7PSF

Crystal Structure of a Class D Carbapenemase Complexed with Imipenem

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0005886	cellular_component	plasma membrane
AAA	0008658	molecular_function	penicillin binding
AAA	0008800	molecular_function	beta-lactamase activity
AAA	0016787	molecular_function	hydrolase activity
AAA	0017001	biological_process	antibiotic catabolic process
AAA	0046677	biological_process	response to antibiotic
AAA	0071555	biological_process	cell wall organization
BBB	0005886	cellular_component	plasma membrane
BBB	0008658	molecular_function	penicillin binding
BBB	0008800	molecular_function	beta-lactamase activity
BBB	0016787	molecular_function	hydrolase activity
BBB	0017001	biological_process	antibiotic catabolic process
BBB	0046677	biological_process	response to antibiotic
BBB	0071555	biological_process	cell wall organization
CCC	0005886	cellular_component	plasma membrane
CCC	0008658	molecular_function	penicillin binding
CCC	0008800	molecular_function	beta-lactamase activity
CCC	0016787	molecular_function	hydrolase activity
CCC	0017001	biological_process	antibiotic catabolic process
CCC	0046677	biological_process	response to antibiotic
CCC	0071555	biological_process	cell wall organization
DDD	0005886	cellular_component	plasma membrane
DDD	0008658	molecular_function	penicillin binding
DDD	0008800	molecular_function	beta-lactamase activity
DDD	0016787	molecular_function	hydrolase activity
DDD	0017001	biological_process	antibiotic catabolic process
DDD	0046677	biological_process	response to antibiotic
DDD	0071555	biological_process	cell wall organization

Functional Information from PROSITE/UniProt

site_id	PS00337
Number of Residues	11
Details	BETA_LACTAMASE_D Beta-lactamase class-D active site. PaSTFKIPnSL

Chain	Residue	Details
AAA	PRO68-LEU78

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PIRSR","id":"PIRSR602137-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25406838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26731698","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31358584","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32150407","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4WMC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FAQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FAS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6V1O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8RLA6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P13661","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PIRSR","id":"PIRSR602137-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19477418","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25406838","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3HBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WMC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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