7PMY
HsPepT2 bound to Ala-Phe in the inward facing partially occluded conformation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006857 | biological_process | oligopeptide transport |
| A | 0015031 | biological_process | protein transport |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015333 | molecular_function | peptide:proton symporter activity |
| A | 0015833 | biological_process | peptide transport |
| A | 0015835 | biological_process | peptidoglycan transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0030670 | cellular_component | phagocytic vesicle membrane |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0035673 | molecular_function | oligopeptide transmembrane transporter activity |
| A | 0042908 | biological_process | xenobiotic transport |
| A | 0042937 | molecular_function | tripeptide transmembrane transporter activity |
| A | 0042938 | biological_process | dipeptide transport |
| A | 0045087 | biological_process | innate immune response |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070293 | biological_process | renal absorption |
| A | 0070424 | biological_process | regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway |
| A | 0071916 | molecular_function | dipeptide transmembrane transporter activity |
| A | 0140206 | biological_process | dipeptide import across plasma membrane |
| A | 0140207 | biological_process | tripeptide import across plasma membrane |
| A | 0140367 | biological_process | antibacterial innate immune response |
| A | 0150104 | biological_process | transport across blood-brain barrier |
| A | 1902600 | biological_process | proton transmembrane transport |
| A | 1990961 | biological_process | xenobiotic detoxification by transmembrane export across the plasma membrane |
Functional Information from PROSITE/UniProt
| site_id | PS01022 |
| Number of Residues | 25 |
| Details | PTR2_1 PTR2 family proton/oligopeptide symporters signature 1. GAAIADsWLGkfkTIiylSlVyvlG |
| Chain | Residue | Details |
| A | GLY100-GLY124 |
| site_id | PS01023 |
| Number of Residues | 13 |
| Details | PTR2_2 PTR2 family proton/oligopeptide symporters signature 2. FsvFYLsINAGSL |
| Chain | Residue | Details |
| A | PHE184-LEU196 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 200 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | MET1-ARG57 | |
| A | ASP105-THR113 | |
| A | LYS161-TYR183 | |
| A | SER239-ASP295 | |
| A | ARG365-MET380 | |
| A | SER633-SER643 | |
| A | TYR696-LEU729 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 240 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE58-ASN78 | |
| A | SER84-ALA104 | |
| A | ILE114-PRO134 | |
| A | VAL140-ILE160 | |
| A | PHE184-MET204 | |
| A | ALA218-GLY238 | |
| A | VAL296-LEU316 | |
| A | MET344-TYR364 | |
| A | ALA381-ILE401 | |
| A | LEU612-PHE632 | |
| A | VAL644-ALA664 | |
| A | PHE675-TYR695 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 264 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | GLU79-THR83 | |
| A | ILE135-GLN139 | |
| A | LEU205-TYR217 | |
| A | ASP317-GLN343 | |
| A | ASN402-GLN611 | |
| A | GLN665-GLU674 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9ES07 |
| Chain | Residue | Details |
| A | SER9 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9ES07 |
| Chain | Residue | Details |
| A | THR12 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q63424 |
| Chain | Residue | Details |
| A | SER28 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 5 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 |
| Chain | Residue | Details |
| A | ASN435 | |
| A | ASN472 | |
| A | ASN528 | |
| A | ASN567 | |
| A | ASN587 |
