7QB9

Structure of the ligand-free GPCR dimer Ste2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000750	biological_process	pheromone-dependent signal transduction involved in conjugation with cellular fusion
A	0000755	biological_process	cytogamy
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004932	molecular_function	mating-type factor pheromone receptor activity
A	0004934	molecular_function	mating-type alpha-factor pheromone receptor activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0016020	cellular_component	membrane
A	0019236	biological_process	response to pheromone
A	0038038	cellular_component	G protein-coupled receptor homodimeric complex
B	0000750	biological_process	pheromone-dependent signal transduction involved in conjugation with cellular fusion
B	0000755	biological_process	cytogamy
B	0004930	molecular_function	G protein-coupled receptor activity
B	0004932	molecular_function	mating-type factor pheromone receptor activity
B	0004934	molecular_function	mating-type alpha-factor pheromone receptor activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0016020	cellular_component	membrane
B	0019236	biological_process	response to pheromone
B	0038038	cellular_component	G protein-coupled receptor homodimeric complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	308
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	GLN51-SER73
B	ILE133-THR155
B	ILE162-SER184
B	ILE209-ARG231
B	PHE244-TYR266
B	VAL276-ALA298
A	ILE80-LEU102
A	ILE133-THR155
A	ILE162-SER184
A	ILE209-ARG231
A	PHE244-TYR266
A	VAL276-ALA298
B	GLN51-SER73
B	ILE80-LEU102

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950

Chain	Residue	Details
A	SER310
A	SER360
A	SER385
B	SER310
B	SER360
B	SER385

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198

Chain	Residue	Details
A	SER315
B	SER315

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:19779198

Chain	Residue	Details
A	THR329
A	THR382
B	THR329
B	THR382

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:19779198

Chain	Residue	Details
A	SER386
A	SER331
B	SER331
B	SER386

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17330950

Chain	Residue	Details
A	THR363
A	THR411
A	THR414
B	THR363
B	THR411
B	THR414

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:15665377, ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:19779198

Chain	Residue	Details
A	SER366
B	SER366

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11583169

Chain	Residue	Details
A	ASN25
A	ASN32
B	ASN25
B	ASN32

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047

Chain	Residue	Details
A	LYS374
A	LYS400
A	LYS422
B	LYS374
B	LYS400
B	LYS422

---

site_id	SWS_FT_FI10
Number of Residues	202
Details	TOPO_DOM: Extracellular => ECO:0000305|PubMed:1653030, ECO:0000305|PubMed:2017168

Chain	Residue	Details
A	MET1-VAL49
A	LEU103-ASN132
A	MET189-ASN205
A	SER267-ASP275
B	MET1-VAL49
B	LEU103-ASN132
B	MET189-ASN205
B	SER267-ASP275

---

site_id	SWS_FT_FI11
Number of Residues	44
Details	TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:11112532, ECO:0000269|PubMed:11467956, ECO:0000269|PubMed:19383463, ECO:0007744|PDB:2K9P

Chain	Residue	Details
A	THR50-THR72
B	THR50-THR72

---

site_id	SWS_FT_FI12
Number of Residues	304
Details	TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:1653030, ECO:0000305|PubMed:2017168

Chain	Residue	Details
A	SER73-THR78
A	ASP157-GLY163
A	ARG231-PHE241
A	ASN300-LEU431
B	SER73-THR78
B	ASP157-GLY163
B	ARG231-PHE241
B	ASN300-LEU431

---

site_id	SWS_FT_FI13
Number of Residues	46
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:11112532, ECO:0000269|PubMed:11467956, ECO:0000269|PubMed:19383463, ECO:0007744|PDB:2K9P

Chain	Residue	Details
A	PRO79-LEU102
B	PRO79-LEU102

---

site_id	SWS_FT_FI14
Number of Residues	46
Details	TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:11112532, ECO:0000269|PubMed:11467956

Chain	Residue	Details
A	ILE133-GLY156
B	ILE133-GLY156

---

site_id	SWS_FT_FI15
Number of Residues	48
Details	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:11112532, ECO:0000269|PubMed:11467956

Chain	Residue	Details
A	LEU164-GLY188
B	LEU164-GLY188

---

site_id	SWS_FT_FI16
Number of Residues	48
Details	TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:11112532, ECO:0000269|PubMed:11467956

Chain	Residue	Details
A	ALA206-ILE230
B	ALA206-ILE230

---

site_id	SWS_FT_FI17
Number of Residues	48
Details	TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:11112532, ECO:0000269|PubMed:11467956, ECO:0000269|PubMed:11473349, ECO:0007744|PDB:1PJD

Chain	Residue	Details
A	ASP242-TYR266
B	ASP242-TYR266

---

site_id	SWS_FT_FI18
Number of Residues	46
Details	TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:11112532, ECO:0000269|PubMed:11467956

Chain	Residue	Details
A	VAL276-ALA299
B	VAL276-ALA299

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:9659916

Chain	Residue	Details
A	LYS337
B	LYS337

---