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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7PF5

Nucleosome 2 of the 4x187 nucleosome array containing H1

Functional Information from GO Data
ChainGOidnamespacecontents
a0000122biological_processnegative regulation of transcription by RNA polymerase II
a0000785cellular_componentchromatin
a0000786cellular_componentnucleosome
a0003677molecular_functionDNA binding
a0003682molecular_functionchromatin binding
a0005515molecular_functionprotein binding
a0005576cellular_componentextracellular region
a0005634cellular_componentnucleus
a0005654cellular_componentnucleoplasm
a0005694cellular_componentchromosome
a0006325biological_processchromatin organization
a0006334biological_processnucleosome assembly
a0010467biological_processgene expression
a0030527molecular_functionstructural constituent of chromatin
a0046982molecular_functionprotein heterodimerization activity
a0070062cellular_componentextracellular exosome
b0000781cellular_componentchromosome, telomeric region
b0000786cellular_componentnucleosome
b0003677molecular_functionDNA binding
b0003723molecular_functionRNA binding
b0005515molecular_functionprotein binding
b0005576cellular_componentextracellular region
b0005634cellular_componentnucleus
b0005654cellular_componentnucleoplasm
b0005694cellular_componentchromosome
b0006325biological_processchromatin organization
b0006334biological_processnucleosome assembly
b0016020cellular_componentmembrane
b0030527molecular_functionstructural constituent of chromatin
b0032200biological_processtelomere organization
b0032991cellular_componentprotein-containing complex
b0043505cellular_componentCENP-A containing nucleosome
b0045653biological_processnegative regulation of megakaryocyte differentiation
b0046982molecular_functionprotein heterodimerization activity
b0061644biological_processprotein localization to CENP-A containing chromatin
b0070062cellular_componentextracellular exosome
c0000786cellular_componentnucleosome
c0003677molecular_functionDNA binding
c0005515molecular_functionprotein binding
c0005634cellular_componentnucleus
c0005694cellular_componentchromosome
c0006325biological_processchromatin organization
c0008285biological_processnegative regulation of cell population proliferation
c0030527molecular_functionstructural constituent of chromatin
c0031507biological_processheterochromatin formation
c0043505cellular_componentCENP-A containing nucleosome
c0046982molecular_functionprotein heterodimerization activity
c0061644biological_processprotein localization to CENP-A containing chromatin
c0070062cellular_componentextracellular exosome
d0000786cellular_componentnucleosome
d0002227biological_processinnate immune response in mucosa
d0003677molecular_functionDNA binding
d0005515molecular_functionprotein binding
d0005615cellular_componentextracellular space
d0005634cellular_componentnucleus
d0005654cellular_componentnucleoplasm
d0005694cellular_componentchromosome
d0005829cellular_componentcytosol
d0019731biological_processantibacterial humoral response
d0030527molecular_functionstructural constituent of chromatin
d0031640biological_processkilling of cells of another organism
d0042742biological_processdefense response to bacterium
d0046982molecular_functionprotein heterodimerization activity
d0050829biological_processdefense response to Gram-negative bacterium
d0050830biological_processdefense response to Gram-positive bacterium
d0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
e0000122biological_processnegative regulation of transcription by RNA polymerase II
e0000785cellular_componentchromatin
e0000786cellular_componentnucleosome
e0003677molecular_functionDNA binding
e0003682molecular_functionchromatin binding
e0005515molecular_functionprotein binding
e0005576cellular_componentextracellular region
e0005634cellular_componentnucleus
e0005654cellular_componentnucleoplasm
e0005694cellular_componentchromosome
e0006325biological_processchromatin organization
e0006334biological_processnucleosome assembly
e0010467biological_processgene expression
e0030527molecular_functionstructural constituent of chromatin
e0046982molecular_functionprotein heterodimerization activity
e0070062cellular_componentextracellular exosome
f0000781cellular_componentchromosome, telomeric region
f0000786cellular_componentnucleosome
f0003677molecular_functionDNA binding
f0003723molecular_functionRNA binding
f0005515molecular_functionprotein binding
f0005576cellular_componentextracellular region
f0005634cellular_componentnucleus
f0005654cellular_componentnucleoplasm
f0005694cellular_componentchromosome
f0006325biological_processchromatin organization
f0006334biological_processnucleosome assembly
f0016020cellular_componentmembrane
f0030527molecular_functionstructural constituent of chromatin
f0032200biological_processtelomere organization
f0032991cellular_componentprotein-containing complex
f0043505cellular_componentCENP-A containing nucleosome
f0045653biological_processnegative regulation of megakaryocyte differentiation
f0046982molecular_functionprotein heterodimerization activity
f0061644biological_processprotein localization to CENP-A containing chromatin
f0070062cellular_componentextracellular exosome
g0000786cellular_componentnucleosome
g0003677molecular_functionDNA binding
g0005515molecular_functionprotein binding
g0005634cellular_componentnucleus
g0005694cellular_componentchromosome
g0006325biological_processchromatin organization
g0008285biological_processnegative regulation of cell population proliferation
g0030527molecular_functionstructural constituent of chromatin
g0031507biological_processheterochromatin formation
g0043505cellular_componentCENP-A containing nucleosome
g0046982molecular_functionprotein heterodimerization activity
g0061644biological_processprotein localization to CENP-A containing chromatin
g0070062cellular_componentextracellular exosome
h0000786cellular_componentnucleosome
h0002227biological_processinnate immune response in mucosa
h0003677molecular_functionDNA binding
h0005515molecular_functionprotein binding
h0005615cellular_componentextracellular space
h0005634cellular_componentnucleus
h0005654cellular_componentnucleoplasm
h0005694cellular_componentchromosome
h0005829cellular_componentcytosol
h0019731biological_processantibacterial humoral response
h0030527molecular_functionstructural constituent of chromatin
h0031640biological_processkilling of cells of another organism
h0042742biological_processdefense response to bacterium
h0046982molecular_functionprotein heterodimerization activity
h0050829biological_processdefense response to Gram-negative bacterium
h0050830biological_processdefense response to Gram-positive bacterium
h0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
u0000122biological_processnegative regulation of transcription by RNA polymerase II
u0000785cellular_componentchromatin
u0000786cellular_componentnucleosome
u0000791cellular_componenteuchromatin
u0000792cellular_componentheterochromatin
u0003677molecular_functionDNA binding
u0003690molecular_functiondouble-stranded DNA binding
u0003723molecular_functionRNA binding
u0005515molecular_functionprotein binding
u0005634cellular_componentnucleus
u0005694cellular_componentchromosome
u0006325biological_processchromatin organization
u0006334biological_processnucleosome assembly
u0006357biological_processregulation of transcription by RNA polymerase II
u0030261biological_processchromosome condensation
u0030527molecular_functionstructural constituent of chromatin
u0031490molecular_functionchromatin DNA binding
u0031492molecular_functionnucleosomal DNA binding
u0042826molecular_functionhistone deacetylase binding
u0045910biological_processnegative regulation of DNA recombination
Functional Information from PROSITE/UniProt
site_idPS00046
Number of Residues7
DetailsHISTONE_H2A Histone H2A signature. AGLqFPV
ChainResidueDetails
cALA21-VAL27
site_idPS00047
Number of Residues5
DetailsHISTONE_H4 Histone H4 signature. GAKRH
ChainResidueDetails
bGLY14-HIS18
site_idPS00322
Number of Residues7
DetailsHISTONE_H3_1 Histone H3 signature 1. KAPRKQL
ChainResidueDetails
aLYS14-LEU20
site_idPS00357
Number of Residues23
DetailsHISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG
ChainResidueDetails
dARG92-GLY114
site_idPS00959
Number of Residues9
DetailsHISTONE_H3_2 Histone H3 signature 2. PFqRLVREI
ChainResidueDetails
aPRO66-ILE74
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsModified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"P68431","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19783980","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues16
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20850016","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29211711","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20850016","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P84243","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues6
DetailsModified residue: {"description":"N6-glutaryllysine; alternate","evidences":[{"source":"PubMed","id":"31542297","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27436229","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"21076176","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsModified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"12086618","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15964846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17967882","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27338793","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsModified residue: {"description":"N6-propionyllysine; alternate","evidences":[{"source":"PubMed","id":"17267393","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by PAK2","evidences":[{"source":"PubMed","id":"21724829","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62806","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62806","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues6
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"19818714","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate","evidences":[{"source":"PubMed","id":"30886146","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues2
DetailsModified residue: {"description":"N6-(beta-hydroxybutyryl)lysine; alternate","evidences":[{"source":"PubMed","id":"27105115","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues2
DetailsModified residue: {"description":"N6-crotonyllysine; alternate","evidences":[{"source":"PubMed","id":"21925322","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues4
DetailsModified residue: {"description":"N6-(2-hydroxyisobutyryl)lysine","evidences":[{"source":"PubMed","id":"24681537","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues2
DetailsModified residue: {"description":"N5-methylglutamine","evidences":[{"source":"PubMed","id":"24352239","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"22713238","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22980979","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22713238","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22980979","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues2
DetailsModified residue: {"description":"PolyADP-ribosyl glutamic acid","evidences":[{"source":"UniProtKB","id":"Q64475","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by AMPK","evidences":[{"source":"UniProtKB","id":"Q8CGP1","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI31
Number of Residues4
DetailsModified residue: {"description":"N6-lactoyllysine; alternate","evidences":[{"source":"PubMed","id":"31645732","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI32
Number of Residues4
DetailsModified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16627869","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI33
Number of Residues2
DetailsModified residue: {"description":"N6-(2-hydroxyisobutyryl)lysine; alternate","evidences":[{"source":"PubMed","id":"24681537","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI34
Number of Residues2
DetailsModified residue: {"description":"Dimethylated arginine","evidences":[{"source":"UniProtKB","id":"Q96A08","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI35
Number of Residues4
DetailsModified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"Q96A08","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI36
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q00729","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI37
Number of Residues2
DetailsGlycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"source":"UniProtKB","id":"P62807","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI38
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"21726816","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI39
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"16307923","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16627869","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16713563","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI40
Number of Residues73
DetailsDomain: {"description":"H15","evidences":[{"source":"PROSITE-ProRule","id":"PRU00837","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI41
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P43274","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI42
Number of Residues5
DetailsModified residue: {"description":"N6-(beta-hydroxybutyryl)lysine","evidences":[{"source":"UniProtKB","id":"P43277","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI43
Number of Residues1
DetailsModified residue: {"description":"Citrulline","evidences":[{"source":"UniProtKB","id":"P43274","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

239803

PDB entries from 2025-08-06

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