7POB

An Irreversible, Promiscuous and Highly Thermostable Claisen-Condensation Biocatalyst Drives the Synthesis of Substituted Pyrroles

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008710	molecular_function	8-amino-7-oxononanoate synthase activity
A	0008890	molecular_function	glycine C-acetyltransferase activity
A	0009058	biological_process	biosynthetic process
A	0009102	biological_process	biotin biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0030170	molecular_function	pyridoxal phosphate binding
B	0008710	molecular_function	8-amino-7-oxononanoate synthase activity
B	0008890	molecular_function	glycine C-acetyltransferase activity
B	0009058	biological_process	biosynthetic process
B	0009102	biological_process	biotin biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0030170	molecular_function	pyridoxal phosphate binding
C	0008710	molecular_function	8-amino-7-oxononanoate synthase activity
C	0008890	molecular_function	glycine C-acetyltransferase activity
C	0009058	biological_process	biosynthetic process
C	0009102	biological_process	biotin biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0030170	molecular_function	pyridoxal phosphate binding
D	0008710	molecular_function	8-amino-7-oxononanoate synthase activity
D	0008890	molecular_function	glycine C-acetyltransferase activity
D	0009058	biological_process	biosynthetic process
D	0009102	biological_process	biotin biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0030170	molecular_function	pyridoxal phosphate binding

Functional Information from PROSITE/UniProt

site_id	PS00599
Number of Residues	10
Details	AA_TRANSFER_CLASS_2 Aminotransferases class-II pyridoxal-phosphate attachment site. TLSKAWAGIG

Chain	Residue	Details
A	THR240-GLY249

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	GLY111
B	ASP208
B	THR240
B	THR357
C	GLY111
C	HIS136
C	SER183
C	ASP208
C	THR240
C	THR357
D	GLY111
A	HIS136
D	HIS136
D	SER183
D	ASP208
D	THR240
D	THR357
A	SER183
A	ASP208
A	THR240
A	THR357
B	GLY111
B	HIS136
B	SER183

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site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000305

Chain	Residue	Details
A	LYS243
B	LYS243
C	LYS243
D	LYS243

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