7PXA

Open-gate mycobacterium 20S CP proteasome in complex MPA - global 3D refinement

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0000502	cellular_component	proteasome complex
0	0004175	molecular_function	endopeptidase activity
0	0004298	molecular_function	threonine-type endopeptidase activity
0	0005515	molecular_function	protein binding
0	0005737	cellular_component	cytoplasm
0	0005839	cellular_component	proteasome core complex
0	0005886	cellular_component	plasma membrane
0	0009274	cellular_component	peptidoglycan-based cell wall
0	0010498	biological_process	proteasomal protein catabolic process
0	0016787	molecular_function	hydrolase activity
0	0019773	cellular_component	proteasome core complex, alpha-subunit complex
0	0019941	biological_process	modification-dependent protein catabolic process
0	0030682	biological_process	symbiont-mediated perturbation of host defenses
0	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
0	0051603	biological_process	proteolysis involved in protein catabolic process
1	0000502	cellular_component	proteasome complex
1	0004176	molecular_function	ATP-dependent peptidase activity
1	0005515	molecular_function	protein binding
1	0005524	molecular_function	ATP binding
1	0005886	cellular_component	plasma membrane
1	0009274	cellular_component	peptidoglycan-based cell wall
1	0010498	biological_process	proteasomal protein catabolic process
1	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
1	0016887	molecular_function	ATP hydrolysis activity
1	0019941	biological_process	modification-dependent protein catabolic process
1	0022623	cellular_component	proteasome-activating nucleotidase complex
1	0030682	biological_process	symbiont-mediated perturbation of host defenses
1	0042802	molecular_function	identical protein binding
1	0043335	biological_process	protein unfolding
1	0051409	biological_process	response to nitrosative stress
1	0052164	biological_process	symbiont defense to host-produced reactive oxygen species
1	0071732	biological_process	cellular response to nitric oxide
1	0140035	molecular_function	ubiquitin-like protein reader activity
2	0000502	cellular_component	proteasome complex
2	0004175	molecular_function	endopeptidase activity
2	0004298	molecular_function	threonine-type endopeptidase activity
2	0005515	molecular_function	protein binding
2	0005737	cellular_component	cytoplasm
2	0005839	cellular_component	proteasome core complex
2	0005886	cellular_component	plasma membrane
2	0009274	cellular_component	peptidoglycan-based cell wall
2	0010498	biological_process	proteasomal protein catabolic process
2	0016787	molecular_function	hydrolase activity
2	0019773	cellular_component	proteasome core complex, alpha-subunit complex
2	0019941	biological_process	modification-dependent protein catabolic process
2	0030682	biological_process	symbiont-mediated perturbation of host defenses
2	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
2	0051603	biological_process	proteolysis involved in protein catabolic process
4	0000502	cellular_component	proteasome complex
4	0004175	molecular_function	endopeptidase activity
4	0004298	molecular_function	threonine-type endopeptidase activity
4	0005515	molecular_function	protein binding
4	0005737	cellular_component	cytoplasm
4	0005839	cellular_component	proteasome core complex
4	0005886	cellular_component	plasma membrane
4	0009274	cellular_component	peptidoglycan-based cell wall
4	0010498	biological_process	proteasomal protein catabolic process
4	0016787	molecular_function	hydrolase activity
4	0019773	cellular_component	proteasome core complex, alpha-subunit complex
4	0019941	biological_process	modification-dependent protein catabolic process
4	0030682	biological_process	symbiont-mediated perturbation of host defenses
4	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
4	0051603	biological_process	proteolysis involved in protein catabolic process
6	0000502	cellular_component	proteasome complex
6	0004175	molecular_function	endopeptidase activity
6	0004298	molecular_function	threonine-type endopeptidase activity
6	0005515	molecular_function	protein binding
6	0005737	cellular_component	cytoplasm
6	0005839	cellular_component	proteasome core complex
6	0005886	cellular_component	plasma membrane
6	0009274	cellular_component	peptidoglycan-based cell wall
6	0010498	biological_process	proteasomal protein catabolic process
6	0016787	molecular_function	hydrolase activity
6	0019773	cellular_component	proteasome core complex, alpha-subunit complex
6	0019941	biological_process	modification-dependent protein catabolic process
6	0030682	biological_process	symbiont-mediated perturbation of host defenses
6	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
6	0051603	biological_process	proteolysis involved in protein catabolic process
8	0000502	cellular_component	proteasome complex
8	0004175	molecular_function	endopeptidase activity
8	0004298	molecular_function	threonine-type endopeptidase activity
8	0005515	molecular_function	protein binding
8	0005737	cellular_component	cytoplasm
8	0005839	cellular_component	proteasome core complex
8	0005886	cellular_component	plasma membrane
8	0009274	cellular_component	peptidoglycan-based cell wall
8	0010498	biological_process	proteasomal protein catabolic process
8	0016787	molecular_function	hydrolase activity
8	0019773	cellular_component	proteasome core complex, alpha-subunit complex
8	0019941	biological_process	modification-dependent protein catabolic process
8	0030682	biological_process	symbiont-mediated perturbation of host defenses
8	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
8	0051603	biological_process	proteolysis involved in protein catabolic process
A	0000502	cellular_component	proteasome complex
A	0004176	molecular_function	ATP-dependent peptidase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0010498	biological_process	proteasomal protein catabolic process
A	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
A	0016887	molecular_function	ATP hydrolysis activity
A	0019941	biological_process	modification-dependent protein catabolic process
A	0022623	cellular_component	proteasome-activating nucleotidase complex
A	0030682	biological_process	symbiont-mediated perturbation of host defenses
A	0042802	molecular_function	identical protein binding
A	0043335	biological_process	protein unfolding
A	0051409	biological_process	response to nitrosative stress
A	0052164	biological_process	symbiont defense to host-produced reactive oxygen species
A	0071732	biological_process	cellular response to nitric oxide
A	0140035	molecular_function	ubiquitin-like protein reader activity
B	0000502	cellular_component	proteasome complex
B	0004176	molecular_function	ATP-dependent peptidase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005886	cellular_component	plasma membrane
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0010498	biological_process	proteasomal protein catabolic process
B	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
B	0016887	molecular_function	ATP hydrolysis activity
B	0019941	biological_process	modification-dependent protein catabolic process
B	0022623	cellular_component	proteasome-activating nucleotidase complex
B	0030682	biological_process	symbiont-mediated perturbation of host defenses
B	0042802	molecular_function	identical protein binding
B	0043335	biological_process	protein unfolding
B	0051409	biological_process	response to nitrosative stress
B	0052164	biological_process	symbiont defense to host-produced reactive oxygen species
B	0071732	biological_process	cellular response to nitric oxide
B	0140035	molecular_function	ubiquitin-like protein reader activity
C	0000502	cellular_component	proteasome complex
C	0004176	molecular_function	ATP-dependent peptidase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005886	cellular_component	plasma membrane
C	0009274	cellular_component	peptidoglycan-based cell wall
C	0010498	biological_process	proteasomal protein catabolic process
C	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
C	0016887	molecular_function	ATP hydrolysis activity
C	0019941	biological_process	modification-dependent protein catabolic process
C	0022623	cellular_component	proteasome-activating nucleotidase complex
C	0030682	biological_process	symbiont-mediated perturbation of host defenses
C	0042802	molecular_function	identical protein binding
C	0043335	biological_process	protein unfolding
C	0051409	biological_process	response to nitrosative stress
C	0052164	biological_process	symbiont defense to host-produced reactive oxygen species
C	0071732	biological_process	cellular response to nitric oxide
C	0140035	molecular_function	ubiquitin-like protein reader activity
D	0000502	cellular_component	proteasome complex
D	0004176	molecular_function	ATP-dependent peptidase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005886	cellular_component	plasma membrane
D	0009274	cellular_component	peptidoglycan-based cell wall
D	0010498	biological_process	proteasomal protein catabolic process
D	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
D	0016887	molecular_function	ATP hydrolysis activity
D	0019941	biological_process	modification-dependent protein catabolic process
D	0022623	cellular_component	proteasome-activating nucleotidase complex
D	0030682	biological_process	symbiont-mediated perturbation of host defenses
D	0042802	molecular_function	identical protein binding
D	0043335	biological_process	protein unfolding
D	0051409	biological_process	response to nitrosative stress
D	0052164	biological_process	symbiont defense to host-produced reactive oxygen species
D	0071732	biological_process	cellular response to nitric oxide
D	0140035	molecular_function	ubiquitin-like protein reader activity
E	0000502	cellular_component	proteasome complex
E	0004176	molecular_function	ATP-dependent peptidase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005886	cellular_component	plasma membrane
E	0009274	cellular_component	peptidoglycan-based cell wall
E	0010498	biological_process	proteasomal protein catabolic process
E	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
E	0016887	molecular_function	ATP hydrolysis activity
E	0019941	biological_process	modification-dependent protein catabolic process
E	0022623	cellular_component	proteasome-activating nucleotidase complex
E	0030682	biological_process	symbiont-mediated perturbation of host defenses
E	0042802	molecular_function	identical protein binding
E	0043335	biological_process	protein unfolding
E	0051409	biological_process	response to nitrosative stress
E	0052164	biological_process	symbiont defense to host-produced reactive oxygen species
E	0071732	biological_process	cellular response to nitric oxide
E	0140035	molecular_function	ubiquitin-like protein reader activity
F	0000502	cellular_component	proteasome complex
F	0004176	molecular_function	ATP-dependent peptidase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005886	cellular_component	plasma membrane
F	0009274	cellular_component	peptidoglycan-based cell wall
F	0010498	biological_process	proteasomal protein catabolic process
F	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
F	0016887	molecular_function	ATP hydrolysis activity
F	0019941	biological_process	modification-dependent protein catabolic process
F	0022623	cellular_component	proteasome-activating nucleotidase complex
F	0030682	biological_process	symbiont-mediated perturbation of host defenses
F	0042802	molecular_function	identical protein binding
F	0043335	biological_process	protein unfolding
F	0051409	biological_process	response to nitrosative stress
F	0052164	biological_process	symbiont defense to host-produced reactive oxygen species
F	0071732	biological_process	cellular response to nitric oxide
F	0140035	molecular_function	ubiquitin-like protein reader activity
H	0000502	cellular_component	proteasome complex
H	0004175	molecular_function	endopeptidase activity
H	0004298	molecular_function	threonine-type endopeptidase activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005737	cellular_component	cytoplasm
H	0005839	cellular_component	proteasome core complex
H	0005886	cellular_component	plasma membrane
H	0006508	biological_process	proteolysis
H	0010498	biological_process	proteasomal protein catabolic process
H	0016787	molecular_function	hydrolase activity
H	0019774	cellular_component	proteasome core complex, beta-subunit complex
H	0019941	biological_process	modification-dependent protein catabolic process
H	0030682	biological_process	symbiont-mediated perturbation of host defenses
H	0035375	molecular_function	zymogen binding
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0051603	biological_process	proteolysis involved in protein catabolic process
I	0000502	cellular_component	proteasome complex
I	0004175	molecular_function	endopeptidase activity
I	0004298	molecular_function	threonine-type endopeptidase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005839	cellular_component	proteasome core complex
I	0005886	cellular_component	plasma membrane
I	0009274	cellular_component	peptidoglycan-based cell wall
I	0010498	biological_process	proteasomal protein catabolic process
I	0016787	molecular_function	hydrolase activity
I	0019773	cellular_component	proteasome core complex, alpha-subunit complex
I	0019941	biological_process	modification-dependent protein catabolic process
I	0030682	biological_process	symbiont-mediated perturbation of host defenses
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0051603	biological_process	proteolysis involved in protein catabolic process
J	0000502	cellular_component	proteasome complex
J	0004175	molecular_function	endopeptidase activity
J	0004298	molecular_function	threonine-type endopeptidase activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005737	cellular_component	cytoplasm
J	0005839	cellular_component	proteasome core complex
J	0005886	cellular_component	plasma membrane
J	0006508	biological_process	proteolysis
J	0010498	biological_process	proteasomal protein catabolic process
J	0016787	molecular_function	hydrolase activity
J	0019774	cellular_component	proteasome core complex, beta-subunit complex
J	0019941	biological_process	modification-dependent protein catabolic process
J	0030682	biological_process	symbiont-mediated perturbation of host defenses
J	0035375	molecular_function	zymogen binding
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0051603	biological_process	proteolysis involved in protein catabolic process
K	0000502	cellular_component	proteasome complex
K	0004175	molecular_function	endopeptidase activity
K	0004298	molecular_function	threonine-type endopeptidase activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005839	cellular_component	proteasome core complex
K	0005886	cellular_component	plasma membrane
K	0009274	cellular_component	peptidoglycan-based cell wall
K	0010498	biological_process	proteasomal protein catabolic process
K	0016787	molecular_function	hydrolase activity
K	0019773	cellular_component	proteasome core complex, alpha-subunit complex
K	0019941	biological_process	modification-dependent protein catabolic process
K	0030682	biological_process	symbiont-mediated perturbation of host defenses
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0051603	biological_process	proteolysis involved in protein catabolic process
L	0000502	cellular_component	proteasome complex
L	0004175	molecular_function	endopeptidase activity
L	0004298	molecular_function	threonine-type endopeptidase activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005737	cellular_component	cytoplasm
L	0005839	cellular_component	proteasome core complex
L	0005886	cellular_component	plasma membrane
L	0006508	biological_process	proteolysis
L	0010498	biological_process	proteasomal protein catabolic process
L	0016787	molecular_function	hydrolase activity
L	0019774	cellular_component	proteasome core complex, beta-subunit complex
L	0019941	biological_process	modification-dependent protein catabolic process
L	0030682	biological_process	symbiont-mediated perturbation of host defenses
L	0035375	molecular_function	zymogen binding
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0051603	biological_process	proteolysis involved in protein catabolic process
M	0000502	cellular_component	proteasome complex
M	0004175	molecular_function	endopeptidase activity
M	0004298	molecular_function	threonine-type endopeptidase activity
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0005737	cellular_component	cytoplasm
M	0005839	cellular_component	proteasome core complex
M	0005886	cellular_component	plasma membrane
M	0006508	biological_process	proteolysis
M	0010498	biological_process	proteasomal protein catabolic process
M	0016787	molecular_function	hydrolase activity
M	0019774	cellular_component	proteasome core complex, beta-subunit complex
M	0019941	biological_process	modification-dependent protein catabolic process
M	0030682	biological_process	symbiont-mediated perturbation of host defenses
M	0035375	molecular_function	zymogen binding
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0051603	biological_process	proteolysis involved in protein catabolic process
N	0000502	cellular_component	proteasome complex
N	0004175	molecular_function	endopeptidase activity
N	0004298	molecular_function	threonine-type endopeptidase activity
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005737	cellular_component	cytoplasm
N	0005839	cellular_component	proteasome core complex
N	0005886	cellular_component	plasma membrane
N	0006508	biological_process	proteolysis
N	0010498	biological_process	proteasomal protein catabolic process
N	0016787	molecular_function	hydrolase activity
N	0019774	cellular_component	proteasome core complex, beta-subunit complex
N	0019941	biological_process	modification-dependent protein catabolic process
N	0030682	biological_process	symbiont-mediated perturbation of host defenses
N	0035375	molecular_function	zymogen binding
N	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0051603	biological_process	proteolysis involved in protein catabolic process
O	0000502	cellular_component	proteasome complex
O	0004175	molecular_function	endopeptidase activity
O	0004298	molecular_function	threonine-type endopeptidase activity
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005839	cellular_component	proteasome core complex
O	0005886	cellular_component	plasma membrane
O	0009274	cellular_component	peptidoglycan-based cell wall
O	0010498	biological_process	proteasomal protein catabolic process
O	0016787	molecular_function	hydrolase activity
O	0019773	cellular_component	proteasome core complex, alpha-subunit complex
O	0019941	biological_process	modification-dependent protein catabolic process
O	0030682	biological_process	symbiont-mediated perturbation of host defenses
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0051603	biological_process	proteolysis involved in protein catabolic process
P	0000502	cellular_component	proteasome complex
P	0004175	molecular_function	endopeptidase activity
P	0004298	molecular_function	threonine-type endopeptidase activity
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005737	cellular_component	cytoplasm
P	0005839	cellular_component	proteasome core complex
P	0005886	cellular_component	plasma membrane
P	0006508	biological_process	proteolysis
P	0010498	biological_process	proteasomal protein catabolic process
P	0016787	molecular_function	hydrolase activity
P	0019774	cellular_component	proteasome core complex, beta-subunit complex
P	0019941	biological_process	modification-dependent protein catabolic process
P	0030682	biological_process	symbiont-mediated perturbation of host defenses
P	0035375	molecular_function	zymogen binding
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0051603	biological_process	proteolysis involved in protein catabolic process
Q	0000502	cellular_component	proteasome complex
Q	0004175	molecular_function	endopeptidase activity
Q	0004298	molecular_function	threonine-type endopeptidase activity
Q	0005515	molecular_function	protein binding
Q	0005737	cellular_component	cytoplasm
Q	0005839	cellular_component	proteasome core complex
Q	0005886	cellular_component	plasma membrane
Q	0009274	cellular_component	peptidoglycan-based cell wall
Q	0010498	biological_process	proteasomal protein catabolic process
Q	0016787	molecular_function	hydrolase activity
Q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Q	0019941	biological_process	modification-dependent protein catabolic process
Q	0030682	biological_process	symbiont-mediated perturbation of host defenses
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0051603	biological_process	proteolysis involved in protein catabolic process
R	0000502	cellular_component	proteasome complex
R	0004175	molecular_function	endopeptidase activity
R	0004298	molecular_function	threonine-type endopeptidase activity
R	0005515	molecular_function	protein binding
R	0005576	cellular_component	extracellular region
R	0005737	cellular_component	cytoplasm
R	0005839	cellular_component	proteasome core complex
R	0005886	cellular_component	plasma membrane
R	0006508	biological_process	proteolysis
R	0010498	biological_process	proteasomal protein catabolic process
R	0016787	molecular_function	hydrolase activity
R	0019774	cellular_component	proteasome core complex, beta-subunit complex
R	0019941	biological_process	modification-dependent protein catabolic process
R	0030682	biological_process	symbiont-mediated perturbation of host defenses
R	0035375	molecular_function	zymogen binding
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0051603	biological_process	proteolysis involved in protein catabolic process
S	0000502	cellular_component	proteasome complex
S	0004175	molecular_function	endopeptidase activity
S	0004298	molecular_function	threonine-type endopeptidase activity
S	0005515	molecular_function	protein binding
S	0005576	cellular_component	extracellular region
S	0005737	cellular_component	cytoplasm
S	0005839	cellular_component	proteasome core complex
S	0005886	cellular_component	plasma membrane
S	0006508	biological_process	proteolysis
S	0010498	biological_process	proteasomal protein catabolic process
S	0016787	molecular_function	hydrolase activity
S	0019774	cellular_component	proteasome core complex, beta-subunit complex
S	0019941	biological_process	modification-dependent protein catabolic process
S	0030682	biological_process	symbiont-mediated perturbation of host defenses
S	0035375	molecular_function	zymogen binding
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0051603	biological_process	proteolysis involved in protein catabolic process
T	0000502	cellular_component	proteasome complex
T	0004175	molecular_function	endopeptidase activity
T	0004298	molecular_function	threonine-type endopeptidase activity
T	0005515	molecular_function	protein binding
T	0005737	cellular_component	cytoplasm
T	0005839	cellular_component	proteasome core complex
T	0005886	cellular_component	plasma membrane
T	0009274	cellular_component	peptidoglycan-based cell wall
T	0010498	biological_process	proteasomal protein catabolic process
T	0016787	molecular_function	hydrolase activity
T	0019773	cellular_component	proteasome core complex, alpha-subunit complex
T	0019941	biological_process	modification-dependent protein catabolic process
T	0030682	biological_process	symbiont-mediated perturbation of host defenses
T	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
T	0051603	biological_process	proteolysis involved in protein catabolic process
U	0000502	cellular_component	proteasome complex
U	0004175	molecular_function	endopeptidase activity
U	0004298	molecular_function	threonine-type endopeptidase activity
U	0005515	molecular_function	protein binding
U	0005576	cellular_component	extracellular region
U	0005737	cellular_component	cytoplasm
U	0005839	cellular_component	proteasome core complex
U	0005886	cellular_component	plasma membrane
U	0006508	biological_process	proteolysis
U	0010498	biological_process	proteasomal protein catabolic process
U	0016787	molecular_function	hydrolase activity
U	0019774	cellular_component	proteasome core complex, beta-subunit complex
U	0019941	biological_process	modification-dependent protein catabolic process
U	0030682	biological_process	symbiont-mediated perturbation of host defenses
U	0035375	molecular_function	zymogen binding
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0051603	biological_process	proteolysis involved in protein catabolic process
V	0000502	cellular_component	proteasome complex
V	0004175	molecular_function	endopeptidase activity
V	0004298	molecular_function	threonine-type endopeptidase activity
V	0005515	molecular_function	protein binding
V	0005576	cellular_component	extracellular region
V	0005737	cellular_component	cytoplasm
V	0005839	cellular_component	proteasome core complex
V	0005886	cellular_component	plasma membrane
V	0006508	biological_process	proteolysis
V	0010498	biological_process	proteasomal protein catabolic process
V	0016787	molecular_function	hydrolase activity
V	0019774	cellular_component	proteasome core complex, beta-subunit complex
V	0019941	biological_process	modification-dependent protein catabolic process
V	0030682	biological_process	symbiont-mediated perturbation of host defenses
V	0035375	molecular_function	zymogen binding
V	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
V	0051603	biological_process	proteolysis involved in protein catabolic process
W	0000502	cellular_component	proteasome complex
W	0004175	molecular_function	endopeptidase activity
W	0004298	molecular_function	threonine-type endopeptidase activity
W	0005515	molecular_function	protein binding
W	0005576	cellular_component	extracellular region
W	0005737	cellular_component	cytoplasm
W	0005839	cellular_component	proteasome core complex
W	0005886	cellular_component	plasma membrane
W	0006508	biological_process	proteolysis
W	0010498	biological_process	proteasomal protein catabolic process
W	0016787	molecular_function	hydrolase activity
W	0019774	cellular_component	proteasome core complex, beta-subunit complex
W	0019941	biological_process	modification-dependent protein catabolic process
W	0030682	biological_process	symbiont-mediated perturbation of host defenses
W	0035375	molecular_function	zymogen binding
W	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
W	0051603	biological_process	proteolysis involved in protein catabolic process
X	0000502	cellular_component	proteasome complex
X	0004175	molecular_function	endopeptidase activity
X	0004298	molecular_function	threonine-type endopeptidase activity
X	0005515	molecular_function	protein binding
X	0005737	cellular_component	cytoplasm
X	0005839	cellular_component	proteasome core complex
X	0005886	cellular_component	plasma membrane
X	0009274	cellular_component	peptidoglycan-based cell wall
X	0010498	biological_process	proteasomal protein catabolic process
X	0016787	molecular_function	hydrolase activity
X	0019773	cellular_component	proteasome core complex, alpha-subunit complex
X	0019941	biological_process	modification-dependent protein catabolic process
X	0030682	biological_process	symbiont-mediated perturbation of host defenses
X	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
X	0051603	biological_process	proteolysis involved in protein catabolic process
Y	0000502	cellular_component	proteasome complex
Y	0004175	molecular_function	endopeptidase activity
Y	0004298	molecular_function	threonine-type endopeptidase activity
Y	0005515	molecular_function	protein binding
Y	0005576	cellular_component	extracellular region
Y	0005737	cellular_component	cytoplasm
Y	0005839	cellular_component	proteasome core complex
Y	0005886	cellular_component	plasma membrane
Y	0006508	biological_process	proteolysis
Y	0010498	biological_process	proteasomal protein catabolic process
Y	0016787	molecular_function	hydrolase activity
Y	0019774	cellular_component	proteasome core complex, beta-subunit complex
Y	0019941	biological_process	modification-dependent protein catabolic process
Y	0030682	biological_process	symbiont-mediated perturbation of host defenses
Y	0035375	molecular_function	zymogen binding
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	0051603	biological_process	proteolysis involved in protein catabolic process
Z	0000502	cellular_component	proteasome complex
Z	0004175	molecular_function	endopeptidase activity
Z	0004298	molecular_function	threonine-type endopeptidase activity
Z	0005515	molecular_function	protein binding
Z	0005737	cellular_component	cytoplasm
Z	0005839	cellular_component	proteasome core complex
Z	0005886	cellular_component	plasma membrane
Z	0009274	cellular_component	peptidoglycan-based cell wall
Z	0010498	biological_process	proteasomal protein catabolic process
Z	0016787	molecular_function	hydrolase activity
Z	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Z	0019941	biological_process	modification-dependent protein catabolic process
Z	0030682	biological_process	symbiont-mediated perturbation of host defenses
Z	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Z	0051603	biological_process	proteolysis involved in protein catabolic process
a	0000502	cellular_component	proteasome complex
a	0004175	molecular_function	endopeptidase activity
a	0004298	molecular_function	threonine-type endopeptidase activity
a	0005515	molecular_function	protein binding
a	0005576	cellular_component	extracellular region
a	0005737	cellular_component	cytoplasm
a	0005839	cellular_component	proteasome core complex
a	0005886	cellular_component	plasma membrane
a	0006508	biological_process	proteolysis
a	0010498	biological_process	proteasomal protein catabolic process
a	0016787	molecular_function	hydrolase activity
a	0019774	cellular_component	proteasome core complex, beta-subunit complex
a	0019941	biological_process	modification-dependent protein catabolic process
a	0030682	biological_process	symbiont-mediated perturbation of host defenses
a	0035375	molecular_function	zymogen binding
a	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
a	0051603	biological_process	proteolysis involved in protein catabolic process
b	0000502	cellular_component	proteasome complex
b	0004175	molecular_function	endopeptidase activity
b	0004298	molecular_function	threonine-type endopeptidase activity
b	0005515	molecular_function	protein binding
b	0005576	cellular_component	extracellular region
b	0005737	cellular_component	cytoplasm
b	0005839	cellular_component	proteasome core complex
b	0005886	cellular_component	plasma membrane
b	0006508	biological_process	proteolysis
b	0010498	biological_process	proteasomal protein catabolic process
b	0016787	molecular_function	hydrolase activity
b	0019774	cellular_component	proteasome core complex, beta-subunit complex
b	0019941	biological_process	modification-dependent protein catabolic process
b	0030682	biological_process	symbiont-mediated perturbation of host defenses
b	0035375	molecular_function	zymogen binding
b	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
b	0051603	biological_process	proteolysis involved in protein catabolic process
d	0000502	cellular_component	proteasome complex
d	0004175	molecular_function	endopeptidase activity
d	0004298	molecular_function	threonine-type endopeptidase activity
d	0005515	molecular_function	protein binding
d	0005737	cellular_component	cytoplasm
d	0005839	cellular_component	proteasome core complex
d	0005886	cellular_component	plasma membrane
d	0009274	cellular_component	peptidoglycan-based cell wall
d	0010498	biological_process	proteasomal protein catabolic process
d	0016787	molecular_function	hydrolase activity
d	0019773	cellular_component	proteasome core complex, alpha-subunit complex
d	0019941	biological_process	modification-dependent protein catabolic process
d	0030682	biological_process	symbiont-mediated perturbation of host defenses
d	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
d	0051603	biological_process	proteolysis involved in protein catabolic process
f	0000502	cellular_component	proteasome complex
f	0004175	molecular_function	endopeptidase activity
f	0004298	molecular_function	threonine-type endopeptidase activity
f	0005515	molecular_function	protein binding
f	0005737	cellular_component	cytoplasm
f	0005839	cellular_component	proteasome core complex
f	0005886	cellular_component	plasma membrane
f	0009274	cellular_component	peptidoglycan-based cell wall
f	0010498	biological_process	proteasomal protein catabolic process
f	0016787	molecular_function	hydrolase activity
f	0019773	cellular_component	proteasome core complex, alpha-subunit complex
f	0019941	biological_process	modification-dependent protein catabolic process
f	0030682	biological_process	symbiont-mediated perturbation of host defenses
f	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
f	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from PROSITE/UniProt

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. ViVIgASNredmIDpAIl.R

Chain	Residue	Details
1	VAL409-ARG427

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	ACT_SITE: Nucleophile => ECO:0000305|PubMed:20711362

Chain	Residue	Details
H	THR301
V	THR301
W	THR301
Y	THR301
a	THR301
b	THR301
J	THR301
L	THR301
M	THR301
N	THR301
P	THR301
R	THR301
S	THR301
U	THR301

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	SITE: Covalent link with the inhibitor MLN-273 => ECO:0000269|PubMed:16468986

Chain	Residue	Details
H	THR301
V	THR301
W	THR301
Y	THR301
a	THR301
b	THR301
8	THR202
I	THR84
I	THR178
I	THR202
K	THR84
J	THR301
K	THR178
K	THR202
O	THR84
O	THR178
O	THR202
Q	THR84
Q	THR178
Q	THR202
T	THR84
T	THR178
L	THR301
T	THR202
X	THR84
X	THR178
X	THR202
Z	THR84
Z	THR178
Z	THR202
d	THR84
d	THR178
d	THR202
M	THR301
f	THR84
f	THR178
f	THR202
N	THR301
P	THR301
R	THR301
S	THR301
U	THR301

---