7QDY
RNA-bound human SKI complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000956 | biological_process | nuclear-transcribed mRNA catabolic process |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003724 | molecular_function | RNA helicase activity |
| A | 0004386 | molecular_function | helicase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006401 | biological_process | RNA catabolic process |
| A | 0006402 | biological_process | mRNA catabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0034458 | molecular_function | 3'-5' RNA helicase activity |
| A | 0055087 | cellular_component | Ski complex |
| A | 0070478 | biological_process | nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay |
| A | 0070481 | biological_process | nuclear-transcribed mRNA catabolic process, non-stop decay |
| A | 0072344 | biological_process | rescue of stalled ribosome |
| B | 0000791 | cellular_component | euchromatin |
| B | 0000956 | biological_process | nuclear-transcribed mRNA catabolic process |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006401 | biological_process | RNA catabolic process |
| B | 0055087 | cellular_component | Ski complex |
| B | 0070478 | biological_process | nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay |
| B | 0072344 | biological_process | rescue of stalled ribosome |
| C | 0000791 | cellular_component | euchromatin |
| C | 0000956 | biological_process | nuclear-transcribed mRNA catabolic process |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006351 | biological_process | DNA-templated transcription |
| C | 0006368 | biological_process | transcription elongation by RNA polymerase II |
| C | 0016055 | biological_process | Wnt signaling pathway |
| C | 0016593 | cellular_component | Cdc73/Paf1 complex |
| C | 0045638 | biological_process | negative regulation of myeloid cell differentiation |
| C | 0055087 | cellular_component | Ski complex |
| C | 0070478 | biological_process | nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay |
| C | 0072344 | biological_process | rescue of stalled ribosome |
| D | 0000791 | cellular_component | euchromatin |
| D | 0000956 | biological_process | nuclear-transcribed mRNA catabolic process |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006351 | biological_process | DNA-templated transcription |
| D | 0006368 | biological_process | transcription elongation by RNA polymerase II |
| D | 0016055 | biological_process | Wnt signaling pathway |
| D | 0016593 | cellular_component | Cdc73/Paf1 complex |
| D | 0045638 | biological_process | negative regulation of myeloid cell differentiation |
| D | 0055087 | cellular_component | Ski complex |
| D | 0070478 | biological_process | nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay |
| D | 0072344 | biological_process | rescue of stalled ribosome |
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. AASSslDaHIRLWDL |
| Chain | Residue | Details |
| C | ALA79-LEU93 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 156 |
| Details | Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 170 |
| Details | Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Motif: {"description":"DEVH box","evidences":[{"source":"PubMed","id":"35120588","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"TPR 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 34 |
| Details | Repeat: {"description":"TPR 8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 32 |
| Details | Repeat: {"description":"TPR 11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 34 |
| Details | Repeat: {"description":"TPR 12"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 34 |
| Details | Repeat: {"description":"TPR 13"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 34 |
| Details | Repeat: {"description":"TPR 14"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 15"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 16"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 34 |
| Details | Repeat: {"description":"TPR 17"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 28 |
| Details | Repeat: {"description":"TPR 18"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 19"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 20"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 86 |
| Details | Repeat: {"description":"WD 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"WD 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"WD 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI25 |
| Number of Residues | 82 |
| Details | Repeat: {"description":"WD 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI26 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"WD 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI27 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"WD 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI28 |
| Number of Residues | 66 |
| Details | Repeat: {"description":"WD 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI29 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI30 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylthreonine; in WD repeat-containing protein 61, N-terminally processed","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
