7PVO

Adenylosuccinate Synthetase from H. pylori in complex with IMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0004019	molecular_function	adenylosuccinate synthase activity
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0016874	molecular_function	ligase activity
A	0044208	biological_process	'de novo' AMP biosynthetic process
A	0046040	biological_process	IMP metabolic process
A	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00513
Number of Residues	12
Details	ADENYLOSUCCIN_SYN_2 Adenylosuccinate synthetase active site. GIGPcYedKmaR

Chain	Residue	Details
A	GLY124-ARG135

---

site_id	PS01266
Number of Residues	8
Details	ADENYLOSUCCIN_SYN_1 Adenylosuccinate synthetase GTP-binding site. QWGDEGKG

Chain	Residue	Details
A	GLN9-GLY16

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00011

Chain	Residue	Details
A	ASP12

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_00011

Chain	Residue	Details
A	HIS40

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00011

Chain	Residue	Details
A	GLY11
A	ASP12
A	GLY39
A	ARG135
A	THR290
A	ARG296
A	LYS322
A	SER400

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_00011

Chain	Residue	Details
A	ASN37
A	THR121
A	GLN215
A	THR230
A	ARG294

---