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7PZZ

Crystal structure of serine hydroxymethyltransferase, isoform 2 from Arabidopsis thaliana (SHM2)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004372molecular_functionglycine hydroxymethyltransferase activity
A0005739cellular_componentmitochondrion
A0005747cellular_componentmitochondrial respiratory chain complex I
A0006544biological_processglycine metabolic process
A0006563biological_processL-serine metabolic process
A0006730biological_processone-carbon metabolic process
A0008270molecular_functionzinc ion binding
A0009536cellular_componentplastid
A0016740molecular_functiontransferase activity
A0019264biological_processglycine biosynthetic process from serine
A0030170molecular_functionpyridoxal phosphate binding
A0035999biological_processtetrahydrofolate interconversion
A0050897molecular_functioncobalt ion binding
B0004372molecular_functionglycine hydroxymethyltransferase activity
B0005739cellular_componentmitochondrion
B0005747cellular_componentmitochondrial respiratory chain complex I
B0006544biological_processglycine metabolic process
B0006563biological_processL-serine metabolic process
B0006730biological_processone-carbon metabolic process
B0008270molecular_functionzinc ion binding
B0009536cellular_componentplastid
B0016740molecular_functiontransferase activity
B0019264biological_processglycine biosynthetic process from serine
B0030170molecular_functionpyridoxal phosphate binding
B0035999biological_processtetrahydrofolate interconversion
B0050897molecular_functioncobalt ion binding
C0004372molecular_functionglycine hydroxymethyltransferase activity
C0005739cellular_componentmitochondrion
C0005747cellular_componentmitochondrial respiratory chain complex I
C0006544biological_processglycine metabolic process
C0006563biological_processL-serine metabolic process
C0006730biological_processone-carbon metabolic process
C0008270molecular_functionzinc ion binding
C0009536cellular_componentplastid
C0016740molecular_functiontransferase activity
C0019264biological_processglycine biosynthetic process from serine
C0030170molecular_functionpyridoxal phosphate binding
C0035999biological_processtetrahydrofolate interconversion
C0050897molecular_functioncobalt ion binding
D0004372molecular_functionglycine hydroxymethyltransferase activity
D0005739cellular_componentmitochondrion
D0005747cellular_componentmitochondrial respiratory chain complex I
D0006544biological_processglycine metabolic process
D0006563biological_processL-serine metabolic process
D0006730biological_processone-carbon metabolic process
D0008270molecular_functionzinc ion binding
D0009536cellular_componentplastid
D0016740molecular_functiontransferase activity
D0019264biological_processglycine biosynthetic process from serine
D0030170molecular_functionpyridoxal phosphate binding
D0035999biological_processtetrahydrofolate interconversion
D0050897molecular_functioncobalt ion binding
Functional Information from PROSITE/UniProt
site_idPS00096
Number of Residues17
DetailsSHMT Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. DVvTTTTHKSLrGPRGA
ChainResidueDetails
AASP278-ALA294

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues40
DetailsBINDING: BINDING => ECO:0000269|PubMed:31873125, ECO:0007744|PDB:6SMN, ECO:0007744|PDB:6SMW
ChainResidueDetails
ASER82
ATYR102
AGLU104
ATYR112
ASER148
ASER232
AHIS260
AGLY331
ALYS414
AARG430
BSER82
BTYR102
BGLU104
BTYR112
BSER148
BSER232
BHIS260
BGLY331
BLYS414
BARG430
CSER82
CTYR102
CGLU104
CTYR112
CSER148
CSER232
CHIS260
CGLY331
CLYS414
CARG430
DSER82
DTYR102
DGLU104
DTYR112
DSER148
DSER232
DHIS260
DGLY331
DLYS414
DARG430

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:31873125, ECO:0007744|PDB:6SMN
ChainResidueDetails
AHIS177
ATHR184
BHIS177
BTHR184
CHIS177
CTHR184
DHIS177
DTHR184

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:31873125, ECO:0007744|PDB:6SMW
ChainResidueDetails
ALLP286
BLLP286
CLLP286
DLLP286

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000250
ChainResidueDetails
ALLP286
BLLP286
CLLP286
DLLP286

219869

PDB entries from 2024-05-15

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