Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7PCK

CRYSTAL STRUCTURE OF WILD TYPE HUMAN PROCATHEPSIN K

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000423	biological_process	mitophagy
A	0001968	molecular_function	fibronectin binding
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005518	molecular_function	collagen binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005764	cellular_component	lysosome
A	0006508	biological_process	proteolysis
A	0006590	biological_process	thyroid hormone generation
A	0008233	molecular_function	peptidase activity
A	0008234	molecular_function	cysteine-type peptidase activity
A	0009897	cellular_component	external side of plasma membrane
A	0016324	cellular_component	apical plasma membrane
A	0016787	molecular_function	hydrolase activity
A	0022617	biological_process	extracellular matrix disassembly
A	0030574	biological_process	collagen catabolic process
A	0036021	cellular_component	endolysosome lumen
A	0043202	cellular_component	lysosomal lumen
A	0043394	molecular_function	proteoglycan binding
A	0051603	biological_process	proteolysis involved in protein catabolic process
B	0000423	biological_process	mitophagy
B	0001968	molecular_function	fibronectin binding
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005518	molecular_function	collagen binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005764	cellular_component	lysosome
B	0006508	biological_process	proteolysis
B	0006590	biological_process	thyroid hormone generation
B	0008233	molecular_function	peptidase activity
B	0008234	molecular_function	cysteine-type peptidase activity
B	0009897	cellular_component	external side of plasma membrane
B	0016324	cellular_component	apical plasma membrane
B	0016787	molecular_function	hydrolase activity
B	0022617	biological_process	extracellular matrix disassembly
B	0030574	biological_process	collagen catabolic process
B	0036021	cellular_component	endolysosome lumen
B	0043202	cellular_component	lysosomal lumen
B	0043394	molecular_function	proteoglycan binding
B	0051603	biological_process	proteolysis involved in protein catabolic process
C	0000423	biological_process	mitophagy
C	0001968	molecular_function	fibronectin binding
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005515	molecular_function	protein binding
C	0005518	molecular_function	collagen binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005764	cellular_component	lysosome
C	0006508	biological_process	proteolysis
C	0006590	biological_process	thyroid hormone generation
C	0008233	molecular_function	peptidase activity
C	0008234	molecular_function	cysteine-type peptidase activity
C	0009897	cellular_component	external side of plasma membrane
C	0016324	cellular_component	apical plasma membrane
C	0016787	molecular_function	hydrolase activity
C	0022617	biological_process	extracellular matrix disassembly
C	0030574	biological_process	collagen catabolic process
C	0036021	cellular_component	endolysosome lumen
C	0043202	cellular_component	lysosomal lumen
C	0043394	molecular_function	proteoglycan binding
C	0051603	biological_process	proteolysis involved in protein catabolic process
D	0000423	biological_process	mitophagy
D	0001968	molecular_function	fibronectin binding
D	0004197	molecular_function	cysteine-type endopeptidase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005515	molecular_function	protein binding
D	0005518	molecular_function	collagen binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005764	cellular_component	lysosome
D	0006508	biological_process	proteolysis
D	0006590	biological_process	thyroid hormone generation
D	0008233	molecular_function	peptidase activity
D	0008234	molecular_function	cysteine-type peptidase activity
D	0009897	cellular_component	external side of plasma membrane
D	0016324	cellular_component	apical plasma membrane
D	0016787	molecular_function	hydrolase activity
D	0022617	biological_process	extracellular matrix disassembly
D	0030574	biological_process	collagen catabolic process
D	0036021	cellular_component	endolysosome lumen
D	0043202	cellular_component	lysosomal lumen
D	0043394	molecular_function	proteoglycan binding
D	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from PROSITE/UniProt

site_id	PS00139
Number of Residues	12
Details	THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGqCGSCWAfSS

Chain	Residue	Details
A	GLN19-SER30

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. LNHAVLAVGYG

Chain	Residue	Details
A	LEU160-GLY170

site_id	PS00640
Number of Residues	20
Details	THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. HWIiKNSWgenWGnkGYIlM

Chain	Residue	Details
A	HIS177-MET196

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	98
Details	Propeptide: {"description":"Activation peptide","featureId":"PRO_0000026295"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1pad

Chain	Residue	Details
A	ASN182
A	CYS25
A	HIS162

site_id	CSA10
Number of Residues	3
Details	Annotated By Reference To The Literature 1pad

Chain	Residue	Details
B	ASN182
B	GLN19
B	HIS162

site_id	CSA11
Number of Residues	3
Details	Annotated By Reference To The Literature 1pad

Chain	Residue	Details
C	ASN182
C	GLN19
C	HIS162

site_id	CSA12
Number of Residues	3
Details	Annotated By Reference To The Literature 1pad

Chain	Residue	Details
D	ASN182
D	GLN19
D	HIS162

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1pad

Chain	Residue	Details
B	ASN182
B	CYS25
B	HIS162

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1pad

Chain	Residue	Details
C	ASN182
C	CYS25
C	HIS162

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1pad

Chain	Residue	Details
D	ASN182
D	CYS25
D	HIS162

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1pad

Chain	Residue	Details
A	GLN19
A	CYS25
A	HIS162

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1pad

Chain	Residue	Details
B	GLN19
B	CYS25
B	HIS162

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1pad

Chain	Residue	Details
C	GLN19
C	CYS25
C	HIS162

site_id	CSA8
Number of Residues	3
Details	Annotated By Reference To The Literature 1pad

Chain	Residue	Details
D	GLN19
D	CYS25
D	HIS162

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1pad

Chain	Residue	Details
A	ASN182
A	GLN19
A	HIS162

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)