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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7Q4P

U2 snRNP after ATP-dependent remodelling

Functional Information from GO Data
ChainGOidnamespacecontents
10000245biological_processspliceosomal complex assembly
10000387biological_processspliceosomal snRNP assembly
10000389biological_processmRNA 3'-splice site recognition
10000398biological_processmRNA splicing, via spliceosome
10003676molecular_functionnucleic acid binding
10003723molecular_functionRNA binding
10005515molecular_functionprotein binding
10005634cellular_componentnucleus
10005654cellular_componentnucleoplasm
10005681cellular_componentspliceosomal complex
10005684cellular_componentU2-type spliceosomal complex
10005686cellular_componentU2 snRNP
10006397biological_processmRNA processing
10008270molecular_functionzinc ion binding
10008380biological_processRNA splicing
10010976biological_processpositive regulation of neuron projection development
10016607cellular_componentnuclear speck
10046872molecular_functionmetal ion binding
10071004cellular_componentU2-type prespliceosome
10071005cellular_componentU2-type precatalytic spliceosome
10071013cellular_componentcatalytic step 2 spliceosome
11903241biological_processU2-type prespliceosome assembly
90000375biological_processRNA splicing, via transesterification reactions
90000387biological_processspliceosomal snRNP assembly
90000389biological_processmRNA 3'-splice site recognition
90000398biological_processmRNA splicing, via spliceosome
90003676molecular_functionnucleic acid binding
90003723molecular_functionRNA binding
90005515molecular_functionprotein binding
90005634cellular_componentnucleus
90005654cellular_componentnucleoplasm
90005681cellular_componentspliceosomal complex
90005684cellular_componentU2-type spliceosomal complex
90005686cellular_componentU2 snRNP
90006397biological_processmRNA processing
90008270molecular_functionzinc ion binding
90008380biological_processRNA splicing
90016607cellular_componentnuclear speck
90046872molecular_functionmetal ion binding
90071005cellular_componentU2-type precatalytic spliceosome
90071013cellular_componentcatalytic step 2 spliceosome
91903241biological_processU2-type prespliceosome assembly
A0000245biological_processspliceosomal complex assembly
A0000375biological_processRNA splicing, via transesterification reactions
A0000387biological_processspliceosomal snRNP assembly
A0000388biological_processspliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
A0000398biological_processmRNA splicing, via spliceosome
A0000785cellular_componentchromatin
A0003723molecular_functionRNA binding
A0003729molecular_functionmRNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005681cellular_componentspliceosomal complex
A0005684cellular_componentU2-type spliceosomal complex
A0005686cellular_componentU2 snRNP
A0005689cellular_componentU12-type spliceosomal complex
A0005730cellular_componentnucleolus
A0006338biological_processchromatin remodeling
A0006397biological_processmRNA processing
A0008380biological_processRNA splicing
A0016607cellular_componentnuclear speck
A0031981cellular_componentnuclear lumen
A0034693cellular_componentU11/U12 snRNP
A0036002molecular_functionpre-mRNA binding
A0045943biological_processpositive regulation of transcription by RNA polymerase I
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0045945biological_processpositive regulation of transcription by RNA polymerase III
A0071004cellular_componentU2-type prespliceosome
A0071005cellular_componentU2-type precatalytic spliceosome
A0071013cellular_componentcatalytic step 2 spliceosome
A1903241biological_processU2-type prespliceosome assembly
A1990935molecular_functionsplicing factor binding
B0000387biological_processspliceosomal snRNP assembly
B0000388biological_processspliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
B0000398biological_processmRNA splicing, via spliceosome
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005681cellular_componentspliceosomal complex
B0005684cellular_componentU2-type spliceosomal complex
B0005686cellular_componentU2 snRNP
B0005689cellular_componentU12-type spliceosomal complex
B0006397biological_processmRNA processing
B0008380biological_processRNA splicing
B0016607cellular_componentnuclear speck
B0071005cellular_componentU2-type precatalytic spliceosome
B0071011cellular_componentprecatalytic spliceosome
B0071013cellular_componentcatalytic step 2 spliceosome
B1903241biological_processU2-type prespliceosome assembly
C0000375biological_processRNA splicing, via transesterification reactions
C0000387biological_processspliceosomal snRNP assembly
C0000388biological_processspliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
C0000398biological_processmRNA splicing, via spliceosome
C0003676molecular_functionnucleic acid binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005681cellular_componentspliceosomal complex
C0005684cellular_componentU2-type spliceosomal complex
C0005686cellular_componentU2 snRNP
C0005689cellular_componentU12-type spliceosomal complex
C0005730cellular_componentnucleolus
C0006282biological_processregulation of DNA repair
C0006397biological_processmRNA processing
C0008380biological_processRNA splicing
C0030620molecular_functionU2 snRNA binding
C0042177biological_processnegative regulation of protein catabolic process
C0043484biological_processregulation of RNA splicing
C0044877molecular_functionprotein-containing complex binding
C0045893biological_processpositive regulation of DNA-templated transcription
C0071005cellular_componentU2-type precatalytic spliceosome
C0071013cellular_componentcatalytic step 2 spliceosome
C1903241biological_processU2-type prespliceosome assembly
E0000387biological_processspliceosomal snRNP assembly
E0000388biological_processspliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
E0000398biological_processmRNA splicing, via spliceosome
E0003723molecular_functionRNA binding
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005681cellular_componentspliceosomal complex
E0005684cellular_componentU2-type spliceosomal complex
E0005686cellular_componentU2 snRNP
E0005689cellular_componentU12-type spliceosomal complex
E0006282biological_processregulation of DNA repair
E0006397biological_processmRNA processing
E0008380biological_processRNA splicing
E0043484biological_processregulation of RNA splicing
E0045893biological_processpositive regulation of DNA-templated transcription
E0071005cellular_componentU2-type precatalytic spliceosome
E0071011cellular_componentprecatalytic spliceosome
E1903241biological_processU2-type prespliceosome assembly
E1990935molecular_functionsplicing factor binding
G0000387biological_processspliceosomal snRNP assembly
G0000388biological_processspliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
G0000398biological_processmRNA splicing, via spliceosome
G0003677molecular_functionDNA binding
G0003723molecular_functionRNA binding
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005681cellular_componentspliceosomal complex
G0005684cellular_componentU2-type spliceosomal complex
G0005686cellular_componentU2 snRNP
G0005689cellular_componentU12-type spliceosomal complex
G0006351biological_processDNA-templated transcription
G0006397biological_processmRNA processing
G0008270molecular_functionzinc ion binding
G0008380biological_processRNA splicing
G0016363cellular_componentnuclear matrix
G0016607cellular_componentnuclear speck
G0045893biological_processpositive regulation of DNA-templated transcription
G0046872molecular_functionmetal ion binding
G0048863biological_processstem cell differentiation
G0071005cellular_componentU2-type precatalytic spliceosome
G0071011cellular_componentprecatalytic spliceosome
G1903241biological_processU2-type prespliceosome assembly
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FVCSATH
ChainResidueDetails
CPHE287-HIS293
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues31
DetailsZinc finger: {"description":"Matrin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00130","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues38
DetailsRepeat: {"description":"HEAT 9"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues38
DetailsRepeat: {"description":"HEAT 10"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues38
DetailsRepeat: {"description":"HEAT 11"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsRegion: {"description":"Interaction with PHF5A","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues56
DetailsRegion: {"description":"Interaction with SF3B3 and SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsSite: {"description":"Interaction with RNA","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsSite: {"description":"Interaction with SF3B3","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsModified residue: {"description":"Symmetric dimethylarginine; by PRMT9; alternate","evidences":[{"source":"PubMed","id":"25737013","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsModified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues37
DetailsRegion: {"description":"Interaction with PHF5A, SF3B1 and SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues56
DetailsRegion: {"description":"Interaction with SF3B1 and SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues21
DetailsRegion: {"description":"Interaction with SF3B1","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues23
DetailsRegion: {"description":"Interaction with SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues5
DetailsSite: {"description":"Interaction with SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsSite: {"description":"Interaction with SF3B1","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues16
DetailsRegion: {"description":"Interaction with SF3B1 and SF3B3","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues3
DetailsRegion: {"description":"Interaction with SF3B3","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"28541300","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IFE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SYB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

247947

PDB entries from 2026-01-21

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