7PKB

C-reactive protein pentamer at pH 7.5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001849	molecular_function	complement component C1q complex binding
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006953	biological_process	acute-phase response
A	0006954	biological_process	inflammatory response
A	0008228	biological_process	opsonization
A	0010628	biological_process	positive regulation of gene expression
A	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
A	0010888	biological_process	negative regulation of lipid storage
A	0030169	molecular_function	low-density lipoprotein particle binding
A	0032677	biological_process	regulation of interleukin-8 production
A	0032930	biological_process	positive regulation of superoxide anion generation
A	0032945	biological_process	negative regulation of mononuclear cell proliferation
A	0033265	molecular_function	choline binding
A	0042310	biological_process	vasoconstriction
A	0042802	molecular_function	identical protein binding
A	0045087	biological_process	innate immune response
A	0046790	molecular_function	virion binding
A	0046872	molecular_function	metal ion binding
A	0050750	molecular_function	low-density lipoprotein particle receptor binding
A	0050830	biological_process	defense response to Gram-positive bacterium
B	0001849	molecular_function	complement component C1q complex binding
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006953	biological_process	acute-phase response
B	0006954	biological_process	inflammatory response
B	0008228	biological_process	opsonization
B	0010628	biological_process	positive regulation of gene expression
B	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
B	0010888	biological_process	negative regulation of lipid storage
B	0030169	molecular_function	low-density lipoprotein particle binding
B	0032677	biological_process	regulation of interleukin-8 production
B	0032930	biological_process	positive regulation of superoxide anion generation
B	0032945	biological_process	negative regulation of mononuclear cell proliferation
B	0033265	molecular_function	choline binding
B	0042310	biological_process	vasoconstriction
B	0042802	molecular_function	identical protein binding
B	0045087	biological_process	innate immune response
B	0046790	molecular_function	virion binding
B	0046872	molecular_function	metal ion binding
B	0050750	molecular_function	low-density lipoprotein particle receptor binding
B	0050830	biological_process	defense response to Gram-positive bacterium
C	0001849	molecular_function	complement component C1q complex binding
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006953	biological_process	acute-phase response
C	0006954	biological_process	inflammatory response
C	0008228	biological_process	opsonization
C	0010628	biological_process	positive regulation of gene expression
C	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
C	0010888	biological_process	negative regulation of lipid storage
C	0030169	molecular_function	low-density lipoprotein particle binding
C	0032677	biological_process	regulation of interleukin-8 production
C	0032930	biological_process	positive regulation of superoxide anion generation
C	0032945	biological_process	negative regulation of mononuclear cell proliferation
C	0033265	molecular_function	choline binding
C	0042310	biological_process	vasoconstriction
C	0042802	molecular_function	identical protein binding
C	0045087	biological_process	innate immune response
C	0046790	molecular_function	virion binding
C	0046872	molecular_function	metal ion binding
C	0050750	molecular_function	low-density lipoprotein particle receptor binding
C	0050830	biological_process	defense response to Gram-positive bacterium
D	0001849	molecular_function	complement component C1q complex binding
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006953	biological_process	acute-phase response
D	0006954	biological_process	inflammatory response
D	0008228	biological_process	opsonization
D	0010628	biological_process	positive regulation of gene expression
D	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
D	0010888	biological_process	negative regulation of lipid storage
D	0030169	molecular_function	low-density lipoprotein particle binding
D	0032677	biological_process	regulation of interleukin-8 production
D	0032930	biological_process	positive regulation of superoxide anion generation
D	0032945	biological_process	negative regulation of mononuclear cell proliferation
D	0033265	molecular_function	choline binding
D	0042310	biological_process	vasoconstriction
D	0042802	molecular_function	identical protein binding
D	0045087	biological_process	innate immune response
D	0046790	molecular_function	virion binding
D	0046872	molecular_function	metal ion binding
D	0050750	molecular_function	low-density lipoprotein particle receptor binding
D	0050830	biological_process	defense response to Gram-positive bacterium
E	0001849	molecular_function	complement component C1q complex binding
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0006953	biological_process	acute-phase response
E	0006954	biological_process	inflammatory response
E	0008228	biological_process	opsonization
E	0010628	biological_process	positive regulation of gene expression
E	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
E	0010888	biological_process	negative regulation of lipid storage
E	0030169	molecular_function	low-density lipoprotein particle binding
E	0032677	biological_process	regulation of interleukin-8 production
E	0032930	biological_process	positive regulation of superoxide anion generation
E	0032945	biological_process	negative regulation of mononuclear cell proliferation
E	0033265	molecular_function	choline binding
E	0042310	biological_process	vasoconstriction
E	0042802	molecular_function	identical protein binding
E	0045087	biological_process	innate immune response
E	0046790	molecular_function	virion binding
E	0046872	molecular_function	metal ion binding
E	0050750	molecular_function	low-density lipoprotein particle receptor binding
E	0050830	biological_process	defense response to Gram-positive bacterium

Functional Information from PROSITE/UniProt

site_id	PS00289
Number of Residues	8
Details	PTX_1 Pentraxin domain signature. HiCtSWeS

Chain	Residue	Details
E	HIS95-SER102

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1005
Details	Domain: {"description":"Pentraxin (PTX)","evidences":[{"source":"PROSITE-ProRule","id":"PRU01172","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01172","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid","evidences":[{"source":"PubMed","id":"762075","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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