7PW7

Human SMG1-9 kinase complex bound to a SMG1 inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
A	0003723	molecular_function	RNA binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004697	molecular_function	diacylglycerol-dependent serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006281	biological_process	DNA repair
A	0006406	biological_process	mRNA export from nucleus
A	0006974	biological_process	DNA damage response
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016740	molecular_function	transferase activity
A	0018105	biological_process	peptidyl-serine phosphorylation
A	0032204	biological_process	regulation of telomere maintenance
A	0033391	cellular_component	chromatoid body
A	0042162	molecular_function	telomeric DNA binding
A	0046777	biological_process	protein autophosphorylation
A	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0106310	molecular_function	protein serine kinase activity
C	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
C	0001654	biological_process	eye development
C	0001701	biological_process	in utero embryonic development
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0007420	biological_process	brain development
C	0007507	biological_process	heart development
C	0042802	molecular_function	identical protein binding
C	0043066	biological_process	negative regulation of apoptotic process

Functional Information from PROSITE/UniProt

site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. StAvmsMvgYIIgLgDRHldN

Chain	Residue	Details
A	SER2320-ASN2340

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	21
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	11
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

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