7PDZ

Structure of capping protein bound to the barbed end of a cytoplasmic actin filament

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0000902	biological_process	cell morphogenesis
E	0003779	molecular_function	actin binding
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005903	cellular_component	brush border
E	0007010	biological_process	cytoskeleton organization
E	0008154	biological_process	actin polymerization or depolymerization
E	0008290	cellular_component	F-actin capping protein complex
E	0010591	biological_process	regulation of lamellipodium assembly
E	0014069	cellular_component	postsynaptic density
E	0016020	cellular_component	membrane
E	0022604	biological_process	regulation of cell morphogenesis
E	0030017	cellular_component	sarcomere
E	0030018	cellular_component	Z disc
E	0030027	cellular_component	lamellipodium
E	0030030	biological_process	cell projection organization
E	0030032	biological_process	lamellipodium assembly
E	0030036	biological_process	actin cytoskeleton organization
E	0030863	cellular_component	cortical cytoskeleton
E	0032279	cellular_component	asymmetric synapse
E	0033150	cellular_component	cytoskeletal calyx
E	0051015	molecular_function	actin filament binding
E	0051016	biological_process	barbed-end actin filament capping
E	0051490	biological_process	negative regulation of filopodium assembly
E	0051693	biological_process	actin filament capping
E	0071203	cellular_component	WASH complex
E	0098685	cellular_component	Schaffer collateral - CA1 synapse
E	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
E	0120212	cellular_component	sperm head-tail coupling apparatus
F	0003779	molecular_function	actin binding
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005903	cellular_component	brush border
F	0005911	cellular_component	cell-cell junction
F	0008290	cellular_component	F-actin capping protein complex
F	0016020	cellular_component	membrane
F	0030036	biological_process	actin cytoskeleton organization
F	0030863	cellular_component	cortical cytoskeleton
F	0034329	biological_process	cell junction assembly
F	0051015	molecular_function	actin filament binding
F	0051016	biological_process	barbed-end actin filament capping
F	0051693	biological_process	actin filament capping
F	0071203	cellular_component	WASH complex
I	0000166	molecular_function	nucleotide binding
I	0000786	cellular_component	nucleosome
I	0001738	biological_process	morphogenesis of a polarized epithelium
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0005884	cellular_component	actin filament
I	0005886	cellular_component	plasma membrane
I	0005903	cellular_component	brush border
I	0005911	cellular_component	cell-cell junction
I	0005912	cellular_component	adherens junction
I	0005925	cellular_component	focal adhesion
I	0007163	biological_process	establishment or maintenance of cell polarity
I	0007409	biological_process	axonogenesis
I	0015629	cellular_component	actin cytoskeleton
I	0016020	cellular_component	membrane
I	0016787	molecular_function	hydrolase activity
I	0016887	molecular_function	ATP hydrolysis activity
I	0019894	molecular_function	kinesin binding
I	0019901	molecular_function	protein kinase binding
I	0030027	cellular_component	lamellipodium
I	0030235	molecular_function	nitric-oxide synthase regulator activity
I	0030424	cellular_component	axon
I	0030863	cellular_component	cortical cytoskeleton
I	0030957	molecular_function	Tat protein binding
I	0032991	cellular_component	protein-containing complex
I	0034333	biological_process	adherens junction assembly
I	0035267	cellular_component	NuA4 histone acetyltransferase complex
I	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
I	0042802	molecular_function	identical protein binding
I	0043296	cellular_component	apical junction complex
I	0044305	cellular_component	calyx of Held
I	0045176	biological_process	apical protein localization
I	0045202	cellular_component	synapse
I	0048870	biological_process	cell motility
I	0050998	molecular_function	nitric-oxide synthase binding
I	0051621	biological_process	regulation of norepinephrine uptake
I	0051726	biological_process	regulation of cell cycle
I	0070160	cellular_component	tight junction
I	0071896	biological_process	protein localization to adherens junction
I	0072749	biological_process	cellular response to cytochalasin B
I	0097433	cellular_component	dense body
I	0098685	cellular_component	Schaffer collateral - CA1 synapse
I	0098871	cellular_component	postsynaptic actin cytoskeleton
I	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
I	0098974	biological_process	postsynaptic actin cytoskeleton organization
I	0098978	cellular_component	glutamatergic synapse
I	0141108	molecular_function	transporter regulator activity
I	0150111	biological_process	regulation of transepithelial transport
I	1900242	biological_process	regulation of synaptic vesicle endocytosis
I	1903076	biological_process	regulation of protein localization to plasma membrane
I	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
I	1990904	cellular_component	ribonucleoprotein complex
J	0000166	molecular_function	nucleotide binding
J	0000786	cellular_component	nucleosome
J	0001738	biological_process	morphogenesis of a polarized epithelium
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005856	cellular_component	cytoskeleton
J	0005884	cellular_component	actin filament
J	0005886	cellular_component	plasma membrane
J	0005903	cellular_component	brush border
J	0005911	cellular_component	cell-cell junction
J	0005912	cellular_component	adherens junction
J	0005925	cellular_component	focal adhesion
J	0007163	biological_process	establishment or maintenance of cell polarity
J	0007409	biological_process	axonogenesis
J	0015629	cellular_component	actin cytoskeleton
J	0016020	cellular_component	membrane
J	0016787	molecular_function	hydrolase activity
J	0016887	molecular_function	ATP hydrolysis activity
J	0019894	molecular_function	kinesin binding
J	0019901	molecular_function	protein kinase binding
J	0030027	cellular_component	lamellipodium
J	0030235	molecular_function	nitric-oxide synthase regulator activity
J	0030424	cellular_component	axon
J	0030863	cellular_component	cortical cytoskeleton
J	0030957	molecular_function	Tat protein binding
J	0032991	cellular_component	protein-containing complex
J	0034333	biological_process	adherens junction assembly
J	0035267	cellular_component	NuA4 histone acetyltransferase complex
J	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
J	0042802	molecular_function	identical protein binding
J	0043296	cellular_component	apical junction complex
J	0044305	cellular_component	calyx of Held
J	0045176	biological_process	apical protein localization
J	0045202	cellular_component	synapse
J	0048870	biological_process	cell motility
J	0050998	molecular_function	nitric-oxide synthase binding
J	0051621	biological_process	regulation of norepinephrine uptake
J	0051726	biological_process	regulation of cell cycle
J	0070160	cellular_component	tight junction
J	0071896	biological_process	protein localization to adherens junction
J	0072749	biological_process	cellular response to cytochalasin B
J	0097433	cellular_component	dense body
J	0098685	cellular_component	Schaffer collateral - CA1 synapse
J	0098871	cellular_component	postsynaptic actin cytoskeleton
J	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
J	0098974	biological_process	postsynaptic actin cytoskeleton organization
J	0098978	cellular_component	glutamatergic synapse
J	0141108	molecular_function	transporter regulator activity
J	0150111	biological_process	regulation of transepithelial transport
J	1900242	biological_process	regulation of synaptic vesicle endocytosis
J	1903076	biological_process	regulation of protein localization to plasma membrane
J	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
J	1990904	cellular_component	ribonucleoprotein complex
K	0000166	molecular_function	nucleotide binding
K	0000786	cellular_component	nucleosome
K	0001738	biological_process	morphogenesis of a polarized epithelium
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0005884	cellular_component	actin filament
K	0005886	cellular_component	plasma membrane
K	0005903	cellular_component	brush border
K	0005911	cellular_component	cell-cell junction
K	0005912	cellular_component	adherens junction
K	0005925	cellular_component	focal adhesion
K	0007163	biological_process	establishment or maintenance of cell polarity
K	0007409	biological_process	axonogenesis
K	0015629	cellular_component	actin cytoskeleton
K	0016020	cellular_component	membrane
K	0016787	molecular_function	hydrolase activity
K	0016887	molecular_function	ATP hydrolysis activity
K	0019894	molecular_function	kinesin binding
K	0019901	molecular_function	protein kinase binding
K	0030027	cellular_component	lamellipodium
K	0030235	molecular_function	nitric-oxide synthase regulator activity
K	0030424	cellular_component	axon
K	0030863	cellular_component	cortical cytoskeleton
K	0030957	molecular_function	Tat protein binding
K	0032991	cellular_component	protein-containing complex
K	0034333	biological_process	adherens junction assembly
K	0035267	cellular_component	NuA4 histone acetyltransferase complex
K	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
K	0042802	molecular_function	identical protein binding
K	0043296	cellular_component	apical junction complex
K	0044305	cellular_component	calyx of Held
K	0045176	biological_process	apical protein localization
K	0045202	cellular_component	synapse
K	0048870	biological_process	cell motility
K	0050998	molecular_function	nitric-oxide synthase binding
K	0051621	biological_process	regulation of norepinephrine uptake
K	0051726	biological_process	regulation of cell cycle
K	0070160	cellular_component	tight junction
K	0071896	biological_process	protein localization to adherens junction
K	0072749	biological_process	cellular response to cytochalasin B
K	0097433	cellular_component	dense body
K	0098685	cellular_component	Schaffer collateral - CA1 synapse
K	0098871	cellular_component	postsynaptic actin cytoskeleton
K	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
K	0098974	biological_process	postsynaptic actin cytoskeleton organization
K	0098978	cellular_component	glutamatergic synapse
K	0141108	molecular_function	transporter regulator activity
K	0150111	biological_process	regulation of transepithelial transport
K	1900242	biological_process	regulation of synaptic vesicle endocytosis
K	1903076	biological_process	regulation of protein localization to plasma membrane
K	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
K	1990904	cellular_component	ribonucleoprotein complex
L	0000166	molecular_function	nucleotide binding
L	0000786	cellular_component	nucleosome
L	0001738	biological_process	morphogenesis of a polarized epithelium
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005856	cellular_component	cytoskeleton
L	0005884	cellular_component	actin filament
L	0005886	cellular_component	plasma membrane
L	0005903	cellular_component	brush border
L	0005911	cellular_component	cell-cell junction
L	0005912	cellular_component	adherens junction
L	0005925	cellular_component	focal adhesion
L	0007163	biological_process	establishment or maintenance of cell polarity
L	0007409	biological_process	axonogenesis
L	0015629	cellular_component	actin cytoskeleton
L	0016020	cellular_component	membrane
L	0016787	molecular_function	hydrolase activity
L	0016887	molecular_function	ATP hydrolysis activity
L	0019894	molecular_function	kinesin binding
L	0019901	molecular_function	protein kinase binding
L	0030027	cellular_component	lamellipodium
L	0030235	molecular_function	nitric-oxide synthase regulator activity
L	0030424	cellular_component	axon
L	0030863	cellular_component	cortical cytoskeleton
L	0030957	molecular_function	Tat protein binding
L	0032991	cellular_component	protein-containing complex
L	0034333	biological_process	adherens junction assembly
L	0035267	cellular_component	NuA4 histone acetyltransferase complex
L	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
L	0042802	molecular_function	identical protein binding
L	0043296	cellular_component	apical junction complex
L	0044305	cellular_component	calyx of Held
L	0045176	biological_process	apical protein localization
L	0045202	cellular_component	synapse
L	0048870	biological_process	cell motility
L	0050998	molecular_function	nitric-oxide synthase binding
L	0051621	biological_process	regulation of norepinephrine uptake
L	0051726	biological_process	regulation of cell cycle
L	0070160	cellular_component	tight junction
L	0071896	biological_process	protein localization to adherens junction
L	0072749	biological_process	cellular response to cytochalasin B
L	0097433	cellular_component	dense body
L	0098685	cellular_component	Schaffer collateral - CA1 synapse
L	0098871	cellular_component	postsynaptic actin cytoskeleton
L	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
L	0098974	biological_process	postsynaptic actin cytoskeleton organization
L	0098978	cellular_component	glutamatergic synapse
L	0141108	molecular_function	transporter regulator activity
L	0150111	biological_process	regulation of transepithelial transport
L	1900242	biological_process	regulation of synaptic vesicle endocytosis
L	1903076	biological_process	regulation of protein localization to plasma membrane
L	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
L	1990904	cellular_component	ribonucleoprotein complex
N	0000166	molecular_function	nucleotide binding
N	0000786	cellular_component	nucleosome
N	0001738	biological_process	morphogenesis of a polarized epithelium
N	0005515	molecular_function	protein binding
N	0005524	molecular_function	ATP binding
N	0005634	cellular_component	nucleus
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005856	cellular_component	cytoskeleton
N	0005884	cellular_component	actin filament
N	0005886	cellular_component	plasma membrane
N	0005903	cellular_component	brush border
N	0005911	cellular_component	cell-cell junction
N	0005912	cellular_component	adherens junction
N	0005925	cellular_component	focal adhesion
N	0007163	biological_process	establishment or maintenance of cell polarity
N	0007409	biological_process	axonogenesis
N	0015629	cellular_component	actin cytoskeleton
N	0016020	cellular_component	membrane
N	0016787	molecular_function	hydrolase activity
N	0016887	molecular_function	ATP hydrolysis activity
N	0019894	molecular_function	kinesin binding
N	0019901	molecular_function	protein kinase binding
N	0030027	cellular_component	lamellipodium
N	0030235	molecular_function	nitric-oxide synthase regulator activity
N	0030424	cellular_component	axon
N	0030863	cellular_component	cortical cytoskeleton
N	0030957	molecular_function	Tat protein binding
N	0032991	cellular_component	protein-containing complex
N	0034333	biological_process	adherens junction assembly
N	0035267	cellular_component	NuA4 histone acetyltransferase complex
N	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
N	0042802	molecular_function	identical protein binding
N	0043296	cellular_component	apical junction complex
N	0044305	cellular_component	calyx of Held
N	0045176	biological_process	apical protein localization
N	0045202	cellular_component	synapse
N	0048870	biological_process	cell motility
N	0050998	molecular_function	nitric-oxide synthase binding
N	0051621	biological_process	regulation of norepinephrine uptake
N	0051726	biological_process	regulation of cell cycle
N	0070160	cellular_component	tight junction
N	0071896	biological_process	protein localization to adherens junction
N	0072749	biological_process	cellular response to cytochalasin B
N	0097433	cellular_component	dense body
N	0098685	cellular_component	Schaffer collateral - CA1 synapse
N	0098871	cellular_component	postsynaptic actin cytoskeleton
N	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
N	0098974	biological_process	postsynaptic actin cytoskeleton organization
N	0098978	cellular_component	glutamatergic synapse
N	0141108	molecular_function	transporter regulator activity
N	0150111	biological_process	regulation of transepithelial transport
N	1900242	biological_process	regulation of synaptic vesicle endocytosis
N	1903076	biological_process	regulation of protein localization to plasma membrane
N	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
N	1990904	cellular_component	ribonucleoprotein complex
O	0000166	molecular_function	nucleotide binding
O	0000786	cellular_component	nucleosome
O	0001738	biological_process	morphogenesis of a polarized epithelium
O	0005515	molecular_function	protein binding
O	0005524	molecular_function	ATP binding
O	0005634	cellular_component	nucleus
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005856	cellular_component	cytoskeleton
O	0005884	cellular_component	actin filament
O	0005886	cellular_component	plasma membrane
O	0005903	cellular_component	brush border
O	0005911	cellular_component	cell-cell junction
O	0005912	cellular_component	adherens junction
O	0005925	cellular_component	focal adhesion
O	0007163	biological_process	establishment or maintenance of cell polarity
O	0007409	biological_process	axonogenesis
O	0015629	cellular_component	actin cytoskeleton
O	0016020	cellular_component	membrane
O	0016787	molecular_function	hydrolase activity
O	0016887	molecular_function	ATP hydrolysis activity
O	0019894	molecular_function	kinesin binding
O	0019901	molecular_function	protein kinase binding
O	0030027	cellular_component	lamellipodium
O	0030235	molecular_function	nitric-oxide synthase regulator activity
O	0030424	cellular_component	axon
O	0030863	cellular_component	cortical cytoskeleton
O	0030957	molecular_function	Tat protein binding
O	0032991	cellular_component	protein-containing complex
O	0034333	biological_process	adherens junction assembly
O	0035267	cellular_component	NuA4 histone acetyltransferase complex
O	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
O	0042802	molecular_function	identical protein binding
O	0043296	cellular_component	apical junction complex
O	0044305	cellular_component	calyx of Held
O	0045176	biological_process	apical protein localization
O	0045202	cellular_component	synapse
O	0048870	biological_process	cell motility
O	0050998	molecular_function	nitric-oxide synthase binding
O	0051621	biological_process	regulation of norepinephrine uptake
O	0051726	biological_process	regulation of cell cycle
O	0070160	cellular_component	tight junction
O	0071896	biological_process	protein localization to adherens junction
O	0072749	biological_process	cellular response to cytochalasin B
O	0097433	cellular_component	dense body
O	0098685	cellular_component	Schaffer collateral - CA1 synapse
O	0098871	cellular_component	postsynaptic actin cytoskeleton
O	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
O	0098974	biological_process	postsynaptic actin cytoskeleton organization
O	0098978	cellular_component	glutamatergic synapse
O	0141108	molecular_function	transporter regulator activity
O	0150111	biological_process	regulation of transepithelial transport
O	1900242	biological_process	regulation of synaptic vesicle endocytosis
O	1903076	biological_process	regulation of protein localization to plasma membrane
O	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
O	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PROSITE/UniProt

site_id	PS00231
Number of Residues	6
Details	F_ACTIN_CAPPING_BETA F-actin capping protein beta subunit signature. CDYNRD

Chain	Residue	Details
E	CYS62-ASP67

---

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
I	TYR53-GLY63

---

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WISKqEYDE

Chain	Residue	Details
I	TRP356-GLU364

---

site_id	PS00748
Number of Residues	9
Details	F_ACTIN_CAPPING_A_1 F-actin capping protein alpha subunit signature 1. VHYYEDGNV

Chain	Residue	Details
F	VAL196-VAL204

---

site_id	PS00749
Number of Residues	11
Details	F_ACTIN_CAPPING_A_2 F-actin capping protein alpha subunit signature 2. KaLRRqLPVTR

Chain	Residue	Details
F	LYS256-ARG266

---

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
I	LEU104-ARG116

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	MOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:P60709

Chain	Residue	Details
I	MET1
J	MET1
K	MET1
L	MET1
N	MET1
O	MET1

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: N-acetylaspartate; in Actin, cytoplasmic 1, N-terminally processed => ECO:0000250|UniProtKB:P60709

Chain	Residue	Details
I	ASP2
J	ASP2
K	ASP2
L	ASP2
N	ASP2
O	ASP2

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	MOD_RES: Methionine (R)-sulfoxide => ECO:0000250|UniProtKB:P60710

Chain	Residue	Details
I	MET44
N	MET47
O	MET44
O	MET47
I	MET47
J	MET44
J	MET47
K	MET44
K	MET47
L	MET44
L	MET47
N	MET44

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Tele-methylhistidine => ECO:0000250|UniProtKB:P60710

Chain	Residue	Details
I	HIC73
J	HIC73
K	HIC73
L	HIC73
N	HIC73
O	HIC73

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: N6-methyllysine => ECO:0000250|UniProtKB:P60709

Chain	Residue	Details
I	LYS84
J	LYS84
K	LYS84
L	LYS84
N	LYS84
O	LYS84

---