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7PCK

CRYSTAL STRUCTURE OF WILD TYPE HUMAN PROCATHEPSIN K

Functional Information from GO Data
ChainGOidnamespacecontents
A0000423biological_processmitophagy
A0001957biological_processintramembranous ossification
A0001968molecular_functionfibronectin binding
A0004197molecular_functioncysteine-type endopeptidase activity
A0004252molecular_functionserine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005518molecular_functioncollagen binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005654cellular_componentnucleoplasm
A0005764cellular_componentlysosome
A0005886cellular_componentplasma membrane
A0006508biological_processproteolysis
A0006590biological_processthyroid hormone generation
A0006915biological_processapoptotic process
A0006955biological_processimmune response
A0008234molecular_functioncysteine-type peptidase activity
A0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
A0009897cellular_componentexternal side of plasma membrane
A0014070biological_processresponse to organic cyclic compound
A0016324cellular_componentapical plasma membrane
A0022617biological_processextracellular matrix disassembly
A0030574biological_processcollagen catabolic process
A0032868biological_processresponse to insulin
A0034224biological_processcellular response to zinc ion starvation
A0036021cellular_componentendolysosome lumen
A0043202cellular_componentlysosomal lumen
A0043231cellular_componentintracellular membrane-bounded organelle
A0043394molecular_functionproteoglycan binding
A0045453biological_processbone resorption
A0045471biological_processresponse to ethanol
A0051603biological_processproteolysis involved in protein catabolic process
A0061037biological_processnegative regulation of cartilage development
A0071356biological_processcellular response to tumor necrosis factor
A0071560biological_processcellular response to transforming growth factor beta stimulus
A1903131biological_processmononuclear cell differentiation
A2001235biological_processpositive regulation of apoptotic signaling pathway
B0000423biological_processmitophagy
B0001957biological_processintramembranous ossification
B0001968molecular_functionfibronectin binding
B0004197molecular_functioncysteine-type endopeptidase activity
B0004252molecular_functionserine-type endopeptidase activity
B0005515molecular_functionprotein binding
B0005518molecular_functioncollagen binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005654cellular_componentnucleoplasm
B0005764cellular_componentlysosome
B0005886cellular_componentplasma membrane
B0006508biological_processproteolysis
B0006590biological_processthyroid hormone generation
B0006915biological_processapoptotic process
B0006955biological_processimmune response
B0008234molecular_functioncysteine-type peptidase activity
B0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
B0009897cellular_componentexternal side of plasma membrane
B0014070biological_processresponse to organic cyclic compound
B0016324cellular_componentapical plasma membrane
B0022617biological_processextracellular matrix disassembly
B0030574biological_processcollagen catabolic process
B0032868biological_processresponse to insulin
B0034224biological_processcellular response to zinc ion starvation
B0036021cellular_componentendolysosome lumen
B0043202cellular_componentlysosomal lumen
B0043231cellular_componentintracellular membrane-bounded organelle
B0043394molecular_functionproteoglycan binding
B0045453biological_processbone resorption
B0045471biological_processresponse to ethanol
B0051603biological_processproteolysis involved in protein catabolic process
B0061037biological_processnegative regulation of cartilage development
B0071356biological_processcellular response to tumor necrosis factor
B0071560biological_processcellular response to transforming growth factor beta stimulus
B1903131biological_processmononuclear cell differentiation
B2001235biological_processpositive regulation of apoptotic signaling pathway
C0000423biological_processmitophagy
C0001957biological_processintramembranous ossification
C0001968molecular_functionfibronectin binding
C0004197molecular_functioncysteine-type endopeptidase activity
C0004252molecular_functionserine-type endopeptidase activity
C0005515molecular_functionprotein binding
C0005518molecular_functioncollagen binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005654cellular_componentnucleoplasm
C0005764cellular_componentlysosome
C0005886cellular_componentplasma membrane
C0006508biological_processproteolysis
C0006590biological_processthyroid hormone generation
C0006915biological_processapoptotic process
C0006955biological_processimmune response
C0008234molecular_functioncysteine-type peptidase activity
C0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
C0009897cellular_componentexternal side of plasma membrane
C0014070biological_processresponse to organic cyclic compound
C0016324cellular_componentapical plasma membrane
C0022617biological_processextracellular matrix disassembly
C0030574biological_processcollagen catabolic process
C0032868biological_processresponse to insulin
C0034224biological_processcellular response to zinc ion starvation
C0036021cellular_componentendolysosome lumen
C0043202cellular_componentlysosomal lumen
C0043231cellular_componentintracellular membrane-bounded organelle
C0043394molecular_functionproteoglycan binding
C0045453biological_processbone resorption
C0045471biological_processresponse to ethanol
C0051603biological_processproteolysis involved in protein catabolic process
C0061037biological_processnegative regulation of cartilage development
C0071356biological_processcellular response to tumor necrosis factor
C0071560biological_processcellular response to transforming growth factor beta stimulus
C1903131biological_processmononuclear cell differentiation
C2001235biological_processpositive regulation of apoptotic signaling pathway
D0000423biological_processmitophagy
D0001957biological_processintramembranous ossification
D0001968molecular_functionfibronectin binding
D0004197molecular_functioncysteine-type endopeptidase activity
D0004252molecular_functionserine-type endopeptidase activity
D0005515molecular_functionprotein binding
D0005518molecular_functioncollagen binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005654cellular_componentnucleoplasm
D0005764cellular_componentlysosome
D0005886cellular_componentplasma membrane
D0006508biological_processproteolysis
D0006590biological_processthyroid hormone generation
D0006915biological_processapoptotic process
D0006955biological_processimmune response
D0008234molecular_functioncysteine-type peptidase activity
D0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
D0009897cellular_componentexternal side of plasma membrane
D0014070biological_processresponse to organic cyclic compound
D0016324cellular_componentapical plasma membrane
D0022617biological_processextracellular matrix disassembly
D0030574biological_processcollagen catabolic process
D0032868biological_processresponse to insulin
D0034224biological_processcellular response to zinc ion starvation
D0036021cellular_componentendolysosome lumen
D0043202cellular_componentlysosomal lumen
D0043231cellular_componentintracellular membrane-bounded organelle
D0043394molecular_functionproteoglycan binding
D0045453biological_processbone resorption
D0045471biological_processresponse to ethanol
D0051603biological_processproteolysis involved in protein catabolic process
D0061037biological_processnegative regulation of cartilage development
D0071356biological_processcellular response to tumor necrosis factor
D0071560biological_processcellular response to transforming growth factor beta stimulus
D1903131biological_processmononuclear cell differentiation
D2001235biological_processpositive regulation of apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00139
Number of Residues12
DetailsTHIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGqCGSCWAfSS
ChainResidueDetails
AGLN19-SER30

site_idPS00639
Number of Residues11
DetailsTHIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. LNHAVLAVGYG
ChainResidueDetails
ALEU160-GLY170

site_idPS00640
Number of Residues20
DetailsTHIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. HWIiKNSWgenWGnkGYIlM
ChainResidueDetails
AHIS177-MET196

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsACT_SITE: ACT_SITE => ECO:0000250
ChainResidueDetails
ACYS25
AHIS162
AASN182
BCYS25
BHIS162
BASN182
CCYS25
CHIS162
CASN182
DCYS25
DHIS162
DASN182

site_idSWS_FT_FI2
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN88
BASN88
CASN88
DASN88

221051

PDB entries from 2024-06-12

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