7PMW
HsPepT1 bound to Ala-Phe in the outward facing occluded conformation
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005427 | molecular_function | proton-dependent oligopeptide secondary active transmembrane transporter activity |
A | 0005886 | cellular_component | plasma membrane |
A | 0005903 | cellular_component | brush border |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0006857 | biological_process | oligopeptide transport |
A | 0015031 | biological_process | protein transport |
A | 0015293 | molecular_function | symporter activity |
A | 0015333 | molecular_function | peptide:proton symporter activity |
A | 0015833 | biological_process | peptide transport |
A | 0016020 | cellular_component | membrane |
A | 0016324 | cellular_component | apical plasma membrane |
A | 0022857 | molecular_function | transmembrane transporter activity |
A | 0035673 | molecular_function | oligopeptide transmembrane transporter activity |
A | 0042937 | molecular_function | tripeptide transmembrane transporter activity |
A | 0055085 | biological_process | transmembrane transport |
A | 0071916 | molecular_function | dipeptide transmembrane transporter activity |
A | 0140206 | biological_process | dipeptide import across plasma membrane |
A | 0140207 | biological_process | tripeptide import across plasma membrane |
A | 1902600 | biological_process | proton transmembrane transport |
Functional Information from PROSITE/UniProt
site_id | PS01022 |
Number of Residues | 25 |
Details | PTR2_1 PTR2 family proton/oligopeptide symporters signature 1. GALIADsWLGkfkTIvslSiVytiG |
Chain | Residue | Details |
A | GLY70-GLY94 |
site_id | PS01023 |
Number of Residues | 13 |
Details | PTR2_2 PTR2 family proton/oligopeptide symporters signature 2. FsiFYLaINAGSL |
Chain | Residue | Details |
A | PHE163-LEU175 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 240 |
Details | TRANSMEM: Helical => ECO:0000255 |
Chain | Residue | Details |
A | MET1-VAL21 | |
A | ILE585-PHE605 | |
A | ALA620-GLY640 | |
A | TRP646-MET666 | |
A | ALA54-ALA74 | |
A | THR83-ILE103 | |
A | PRO119-ILE139 | |
A | PHE162-PRO182 | |
A | PRO199-GLY219 | |
A | ILE277-PHE297 | |
A | VAL328-ILE348 | |
A | ALA362-ILE382 |
site_id | SWS_FT_FI2 |
Number of Residues | 294 |
Details | TOPO_DOM: Extracellular => ECO:0000255 |
Chain | Residue | Details |
A | ASN22-THR53 | |
A | ASN104-LEU118 | |
A | MET183-TYR198 | |
A | ASP298-THR327 | |
A | ASP383-GLN584 | |
A | GLN641-GLN645 |
site_id | SWS_FT_FI3 |
Number of Residues | 150 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
Chain | Residue | Details |
A | ASP75-LYS82 | |
A | LYS140-ARG161 | |
A | SER220-GLN276 | |
A | ALA349-MET361 | |
A | SER606-GLN619 | |
A | ALA667-MET708 |
site_id | SWS_FT_FI4 |
Number of Residues | 7 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN50 | |
A | ASN404 | |
A | ASN408 | |
A | ASN439 | |
A | ASN509 | |
A | ASN514 | |
A | ASN562 |