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7QEQ

human Connexin 26 dodecamer at 90mmHg PCO2, pH7.4

Functional Information from GO Data
ChainGOidnamespacecontents
A0002931biological_processresponse to ischemia
A0005243molecular_functiongap junction channel activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
A0005886cellular_componentplasma membrane
A0005921cellular_componentgap junction
A0005922cellular_componentconnexin complex
A0007154biological_processcell communication
A0007267biological_processcell-cell signaling
A0007565biological_processfemale pregnancy
A0007605biological_processsensory perception of sound
A0010644biological_processcell communication by electrical coupling
A0016264biological_processgap junction assembly
A0016328cellular_componentlateral plasma membrane
A0030054cellular_componentcell junction
A0032355biological_processresponse to estradiol
A0032496biological_processresponse to lipopolysaccharide
A0032526biological_processresponse to retinoic acid
A0032570biological_processresponse to progesterone
A0034599biological_processcellular response to oxidative stress
A0042802molecular_functionidentical protein binding
A0044297cellular_componentcell body
A0044752biological_processresponse to human chorionic gonadotropin
A0046697biological_processdecidualization
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0048839biological_processinner ear development
A0055085biological_processtransmembrane transport
A0071377biological_processcellular response to glucagon stimulus
A0071549biological_processcellular response to dexamethasone stimulus
A0097449cellular_componentastrocyte projection
A1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
A1905867biological_processepididymis development
A1990349biological_processgap junction-mediated intercellular transport
B0002931biological_processresponse to ischemia
B0005243molecular_functiongap junction channel activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
B0005886cellular_componentplasma membrane
B0005921cellular_componentgap junction
B0005922cellular_componentconnexin complex
B0007154biological_processcell communication
B0007267biological_processcell-cell signaling
B0007565biological_processfemale pregnancy
B0007605biological_processsensory perception of sound
B0010644biological_processcell communication by electrical coupling
B0016264biological_processgap junction assembly
B0016328cellular_componentlateral plasma membrane
B0030054cellular_componentcell junction
B0032355biological_processresponse to estradiol
B0032496biological_processresponse to lipopolysaccharide
B0032526biological_processresponse to retinoic acid
B0032570biological_processresponse to progesterone
B0034599biological_processcellular response to oxidative stress
B0042802molecular_functionidentical protein binding
B0044297cellular_componentcell body
B0044752biological_processresponse to human chorionic gonadotropin
B0046697biological_processdecidualization
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
B0048839biological_processinner ear development
B0055085biological_processtransmembrane transport
B0071377biological_processcellular response to glucagon stimulus
B0071549biological_processcellular response to dexamethasone stimulus
B0097449cellular_componentastrocyte projection
B1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
B1905867biological_processepididymis development
B1990349biological_processgap junction-mediated intercellular transport
C0002931biological_processresponse to ischemia
C0005243molecular_functiongap junction channel activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
C0005886cellular_componentplasma membrane
C0005921cellular_componentgap junction
C0005922cellular_componentconnexin complex
C0007154biological_processcell communication
C0007267biological_processcell-cell signaling
C0007565biological_processfemale pregnancy
C0007605biological_processsensory perception of sound
C0010644biological_processcell communication by electrical coupling
C0016264biological_processgap junction assembly
C0016328cellular_componentlateral plasma membrane
C0030054cellular_componentcell junction
C0032355biological_processresponse to estradiol
C0032496biological_processresponse to lipopolysaccharide
C0032526biological_processresponse to retinoic acid
C0032570biological_processresponse to progesterone
C0034599biological_processcellular response to oxidative stress
C0042802molecular_functionidentical protein binding
C0044297cellular_componentcell body
C0044752biological_processresponse to human chorionic gonadotropin
C0046697biological_processdecidualization
C0046872molecular_functionmetal ion binding
C0048471cellular_componentperinuclear region of cytoplasm
C0048839biological_processinner ear development
C0055085biological_processtransmembrane transport
C0071377biological_processcellular response to glucagon stimulus
C0071549biological_processcellular response to dexamethasone stimulus
C0097449cellular_componentastrocyte projection
C1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
C1905867biological_processepididymis development
C1990349biological_processgap junction-mediated intercellular transport
D0002931biological_processresponse to ischemia
D0005243molecular_functiongap junction channel activity
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
D0005886cellular_componentplasma membrane
D0005921cellular_componentgap junction
D0005922cellular_componentconnexin complex
D0007154biological_processcell communication
D0007267biological_processcell-cell signaling
D0007565biological_processfemale pregnancy
D0007605biological_processsensory perception of sound
D0010644biological_processcell communication by electrical coupling
D0016264biological_processgap junction assembly
D0016328cellular_componentlateral plasma membrane
D0030054cellular_componentcell junction
D0032355biological_processresponse to estradiol
D0032496biological_processresponse to lipopolysaccharide
D0032526biological_processresponse to retinoic acid
D0032570biological_processresponse to progesterone
D0034599biological_processcellular response to oxidative stress
D0042802molecular_functionidentical protein binding
D0044297cellular_componentcell body
D0044752biological_processresponse to human chorionic gonadotropin
D0046697biological_processdecidualization
D0046872molecular_functionmetal ion binding
D0048471cellular_componentperinuclear region of cytoplasm
D0048839biological_processinner ear development
D0055085biological_processtransmembrane transport
D0071377biological_processcellular response to glucagon stimulus
D0071549biological_processcellular response to dexamethasone stimulus
D0097449cellular_componentastrocyte projection
D1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
D1905867biological_processepididymis development
D1990349biological_processgap junction-mediated intercellular transport
E0002931biological_processresponse to ischemia
E0005243molecular_functiongap junction channel activity
E0005509molecular_functioncalcium ion binding
E0005515molecular_functionprotein binding
E0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
E0005886cellular_componentplasma membrane
E0005921cellular_componentgap junction
E0005922cellular_componentconnexin complex
E0007154biological_processcell communication
E0007267biological_processcell-cell signaling
E0007565biological_processfemale pregnancy
E0007605biological_processsensory perception of sound
E0010644biological_processcell communication by electrical coupling
E0016264biological_processgap junction assembly
E0016328cellular_componentlateral plasma membrane
E0030054cellular_componentcell junction
E0032355biological_processresponse to estradiol
E0032496biological_processresponse to lipopolysaccharide
E0032526biological_processresponse to retinoic acid
E0032570biological_processresponse to progesterone
E0034599biological_processcellular response to oxidative stress
E0042802molecular_functionidentical protein binding
E0044297cellular_componentcell body
E0044752biological_processresponse to human chorionic gonadotropin
E0046697biological_processdecidualization
E0046872molecular_functionmetal ion binding
E0048471cellular_componentperinuclear region of cytoplasm
E0048839biological_processinner ear development
E0055085biological_processtransmembrane transport
E0071377biological_processcellular response to glucagon stimulus
E0071549biological_processcellular response to dexamethasone stimulus
E0097449cellular_componentastrocyte projection
E1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
E1905867biological_processepididymis development
E1990349biological_processgap junction-mediated intercellular transport
F0002931biological_processresponse to ischemia
F0005243molecular_functiongap junction channel activity
F0005509molecular_functioncalcium ion binding
F0005515molecular_functionprotein binding
F0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
F0005886cellular_componentplasma membrane
F0005921cellular_componentgap junction
F0005922cellular_componentconnexin complex
F0007154biological_processcell communication
F0007267biological_processcell-cell signaling
F0007565biological_processfemale pregnancy
F0007605biological_processsensory perception of sound
F0010644biological_processcell communication by electrical coupling
F0016264biological_processgap junction assembly
F0016328cellular_componentlateral plasma membrane
F0030054cellular_componentcell junction
F0032355biological_processresponse to estradiol
F0032496biological_processresponse to lipopolysaccharide
F0032526biological_processresponse to retinoic acid
F0032570biological_processresponse to progesterone
F0034599biological_processcellular response to oxidative stress
F0042802molecular_functionidentical protein binding
F0044297cellular_componentcell body
F0044752biological_processresponse to human chorionic gonadotropin
F0046697biological_processdecidualization
F0046872molecular_functionmetal ion binding
F0048471cellular_componentperinuclear region of cytoplasm
F0048839biological_processinner ear development
F0055085biological_processtransmembrane transport
F0071377biological_processcellular response to glucagon stimulus
F0071549biological_processcellular response to dexamethasone stimulus
F0097449cellular_componentastrocyte projection
F1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
F1905867biological_processepididymis development
F1990349biological_processgap junction-mediated intercellular transport
G0002931biological_processresponse to ischemia
G0005243molecular_functiongap junction channel activity
G0005509molecular_functioncalcium ion binding
G0005515molecular_functionprotein binding
G0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
G0005886cellular_componentplasma membrane
G0005921cellular_componentgap junction
G0005922cellular_componentconnexin complex
G0007154biological_processcell communication
G0007267biological_processcell-cell signaling
G0007565biological_processfemale pregnancy
G0007605biological_processsensory perception of sound
G0010644biological_processcell communication by electrical coupling
G0016264biological_processgap junction assembly
G0016328cellular_componentlateral plasma membrane
G0030054cellular_componentcell junction
G0032355biological_processresponse to estradiol
G0032496biological_processresponse to lipopolysaccharide
G0032526biological_processresponse to retinoic acid
G0032570biological_processresponse to progesterone
G0034599biological_processcellular response to oxidative stress
G0042802molecular_functionidentical protein binding
G0044297cellular_componentcell body
G0044752biological_processresponse to human chorionic gonadotropin
G0046697biological_processdecidualization
G0046872molecular_functionmetal ion binding
G0048471cellular_componentperinuclear region of cytoplasm
G0048839biological_processinner ear development
G0055085biological_processtransmembrane transport
G0071377biological_processcellular response to glucagon stimulus
G0071549biological_processcellular response to dexamethasone stimulus
G0097449cellular_componentastrocyte projection
G1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
G1905867biological_processepididymis development
G1990349biological_processgap junction-mediated intercellular transport
H0002931biological_processresponse to ischemia
H0005243molecular_functiongap junction channel activity
H0005509molecular_functioncalcium ion binding
H0005515molecular_functionprotein binding
H0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
H0005886cellular_componentplasma membrane
H0005921cellular_componentgap junction
H0005922cellular_componentconnexin complex
H0007154biological_processcell communication
H0007267biological_processcell-cell signaling
H0007565biological_processfemale pregnancy
H0007605biological_processsensory perception of sound
H0010644biological_processcell communication by electrical coupling
H0016264biological_processgap junction assembly
H0016328cellular_componentlateral plasma membrane
H0030054cellular_componentcell junction
H0032355biological_processresponse to estradiol
H0032496biological_processresponse to lipopolysaccharide
H0032526biological_processresponse to retinoic acid
H0032570biological_processresponse to progesterone
H0034599biological_processcellular response to oxidative stress
H0042802molecular_functionidentical protein binding
H0044297cellular_componentcell body
H0044752biological_processresponse to human chorionic gonadotropin
H0046697biological_processdecidualization
H0046872molecular_functionmetal ion binding
H0048471cellular_componentperinuclear region of cytoplasm
H0048839biological_processinner ear development
H0055085biological_processtransmembrane transport
H0071377biological_processcellular response to glucagon stimulus
H0071549biological_processcellular response to dexamethasone stimulus
H0097449cellular_componentastrocyte projection
H1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
H1905867biological_processepididymis development
H1990349biological_processgap junction-mediated intercellular transport
I0002931biological_processresponse to ischemia
I0005243molecular_functiongap junction channel activity
I0005509molecular_functioncalcium ion binding
I0005515molecular_functionprotein binding
I0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
I0005886cellular_componentplasma membrane
I0005921cellular_componentgap junction
I0005922cellular_componentconnexin complex
I0007154biological_processcell communication
I0007267biological_processcell-cell signaling
I0007565biological_processfemale pregnancy
I0007605biological_processsensory perception of sound
I0010644biological_processcell communication by electrical coupling
I0016264biological_processgap junction assembly
I0016328cellular_componentlateral plasma membrane
I0030054cellular_componentcell junction
I0032355biological_processresponse to estradiol
I0032496biological_processresponse to lipopolysaccharide
I0032526biological_processresponse to retinoic acid
I0032570biological_processresponse to progesterone
I0034599biological_processcellular response to oxidative stress
I0042802molecular_functionidentical protein binding
I0044297cellular_componentcell body
I0044752biological_processresponse to human chorionic gonadotropin
I0046697biological_processdecidualization
I0046872molecular_functionmetal ion binding
I0048471cellular_componentperinuclear region of cytoplasm
I0048839biological_processinner ear development
I0055085biological_processtransmembrane transport
I0071377biological_processcellular response to glucagon stimulus
I0071549biological_processcellular response to dexamethasone stimulus
I0097449cellular_componentastrocyte projection
I1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
I1905867biological_processepididymis development
I1990349biological_processgap junction-mediated intercellular transport
J0002931biological_processresponse to ischemia
J0005243molecular_functiongap junction channel activity
J0005509molecular_functioncalcium ion binding
J0005515molecular_functionprotein binding
J0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
J0005886cellular_componentplasma membrane
J0005921cellular_componentgap junction
J0005922cellular_componentconnexin complex
J0007154biological_processcell communication
J0007267biological_processcell-cell signaling
J0007565biological_processfemale pregnancy
J0007605biological_processsensory perception of sound
J0010644biological_processcell communication by electrical coupling
J0016264biological_processgap junction assembly
J0016328cellular_componentlateral plasma membrane
J0030054cellular_componentcell junction
J0032355biological_processresponse to estradiol
J0032496biological_processresponse to lipopolysaccharide
J0032526biological_processresponse to retinoic acid
J0032570biological_processresponse to progesterone
J0034599biological_processcellular response to oxidative stress
J0042802molecular_functionidentical protein binding
J0044297cellular_componentcell body
J0044752biological_processresponse to human chorionic gonadotropin
J0046697biological_processdecidualization
J0046872molecular_functionmetal ion binding
J0048471cellular_componentperinuclear region of cytoplasm
J0048839biological_processinner ear development
J0055085biological_processtransmembrane transport
J0071377biological_processcellular response to glucagon stimulus
J0071549biological_processcellular response to dexamethasone stimulus
J0097449cellular_componentastrocyte projection
J1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
J1905867biological_processepididymis development
J1990349biological_processgap junction-mediated intercellular transport
K0002931biological_processresponse to ischemia
K0005243molecular_functiongap junction channel activity
K0005509molecular_functioncalcium ion binding
K0005515molecular_functionprotein binding
K0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
K0005886cellular_componentplasma membrane
K0005921cellular_componentgap junction
K0005922cellular_componentconnexin complex
K0007154biological_processcell communication
K0007267biological_processcell-cell signaling
K0007565biological_processfemale pregnancy
K0007605biological_processsensory perception of sound
K0010644biological_processcell communication by electrical coupling
K0016264biological_processgap junction assembly
K0016328cellular_componentlateral plasma membrane
K0030054cellular_componentcell junction
K0032355biological_processresponse to estradiol
K0032496biological_processresponse to lipopolysaccharide
K0032526biological_processresponse to retinoic acid
K0032570biological_processresponse to progesterone
K0034599biological_processcellular response to oxidative stress
K0042802molecular_functionidentical protein binding
K0044297cellular_componentcell body
K0044752biological_processresponse to human chorionic gonadotropin
K0046697biological_processdecidualization
K0046872molecular_functionmetal ion binding
K0048471cellular_componentperinuclear region of cytoplasm
K0048839biological_processinner ear development
K0055085biological_processtransmembrane transport
K0071377biological_processcellular response to glucagon stimulus
K0071549biological_processcellular response to dexamethasone stimulus
K0097449cellular_componentastrocyte projection
K1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
K1905867biological_processepididymis development
K1990349biological_processgap junction-mediated intercellular transport
L0002931biological_processresponse to ischemia
L0005243molecular_functiongap junction channel activity
L0005509molecular_functioncalcium ion binding
L0005515molecular_functionprotein binding
L0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
L0005886cellular_componentplasma membrane
L0005921cellular_componentgap junction
L0005922cellular_componentconnexin complex
L0007154biological_processcell communication
L0007267biological_processcell-cell signaling
L0007565biological_processfemale pregnancy
L0007605biological_processsensory perception of sound
L0010644biological_processcell communication by electrical coupling
L0016264biological_processgap junction assembly
L0016328cellular_componentlateral plasma membrane
L0030054cellular_componentcell junction
L0032355biological_processresponse to estradiol
L0032496biological_processresponse to lipopolysaccharide
L0032526biological_processresponse to retinoic acid
L0032570biological_processresponse to progesterone
L0034599biological_processcellular response to oxidative stress
L0042802molecular_functionidentical protein binding
L0044297cellular_componentcell body
L0044752biological_processresponse to human chorionic gonadotropin
L0046697biological_processdecidualization
L0046872molecular_functionmetal ion binding
L0048471cellular_componentperinuclear region of cytoplasm
L0048839biological_processinner ear development
L0055085biological_processtransmembrane transport
L0071377biological_processcellular response to glucagon stimulus
L0071549biological_processcellular response to dexamethasone stimulus
L0097449cellular_componentastrocyte projection
L1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
L1905867biological_processepididymis development
L1990349biological_processgap junction-mediated intercellular transport
Functional Information from PROSITE/UniProt
site_idPS00407
Number of Residues14
DetailsCONNEXINS_1 Connexins signature 1. CNTlQPGCknVCYD
ChainResidueDetails
ACYS53-ASP66

site_idPS00408
Number of Residues17
DetailsCONNEXINS_2 Connexins signature 2. Cnaw.PCpntVDCFVSRP
ChainResidueDetails
ACYS169-PRO185

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues132
DetailsINTRAMEM: INTRAMEM => ECO:0000269|PubMed:26753910
ChainResidueDetails
AASP2-VAL13
JASP2-VAL13
KASP2-VAL13
LASP2-VAL13
BASP2-VAL13
CASP2-VAL13
DASP2-VAL13
EASP2-VAL13
FASP2-VAL13
GASP2-VAL13
HASP2-VAL13
IASP2-VAL13

site_idSWS_FT_FI2
Number of Residues732
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:26753910
ChainResidueDetails
AASN14-ILE20
DASN14-ILE20
DVAL95-THR135
DCYS211-VAL226
EASN14-ILE20
EVAL95-THR135
ECYS211-VAL226
FASN14-ILE20
FVAL95-THR135
FCYS211-VAL226
GASN14-ILE20
AVAL95-THR135
GVAL95-THR135
GCYS211-VAL226
HASN14-ILE20
HVAL95-THR135
HCYS211-VAL226
IASN14-ILE20
IVAL95-THR135
ICYS211-VAL226
JASN14-ILE20
JVAL95-THR135
ACYS211-VAL226
JCYS211-VAL226
KASN14-ILE20
KVAL95-THR135
KCYS211-VAL226
LASN14-ILE20
LVAL95-THR135
LCYS211-VAL226
BASN14-ILE20
BVAL95-THR135
BCYS211-VAL226
CASN14-ILE20
CVAL95-THR135
CCYS211-VAL226

site_idSWS_FT_FI3
Number of Residues948
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:26753910
ChainResidueDetails
AGLY21-ALA40
CILE74-HIS94
CTYR136-VAL156
CVAL190-LEU210
DGLY21-ALA40
DILE74-HIS94
DTYR136-VAL156
DVAL190-LEU210
EGLY21-ALA40
EILE74-HIS94
ETYR136-VAL156
AILE74-HIS94
EVAL190-LEU210
FGLY21-ALA40
FILE74-HIS94
FTYR136-VAL156
FVAL190-LEU210
GGLY21-ALA40
GILE74-HIS94
GTYR136-VAL156
GVAL190-LEU210
HGLY21-ALA40
ATYR136-VAL156
HILE74-HIS94
HTYR136-VAL156
HVAL190-LEU210
IGLY21-ALA40
IILE74-HIS94
ITYR136-VAL156
IVAL190-LEU210
JGLY21-ALA40
JILE74-HIS94
JTYR136-VAL156
AVAL190-LEU210
JVAL190-LEU210
KGLY21-ALA40
KILE74-HIS94
KTYR136-VAL156
KVAL190-LEU210
LGLY21-ALA40
LILE74-HIS94
LTYR136-VAL156
LVAL190-LEU210
BGLY21-ALA40
BILE74-HIS94
BTYR136-VAL156
BVAL190-LEU210
CGLY21-ALA40

site_idSWS_FT_FI4
Number of Residues768
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:26753910
ChainResidueDetails
ALYS41-HIS73
EMET157-THR189
FLYS41-HIS73
FMET157-THR189
GLYS41-HIS73
GMET157-THR189
HLYS41-HIS73
HMET157-THR189
ILYS41-HIS73
IMET157-THR189
JLYS41-HIS73
AMET157-THR189
JMET157-THR189
KLYS41-HIS73
KMET157-THR189
LLYS41-HIS73
LMET157-THR189
BLYS41-HIS73
BMET157-THR189
CLYS41-HIS73
CMET157-THR189
DLYS41-HIS73
DMET157-THR189
ELYS41-HIS73

site_idSWS_FT_FI5
Number of Residues12
DetailsBINDING: in other chain => ECO:0000305|PubMed:26753910, ECO:0007744|PDB:5ER7
ChainResidueDetails
AGLU42
JGLU42
KGLU42
LGLU42
BGLU42
CGLU42
DGLU42
EGLU42
FGLU42
GGLU42
HGLU42
IGLU42

site_idSWS_FT_FI6
Number of Residues24
DetailsBINDING: BINDING => ECO:0000305|PubMed:26753910, ECO:0007744|PDB:5ER7
ChainResidueDetails
AGLY45
GGLY45
GGLU47
HGLY45
HGLU47
IGLY45
IGLU47
JGLY45
JGLU47
KGLY45
KGLU47
LGLY45
LGLU47
AGLU47
BGLY45
BGLU47
CGLY45
CGLU47
DGLY45
DGLU47
EGLY45
EGLU47
FGLY45
FGLU47

219869

PDB entries from 2024-05-15

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