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7QDZ

80S-bound human SKI complex in the closed state

Functional Information from GO Data
ChainGOidnamespacecontents
A0003676molecular_functionnucleic acid binding
A0003723molecular_functionRNA binding
A0003724molecular_functionRNA helicase activity
A0004386molecular_functionhelicase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006401biological_processRNA catabolic process
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0034458molecular_function3'-5' RNA helicase activity
A0055087cellular_componentSki complex
A0070478biological_processnuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
A0072344biological_processrescue of stalled ribosome
B0000791cellular_componenteuchromatin
B0000956biological_processnuclear-transcribed mRNA catabolic process
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006401biological_processRNA catabolic process
B0055087cellular_componentSki complex
B0070478biological_processnuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
B0072344biological_processrescue of stalled ribosome
C0000791cellular_componenteuchromatin
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006368biological_processtranscription elongation by RNA polymerase II
C0016055biological_processWnt signaling pathway
C0016593cellular_componentCdc73/Paf1 complex
C0045638biological_processnegative regulation of myeloid cell differentiation
C0055087cellular_componentSki complex
C0070478biological_processnuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
C0072344biological_processrescue of stalled ribosome
D0000791cellular_componenteuchromatin
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006368biological_processtranscription elongation by RNA polymerase II
D0016055biological_processWnt signaling pathway
D0016593cellular_componentCdc73/Paf1 complex
D0045638biological_processnegative regulation of myeloid cell differentiation
D0055087cellular_componentSki complex
D0070478biological_processnuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
D0072344biological_processrescue of stalled ribosome
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. AASSslDaHIRLWDL
ChainResidueDetails
CALA79-LEU93

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22223895
ChainResidueDetails
CMET1
DMET1

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N-acetylthreonine; in WD repeat-containing protein 61, N-terminally processed => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895
ChainResidueDetails
CTHR2
DTHR2

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER256

222624

PDB entries from 2024-07-17

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