7QBC
Structure of the GPCR dimer Ste2 in the inactive-like state bound to agonist
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000750 | biological_process | pheromone-dependent signal transduction involved in conjugation with cellular fusion |
A | 0000755 | biological_process | cytogamy |
A | 0004930 | molecular_function | G protein-coupled receptor activity |
A | 0004932 | molecular_function | mating-type factor pheromone receptor activity |
A | 0004934 | molecular_function | mating-type alpha-factor pheromone receptor activity |
A | 0005515 | molecular_function | protein binding |
A | 0005886 | cellular_component | plasma membrane |
A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
A | 0016020 | cellular_component | membrane |
A | 0019236 | biological_process | response to pheromone |
A | 0038038 | cellular_component | G protein-coupled receptor homodimeric complex |
B | 0000750 | biological_process | pheromone-dependent signal transduction involved in conjugation with cellular fusion |
B | 0000755 | biological_process | cytogamy |
B | 0004930 | molecular_function | G protein-coupled receptor activity |
B | 0004932 | molecular_function | mating-type factor pheromone receptor activity |
B | 0004934 | molecular_function | mating-type alpha-factor pheromone receptor activity |
B | 0005515 | molecular_function | protein binding |
B | 0005886 | cellular_component | plasma membrane |
B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
B | 0016020 | cellular_component | membrane |
B | 0019236 | biological_process | response to pheromone |
B | 0038038 | cellular_component | G protein-coupled receptor homodimeric complex |
I | 0000772 | molecular_function | mating pheromone activity |
I | 0005576 | cellular_component | extracellular region |
I | 0019953 | biological_process | sexual reproduction |
K | 0000772 | molecular_function | mating pheromone activity |
K | 0005576 | cellular_component | extracellular region |
K | 0019953 | biological_process | sexual reproduction |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 308 |
Details | TRANSMEM: Helical => ECO:0000255 |
Chain | Residue | Details |
A | GLN51-SER73 | |
B | ILE133-THR155 | |
B | ILE162-SER184 | |
B | ILE209-ARG231 | |
B | PHE244-TYR266 | |
B | VAL276-ALA298 | |
A | ILE80-LEU102 | |
A | ILE133-THR155 | |
A | ILE162-SER184 | |
A | ILE209-ARG231 | |
A | PHE244-TYR266 | |
A | VAL276-ALA298 | |
B | GLN51-SER73 | |
B | ILE80-LEU102 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950 |
Chain | Residue | Details |
A | SER310 | |
A | SER360 | |
A | SER385 | |
B | SER310 | |
B | SER360 | |
B | SER385 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198 |
Chain | Residue | Details |
A | SER315 | |
B | SER315 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:19779198 |
Chain | Residue | Details |
A | THR329 | |
A | THR382 | |
B | THR329 | |
B | THR382 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:19779198 |
Chain | Residue | Details |
A | SER331 | |
A | SER386 | |
B | SER331 | |
B | SER386 |
site_id | SWS_FT_FI6 |
Number of Residues | 6 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17330950 |
Chain | Residue | Details |
A | THR363 | |
A | THR411 | |
A | THR414 | |
B | THR363 | |
B | THR411 | |
B | THR414 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:15665377, ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:19779198 |
Chain | Residue | Details |
A | SER366 | |
B | SER366 |
site_id | SWS_FT_FI8 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11583169 |
Chain | Residue | Details |
A | ASN25 | |
A | ASN32 | |
B | ASN25 | |
B | ASN32 |
site_id | SWS_FT_FI9 |
Number of Residues | 8 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 |
Chain | Residue | Details |
A | LYS374 | |
A | LYS400 | |
A | LYS422 | |
B | LYS374 | |
B | LYS400 | |
B | LYS422 |
site_id | SWS_FT_FI10 |
Number of Residues | 202 |
Details | TOPO_DOM: Extracellular => ECO:0000305|PubMed:1653030, ECO:0000305|PubMed:2017168 |
Chain | Residue | Details |
A | MET1-VAL49 | |
A | LEU103-ASN132 | |
A | MET189-ASN205 | |
A | SER267-ASP275 | |
B | MET1-VAL49 | |
B | LEU103-ASN132 | |
B | MET189-ASN205 | |
B | SER267-ASP275 |
site_id | SWS_FT_FI11 |
Number of Residues | 44 |
Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:11112532, ECO:0000269|PubMed:11467956, ECO:0000269|PubMed:19383463, ECO:0007744|PDB:2K9P |
Chain | Residue | Details |
A | THR50-THR72 | |
B | THR50-THR72 |
site_id | SWS_FT_FI12 |
Number of Residues | 304 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:1653030, ECO:0000305|PubMed:2017168 |
Chain | Residue | Details |
A | SER73-THR78 | |
A | ASP157-GLY163 | |
A | ARG231-PHE241 | |
A | ASN300-LEU431 | |
B | SER73-THR78 | |
B | ASP157-GLY163 | |
B | ARG231-PHE241 | |
B | ASN300-LEU431 |
site_id | SWS_FT_FI13 |
Number of Residues | 46 |
Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:11112532, ECO:0000269|PubMed:11467956, ECO:0000269|PubMed:19383463, ECO:0007744|PDB:2K9P |
Chain | Residue | Details |
A | PRO79-LEU102 | |
B | PRO79-LEU102 |
site_id | SWS_FT_FI14 |
Number of Residues | 46 |
Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:11112532, ECO:0000269|PubMed:11467956 |
Chain | Residue | Details |
A | ILE133-GLY156 | |
B | ILE133-GLY156 |
site_id | SWS_FT_FI15 |
Number of Residues | 48 |
Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:11112532, ECO:0000269|PubMed:11467956 |
Chain | Residue | Details |
A | LEU164-GLY188 | |
B | LEU164-GLY188 |
site_id | SWS_FT_FI16 |
Number of Residues | 48 |
Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:11112532, ECO:0000269|PubMed:11467956 |
Chain | Residue | Details |
A | ALA206-ILE230 | |
B | ALA206-ILE230 |
site_id | SWS_FT_FI17 |
Number of Residues | 48 |
Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:11112532, ECO:0000269|PubMed:11467956, ECO:0000269|PubMed:11473349, ECO:0007744|PDB:1PJD |
Chain | Residue | Details |
A | ASP242-TYR266 | |
B | ASP242-TYR266 |
site_id | SWS_FT_FI18 |
Number of Residues | 46 |
Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:11112532, ECO:0000269|PubMed:11467956 |
Chain | Residue | Details |
A | VAL276-ALA299 | |
B | VAL276-ALA299 |
site_id | SWS_FT_FI19 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:9659916 |
Chain | Residue | Details |
A | LYS337 | |
B | LYS337 |