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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7PWN

URATE OXYDASE AZA-XANTHINE COMPLEX AT 1000 BARS (100 MPa) OF ARGON

Functional Information from GO Data
ChainGOidnamespacecontents
A0004846molecular_functionurate oxidase activity
A0005777cellular_componentperoxisome
A0006144biological_processpurine nucleobase metabolic process
A0006145biological_processpurine nucleobase catabolic process
A0016491molecular_functionoxidoreductase activity
A0019628biological_processurate catabolic process
B0004846molecular_functionurate oxidase activity
B0005777cellular_componentperoxisome
B0006144biological_processpurine nucleobase metabolic process
B0006145biological_processpurine nucleobase catabolic process
B0016491molecular_functionoxidoreductase activity
B0019628biological_processurate catabolic process
Functional Information from PROSITE/UniProt
site_idPS00366
Number of Residues28
DetailsURICASE Uricase signature. LtVLKSTnSqFwgFlrdeYttLketwdR
ChainResidueDetails
ALEU149-ARG176
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsACT_SITE: Charge relay system => ECO:0000269|PubMed:24466188, ECO:0007744|PDB:4N3M, ECO:0007744|PDB:4N9M, ECO:0007744|PDB:4N9S, ECO:0007744|PDB:4N9V
ChainResidueDetails
ALYS10
ATHR57
AHIS256
BLYS10
BTHR57
BHIS256
site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000305|PubMed:9360612, ECO:0007744|PDB:1R4S, ECO:0007744|PDB:1R51, ECO:0007744|PDB:1WS2, ECO:0007744|PDB:2FUB, ECO:0007744|PDB:2FXL, ECO:0007744|PDB:2IBA, ECO:0007744|PDB:2IC0, ECO:0007744|PDB:2ICQ, ECO:0007744|PDB:2PES, ECO:0007744|PDB:2ZKA, ECO:0007744|PDB:2ZKB, ECO:0007744|PDB:3BK8, ECO:0007744|PDB:3CKS, ECO:0007744|PDB:3CKU, ECO:0007744|PDB:3F2M, ECO:0007744|PDB:3GKO, ECO:0007744|PDB:3LBG, ECO:0007744|PDB:3LD4, ECO:0007744|PDB:3P9F, ECO:0007744|PDB:3PJK, ECO:0007744|PDB:3PK3, ECO:0007744|PDB:3PK4, ECO:0007744|PDB:3PK5, ECO:0007744|PDB:3PK6, ECO:0007744|PDB:3PK8, ECO:0007744|PDB:3PKF, ECO:0007744|PDB:3PKG, ECO:0007744|PDB:3PKH, ECO:0007744|PDB:3PKK, ECO:0007744|PDB:3PKL, ECO:0007744|PDB:3PKS, ECO:0007744|PDB:3PKT, ECO:0007744|PDB:3PKU, ECO:0007744|PDB:3PLE, ECO:0007744|PDB:3PLG, ECO:0007744|PDB:3PLH, ECO:0007744|PDB:3PLI, ECO:0007744|PDB:3PLJ, ECO:0007744|PDB:3PLM, ECO:0007744|PDB:4CW0, ECO:0007744|PDB:4CW2, ECO:0007744|PDB:4CW3, ECO:0007744|PDB:4CW6, ECO:0007744|PDB:4N9S, ECO:0007744|PDB:4N9V, ECO:0007744|PDB:4OP6, ECO:0007744|PDB:4OP9, ECO:0007744|PDB:5FRC
ChainResidueDetails
ATHR57
BTHR57
site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000305|PubMed:9360612, ECO:0007744|PDB:1R4S, ECO:0007744|PDB:3LBG, ECO:0007744|PDB:3LD4, ECO:0007744|PDB:4CW0, ECO:0007744|PDB:4CW2, ECO:0007744|PDB:4CW3, ECO:0007744|PDB:4CW6, ECO:0007744|PDB:4N9S
ChainResidueDetails
AASP58
BASP58
site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: BINDING => ECO:0000305|PubMed:9360612, ECO:0007744|PDB:1R4S, ECO:0007744|PDB:1R51, ECO:0007744|PDB:1WS3, ECO:0007744|PDB:1XT4, ECO:0007744|PDB:1XY3, ECO:0007744|PDB:2FUB, ECO:0007744|PDB:2IBA, ECO:0007744|PDB:2IC0, ECO:0007744|PDB:2ICQ, ECO:0007744|PDB:2PES, ECO:0007744|PDB:2ZKA, ECO:0007744|PDB:2ZKB, ECO:0007744|PDB:3BK8, ECO:0007744|PDB:3CKS, ECO:0007744|PDB:3CKU, ECO:0007744|PDB:3F2M, ECO:0007744|PDB:3GKO, ECO:0007744|PDB:3L8W, ECO:0007744|PDB:3P9F, ECO:0007744|PDB:3PJK, ECO:0007744|PDB:3PK3, ECO:0007744|PDB:3PK4, ECO:0007744|PDB:3PK5, ECO:0007744|PDB:3PK6, ECO:0007744|PDB:3PK8, ECO:0007744|PDB:3PKF, ECO:0007744|PDB:3PKG, ECO:0007744|PDB:3PKH, ECO:0007744|PDB:3PKK, ECO:0007744|PDB:3PKL, ECO:0007744|PDB:3PKS, ECO:0007744|PDB:3PKT, ECO:0007744|PDB:3PKU, ECO:0007744|PDB:3PLE, ECO:0007744|PDB:3PLG, ECO:0007744|PDB:3PLH, ECO:0007744|PDB:3PLI, ECO:0007744|PDB:3PLJ, ECO:0007744|PDB:3PLM, ECO:0007744|PDB:4CW0, ECO:0007744|PDB:4CW2, ECO:0007744|PDB:4CW3, ECO:0007744|PDB:4CW6, ECO:0007744|PDB:4N9V, ECO:0007744|PDB:4OP6, ECO:0007744|PDB:4OP9, ECO:0007744|PDB:5FRC
ChainResidueDetails
APHE159
BPHE159
site_idSWS_FT_FI5
Number of Residues2
DetailsBINDING: BINDING => ECO:0000305|PubMed:9360612, ECO:0007744|PDB:1R4S, ECO:0007744|PDB:1R51, ECO:0007744|PDB:1WRR, ECO:0007744|PDB:1WS2, ECO:0007744|PDB:1WS3, ECO:0007744|PDB:1XT4, ECO:0007744|PDB:1XXJ, ECO:0007744|PDB:1XY3, ECO:0007744|PDB:2FUB, ECO:0007744|PDB:2IBA, ECO:0007744|PDB:2IC0, ECO:0007744|PDB:2ICQ, ECO:0007744|PDB:2PES, ECO:0007744|PDB:2ZKA, ECO:0007744|PDB:2ZKB, ECO:0007744|PDB:3BK8, ECO:0007744|PDB:3CKS, ECO:0007744|PDB:3CKU, ECO:0007744|PDB:3F2M, ECO:0007744|PDB:3GKO, ECO:0007744|PDB:3L8W, ECO:0007744|PDB:3LBG, ECO:0007744|PDB:3P9F, ECO:0007744|PDB:3PJK, ECO:0007744|PDB:3PK3, ECO:0007744|PDB:3PK4, ECO:0007744|PDB:3PK5, ECO:0007744|PDB:3PK6, ECO:0007744|PDB:3PK8, ECO:0007744|PDB:3PKF, ECO:0007744|PDB:3PKG, ECO:0007744|PDB:3PKH, ECO:0007744|PDB:3PKK, ECO:0007744|PDB:3PKL, ECO:0007744|PDB:3PKS, ECO:0007744|PDB:3PKT, ECO:0007744|PDB:3PKU, ECO:0007744|PDB:3PLE, ECO:0007744|PDB:3PLG, ECO:0007744|PDB:3PLH, ECO:0007744|PDB:3PLI, ECO:0007744|PDB:3PLJ, ECO:0007744|PDB:3PLM, ECO:0007744|PDB:4CW0, ECO:0007744|PDB:4CW2, ECO:0007744|PDB:4CW3, ECO:0007744|PDB:4CW6, ECO:0007744|PDB:4N9V, ECO:0007744|PDB:4OP6, ECO:0007744|PDB:4OP9, ECO:0007744|PDB:5FRC
ChainResidueDetails
AARG176
BARG176
site_idSWS_FT_FI6
Number of Residues2
DetailsBINDING: BINDING => ECO:0000305|PubMed:9360612, ECO:0007744|PDB:1R4S, ECO:0007744|PDB:1R51, ECO:0007744|PDB:1WRR, ECO:0007744|PDB:1XT4, ECO:0007744|PDB:1XXJ, ECO:0007744|PDB:1XY3, ECO:0007744|PDB:2FUB, ECO:0007744|PDB:2IBA, ECO:0007744|PDB:2IC0, ECO:0007744|PDB:2ICQ, ECO:0007744|PDB:2PES, ECO:0007744|PDB:2ZKA, ECO:0007744|PDB:2ZKB, ECO:0007744|PDB:3BK8, ECO:0007744|PDB:3CKS, ECO:0007744|PDB:3CKU, ECO:0007744|PDB:3F2M, ECO:0007744|PDB:3GKO, ECO:0007744|PDB:3L8W, ECO:0007744|PDB:3P9F, ECO:0007744|PDB:3PJK, ECO:0007744|PDB:3PK3, ECO:0007744|PDB:3PK4, ECO:0007744|PDB:3PK5, ECO:0007744|PDB:3PK6, ECO:0007744|PDB:3PK8, ECO:0007744|PDB:3PKF, ECO:0007744|PDB:3PKG, ECO:0007744|PDB:3PKH, ECO:0007744|PDB:3PKK, ECO:0007744|PDB:3PKL, ECO:0007744|PDB:3PKS, ECO:0007744|PDB:3PKT, ECO:0007744|PDB:3PKU, ECO:0007744|PDB:3PLE, ECO:0007744|PDB:3PLG, ECO:0007744|PDB:3PLH, ECO:0007744|PDB:3PLI, ECO:0007744|PDB:3PLJ, ECO:0007744|PDB:3PLM, ECO:0007744|PDB:4CW0, ECO:0007744|PDB:4CW2, ECO:0007744|PDB:4CW3, ECO:0007744|PDB:4CW6, ECO:0007744|PDB:4N9V, ECO:0007744|PDB:4OP6, ECO:0007744|PDB:4OP9, ECO:0007744|PDB:5FRC
ChainResidueDetails
AVAL227
BVAL227
site_idSWS_FT_FI7
Number of Residues2
DetailsBINDING: BINDING => ECO:0000305|PubMed:9360612, ECO:0007744|PDB:1R4S, ECO:0007744|PDB:1R51, ECO:0007744|PDB:1WRR, ECO:0007744|PDB:1WS2, ECO:0007744|PDB:1XT4, ECO:0007744|PDB:1XXJ, ECO:0007744|PDB:1XY3, ECO:0007744|PDB:2FUB, ECO:0007744|PDB:2IBA, ECO:0007744|PDB:2IC0, ECO:0007744|PDB:2ICQ, ECO:0007744|PDB:2PES, ECO:0007744|PDB:2ZKA, ECO:0007744|PDB:2ZKB, ECO:0007744|PDB:3BK8, ECO:0007744|PDB:3CKS, ECO:0007744|PDB:3CKU, ECO:0007744|PDB:3F2M, ECO:0007744|PDB:3GKO, ECO:0007744|PDB:3L8W, ECO:0007744|PDB:3LBG, ECO:0007744|PDB:3LD4, ECO:0007744|PDB:3P9F, ECO:0007744|PDB:3PJK, ECO:0007744|PDB:3PK3, ECO:0007744|PDB:3PK4, ECO:0007744|PDB:3PK5, ECO:0007744|PDB:3PK6, ECO:0007744|PDB:3PK8, ECO:0007744|PDB:3PKF, ECO:0007744|PDB:3PKG, ECO:0007744|PDB:3PKH, ECO:0007744|PDB:3PKK, ECO:0007744|PDB:3PKL, ECO:0007744|PDB:3PKS, ECO:0007744|PDB:3PKT, ECO:0007744|PDB:3PKU, ECO:0007744|PDB:3PLE, ECO:0007744|PDB:3PLG, ECO:0007744|PDB:3PLH, ECO:0007744|PDB:3PLI, ECO:0007744|PDB:3PLJ, ECO:0007744|PDB:3PLM, ECO:0007744|PDB:4CW0, ECO:0007744|PDB:4CW2, ECO:0007744|PDB:4CW3, ECO:0007744|PDB:4CW6, ECO:0007744|PDB:4N9S, ECO:0007744|PDB:4N9V, ECO:0007744|PDB:4OP6, ECO:0007744|PDB:4OP9, ECO:0007744|PDB:5FRC
ChainResidueDetails
AGLN228
BGLN228
site_idSWS_FT_FI8
Number of Residues2
DetailsBINDING: BINDING => ECO:0007744|PDB:4CW2, ECO:0007744|PDB:4CW3, ECO:0007744|PDB:4CW6
ChainResidueDetails
AASN254
BASN254
site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: N-acetylserine => ECO:0000305|PubMed:1339455, ECO:0007744|PDB:1R4S, ECO:0007744|PDB:1R4U, ECO:0007744|PDB:1R51, ECO:0007744|PDB:1R56, ECO:0007744|PDB:1WRR, ECO:0007744|PDB:1WS2, ECO:0007744|PDB:1WS3, ECO:0007744|PDB:1XT4, ECO:0007744|PDB:1XXJ, ECO:0007744|PDB:1XY3, ECO:0007744|PDB:2FXL, ECO:0007744|PDB:3BJP, ECO:0007744|PDB:4FSK
ChainResidueDetails
ASER1
BSER1
Catalytic Information from CSA
site_idMCSA1
Number of Residues5
DetailsM-CSA 118
ChainResidueDetails
AARG14hydrogen bond donor, proton acceptor, proton donor, proton relay
ALYS61electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
ATHR180electrostatic stabiliser
ATYR232electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
AILE260hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
site_idMCSA2
Number of Residues5
DetailsM-CSA 118
ChainResidueDetails
BARG14hydrogen bond donor, proton acceptor, proton donor, proton relay
BLYS61electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
BTHR180electrostatic stabiliser
BTYR232electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
BILE260hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay

238268

PDB entries from 2025-07-02

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