7QDX

bacterial IMPDH chimera

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003938	molecular_function	IMP dehydrogenase activity
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
B	0003824	molecular_function	catalytic activity
B	0003938	molecular_function	IMP dehydrogenase activity
B	0006164	biological_process	purine nucleotide biosynthetic process
B	0016491	molecular_function	oxidoreductase activity

Functional Information from PROSITE/UniProt

site_id	PS00487
Number of Residues	13
Details	IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. VKVGIGpGSICtT

Chain	Residue	Details
A	VAL314-THR326

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Thioimidate intermediate => ECO:0000255|HAMAP-Rule:MF_01964

Chain	Residue	Details
A	CYS324
B	CYS324

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_01964

Chain	Residue	Details
A	ARG420
B	ARG420

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site_id	SWS_FT_FI3
Number of Residues	20
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01964

Chain	Residue	Details
A	ASP267
A	HIS490
B	ASP267
B	GLY317
B	SER322
B	ASP357
B	GLY380
B	TYR404
B	GLU434
B	GLU488
B	SER489
A	GLY317
B	HIS490
A	SER322
A	ASP357
A	GLY380
A	TYR404
A	GLU434
A	GLU488
A	SER489

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site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_01964

Chain	Residue	Details
A	GLY319
A	GLY321
A	CYS324
B	GLY319
B	GLY321
B	CYS324

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site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18723842

Chain	Residue	Details
A	LYS286
A	LYS447
B	LYS286
B	LYS447

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