7PSQ

Crystal structure of S100A4 labeled with NU074381b.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001837	biological_process	epithelial to mesenchymal transition
A	0003723	molecular_function	RNA binding
A	0003779	molecular_function	actin binding
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0031012	cellular_component	extracellular matrix
A	0042056	molecular_function	chemoattractant activity
A	0042802	molecular_function	identical protein binding
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0046872	molecular_function	metal ion binding
A	0046914	molecular_function	transition metal ion binding
A	0048306	molecular_function	calcium-dependent protein binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050786	molecular_function	RAGE receptor binding
A	0050918	biological_process	positive chemotaxis
A	0070062	cellular_component	extracellular exosome
C	0001837	biological_process	epithelial to mesenchymal transition
C	0003723	molecular_function	RNA binding
C	0003779	molecular_function	actin binding
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0031012	cellular_component	extracellular matrix
C	0042056	molecular_function	chemoattractant activity
C	0042802	molecular_function	identical protein binding
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0046872	molecular_function	metal ion binding
C	0046914	molecular_function	transition metal ion binding
C	0048306	molecular_function	calcium-dependent protein binding
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0050786	molecular_function	RAGE receptor binding
C	0050918	biological_process	positive chemotaxis
C	0070062	cellular_component	extracellular exosome
E	0001837	biological_process	epithelial to mesenchymal transition
E	0003723	molecular_function	RNA binding
E	0003779	molecular_function	actin binding
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0031012	cellular_component	extracellular matrix
E	0042056	molecular_function	chemoattractant activity
E	0042802	molecular_function	identical protein binding
E	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
E	0046872	molecular_function	metal ion binding
E	0046914	molecular_function	transition metal ion binding
E	0048306	molecular_function	calcium-dependent protein binding
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0050786	molecular_function	RAGE receptor binding
E	0050918	biological_process	positive chemotaxis
E	0070062	cellular_component	extracellular exosome
G	0001837	biological_process	epithelial to mesenchymal transition
G	0003723	molecular_function	RNA binding
G	0003779	molecular_function	actin binding
G	0005509	molecular_function	calcium ion binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0031012	cellular_component	extracellular matrix
G	0042056	molecular_function	chemoattractant activity
G	0042802	molecular_function	identical protein binding
G	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
G	0046872	molecular_function	metal ion binding
G	0046914	molecular_function	transition metal ion binding
G	0048306	molecular_function	calcium-dependent protein binding
G	0048471	cellular_component	perinuclear region of cytoplasm
G	0050786	molecular_function	RAGE receptor binding
G	0050918	biological_process	positive chemotaxis
G	0070062	cellular_component	extracellular exosome

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DSNRDNEVDfqEY

Chain	Residue	Details
A	ASP63-TYR75

---

site_id	PS00303
Number of Residues	22
Details	S100_CABP S-100/ICaBP type calcium binding protein signature. LMsnLDsnrDnevDFqEYcvFL

Chain	Residue	Details
A	LEU58-LEU79

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	140
Details	Domain: {"description":"EF-hand 1","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	140
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"P35466","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---