7PFP
Full-length cryo-EM structure of the native human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00010 |
| Number of Residues | 12 |
| Details | ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CvNtpgsFsCvC |
| Chain | Residue | Details |
| A | CYS83-CYS94 | |
| A | CYS126-CYS137 |
| site_id | PS00682 |
| Number of Residues | 41 |
| Details | ZP_1 ZP domain signature. VgtmldggDlsrFaLlMtnCYaTPss..NaTdplkyfIIqdr.C |
| Chain | Residue | Details |
| A | VAL487-CYS527 |
| site_id | PS01186 |
| Number of Residues | 14 |
| Details | EGF_2 EGF-like domain signature 2. CtCqeGFtgdglt..C |
| Chain | Residue | Details |
| A | CYS50-CYS63 | |
| A | CYS92-CYS106 | |
| A | CYS135-CYS150 |
| site_id | PS01187 |
| Number of Residues | 28 |
| Details | EGF_CA Calcium-binding EGF-like domain signature. DlDECaipgahn.......Csanss..CvNtpgsFsC |
| Chain | Residue | Details |
| A | ASP65-CYS92 | |
| A | ASP108-CYS135 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | SITE: Cleavage => ECO:0000269|PubMed:18375198 |
| Chain | Residue | Details |
| A | PHE587 | |
| B | PHE587 | |
| C | PHE587 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | LIPID: GPI-anchor amidated serine => ECO:0000255 |
| Chain | Residue | Details |
| A | SER614 | |
| B | SER614 | |
| C | SER614 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:32616672 |
| Chain | Residue | Details |
| A | ASN38 | |
| B | ASN38 | |
| C | ASN38 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:32616672, ECO:0000269|PubMed:35273390, ECO:0007744|PDB:7PFP, ECO:0007744|PDB:7Q3N |
| Chain | Residue | Details |
| A | ASN76 | |
| A | ASN80 | |
| B | ASN76 | |
| B | ASN80 | |
| C | ASN76 | |
| C | ASN80 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:22171320, ECO:0000269|PubMed:26811476, ECO:0000269|PubMed:32616672, ECO:0000269|PubMed:35273390, ECO:0007744|PDB:7PFP, ECO:0007744|PDB:7Q3N |
| Chain | Residue | Details |
| A | ASN232 | |
| B | ASN232 | |
| C | ASN232 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine => ECO:0000269|PubMed:32616672, ECO:0000269|PubMed:35273390, ECO:0007744|PDB:7PFP, ECO:0007744|PDB:7Q3N |
| Chain | Residue | Details |
| A | ASN275 | |
| B | ASN275 | |
| C | ASN275 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:22171320, ECO:0000269|PubMed:32616672, ECO:0000269|PubMed:33196145, ECO:0000269|PubMed:35273390, ECO:0007744|PDB:6TQK, ECO:0007744|PDB:6TQL, ECO:0007744|PDB:7PFP |
| Chain | Residue | Details |
| A | ASN322 | |
| B | ASN322 | |
| C | ASN322 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:22171320, ECO:0000269|PubMed:32616672, ECO:0000269|PubMed:32815518, ECO:0000269|PubMed:33196145, ECO:0000269|PubMed:35273390, ECO:0007744|PDB:6TQK, ECO:0007744|PDB:6TQL, ECO:0007744|PDB:6ZS5, ECO:0007744|PDB:6ZYA, ECO:0007744|PDB:7PFP |
| Chain | Residue | Details |
| A | ASN396 | |
| B | ASN396 | |
| C | ASN396 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine; alternate => ECO:0000269|PubMed:32616672, ECO:0000269|PubMed:32815518, ECO:0000269|PubMed:33196145, ECO:0007744|PDB:6TQK, ECO:0007744|PDB:6TQL, ECO:0007744|PDB:6ZS5, ECO:0007744|PDB:6ZYA, ECO:0007744|PDB:7PFP |
| Chain | Residue | Details |
| A | ASN513 | |
| B | ASN513 | |
| C | ASN513 |
