7POG
High-resolution structure of native toxin A from Clostridioides difficile
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0008289 | molecular_function | lipid binding |
| A | 0016020 | cellular_component | membrane |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0020002 | cellular_component | host cell plasma membrane |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0044164 | cellular_component | host cell cytosol |
| A | 0044174 | cellular_component | host cell endosome |
| A | 0044175 | cellular_component | host cell endosome membrane |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0090729 | molecular_function | toxin activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: For protease activity => ECO:0000255|PROSITE-ProRule:PRU01107, ECO:0000269|PubMed:19553670, ECO:0000269|PubMed:27571750 |
| Chain | Residue | Details |
| A | HIS655 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile; for protease activity => ECO:0000255|PROSITE-ProRule:PRU01107, ECO:0000269|PubMed:19553670, ECO:0000269|PubMed:27571750 |
| Chain | Residue | Details |
| A | CYS700 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22267739, ECO:0000269|PubMed:22747490, ECO:0000269|PubMed:28433497, ECO:0007744|PDB:3SRZ, ECO:0007744|PDB:4DMV, ECO:0007744|PDB:5UQK, ECO:0007744|PDB:5UQL |
| Chain | Residue | Details |
| A | VAL100 | |
| A | SER268 | |
| A | SER517 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22267739, ECO:0000269|PubMed:28433497, ECO:0007744|PDB:3SRZ, ECO:0007744|PDB:5UQK, ECO:0007744|PDB:5UQL |
| Chain | Residue | Details |
| A | ASN138 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22267739, ECO:0007744|PDB:3SS1 |
| Chain | Residue | Details |
| A | ASP285 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22267739, ECO:0000269|PubMed:22747490, ECO:0000269|PubMed:28433497, ECO:0007744|PDB:3SRZ, ECO:0007744|PDB:3SS1, ECO:0007744|PDB:5UQK, ECO:0007744|PDB:5UQL |
| Chain | Residue | Details |
| A | ASP287 | |
| A | GLU514 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27571750, ECO:0007744|PDB:4R04 |
| Chain | Residue | Details |
| A | GLU544 | |
| A | ASP545 | |
| A | HIS655 | |
| A | HIS759 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:19553670, ECO:0007744|PDB:3HO6 |
| Chain | Residue | Details |
| A | ASN551 | |
| A | TYR579 | |
| A | LYS602 | |
| A | LYS649 | |
| A | ARG753 | |
| A | LYS766 | |
| A | LYS777 | |
| A | LYS794 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16622409, ECO:0007744|PDB:2G7C |
| Chain | Residue | Details |
| A | ASP2540 | |
| A | GLN2547 | |
| A | ASN2567 | |
| A | ASP2631 | |
| A | GLN2638 | |
| A | ASN2658 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by autolysis => ECO:0000305|PubMed:19553670 |
| Chain | Residue | Details |
| A | LEU542 |
