7Q5T
The tandem SH2 domains of SYK with a bound FCER1G diphospho-ITAM peptide
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| AAA | 0004715 | molecular_function | non-membrane spanning protein tyrosine kinase activity |
| BBB | 0004715 | molecular_function | non-membrane spanning protein tyrosine kinase activity |
| CCC | 0004715 | molecular_function | non-membrane spanning protein tyrosine kinase activity |
| DDD | 0004715 | molecular_function | non-membrane spanning protein tyrosine kinase activity |
| EEE | 0004715 | molecular_function | non-membrane spanning protein tyrosine kinase activity |
| FFF | 0004715 | molecular_function | non-membrane spanning protein tyrosine kinase activity |
| GGG | 0004888 | molecular_function | transmembrane signaling receptor activity |
| GGG | 0007166 | biological_process | cell surface receptor signaling pathway |
| GGG | 0016020 | cellular_component | membrane |
| HHH | 0004888 | molecular_function | transmembrane signaling receptor activity |
| HHH | 0007166 | biological_process | cell surface receptor signaling pathway |
| HHH | 0016020 | cellular_component | membrane |
| III | 0004888 | molecular_function | transmembrane signaling receptor activity |
| III | 0007166 | biological_process | cell surface receptor signaling pathway |
| III | 0016020 | cellular_component | membrane |
| JJJ | 0004888 | molecular_function | transmembrane signaling receptor activity |
| JJJ | 0007166 | biological_process | cell surface receptor signaling pathway |
| JJJ | 0016020 | cellular_component | membrane |
| KKK | 0004888 | molecular_function | transmembrane signaling receptor activity |
| KKK | 0007166 | biological_process | cell surface receptor signaling pathway |
| KKK | 0016020 | cellular_component | membrane |
| LLL | 0004888 | molecular_function | transmembrane signaling receptor activity |
| LLL | 0007166 | biological_process | cell surface receptor signaling pathway |
| LLL | 0016020 | cellular_component | membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 552 |
| Details | Domain: {"description":"SH2 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 546 |
| Details | Domain: {"description":"SH2 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 236 |
| Details | Region: {"description":"Interdomain A"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"21469132","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21469132","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"21469132","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"21469132","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 5 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P20491","evidenceCode":"ECO:0000250"},{"source":"PROSITE-ProRule","id":"PRU00379","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
