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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7PEZ

Nucleosome 4 of the 4x177 nucleosome array containing H1

Functional Information from GO Data
ChainGOidnamespacecontents
e0000786cellular_componentnucleosome
e0002227biological_processinnate immune response in mucosa
e0003677molecular_functionDNA binding
e0005515molecular_functionprotein binding
e0005615cellular_componentextracellular space
e0005634cellular_componentnucleus
e0005654cellular_componentnucleoplasm
e0005694cellular_componentchromosome
e0006325biological_processchromatin organization
e0019731biological_processantibacterial humoral response
e0030527molecular_functionstructural constituent of chromatin
e0031640biological_processkilling of cells of another organism
e0042742biological_processdefense response to bacterium
e0046982molecular_functionprotein heterodimerization activity
e0050829biological_processdefense response to Gram-negative bacterium
e0050830biological_processdefense response to Gram-positive bacterium
e0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
k0000786cellular_componentnucleosome
k0003677molecular_functionDNA binding
k0005515molecular_functionprotein binding
k0005576cellular_componentextracellular region
k0005634cellular_componentnucleus
k0005654cellular_componentnucleoplasm
k0005694cellular_componentchromosome
k0006325biological_processchromatin organization
k0006334biological_processnucleosome assembly
k0030527molecular_functionstructural constituent of chromatin
k0031492molecular_functionnucleosomal DNA binding
k0031507biological_processheterochromatin formation
k0046982molecular_functionprotein heterodimerization activity
k0070062cellular_componentextracellular exosome
l0000781cellular_componentchromosome, telomeric region
l0000786cellular_componentnucleosome
l0003677molecular_functionDNA binding
l0003723molecular_functionRNA binding
l0005515molecular_functionprotein binding
l0005576cellular_componentextracellular region
l0005634cellular_componentnucleus
l0005654cellular_componentnucleoplasm
l0005694cellular_componentchromosome
l0006325biological_processchromatin organization
l0006334biological_processnucleosome assembly
l0016020cellular_componentmembrane
l0030527molecular_functionstructural constituent of chromatin
l0032200biological_processtelomere organization
l0032991cellular_componentprotein-containing complex
l0045653biological_processnegative regulation of megakaryocyte differentiation
l0046982molecular_functionprotein heterodimerization activity
l0061644biological_processprotein localization to CENP-A containing chromatin
l0070062cellular_componentextracellular exosome
m0000786cellular_componentnucleosome
m0003677molecular_functionDNA binding
m0005515molecular_functionprotein binding
m0005634cellular_componentnucleus
m0005654cellular_componentnucleoplasm
m0005694cellular_componentchromosome
m0006325biological_processchromatin organization
m0008285biological_processnegative regulation of cell population proliferation
m0030527molecular_functionstructural constituent of chromatin
m0031507biological_processheterochromatin formation
m0046982molecular_functionprotein heterodimerization activity
m0061644biological_processprotein localization to CENP-A containing chromatin
m0070062cellular_componentextracellular exosome
n0000786cellular_componentnucleosome
n0002227biological_processinnate immune response in mucosa
n0003677molecular_functionDNA binding
n0005515molecular_functionprotein binding
n0005615cellular_componentextracellular space
n0005634cellular_componentnucleus
n0005654cellular_componentnucleoplasm
n0005694cellular_componentchromosome
n0006325biological_processchromatin organization
n0019731biological_processantibacterial humoral response
n0030527molecular_functionstructural constituent of chromatin
n0031640biological_processkilling of cells of another organism
n0042742biological_processdefense response to bacterium
n0046982molecular_functionprotein heterodimerization activity
n0050829biological_processdefense response to Gram-negative bacterium
n0050830biological_processdefense response to Gram-positive bacterium
n0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
o0000786cellular_componentnucleosome
o0003677molecular_functionDNA binding
o0005515molecular_functionprotein binding
o0005576cellular_componentextracellular region
o0005634cellular_componentnucleus
o0005654cellular_componentnucleoplasm
o0005694cellular_componentchromosome
o0006325biological_processchromatin organization
o0006334biological_processnucleosome assembly
o0030527molecular_functionstructural constituent of chromatin
o0031492molecular_functionnucleosomal DNA binding
o0031507biological_processheterochromatin formation
o0046982molecular_functionprotein heterodimerization activity
o0070062cellular_componentextracellular exosome
p0000781cellular_componentchromosome, telomeric region
p0000786cellular_componentnucleosome
p0003677molecular_functionDNA binding
p0003723molecular_functionRNA binding
p0005515molecular_functionprotein binding
p0005576cellular_componentextracellular region
p0005634cellular_componentnucleus
p0005654cellular_componentnucleoplasm
p0005694cellular_componentchromosome
p0006325biological_processchromatin organization
p0006334biological_processnucleosome assembly
p0016020cellular_componentmembrane
p0030527molecular_functionstructural constituent of chromatin
p0032200biological_processtelomere organization
p0032991cellular_componentprotein-containing complex
p0045653biological_processnegative regulation of megakaryocyte differentiation
p0046982molecular_functionprotein heterodimerization activity
p0061644biological_processprotein localization to CENP-A containing chromatin
p0070062cellular_componentextracellular exosome
q0000786cellular_componentnucleosome
q0003677molecular_functionDNA binding
q0005515molecular_functionprotein binding
q0005634cellular_componentnucleus
q0005654cellular_componentnucleoplasm
q0005694cellular_componentchromosome
q0006325biological_processchromatin organization
q0008285biological_processnegative regulation of cell population proliferation
q0030527molecular_functionstructural constituent of chromatin
q0031507biological_processheterochromatin formation
q0046982molecular_functionprotein heterodimerization activity
q0061644biological_processprotein localization to CENP-A containing chromatin
q0070062cellular_componentextracellular exosome
s0000785cellular_componentchromatin
s0000786cellular_componentnucleosome
s0000791cellular_componenteuchromatin
s0000792cellular_componentheterochromatin
s0003677molecular_functionDNA binding
s0003690molecular_functiondouble-stranded DNA binding
s0003723molecular_functionRNA binding
s0005515molecular_functionprotein binding
s0005634cellular_componentnucleus
s0005694cellular_componentchromosome
s0006334biological_processnucleosome assembly
s0016607cellular_componentnuclear speck
s0030261biological_processchromosome condensation
s0030527molecular_functionstructural constituent of chromatin
s0031490molecular_functionchromatin DNA binding
s0031492molecular_functionnucleosomal DNA binding
s0042826molecular_functionhistone deacetylase binding
s0045910biological_processnegative regulation of DNA recombination
Functional Information from PROSITE/UniProt
site_idPS00046
Number of Residues7
DetailsHISTONE_H2A Histone H2A signature. AGLqFPV
ChainResidueDetails
mALA21-VAL27
site_idPS00047
Number of Residues5
DetailsHISTONE_H4 Histone H4 signature. GAKRH
ChainResidueDetails
lGLY14-HIS18
site_idPS00322
Number of Residues7
DetailsHISTONE_H3_1 Histone H3 signature 1. KAPRKQL
ChainResidueDetails
kLYS14-LEU20
site_idPS00357
Number of Residues23
DetailsHISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG
ChainResidueDetails
nARG92-GLY114
site_idPS00959
Number of Residues9
DetailsHISTONE_H3_2 Histone H3 signature 2. PFqRLVREI
ChainResidueDetails
kPRO66-ILE74
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsModified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"P68431","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19783980","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues16
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20850016","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29211711","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20850016","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P84243","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues6
DetailsModified residue: {"description":"N6-glutaryllysine; alternate","evidences":[{"source":"PubMed","id":"31542297","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27436229","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"21076176","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsModified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"12086618","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15964846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17967882","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27338793","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsModified residue: {"description":"N6-propionyllysine; alternate","evidences":[{"source":"PubMed","id":"17267393","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by PAK2","evidences":[{"source":"PubMed","id":"21724829","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62806","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62806","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues6
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"19818714","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate","evidences":[{"source":"PubMed","id":"30886146","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues2
DetailsModified residue: {"description":"N6-(beta-hydroxybutyryl)lysine; alternate","evidences":[{"source":"PubMed","id":"27105115","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues2
DetailsModified residue: {"description":"N6-crotonyllysine; alternate","evidences":[{"source":"PubMed","id":"21925322","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues4
DetailsModified residue: {"description":"N6-(2-hydroxyisobutyryl)lysine","evidences":[{"source":"PubMed","id":"24681537","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues2
DetailsModified residue: {"description":"N5-methylglutamine","evidences":[{"source":"PubMed","id":"24352239","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"22713238","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22980979","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22713238","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22980979","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues2
DetailsModified residue: {"description":"PolyADP-ribosyl glutamic acid","evidences":[{"source":"UniProtKB","id":"Q64475","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by AMPK","evidences":[{"source":"UniProtKB","id":"Q8CGP1","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI31
Number of Residues4
DetailsModified residue: {"description":"N6-lactoyllysine; alternate","evidences":[{"source":"PubMed","id":"31645732","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI32
Number of Residues4
DetailsModified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16627869","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI33
Number of Residues2
DetailsModified residue: {"description":"N6-(2-hydroxyisobutyryl)lysine; alternate","evidences":[{"source":"PubMed","id":"24681537","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI34
Number of Residues2
DetailsModified residue: {"description":"Dimethylated arginine","evidences":[{"source":"UniProtKB","id":"Q96A08","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI35
Number of Residues4
DetailsModified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"Q96A08","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI36
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q00729","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI37
Number of Residues2
DetailsGlycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"source":"UniProtKB","id":"P62807","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI38
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"21726816","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI39
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"16307923","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16627869","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16713563","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI40
Number of Residues73
DetailsDomain: {"description":"H15","evidences":[{"source":"PROSITE-ProRule","id":"PRU00837","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI41
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P43274","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI42
Number of Residues5
DetailsModified residue: {"description":"N6-(beta-hydroxybutyryl)lysine","evidences":[{"source":"UniProtKB","id":"P43277","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI43
Number of Residues1
DetailsModified residue: {"description":"Citrulline","evidences":[{"source":"UniProtKB","id":"P43274","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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