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7PPZ

Crystal structure of the Burkholderia Lethal Factor 1 (BLF1) C94S inactive mutant in complex with human eIF4A - Crystal form A

Functional Information from GO Data
ChainGOidnamespacecontents
A0051097biological_processnegative regulation of helicase activity
B0000339molecular_functionRNA cap binding
B0002183biological_processcytoplasmic translational initiation
B0003676molecular_functionnucleic acid binding
B0003689molecular_functionDNA clamp loader activity
B0003723molecular_functionRNA binding
B0003724molecular_functionRNA helicase activity
B0003725molecular_functiondouble-stranded RNA binding
B0003729molecular_functionmRNA binding
B0003743molecular_functiontranslation initiation factor activity
B0004386molecular_functionhelicase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006338biological_processchromatin remodeling
B0006412biological_processtranslation
B0006413biological_processtranslational initiation
B0008135molecular_functiontranslation factor activity, RNA binding
B0010494cellular_componentcytoplasmic stress granule
B0016020cellular_componentmembrane
B0016281cellular_componenteukaryotic translation initiation factor 4F complex
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0048471cellular_componentperinuclear region of cytoplasm
B0061775molecular_functioncohesin loader activity
B0070062cellular_componentextracellular exosome
B0097165cellular_componentnuclear stress granule
B0140584molecular_functionchromatin extrusion motor activity
B0140588biological_processchromatin looping
B0140665molecular_functionATP-dependent H3-H4 histone complex chaperone activity
B0140849molecular_functionATP-dependent H2AZ histone chaperone activity
Functional Information from PROSITE/UniProt
site_idPS00039
Number of Residues9
DetailsDEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADEmL
ChainResidueDetails
BVAL180-LEU188

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541
ChainResidueDetails
BALA76

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
BLYS118
BLYS174

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BTHR158

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P60843
ChainResidueDetails
BLYS193

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P60843
ChainResidueDetails
BLYS238

site_idSWS_FT_FI6
Number of Residues6
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
BLYS146
BLYS225
BLYS309
BLYS369
BLYS381

site_idSWS_FT_FI7
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733
ChainResidueDetails
BLYS238

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PDB entries from 2024-11-06

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