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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7QHS

S. cerevisiae CMGE nucleating origin DNA melting

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
20003677molecular_functionDNA binding
20005524molecular_functionATP binding
20005634cellular_componentnucleus
20006260biological_processDNA replication
20006270biological_processDNA replication initiation
20042555cellular_componentMCM complex
30000166molecular_functionnucleotide binding
30000727biological_processdouble-strand break repair via break-induced replication
30000781cellular_componentchromosome, telomeric region
30003677molecular_functionDNA binding
30003678molecular_functionDNA helicase activity
30003682molecular_functionchromatin binding
30003688molecular_functionDNA replication origin binding
30003697molecular_functionsingle-stranded DNA binding
30004386molecular_functionhelicase activity
30005515molecular_functionprotein binding
30005524molecular_functionATP binding
30005634cellular_componentnucleus
30005654cellular_componentnucleoplasm
30005656cellular_componentnuclear pre-replicative complex
30005737cellular_componentcytoplasm
30006260biological_processDNA replication
30006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
30006270biological_processDNA replication initiation
30006271biological_processDNA strand elongation involved in DNA replication
30006279biological_processpremeiotic DNA replication
30016787molecular_functionhydrolase activity
30016887molecular_functionATP hydrolysis activity
30017116molecular_functionsingle-stranded DNA helicase activity
30030466biological_processsilent mating-type cassette heterochromatin formation
30031261cellular_componentDNA replication preinitiation complex
30031509biological_processsubtelomeric heterochromatin formation
30042555cellular_componentMCM complex
30043596cellular_componentnuclear replication fork
30071162cellular_componentCMG complex
31902975biological_processmitotic DNA replication initiation
31904931molecular_functionMCM complex binding
40000166molecular_functionnucleotide binding
40000727biological_processdouble-strand break repair via break-induced replication
40003677molecular_functionDNA binding
40003678molecular_functionDNA helicase activity
40003688molecular_functionDNA replication origin binding
40003697molecular_functionsingle-stranded DNA binding
40004386molecular_functionhelicase activity
40005515molecular_functionprotein binding
40005524molecular_functionATP binding
40005634cellular_componentnucleus
40005654cellular_componentnucleoplasm
40005656cellular_componentnuclear pre-replicative complex
40005737cellular_componentcytoplasm
40006260biological_processDNA replication
40006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
40006270biological_processDNA replication initiation
40006271biological_processDNA strand elongation involved in DNA replication
40006279biological_processpremeiotic DNA replication
40008270molecular_functionzinc ion binding
40009378molecular_functionfour-way junction helicase activity
40016787molecular_functionhydrolase activity
40016887molecular_functionATP hydrolysis activity
40017116molecular_functionsingle-stranded DNA helicase activity
40031261cellular_componentDNA replication preinitiation complex
40033260biological_processnuclear DNA replication
40042555cellular_componentMCM complex
40043138molecular_function3'-5' DNA helicase activity
40043596cellular_componentnuclear replication fork
40071162cellular_componentCMG complex
40097373cellular_componentMCM core complex
41902975biological_processmitotic DNA replication initiation
50003677molecular_functionDNA binding
50003688molecular_functionDNA replication origin binding
50005524molecular_functionATP binding
50005634cellular_componentnucleus
50006260biological_processDNA replication
50006270biological_processDNA replication initiation
50042555cellular_componentMCM complex
60000166molecular_functionnucleotide binding
60000727biological_processdouble-strand break repair via break-induced replication
60003677molecular_functionDNA binding
60003678molecular_functionDNA helicase activity
60003688molecular_functionDNA replication origin binding
60003697molecular_functionsingle-stranded DNA binding
60004386molecular_functionhelicase activity
60005515molecular_functionprotein binding
60005524molecular_functionATP binding
60005634cellular_componentnucleus
60005654cellular_componentnucleoplasm
60005656cellular_componentnuclear pre-replicative complex
60005737cellular_componentcytoplasm
60005777cellular_componentperoxisome
60006260biological_processDNA replication
60006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
60006270biological_processDNA replication initiation
60006271biological_processDNA strand elongation involved in DNA replication
60006279biological_processpremeiotic DNA replication
60008270molecular_functionzinc ion binding
60009378molecular_functionfour-way junction helicase activity
60016787molecular_functionhydrolase activity
60016887molecular_functionATP hydrolysis activity
60017116molecular_functionsingle-stranded DNA helicase activity
60031261cellular_componentDNA replication preinitiation complex
60042555cellular_componentMCM complex
60043138molecular_function3'-5' DNA helicase activity
60043596cellular_componentnuclear replication fork
60071162cellular_componentCMG complex
60097373cellular_componentMCM core complex
61902969biological_processmitotic DNA replication
61990518molecular_functionsingle-stranded 3'-5' DNA helicase activity
70000166molecular_functionnucleotide binding
70000727biological_processdouble-strand break repair via break-induced replication
70000781cellular_componentchromosome, telomeric region
70003677molecular_functionDNA binding
70003678molecular_functionDNA helicase activity
70003682molecular_functionchromatin binding
70003688molecular_functionDNA replication origin binding
70003697molecular_functionsingle-stranded DNA binding
70004386molecular_functionhelicase activity
70005515molecular_functionprotein binding
70005524molecular_functionATP binding
70005634cellular_componentnucleus
70005654cellular_componentnucleoplasm
70005656cellular_componentnuclear pre-replicative complex
70005737cellular_componentcytoplasm
70006260biological_processDNA replication
70006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
70006270biological_processDNA replication initiation
70006271biological_processDNA strand elongation involved in DNA replication
70006279biological_processpremeiotic DNA replication
70008270molecular_functionzinc ion binding
70009378molecular_functionfour-way junction helicase activity
70016787molecular_functionhydrolase activity
70016887molecular_functionATP hydrolysis activity
70017116molecular_functionsingle-stranded DNA helicase activity
70030466biological_processsilent mating-type cassette heterochromatin formation
70031261cellular_componentDNA replication preinitiation complex
70031509biological_processsubtelomeric heterochromatin formation
70033260biological_processnuclear DNA replication
70042555cellular_componentMCM complex
70043138molecular_function3'-5' DNA helicase activity
70043596cellular_componentnuclear replication fork
70071162cellular_componentCMG complex
70097373cellular_componentMCM core complex
71904931molecular_functionMCM complex binding
C0000727biological_processdouble-strand break repair via break-induced replication
C0000811cellular_componentGINS complex
C0003674molecular_functionmolecular_function
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0006260biological_processDNA replication
C0006261biological_processDNA-templated DNA replication
C0006270biological_processDNA replication initiation
C0031261cellular_componentDNA replication preinitiation complex
C0043596cellular_componentnuclear replication fork
C0071162cellular_componentCMG complex
D0000727biological_processdouble-strand break repair via break-induced replication
D0000811cellular_componentGINS complex
D0003674molecular_functionmolecular_function
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0006260biological_processDNA replication
D0006261biological_processDNA-templated DNA replication
D0031261cellular_componentDNA replication preinitiation complex
D0043596cellular_componentnuclear replication fork
D0071162cellular_componentCMG complex
E0006270biological_processDNA replication initiation
F0003677molecular_functionDNA binding
F0003690molecular_functiondouble-stranded DNA binding
F0003697molecular_functionsingle-stranded DNA binding
F0003887molecular_functionDNA-directed DNA polymerase activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005694cellular_componentchromosome
F0005737cellular_componentcytoplasm
F0006260biological_processDNA replication
F0006261biological_processDNA-templated DNA replication
F0008622cellular_componentepsilon DNA polymerase complex
F0030337molecular_functionDNA polymerase processivity factor activity
F0031981cellular_componentnuclear lumen
F0042276biological_processerror-prone translesion synthesis
F0043596cellular_componentnuclear replication fork
F0045005biological_processDNA-templated DNA replication maintenance of fidelity
G0000166molecular_functionnucleotide binding
G0000278biological_processmitotic cell cycle
G0003676molecular_functionnucleic acid binding
G0003677molecular_functionDNA binding
G0003690molecular_functiondouble-stranded DNA binding
G0003697molecular_functionsingle-stranded DNA binding
G0003729molecular_functionmRNA binding
G0003887molecular_functionDNA-directed DNA polymerase activity
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005657cellular_componentreplication fork
G0006260biological_processDNA replication
G0006261biological_processDNA-templated DNA replication
G0006272biological_processleading strand elongation
G0006281biological_processDNA repair
G0006284biological_processbase-excision repair
G0006287biological_processbase-excision repair, gap-filling
G0006297biological_processnucleotide-excision repair, DNA gap filling
G0006302biological_processdouble-strand break repair
G0006303biological_processdouble-strand break repair via nonhomologous end joining
G0007064biological_processmitotic sister chromatid cohesion
G0008270molecular_functionzinc ion binding
G0008310molecular_functionsingle-stranded DNA 3'-5' DNA exonuclease activity
G0008622cellular_componentepsilon DNA polymerase complex
G0016740molecular_functiontransferase activity
G0016779molecular_functionnucleotidyltransferase activity
G0016787molecular_functionhydrolase activity
G0031573biological_processmitotic intra-S DNA damage checkpoint signaling
G0032183molecular_functionSUMO binding
G0033314biological_processmitotic DNA replication checkpoint signaling
G0034061molecular_functionDNA polymerase activity
G0035822biological_processgene conversion
G0042276biological_processerror-prone translesion synthesis
G0043596cellular_componentnuclear replication fork
G0045004biological_processDNA replication proofreading
G0046872molecular_functionmetal ion binding
G0051536molecular_functioniron-sulfur cluster binding
G0051539molecular_function4 iron, 4 sulfur cluster binding
H0000811cellular_componentGINS complex
H0006260biological_processDNA replication
I0005634cellular_componentnucleus
I0006260biological_processDNA replication
Functional Information from PROSITE/UniProt
site_idPS00847
Number of Residues9
DetailsMCM_1 MCM family signature. GVVCIDEFD
ChainResidueDetails
5GLY475-ASP483
6GLY634-ASP642
3GLY468-ASP476
7GLY519-ASP527
2GLY602-ASP610
4GLY627-ASP635
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues828
DetailsDomain: {"description":"MCM"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues12
DetailsMotif: {"description":"Arginine finger"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues21
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P33993","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"14747467","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues25
DetailsZinc finger: {"description":"CysA-type","evidences":[{"source":"UniProtKB","id":"P15436","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues17
DetailsMotif: {"description":"CysB motif","evidences":[{"source":"UniProtKB","id":"P15436","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P15436","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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