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7PSU

Structure of protein kinase CK2alpha mutant K198R associated with the Okur-Chung Neurodevelopmental Syndrome

Functional Information from GO Data
ChainGOidnamespacecontents
A0000077biological_processDNA damage checkpoint signaling
A0000166molecular_functionnucleotide binding
A0000290biological_processdeadenylation-dependent decapping of nuclear-transcribed mRNA
A0000724biological_processdouble-strand break repair via homologous recombination
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005956cellular_componentprotein kinase CK2 complex
A0006302biological_processdouble-strand break repair
A0006357biological_processregulation of transcription by RNA polymerase II
A0006457biological_processprotein folding
A0006468biological_processprotein phosphorylation
A0006915biological_processapoptotic process
A0006974biological_processDNA damage response
A0007165biological_processsignal transduction
A0008284biological_processpositive regulation of cell population proliferation
A0016055biological_processWnt signaling pathway
A0016301molecular_functionkinase activity
A0016605cellular_componentPML body
A0016740molecular_functiontransferase activity
A0017148biological_processnegative regulation of translation
A0030163biological_processprotein catabolic process
A0030177biological_processpositive regulation of Wnt signaling pathway
A0030307biological_processpositive regulation of cell growth
A0031519cellular_componentPcG protein complex
A0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
A0035973biological_processaggrephagy
A0042176biological_processregulation of protein catabolic process
A0042802molecular_functionidentical protein binding
A0045732biological_processpositive regulation of protein catabolic process
A0045947biological_processnegative regulation of translational initiation
A0048511biological_processrhythmic process
A0050821biological_processprotein stabilization
A0051726biological_processregulation of cell cycle
A0051879molecular_functionHsp90 protein binding
A0070822cellular_componentSin3-type complex
A0071211biological_processprotein targeting to vacuole involved in autophagy
A0075342biological_processsymbiont-mediated disruption of host cell PML body
A0097194biological_processexecution phase of apoptosis
A0097680biological_processdouble-strand break repair via classical nonhomologous end joining
A0106310molecular_functionprotein serine kinase activity
A0140694biological_processmembraneless organelle assembly
A1901797biological_processnegative regulation of signal transduction by p53 class mediator
A1905337biological_processpositive regulation of aggrephagy
A1905818biological_processregulation of chromosome separation
A1990166biological_processprotein localization to site of double-strand break
A2000042biological_processnegative regulation of double-strand break repair via homologous recombination
A2001234biological_processnegative regulation of apoptotic signaling pathway
B0000077biological_processDNA damage checkpoint signaling
B0000166molecular_functionnucleotide binding
B0000290biological_processdeadenylation-dependent decapping of nuclear-transcribed mRNA
B0000724biological_processdouble-strand break repair via homologous recombination
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005956cellular_componentprotein kinase CK2 complex
B0006302biological_processdouble-strand break repair
B0006357biological_processregulation of transcription by RNA polymerase II
B0006457biological_processprotein folding
B0006468biological_processprotein phosphorylation
B0006915biological_processapoptotic process
B0006974biological_processDNA damage response
B0007165biological_processsignal transduction
B0008284biological_processpositive regulation of cell population proliferation
B0016055biological_processWnt signaling pathway
B0016301molecular_functionkinase activity
B0016605cellular_componentPML body
B0016740molecular_functiontransferase activity
B0017148biological_processnegative regulation of translation
B0030163biological_processprotein catabolic process
B0030177biological_processpositive regulation of Wnt signaling pathway
B0030307biological_processpositive regulation of cell growth
B0031519cellular_componentPcG protein complex
B0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
B0035973biological_processaggrephagy
B0042176biological_processregulation of protein catabolic process
B0042802molecular_functionidentical protein binding
B0045732biological_processpositive regulation of protein catabolic process
B0045947biological_processnegative regulation of translational initiation
B0048511biological_processrhythmic process
B0050821biological_processprotein stabilization
B0051726biological_processregulation of cell cycle
B0051879molecular_functionHsp90 protein binding
B0070822cellular_componentSin3-type complex
B0071211biological_processprotein targeting to vacuole involved in autophagy
B0075342biological_processsymbiont-mediated disruption of host cell PML body
B0097194biological_processexecution phase of apoptosis
B0097680biological_processdouble-strand break repair via classical nonhomologous end joining
B0106310molecular_functionprotein serine kinase activity
B0140694biological_processmembraneless organelle assembly
B1901797biological_processnegative regulation of signal transduction by p53 class mediator
B1905337biological_processpositive regulation of aggrephagy
B1905818biological_processregulation of chromosome separation
B1990166biological_processprotein localization to site of double-strand break
B2000042biological_processnegative regulation of double-strand break repair via homologous recombination
B2001234biological_processnegative regulation of apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnnek..........VVVK
ChainResidueDetails
ALEU45-LYS68

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI
ChainResidueDetails
AILE152-ILE164

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues570
DetailsDomain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues10
DetailsRegion: {"description":"Interaction with beta subunit","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsActive site: {"description":"Proton acceptor"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues18
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

239149

PDB entries from 2025-07-23

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