Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7PFP

Full-length cryo-EM structure of the native human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
B	0005509	molecular_function	calcium ion binding
C	0005509	molecular_function	calcium ion binding

Functional Information from PROSITE/UniProt

site_id	PS00010
Number of Residues	12
Details	ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CvNtpgsFsCvC

Chain	Residue	Details
A	CYS83-CYS94
A	CYS126-CYS137

site_id	PS00682
Number of Residues	41
Details	ZP_1 ZP domain signature. VgtmldggDlsrFaLlMtnCYaTPss..NaTdplkyfIIqdr.C

Chain	Residue	Details
A	VAL487-CYS527

site_id	PS01186
Number of Residues	14
Details	EGF_2 EGF-like domain signature 2. CtCqeGFtgdglt..C

Chain	Residue	Details
A	CYS50-CYS63
A	CYS92-CYS106
A	CYS135-CYS150

site_id	PS01187
Number of Residues	28
Details	EGF_CA Calcium-binding EGF-like domain signature. DlDECaipgahn.......Csanss..CvNtpgsFsC

Chain	Residue	Details
A	ASP65-CYS92
A	ASP108-CYS135

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	Domain: {"description":"EGF-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	84
Details	Domain: {"description":"EGF-like 2; calcium-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	82
Details	Domain: {"description":"EGF-like 3; calcium-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	62
Details	Domain: {"description":"EGF-like 4","evidences":[{"source":"PubMed","id":"26811476","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35273390","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	42
Details	Region: {"description":"Beta hairpin","evidences":[{"source":"PubMed","id":"35273390","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	238
Details	Region: {"description":"D10C","evidences":[{"source":"PubMed","id":"35273390","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	190
Details	Region: {"description":"ZP-N","evidences":[{"source":"PubMed","id":"26811476","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32815518","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35273390","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	23
Details	Region: {"description":"Flexible ZP-N/ZP-C linker; important for secretion and polymerization into filaments","evidences":[{"source":"PubMed","id":"26811476","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	22
Details	Region: {"description":"Internal hydrophobic patch (IHP)","evidences":[{"source":"PubMed","id":"26811476","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32815518","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"32616672","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"32616672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35273390","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q3N","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"22171320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26811476","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32616672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35273390","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q3N","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (high mannose) asparagine","evidences":[{"source":"PubMed","id":"32616672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35273390","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q3N","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"22171320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32616672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35273390","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6TQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PFP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"22171320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32616672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32815518","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35273390","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6TQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZS5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZYA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PFP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (high mannose) asparagine; alternate","evidences":[{"source":"PubMed","id":"32616672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32815518","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6TQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZS5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZYA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PFP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)