7PSX

Structure of HOXB13 bound to hydroxymethylated DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
A	0003677	molecular_function	DNA binding
A	0006355	biological_process	regulation of DNA-templated transcription
B	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
B	0003677	molecular_function	DNA binding
B	0006355	biological_process	regulation of DNA-templated transcription
G	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
G	0003677	molecular_function	DNA binding
G	0006355	biological_process	regulation of DNA-templated transcription
J	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
J	0003677	molecular_function	DNA binding
J	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PROSITE/UniProt

site_id	PS00027
Number of Residues	24
Details	HOMEOBOX_1 'Homeobox' domain signature. ISaaTsLSerQITIWFqNrrvkeK

Chain	Residue	Details
A	ILE249-LYS272

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	70
Details	Region: {"description":"Interaction with DNA","evidences":[{"source":"PubMed","id":"28473536","evidenceCode":"ECO:0000305"},{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"submission","publicationDate":"OCT-2015","submissionDatabase":"PDB data bank","title":"Molecular basis of recognition of two distinct DNA sequences by a single transcription factor.","authors":["Morgunova E.","Yin Y.","Jolma A.","Popov A.","Taipale J."]}}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	44
Details	Region: {"description":"Interaction with 5-mCpG DNA","evidences":[{"source":"PubMed","id":"28473536","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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