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7PSX

Structure of HOXB13 bound to hydroxymethylated DNA

Functional Information from GO Data
ChainGOidnamespacecontents
A0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
A0003677molecular_functionDNA binding
A0006355biological_processregulation of DNA-templated transcription
B0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
B0003677molecular_functionDNA binding
B0006355biological_processregulation of DNA-templated transcription
G0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
G0003677molecular_functionDNA binding
G0006355biological_processregulation of DNA-templated transcription
J0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
J0003677molecular_functionDNA binding
J0006355biological_processregulation of DNA-templated transcription
Functional Information from PROSITE/UniProt
site_idPS00027
Number of Residues24
DetailsHOMEOBOX_1 'Homeobox' domain signature. ISaaTsLSerQITIWFqNrrvkeK
ChainResidueDetails
AILE249-LYS272

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues70
DetailsRegion: {"description":"Interaction with DNA","evidences":[{"source":"PubMed","id":"28473536","evidenceCode":"ECO:0000305"},{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"submission","publicationDate":"OCT-2015","submissionDatabase":"PDB data bank","title":"Molecular basis of recognition of two distinct DNA sequences by a single transcription factor.","authors":["Morgunova E.","Yin Y.","Jolma A.","Popov A.","Taipale J."]}}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues44
DetailsRegion: {"description":"Interaction with 5-mCpG DNA","evidences":[{"source":"PubMed","id":"28473536","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

238582

PDB entries from 2025-07-09

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