7PBX

Cryo-EM structure of the GroEL-GroES complex with ADP bound to both rings ("tight" conformation).

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
Ac	0000166	molecular_function	nucleotide binding
Ac	0000287	molecular_function	magnesium ion binding
Ac	0005515	molecular_function	protein binding
Ac	0005524	molecular_function	ATP binding
Ac	0005737	cellular_component	cytoplasm
Ac	0005829	cellular_component	cytosol
Ac	0006457	biological_process	protein folding
Ac	0009314	biological_process	response to radiation
Ac	0009408	biological_process	response to heat
Ac	0016020	cellular_component	membrane
Ac	0016853	molecular_function	isomerase activity
Ac	0016887	molecular_function	ATP hydrolysis activity
Ac	0019068	biological_process	virion assembly
Ac	0042026	biological_process	protein refolding
Ac	0042802	molecular_function	identical protein binding
Ac	0051082	molecular_function	unfolded protein binding
Ac	0140662	molecular_function	ATP-dependent protein folding chaperone
Ac	1990220	cellular_component	GroEL-GroES complex
Ad	0000166	molecular_function	nucleotide binding
Ad	0000287	molecular_function	magnesium ion binding
Ad	0005515	molecular_function	protein binding
Ad	0005524	molecular_function	ATP binding
Ad	0005737	cellular_component	cytoplasm
Ad	0005829	cellular_component	cytosol
Ad	0006457	biological_process	protein folding
Ad	0009314	biological_process	response to radiation
Ad	0009408	biological_process	response to heat
Ad	0016020	cellular_component	membrane
Ad	0016853	molecular_function	isomerase activity
Ad	0016887	molecular_function	ATP hydrolysis activity
Ad	0019068	biological_process	virion assembly
Ad	0042026	biological_process	protein refolding
Ad	0042802	molecular_function	identical protein binding
Ad	0051082	molecular_function	unfolded protein binding
Ad	0140662	molecular_function	ATP-dependent protein folding chaperone
Ad	1990220	cellular_component	GroEL-GroES complex
Af	0005515	molecular_function	protein binding
Af	0005524	molecular_function	ATP binding
Af	0005737	cellular_component	cytoplasm
Af	0005829	cellular_component	cytosol
Af	0006457	biological_process	protein folding
Af	0009408	biological_process	response to heat
Af	0019068	biological_process	virion assembly
Af	0042802	molecular_function	identical protein binding
Af	0044183	molecular_function	protein folding chaperone
Af	0046872	molecular_function	metal ion binding
Af	0051082	molecular_function	unfolded protein binding
Af	0051087	molecular_function	protein-folding chaperone binding
Af	1990220	cellular_component	GroEL-GroES complex
Ai	0000166	molecular_function	nucleotide binding
Ai	0000287	molecular_function	magnesium ion binding
Ai	0005515	molecular_function	protein binding
Ai	0005524	molecular_function	ATP binding
Ai	0005737	cellular_component	cytoplasm
Ai	0005829	cellular_component	cytosol
Ai	0006457	biological_process	protein folding
Ai	0009314	biological_process	response to radiation
Ai	0009408	biological_process	response to heat
Ai	0016020	cellular_component	membrane
Ai	0016853	molecular_function	isomerase activity
Ai	0016887	molecular_function	ATP hydrolysis activity
Ai	0019068	biological_process	virion assembly
Ai	0042026	biological_process	protein refolding
Ai	0042802	molecular_function	identical protein binding
Ai	0051082	molecular_function	unfolded protein binding
Ai	0140662	molecular_function	ATP-dependent protein folding chaperone
Ai	1990220	cellular_component	GroEL-GroES complex
Aj	0000166	molecular_function	nucleotide binding
Aj	0000287	molecular_function	magnesium ion binding
Aj	0005515	molecular_function	protein binding
Aj	0005524	molecular_function	ATP binding
Aj	0005737	cellular_component	cytoplasm
Aj	0005829	cellular_component	cytosol
Aj	0006457	biological_process	protein folding
Aj	0009314	biological_process	response to radiation
Aj	0009408	biological_process	response to heat
Aj	0016020	cellular_component	membrane
Aj	0016853	molecular_function	isomerase activity
Aj	0016887	molecular_function	ATP hydrolysis activity
Aj	0019068	biological_process	virion assembly
Aj	0042026	biological_process	protein refolding
Aj	0042802	molecular_function	identical protein binding
Aj	0051082	molecular_function	unfolded protein binding
Aj	0140662	molecular_function	ATP-dependent protein folding chaperone
Aj	1990220	cellular_component	GroEL-GroES complex
Al	0005515	molecular_function	protein binding
Al	0005524	molecular_function	ATP binding
Al	0005737	cellular_component	cytoplasm
Al	0005829	cellular_component	cytosol
Al	0006457	biological_process	protein folding
Al	0009408	biological_process	response to heat
Al	0019068	biological_process	virion assembly
Al	0042802	molecular_function	identical protein binding
Al	0044183	molecular_function	protein folding chaperone
Al	0046872	molecular_function	metal ion binding
Al	0051082	molecular_function	unfolded protein binding
Al	0051087	molecular_function	protein-folding chaperone binding
Al	1990220	cellular_component	GroEL-GroES complex
Ao	0000166	molecular_function	nucleotide binding
Ao	0000287	molecular_function	magnesium ion binding
Ao	0005515	molecular_function	protein binding
Ao	0005524	molecular_function	ATP binding
Ao	0005737	cellular_component	cytoplasm
Ao	0005829	cellular_component	cytosol
Ao	0006457	biological_process	protein folding
Ao	0009314	biological_process	response to radiation
Ao	0009408	biological_process	response to heat
Ao	0016020	cellular_component	membrane
Ao	0016853	molecular_function	isomerase activity
Ao	0016887	molecular_function	ATP hydrolysis activity
Ao	0019068	biological_process	virion assembly
Ao	0042026	biological_process	protein refolding
Ao	0042802	molecular_function	identical protein binding
Ao	0051082	molecular_function	unfolded protein binding
Ao	0140662	molecular_function	ATP-dependent protein folding chaperone
Ao	1990220	cellular_component	GroEL-GroES complex
Ap	0000166	molecular_function	nucleotide binding
Ap	0000287	molecular_function	magnesium ion binding
Ap	0005515	molecular_function	protein binding
Ap	0005524	molecular_function	ATP binding
Ap	0005737	cellular_component	cytoplasm
Ap	0005829	cellular_component	cytosol
Ap	0006457	biological_process	protein folding
Ap	0009314	biological_process	response to radiation
Ap	0009408	biological_process	response to heat
Ap	0016020	cellular_component	membrane
Ap	0016853	molecular_function	isomerase activity
Ap	0016887	molecular_function	ATP hydrolysis activity
Ap	0019068	biological_process	virion assembly
Ap	0042026	biological_process	protein refolding
Ap	0042802	molecular_function	identical protein binding
Ap	0051082	molecular_function	unfolded protein binding
Ap	0140662	molecular_function	ATP-dependent protein folding chaperone
Ap	1990220	cellular_component	GroEL-GroES complex
Ar	0005515	molecular_function	protein binding
Ar	0005524	molecular_function	ATP binding
Ar	0005737	cellular_component	cytoplasm
Ar	0005829	cellular_component	cytosol
Ar	0006457	biological_process	protein folding
Ar	0009408	biological_process	response to heat
Ar	0019068	biological_process	virion assembly
Ar	0042802	molecular_function	identical protein binding
Ar	0044183	molecular_function	protein folding chaperone
Ar	0046872	molecular_function	metal ion binding
Ar	0051082	molecular_function	unfolded protein binding
Ar	0051087	molecular_function	protein-folding chaperone binding
Ar	1990220	cellular_component	GroEL-GroES complex
Au	0000166	molecular_function	nucleotide binding
Au	0000287	molecular_function	magnesium ion binding
Au	0005515	molecular_function	protein binding
Au	0005524	molecular_function	ATP binding
Au	0005737	cellular_component	cytoplasm
Au	0005829	cellular_component	cytosol
Au	0006457	biological_process	protein folding
Au	0009314	biological_process	response to radiation
Au	0009408	biological_process	response to heat
Au	0016020	cellular_component	membrane
Au	0016853	molecular_function	isomerase activity
Au	0016887	molecular_function	ATP hydrolysis activity
Au	0019068	biological_process	virion assembly
Au	0042026	biological_process	protein refolding
Au	0042802	molecular_function	identical protein binding
Au	0051082	molecular_function	unfolded protein binding
Au	0140662	molecular_function	ATP-dependent protein folding chaperone
Au	1990220	cellular_component	GroEL-GroES complex
Av	0000166	molecular_function	nucleotide binding
Av	0000287	molecular_function	magnesium ion binding
Av	0005515	molecular_function	protein binding
Av	0005524	molecular_function	ATP binding
Av	0005737	cellular_component	cytoplasm
Av	0005829	cellular_component	cytosol
Av	0006457	biological_process	protein folding
Av	0009314	biological_process	response to radiation
Av	0009408	biological_process	response to heat
Av	0016020	cellular_component	membrane
Av	0016853	molecular_function	isomerase activity
Av	0016887	molecular_function	ATP hydrolysis activity
Av	0019068	biological_process	virion assembly
Av	0042026	biological_process	protein refolding
Av	0042802	molecular_function	identical protein binding
Av	0051082	molecular_function	unfolded protein binding
Av	0140662	molecular_function	ATP-dependent protein folding chaperone
Av	1990220	cellular_component	GroEL-GroES complex
Ax	0005515	molecular_function	protein binding
Ax	0005524	molecular_function	ATP binding
Ax	0005737	cellular_component	cytoplasm
Ax	0005829	cellular_component	cytosol
Ax	0006457	biological_process	protein folding
Ax	0009408	biological_process	response to heat
Ax	0019068	biological_process	virion assembly
Ax	0042802	molecular_function	identical protein binding
Ax	0044183	molecular_function	protein folding chaperone
Ax	0046872	molecular_function	metal ion binding
Ax	0051082	molecular_function	unfolded protein binding
Ax	0051087	molecular_function	protein-folding chaperone binding
Ax	1990220	cellular_component	GroEL-GroES complex
Ba	0000166	molecular_function	nucleotide binding
Ba	0000287	molecular_function	magnesium ion binding
Ba	0005515	molecular_function	protein binding
Ba	0005524	molecular_function	ATP binding
Ba	0005737	cellular_component	cytoplasm
Ba	0005829	cellular_component	cytosol
Ba	0006457	biological_process	protein folding
Ba	0009314	biological_process	response to radiation
Ba	0009408	biological_process	response to heat
Ba	0016020	cellular_component	membrane
Ba	0016853	molecular_function	isomerase activity
Ba	0016887	molecular_function	ATP hydrolysis activity
Ba	0019068	biological_process	virion assembly
Ba	0042026	biological_process	protein refolding
Ba	0042802	molecular_function	identical protein binding
Ba	0051082	molecular_function	unfolded protein binding
Ba	0140662	molecular_function	ATP-dependent protein folding chaperone
Ba	1990220	cellular_component	GroEL-GroES complex
Bb	0000166	molecular_function	nucleotide binding
Bb	0000287	molecular_function	magnesium ion binding
Bb	0005515	molecular_function	protein binding
Bb	0005524	molecular_function	ATP binding
Bb	0005737	cellular_component	cytoplasm
Bb	0005829	cellular_component	cytosol
Bb	0006457	biological_process	protein folding
Bb	0009314	biological_process	response to radiation
Bb	0009408	biological_process	response to heat
Bb	0016020	cellular_component	membrane
Bb	0016853	molecular_function	isomerase activity
Bb	0016887	molecular_function	ATP hydrolysis activity
Bb	0019068	biological_process	virion assembly
Bb	0042026	biological_process	protein refolding
Bb	0042802	molecular_function	identical protein binding
Bb	0051082	molecular_function	unfolded protein binding
Bb	0140662	molecular_function	ATP-dependent protein folding chaperone
Bb	1990220	cellular_component	GroEL-GroES complex
Bd	0005515	molecular_function	protein binding
Bd	0005524	molecular_function	ATP binding
Bd	0005737	cellular_component	cytoplasm
Bd	0005829	cellular_component	cytosol
Bd	0006457	biological_process	protein folding
Bd	0009408	biological_process	response to heat
Bd	0019068	biological_process	virion assembly
Bd	0042802	molecular_function	identical protein binding
Bd	0044183	molecular_function	protein folding chaperone
Bd	0046872	molecular_function	metal ion binding
Bd	0051082	molecular_function	unfolded protein binding
Bd	0051087	molecular_function	protein-folding chaperone binding
Bd	1990220	cellular_component	GroEL-GroES complex
Bg	0000166	molecular_function	nucleotide binding
Bg	0000287	molecular_function	magnesium ion binding
Bg	0005515	molecular_function	protein binding
Bg	0005524	molecular_function	ATP binding
Bg	0005737	cellular_component	cytoplasm
Bg	0005829	cellular_component	cytosol
Bg	0006457	biological_process	protein folding
Bg	0009314	biological_process	response to radiation
Bg	0009408	biological_process	response to heat
Bg	0016020	cellular_component	membrane
Bg	0016853	molecular_function	isomerase activity
Bg	0016887	molecular_function	ATP hydrolysis activity
Bg	0019068	biological_process	virion assembly
Bg	0042026	biological_process	protein refolding
Bg	0042802	molecular_function	identical protein binding
Bg	0051082	molecular_function	unfolded protein binding
Bg	0140662	molecular_function	ATP-dependent protein folding chaperone
Bg	1990220	cellular_component	GroEL-GroES complex
Bh	0000166	molecular_function	nucleotide binding
Bh	0000287	molecular_function	magnesium ion binding
Bh	0005515	molecular_function	protein binding
Bh	0005524	molecular_function	ATP binding
Bh	0005737	cellular_component	cytoplasm
Bh	0005829	cellular_component	cytosol
Bh	0006457	biological_process	protein folding
Bh	0009314	biological_process	response to radiation
Bh	0009408	biological_process	response to heat
Bh	0016020	cellular_component	membrane
Bh	0016853	molecular_function	isomerase activity
Bh	0016887	molecular_function	ATP hydrolysis activity
Bh	0019068	biological_process	virion assembly
Bh	0042026	biological_process	protein refolding
Bh	0042802	molecular_function	identical protein binding
Bh	0051082	molecular_function	unfolded protein binding
Bh	0140662	molecular_function	ATP-dependent protein folding chaperone
Bh	1990220	cellular_component	GroEL-GroES complex
Bj	0005515	molecular_function	protein binding
Bj	0005524	molecular_function	ATP binding
Bj	0005737	cellular_component	cytoplasm
Bj	0005829	cellular_component	cytosol
Bj	0006457	biological_process	protein folding
Bj	0009408	biological_process	response to heat
Bj	0019068	biological_process	virion assembly
Bj	0042802	molecular_function	identical protein binding
Bj	0044183	molecular_function	protein folding chaperone
Bj	0046872	molecular_function	metal ion binding
Bj	0051082	molecular_function	unfolded protein binding
Bj	0051087	molecular_function	protein-folding chaperone binding
Bj	1990220	cellular_component	GroEL-GroES complex
Bm	0000166	molecular_function	nucleotide binding
Bm	0000287	molecular_function	magnesium ion binding
Bm	0005515	molecular_function	protein binding
Bm	0005524	molecular_function	ATP binding
Bm	0005737	cellular_component	cytoplasm
Bm	0005829	cellular_component	cytosol
Bm	0006457	biological_process	protein folding
Bm	0009314	biological_process	response to radiation
Bm	0009408	biological_process	response to heat
Bm	0016020	cellular_component	membrane
Bm	0016853	molecular_function	isomerase activity
Bm	0016887	molecular_function	ATP hydrolysis activity
Bm	0019068	biological_process	virion assembly
Bm	0042026	biological_process	protein refolding
Bm	0042802	molecular_function	identical protein binding
Bm	0051082	molecular_function	unfolded protein binding
Bm	0140662	molecular_function	ATP-dependent protein folding chaperone
Bm	1990220	cellular_component	GroEL-GroES complex
Bn	0000166	molecular_function	nucleotide binding
Bn	0000287	molecular_function	magnesium ion binding
Bn	0005515	molecular_function	protein binding
Bn	0005524	molecular_function	ATP binding
Bn	0005737	cellular_component	cytoplasm
Bn	0005829	cellular_component	cytosol
Bn	0006457	biological_process	protein folding
Bn	0009314	biological_process	response to radiation
Bn	0009408	biological_process	response to heat
Bn	0016020	cellular_component	membrane
Bn	0016853	molecular_function	isomerase activity
Bn	0016887	molecular_function	ATP hydrolysis activity
Bn	0019068	biological_process	virion assembly
Bn	0042026	biological_process	protein refolding
Bn	0042802	molecular_function	identical protein binding
Bn	0051082	molecular_function	unfolded protein binding
Bn	0140662	molecular_function	ATP-dependent protein folding chaperone
Bn	1990220	cellular_component	GroEL-GroES complex
Bp	0005515	molecular_function	protein binding
Bp	0005524	molecular_function	ATP binding
Bp	0005737	cellular_component	cytoplasm
Bp	0005829	cellular_component	cytosol
Bp	0006457	biological_process	protein folding
Bp	0009408	biological_process	response to heat
Bp	0019068	biological_process	virion assembly
Bp	0042802	molecular_function	identical protein binding
Bp	0044183	molecular_function	protein folding chaperone
Bp	0046872	molecular_function	metal ion binding
Bp	0051082	molecular_function	unfolded protein binding
Bp	0051087	molecular_function	protein-folding chaperone binding
Bp	1990220	cellular_component	GroEL-GroES complex

Functional Information from PROSITE/UniProt

site_id	PS00681
Number of Residues	25
Details	CHAPERONINS_CPN10 Chaperonins cpn10 signature. IrPLhDRVIVKrkevetksaGgIVL

Chain	Residue	Details
Af	ILE3-LEU27

---

site_id	PS00296
Number of Residues	12
Details	CHAPERONINS_CPN60 Chaperonins cpn60 signature. AAVEEGVVaGGG

Chain	Residue	Details
Ac	ALA405-GLY416

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	154
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00600","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25174333","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14517228","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9285585","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1AON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PCQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WVL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00600","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25174333","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14517228","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9285585","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1AON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WVL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	77
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"PubMed","id":"21151122","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	14
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"21151122","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---