process	mitotic spindle assembly
l	0000226	biological_process	microtubule cytoskeleton organization
l	0000278	biological_process	mitotic cell cycle
l	0000922	cellular_component	spindle pole
l	0000930	cellular_component	gamma-tubulin complex
l	0000931	cellular_component	gamma-tubulin ring complex
l	0005515	molecular_function	protein binding
l	0005813	cellular_component	centrosome
l	0005815	cellular_component	microtubule organizing center
l	0005829	cellular_component	cytosol
l	0005874	cellular_component	microtubule
l	0005929	cellular_component	cilium
l	0007020	biological_process	microtubule nucleation
l	0008017	molecular_function	microtubule binding
l	0031122	biological_process	cytoplasmic microtubule organization
l	0035869	cellular_component	ciliary transition zone
l	0036064	cellular_component	ciliary basal body
l	0043015	molecular_function	gamma-tubulin binding
l	0051011	molecular_function	microtubule minus-end binding
l	0051225	biological_process	spindle assembly
l	0051321	biological_process	meiotic cell cycle
m	0000931	cellular_component	gamma-tubulin ring complex
m	0005515	molecular_function	protein binding
m	0005813	cellular_component	centrosome
m	0005819	cellular_component	spindle
m	0005829	cellular_component	cytosol
m	0031021	cellular_component	interphase microtubule organizing center
m	0033566	biological_process	gamma-tubulin complex localization
m	0051415	biological_process	microtubule nucleation by interphase microtubule organizing center
m	0090307	biological_process	mitotic spindle assembly

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. AGGTGSG

Chain	Residue	Details
U	ALA142-GLY148

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine; by BRSK1","evidences":[{"source":"UniProtKB","id":"P83887","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---