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7PHK

Human voltage-gated potassium channel Kv3.1 in dimeric state (with Zn)

Functional Information from GO Data
ChainGOidnamespacecontents
A0001508biological_processaction potential
A0005216molecular_functionmonoatomic ion channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005251molecular_functiondelayed rectifier potassium channel activity
A0005267molecular_functionpotassium channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0008076cellular_componentvoltage-gated potassium channel complex
A0009636biological_processresponse to toxic substance
A0009642biological_processresponse to light intensity
A0009986cellular_componentcell surface
A0010996biological_processresponse to auditory stimulus
A0014075biological_processresponse to amine
A0016020cellular_componentmembrane
A0019894molecular_functionkinesin binding
A0021549biological_processcerebellum development
A0021554biological_processoptic nerve development
A0021759biological_processglobus pallidus development
A0022038biological_processcorpus callosum development
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030673cellular_componentaxolemma
A0032589cellular_componentneuron projection membrane
A0032590cellular_componentdendrite membrane
A0032809cellular_componentneuronal cell body membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0034702cellular_componentmonoatomic ion channel complex
A0034765biological_processregulation of monoatomic ion transmembrane transport
A0034767biological_processpositive regulation of monoatomic ion transmembrane transport
A0035864biological_processresponse to potassium ion
A0042734cellular_componentpresynaptic membrane
A0043025cellular_componentneuronal cell body
A0043679cellular_componentaxon terminus
A0044305cellular_componentcalyx of Held
A0044325molecular_functiontransmembrane transporter binding
A0045211cellular_componentpostsynaptic membrane
A0051260biological_processprotein homooligomerization
A0051262biological_processprotein tetramerization
A0055085biological_processtransmembrane transport
A0071466biological_processcellular response to xenobiotic stimulus
A0071774biological_processresponse to fibroblast growth factor
A0071805biological_processpotassium ion transmembrane transport
A0099505biological_processregulation of presynaptic membrane potential
A0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
A1901379biological_processregulation of potassium ion transmembrane transport
A1901381biological_processpositive regulation of potassium ion transmembrane transport
A1990089biological_processresponse to nerve growth factor
B0001508biological_processaction potential
B0005216molecular_functionmonoatomic ion channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005251molecular_functiondelayed rectifier potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0008076cellular_componentvoltage-gated potassium channel complex
B0009636biological_processresponse to toxic substance
B0009642biological_processresponse to light intensity
B0009986cellular_componentcell surface
B0010996biological_processresponse to auditory stimulus
B0014075biological_processresponse to amine
B0016020cellular_componentmembrane
B0019894molecular_functionkinesin binding
B0021549biological_processcerebellum development
B0021554biological_processoptic nerve development
B0021759biological_processglobus pallidus development
B0022038biological_processcorpus callosum development
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0030673cellular_componentaxolemma
B0032589cellular_componentneuron projection membrane
B0032590cellular_componentdendrite membrane
B0032809cellular_componentneuronal cell body membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0034702cellular_componentmonoatomic ion channel complex
B0034765biological_processregulation of monoatomic ion transmembrane transport
B0034767biological_processpositive regulation of monoatomic ion transmembrane transport
B0035864biological_processresponse to potassium ion
B0042734cellular_componentpresynaptic membrane
B0043025cellular_componentneuronal cell body
B0043679cellular_componentaxon terminus
B0044305cellular_componentcalyx of Held
B0044325molecular_functiontransmembrane transporter binding
B0045211cellular_componentpostsynaptic membrane
B0051260biological_processprotein homooligomerization
B0051262biological_processprotein tetramerization
B0055085biological_processtransmembrane transport
B0071466biological_processcellular response to xenobiotic stimulus
B0071774biological_processresponse to fibroblast growth factor
B0071805biological_processpotassium ion transmembrane transport
B0099505biological_processregulation of presynaptic membrane potential
B0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
B1901379biological_processregulation of potassium ion transmembrane transport
B1901381biological_processpositive regulation of potassium ion transmembrane transport
B1990089biological_processresponse to nerve growth factor
C0001508biological_processaction potential
C0005216molecular_functionmonoatomic ion channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0005251molecular_functiondelayed rectifier potassium channel activity
C0005267molecular_functionpotassium channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0008076cellular_componentvoltage-gated potassium channel complex
C0009636biological_processresponse to toxic substance
C0009642biological_processresponse to light intensity
C0009986cellular_componentcell surface
C0010996biological_processresponse to auditory stimulus
C0014075biological_processresponse to amine
C0016020cellular_componentmembrane
C0019894molecular_functionkinesin binding
C0021549biological_processcerebellum development
C0021554biological_processoptic nerve development
C0021759biological_processglobus pallidus development
C0022038biological_processcorpus callosum development
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0030673cellular_componentaxolemma
C0032589cellular_componentneuron projection membrane
C0032590cellular_componentdendrite membrane
C0032809cellular_componentneuronal cell body membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0034702cellular_componentmonoatomic ion channel complex
C0034765biological_processregulation of monoatomic ion transmembrane transport
C0034767biological_processpositive regulation of monoatomic ion transmembrane transport
C0035864biological_processresponse to potassium ion
C0042734cellular_componentpresynaptic membrane
C0043025cellular_componentneuronal cell body
C0043679cellular_componentaxon terminus
C0044305cellular_componentcalyx of Held
C0044325molecular_functiontransmembrane transporter binding
C0045211cellular_componentpostsynaptic membrane
C0051260biological_processprotein homooligomerization
C0051262biological_processprotein tetramerization
C0055085biological_processtransmembrane transport
C0071466biological_processcellular response to xenobiotic stimulus
C0071774biological_processresponse to fibroblast growth factor
C0071805biological_processpotassium ion transmembrane transport
C0099505biological_processregulation of presynaptic membrane potential
C0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
C1901379biological_processregulation of potassium ion transmembrane transport
C1901381biological_processpositive regulation of potassium ion transmembrane transport
C1990089biological_processresponse to nerve growth factor
D0001508biological_processaction potential
D0005216molecular_functionmonoatomic ion channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005251molecular_functiondelayed rectifier potassium channel activity
D0005267molecular_functionpotassium channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0008076cellular_componentvoltage-gated potassium channel complex
D0009636biological_processresponse to toxic substance
D0009642biological_processresponse to light intensity
D0009986cellular_componentcell surface
D0010996biological_processresponse to auditory stimulus
D0014075biological_processresponse to amine
D0016020cellular_componentmembrane
D0019894molecular_functionkinesin binding
D0021549biological_processcerebellum development
D0021554biological_processoptic nerve development
D0021759biological_processglobus pallidus development
D0022038biological_processcorpus callosum development
D0030424cellular_componentaxon
D0030425cellular_componentdendrite
D0030673cellular_componentaxolemma
D0032589cellular_componentneuron projection membrane
D0032590cellular_componentdendrite membrane
D0032809cellular_componentneuronal cell body membrane
D0034220biological_processmonoatomic ion transmembrane transport
D0034702cellular_componentmonoatomic ion channel complex
D0034765biological_processregulation of monoatomic ion transmembrane transport
D0034767biological_processpositive regulation of monoatomic ion transmembrane transport
D0035864biological_processresponse to potassium ion
D0042734cellular_componentpresynaptic membrane
D0043025cellular_componentneuronal cell body
D0043679cellular_componentaxon terminus
D0044305cellular_componentcalyx of Held
D0044325molecular_functiontransmembrane transporter binding
D0045211cellular_componentpostsynaptic membrane
D0051260biological_processprotein homooligomerization
D0051262biological_processprotein tetramerization
D0055085biological_processtransmembrane transport
D0071466biological_processcellular response to xenobiotic stimulus
D0071774biological_processresponse to fibroblast growth factor
D0071805biological_processpotassium ion transmembrane transport
D0099505biological_processregulation of presynaptic membrane potential
D0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
D1901379biological_processregulation of potassium ion transmembrane transport
D1901381biological_processpositive regulation of potassium ion transmembrane transport
D1990089biological_processresponse to nerve growth factor
E0001508biological_processaction potential
E0005216molecular_functionmonoatomic ion channel activity
E0005249molecular_functionvoltage-gated potassium channel activity
E0005251molecular_functiondelayed rectifier potassium channel activity
E0005267molecular_functionpotassium channel activity
E0005515molecular_functionprotein binding
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0006813biological_processpotassium ion transport
E0008076cellular_componentvoltage-gated potassium channel complex
E0009636biological_processresponse to toxic substance
E0009642biological_processresponse to light intensity
E0009986cellular_componentcell surface
E0010996biological_processresponse to auditory stimulus
E0014075biological_processresponse to amine
E0016020cellular_componentmembrane
E0019894molecular_functionkinesin binding
E0021549biological_processcerebellum development
E0021554biological_processoptic nerve development
E0021759biological_processglobus pallidus development
E0022038biological_processcorpus callosum development
E0030424cellular_componentaxon
E0030425cellular_componentdendrite
E0030673cellular_componentaxolemma
E0032589cellular_componentneuron projection membrane
E0032590cellular_componentdendrite membrane
E0032809cellular_componentneuronal cell body membrane
E0034220biological_processmonoatomic ion transmembrane transport
E0034702cellular_componentmonoatomic ion channel complex
E0034765biological_processregulation of monoatomic ion transmembrane transport
E0034767biological_processpositive regulation of monoatomic ion transmembrane transport
E0035864biological_processresponse to potassium ion
E0042734cellular_componentpresynaptic membrane
E0043025cellular_componentneuronal cell body
E0043679cellular_componentaxon terminus
E0044305cellular_componentcalyx of Held
E0044325molecular_functiontransmembrane transporter binding
E0045211cellular_componentpostsynaptic membrane
E0051260biological_processprotein homooligomerization
E0051262biological_processprotein tetramerization
E0055085biological_processtransmembrane transport
E0071466biological_processcellular response to xenobiotic stimulus
E0071774biological_processresponse to fibroblast growth factor
E0071805biological_processpotassium ion transmembrane transport
E0099505biological_processregulation of presynaptic membrane potential
E0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
E1901379biological_processregulation of potassium ion transmembrane transport
E1901381biological_processpositive regulation of potassium ion transmembrane transport
E1990089biological_processresponse to nerve growth factor
F0001508biological_processaction potential
F0005216molecular_functionmonoatomic ion channel activity
F0005249molecular_functionvoltage-gated potassium channel activity
F0005251molecular_functiondelayed rectifier potassium channel activity
F0005267molecular_functionpotassium channel activity
F0005515molecular_functionprotein binding
F0005886cellular_componentplasma membrane
F0006811biological_processmonoatomic ion transport
F0006813biological_processpotassium ion transport
F0008076cellular_componentvoltage-gated potassium channel complex
F0009636biological_processresponse to toxic substance
F0009642biological_processresponse to light intensity
F0009986cellular_componentcell surface
F0010996biological_processresponse to auditory stimulus
F0014075biological_processresponse to amine
F0016020cellular_componentmembrane
F0019894molecular_functionkinesin binding
F0021549biological_processcerebellum development
F0021554biological_processoptic nerve development
F0021759biological_processglobus pallidus development
F0022038biological_processcorpus callosum development
F0030424cellular_componentaxon
F0030425cellular_componentdendrite
F0030673cellular_componentaxolemma
F0032589cellular_componentneuron projection membrane
F0032590cellular_componentdendrite membrane
F0032809cellular_componentneuronal cell body membrane
F0034220biological_processmonoatomic ion transmembrane transport
F0034702cellular_componentmonoatomic ion channel complex
F0034765biological_processregulation of monoatomic ion transmembrane transport
F0034767biological_processpositive regulation of monoatomic ion transmembrane transport
F0035864biological_processresponse to potassium ion
F0042734cellular_componentpresynaptic membrane
F0043025cellular_componentneuronal cell body
F0043679cellular_componentaxon terminus
F0044305cellular_componentcalyx of Held
F0044325molecular_functiontransmembrane transporter binding
F0045211cellular_componentpostsynaptic membrane
F0051260biological_processprotein homooligomerization
F0051262biological_processprotein tetramerization
F0055085biological_processtransmembrane transport
F0071466biological_processcellular response to xenobiotic stimulus
F0071774biological_processresponse to fibroblast growth factor
F0071805biological_processpotassium ion transmembrane transport
F0099505biological_processregulation of presynaptic membrane potential
F0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
F1901379biological_processregulation of potassium ion transmembrane transport
F1901381biological_processpositive regulation of potassium ion transmembrane transport
F1990089biological_processresponse to nerve growth factor
G0001508biological_processaction potential
G0005216molecular_functionmonoatomic ion channel activity
G0005249molecular_functionvoltage-gated potassium channel activity
G0005251molecular_functiondelayed rectifier potassium channel activity
G0005267molecular_functionpotassium channel activity
G0005515molecular_functionprotein binding
G0005886cellular_componentplasma membrane
G0006811biological_processmonoatomic ion transport
G0006813biological_processpotassium ion transport
G0008076cellular_componentvoltage-gated potassium channel complex
G0009636biological_processresponse to toxic substance
G0009642biological_processresponse to light intensity
G0009986cellular_componentcell surface
G0010996biological_processresponse to auditory stimulus
G0014075biological_processresponse to amine
G0016020cellular_componentmembrane
G0019894molecular_functionkinesin binding
G0021549biological_processcerebellum development
G0021554biological_processoptic nerve development
G0021759biological_processglobus pallidus development
G0022038biological_processcorpus callosum development
G0030424cellular_componentaxon
G0030425cellular_componentdendrite
G0030673cellular_componentaxolemma
G0032589cellular_componentneuron projection membrane
G0032590cellular_componentdendrite membrane
G0032809cellular_componentneuronal cell body membrane
G0034220biological_processmonoatomic ion transmembrane transport
G0034702cellular_componentmonoatomic ion channel complex
G0034765biological_processregulation of monoatomic ion transmembrane transport
G0034767biological_processpositive regulation of monoatomic ion transmembrane transport
G0035864biological_processresponse to potassium ion
G0042734cellular_componentpresynaptic membrane
G0043025cellular_componentneuronal cell body
G0043679cellular_componentaxon terminus
G0044305cellular_componentcalyx of Held
G0044325molecular_functiontransmembrane transporter binding
G0045211cellular_componentpostsynaptic membrane
G0051260biological_processprotein homooligomerization
G0051262biological_processprotein tetramerization
G0055085biological_processtransmembrane transport
G0071466biological_processcellular response to xenobiotic stimulus
G0071774biological_processresponse to fibroblast growth factor
G0071805biological_processpotassium ion transmembrane transport
G0099505biological_processregulation of presynaptic membrane potential
G0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
G1901379biological_processregulation of potassium ion transmembrane transport
G1901381biological_processpositive regulation of potassium ion transmembrane transport
G1990089biological_processresponse to nerve growth factor
H0001508biological_processaction potential
H0005216molecular_functionmonoatomic ion channel activity
H0005249molecular_functionvoltage-gated potassium channel activity
H0005251molecular_functiondelayed rectifier potassium channel activity
H0005267molecular_functionpotassium channel activity
H0005515molecular_functionprotein binding
H0005886cellular_componentplasma membrane
H0006811biological_processmonoatomic ion transport
H0006813biological_processpotassium ion transport
H0008076cellular_componentvoltage-gated potassium channel complex
H0009636biological_processresponse to toxic substance
H0009642biological_processresponse to light intensity
H0009986cellular_componentcell surface
H0010996biological_processresponse to auditory stimulus
H0014075biological_processresponse to amine
H0016020cellular_componentmembrane
H0019894molecular_functionkinesin binding
H0021549biological_processcerebellum development
H0021554biological_processoptic nerve development
H0021759biological_processglobus pallidus development
H0022038biological_processcorpus callosum development
H0030424cellular_componentaxon
H0030425cellular_componentdendrite
H0030673cellular_componentaxolemma
H0032589cellular_componentneuron projection membrane
H0032590cellular_componentdendrite membrane
H0032809cellular_componentneuronal cell body membrane
H0034220biological_processmonoatomic ion transmembrane transport
H0034702cellular_componentmonoatomic ion channel complex
H0034765biological_processregulation of monoatomic ion transmembrane transport
H0034767biological_processpositive regulation of monoatomic ion transmembrane transport
H0035864biological_processresponse to potassium ion
H0042734cellular_componentpresynaptic membrane
H0043025cellular_componentneuronal cell body
H0043679cellular_componentaxon terminus
H0044305cellular_componentcalyx of Held
H0044325molecular_functiontransmembrane transporter binding
H0045211cellular_componentpostsynaptic membrane
H0051260biological_processprotein homooligomerization
H0051262biological_processprotein tetramerization
H0055085biological_processtransmembrane transport
H0071466biological_processcellular response to xenobiotic stimulus
H0071774biological_processresponse to fibroblast growth factor
H0071805biological_processpotassium ion transmembrane transport
H0099505biological_processregulation of presynaptic membrane potential
H0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
H1901379biological_processregulation of potassium ion transmembrane transport
H1901381biological_processpositive regulation of potassium ion transmembrane transport
H1990089biological_processresponse to nerve growth factor
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues144
DetailsTransmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues152
DetailsTransmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues160
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues144
DetailsTransmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues176
DetailsTransmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues168
DetailsTransmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues168
DetailsTransmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues40
DetailsMotif: {"description":"Selectivity filter","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35840580","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PHK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PHL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues24
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35840580","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PHH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PHK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PHL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35840580","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PHH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35840580","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PHL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35840580","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PHH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PHK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PHL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35840580","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PHH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PHK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P25122","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI16
Number of Residues8
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

243083

PDB entries from 2025-10-15

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