7PSQ

Crystal structure of S100A4 labeled with NU074381b.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001837	biological_process	epithelial to mesenchymal transition
A	0003723	molecular_function	RNA binding
A	0003779	molecular_function	actin binding
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0042056	molecular_function	chemoattractant activity
A	0042802	molecular_function	identical protein binding
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0046872	molecular_function	metal ion binding
A	0046914	molecular_function	transition metal ion binding
A	0048306	molecular_function	calcium-dependent protein binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050786	molecular_function	RAGE receptor binding
A	0050918	biological_process	positive chemotaxis
A	0062023	cellular_component	collagen-containing extracellular matrix
A	0070062	cellular_component	extracellular exosome
C	0001837	biological_process	epithelial to mesenchymal transition
C	0003723	molecular_function	RNA binding
C	0003779	molecular_function	actin binding
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0042056	molecular_function	chemoattractant activity
C	0042802	molecular_function	identical protein binding
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0046872	molecular_function	metal ion binding
C	0046914	molecular_function	transition metal ion binding
C	0048306	molecular_function	calcium-dependent protein binding
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0050786	molecular_function	RAGE receptor binding
C	0050918	biological_process	positive chemotaxis
C	0062023	cellular_component	collagen-containing extracellular matrix
C	0070062	cellular_component	extracellular exosome
E	0001837	biological_process	epithelial to mesenchymal transition
E	0003723	molecular_function	RNA binding
E	0003779	molecular_function	actin binding
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0042056	molecular_function	chemoattractant activity
E	0042802	molecular_function	identical protein binding
E	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
E	0046872	molecular_function	metal ion binding
E	0046914	molecular_function	transition metal ion binding
E	0048306	molecular_function	calcium-dependent protein binding
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0050786	molecular_function	RAGE receptor binding
E	0050918	biological_process	positive chemotaxis
E	0062023	cellular_component	collagen-containing extracellular matrix
E	0070062	cellular_component	extracellular exosome
G	0001837	biological_process	epithelial to mesenchymal transition
G	0003723	molecular_function	RNA binding
G	0003779	molecular_function	actin binding
G	0005509	molecular_function	calcium ion binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0042056	molecular_function	chemoattractant activity
G	0042802	molecular_function	identical protein binding
G	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
G	0046872	molecular_function	metal ion binding
G	0046914	molecular_function	transition metal ion binding
G	0048306	molecular_function	calcium-dependent protein binding
G	0048471	cellular_component	perinuclear region of cytoplasm
G	0050786	molecular_function	RAGE receptor binding
G	0050918	biological_process	positive chemotaxis
G	0062023	cellular_component	collagen-containing extracellular matrix
G	0070062	cellular_component	extracellular exosome

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DSNRDNEVDfqEY

Chain	Residue	Details
A	ASP63-TYR75

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site_id	PS00303
Number of Residues	22
Details	S100_CABP S-100/ICaBP type calcium binding protein signature. LMsnLDsnrDnevDFqEYcvFL

Chain	Residue	Details
A	LEU58-LEU79

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
A	LYS28
A	GLU33
C	LYS28
C	GLU33
E	LYS28
E	GLU33
G	LYS28
G	GLU33

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448

Chain	Residue	Details
A	ASP63
A	ASN65
A	ASP67
A	GLU69
A	GLU74
C	ASP63
C	ASN65
C	ASP67
C	GLU69
C	GLU74
E	ASP63
E	ASN65
E	ASP67
E	GLU69
E	GLU74
G	ASP63
G	ASN65
G	ASP67
G	GLU69
G	GLU74

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P35466

Chain	Residue	Details
A	ALA2
C	ALA2
E	ALA2
G	ALA2

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS7
A	LYS35
C	LYS7
C	LYS35
E	LYS7
E	LYS35
G	LYS7
G	LYS35

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