7PA3

PARK7 with covalent inhibitor JYQ-88

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000785	cellular_component	chromatin
AAA	0001046	molecular_function	core promoter sequence-specific DNA binding
AAA	0001933	biological_process	negative regulation of protein phosphorylation
AAA	0001963	biological_process	synaptic transmission, dopaminergic
AAA	0002866	biological_process	positive regulation of acute inflammatory response to antigenic stimulus
AAA	0003690	molecular_function	double-stranded DNA binding
AAA	0003697	molecular_function	single-stranded DNA binding
AAA	0003713	molecular_function	transcription coactivator activity
AAA	0003723	molecular_function	RNA binding
AAA	0003729	molecular_function	mRNA binding
AAA	0005102	molecular_function	signaling receptor binding
AAA	0005507	molecular_function	copper ion binding
AAA	0005515	molecular_function	protein binding
AAA	0005634	cellular_component	nucleus
AAA	0005654	cellular_component	nucleoplasm
AAA	0005737	cellular_component	cytoplasm
AAA	0005739	cellular_component	mitochondrion
AAA	0005758	cellular_component	mitochondrial intermembrane space
AAA	0005759	cellular_component	mitochondrial matrix
AAA	0005783	cellular_component	endoplasmic reticulum
AAA	0005829	cellular_component	cytosol
AAA	0005886	cellular_component	plasma membrane
AAA	0005912	cellular_component	adherens junction
AAA	0006281	biological_process	DNA repair
AAA	0006469	biological_process	negative regulation of protein kinase activity
AAA	0006508	biological_process	proteolysis
AAA	0006517	biological_process	protein deglycosylation
AAA	0006914	biological_process	autophagy
AAA	0006954	biological_process	inflammatory response
AAA	0006979	biological_process	response to oxidative stress
AAA	0007005	biological_process	mitochondrion organization
AAA	0007265	biological_process	Ras protein signal transduction
AAA	0007338	biological_process	single fertilization
AAA	0008233	molecular_function	peptidase activity
AAA	0008344	biological_process	adult locomotory behavior
AAA	0009438	biological_process	methylglyoxal metabolic process
AAA	0010273	biological_process	detoxification of copper ion
AAA	0010628	biological_process	positive regulation of gene expression
AAA	0010629	biological_process	negative regulation of gene expression
AAA	0016532	molecular_function	superoxide dismutase copper chaperone activity
AAA	0016605	cellular_component	PML body
AAA	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
AAA	0019249	biological_process	lactate biosynthetic process
AAA	0019826	molecular_function	oxygen sensor activity
AAA	0019899	molecular_function	enzyme binding
AAA	0019900	molecular_function	kinase binding
AAA	0019955	molecular_function	cytokine binding
AAA	0030073	biological_process	insulin secretion
AAA	0030424	cellular_component	axon
AAA	0031334	biological_process	positive regulation of protein-containing complex assembly
AAA	0031397	biological_process	negative regulation of protein ubiquitination
AAA	0032091	biological_process	negative regulation of protein binding
AAA	0032148	biological_process	activation of protein kinase B activity
AAA	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
AAA	0032679	biological_process	regulation of TRAIL production
AAA	0032757	biological_process	positive regulation of interleukin-8 production
AAA	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
AAA	0033234	biological_process	negative regulation of protein sumoylation
AAA	0033864	biological_process	positive regulation of NAD(P)H oxidase activity
AAA	0034599	biological_process	cellular response to oxidative stress
AAA	0034614	biological_process	cellular response to reactive oxygen species
AAA	0036470	molecular_function	tyrosine 3-monooxygenase activator activity
AAA	0036471	biological_process	cellular response to glyoxal
AAA	0036478	molecular_function	L-dopa decarboxylase activator activity
AAA	0036524	molecular_function	protein deglycase activity
AAA	0036526	biological_process	peptidyl-cysteine deglycation
AAA	0036527	biological_process	peptidyl-arginine deglycation
AAA	0036528	biological_process	peptidyl-lysine deglycation
AAA	0036529	biological_process	protein deglycation, glyoxal removal
AAA	0036530	biological_process	protein deglycation, methylglyoxal removal
AAA	0036531	biological_process	glutathione deglycation
AAA	0042177	biological_process	negative regulation of protein catabolic process
AAA	0042542	biological_process	response to hydrogen peroxide
AAA	0042593	biological_process	glucose homeostasis
AAA	0042743	biological_process	hydrogen peroxide metabolic process
AAA	0042802	molecular_function	identical protein binding
AAA	0042803	molecular_function	protein homodimerization activity
AAA	0043005	cellular_component	neuron projection
AAA	0043523	biological_process	regulation of neuron apoptotic process
AAA	0043524	biological_process	negative regulation of neuron apoptotic process
AAA	0044297	cellular_component	cell body
AAA	0044388	molecular_function	small protein activating enzyme binding
AAA	0044390	molecular_function	ubiquitin-like protein conjugating enzyme binding
AAA	0044877	molecular_function	protein-containing complex binding
AAA	0045121	cellular_component	membrane raft
AAA	0045202	cellular_component	synapse
AAA	0045296	molecular_function	cadherin binding
AAA	0045340	molecular_function	mercury ion binding
AAA	0045944	biological_process	positive regulation of transcription by RNA polymerase II
AAA	0046295	biological_process	glycolate biosynthetic process
AAA	0046826	biological_process	negative regulation of protein export from nucleus
AAA	0048471	cellular_component	perinuclear region of cytoplasm
AAA	0050681	molecular_function	nuclear androgen receptor binding
AAA	0050727	biological_process	regulation of inflammatory response
AAA	0050787	biological_process	detoxification of mercury ion
AAA	0050821	biological_process	protein stabilization
AAA	0051091	biological_process	positive regulation of DNA-binding transcription factor activity
AAA	0051444	biological_process	negative regulation of ubiquitin-protein transferase activity
AAA	0051583	biological_process	dopamine uptake involved in synaptic transmission
AAA	0051881	biological_process	regulation of mitochondrial membrane potential
AAA	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
AAA	0051899	biological_process	membrane depolarization
AAA	0051920	molecular_function	peroxiredoxin activity
AAA	0060081	biological_process	membrane hyperpolarization
AAA	0060765	biological_process	regulation of androgen receptor signaling pathway
AAA	0061691	biological_process	detoxification of hydrogen peroxide
AAA	0061727	biological_process	methylglyoxal catabolic process to lactate
AAA	0070062	cellular_component	extracellular exosome
AAA	0070301	biological_process	cellular response to hydrogen peroxide
AAA	0070994	biological_process	detection of oxidative stress
AAA	0097110	molecular_function	scaffold protein binding
AAA	0098793	cellular_component	presynapse
AAA	0098869	biological_process	cellular oxidant detoxification
AAA	0106044	biological_process	guanine deglycation
AAA	0106045	biological_process	guanine deglycation, methylglyoxal removal
AAA	0106046	biological_process	guanine deglycation, glyoxal removal
AAA	0110095	biological_process	cellular detoxification of aldehyde
AAA	0140041	biological_process	cellular detoxification of methylglyoxal
AAA	0140297	molecular_function	DNA-binding transcription factor binding
AAA	1900182	biological_process	positive regulation of protein localization to nucleus
AAA	1901671	biological_process	positive regulation of superoxide dismutase activity
AAA	1901984	biological_process	negative regulation of protein acetylation
AAA	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
AAA	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
AAA	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
AAA	1902903	biological_process	regulation of supramolecular fiber organization
AAA	1902958	biological_process	positive regulation of mitochondrial electron transport, NADH to ubiquinone
AAA	1903073	biological_process	negative regulation of death-inducing signaling complex assembly
AAA	1903094	biological_process	negative regulation of protein K48-linked deubiquitination
AAA	1903122	biological_process	negative regulation of TRAIL-activated apoptotic signaling pathway
AAA	1903135	molecular_function	cupric ion binding
AAA	1903136	molecular_function	cuprous ion binding
AAA	1903168	biological_process	positive regulation of pyrroline-5-carboxylate reductase activity
AAA	1903178	biological_process	positive regulation of tyrosine 3-monooxygenase activity
AAA	1903181	biological_process	positive regulation of dopamine biosynthetic process
AAA	1903189	biological_process	glyoxal metabolic process
AAA	1903190	biological_process	glyoxal catabolic process
AAA	1903197	biological_process	positive regulation of L-dopa biosynthetic process
AAA	1903200	biological_process	positive regulation of L-dopa decarboxylase activity
AAA	1903376	biological_process	regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
AAA	1903377	biological_process	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
AAA	1903384	biological_process	negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
AAA	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
AAA	1903428	biological_process	positive regulation of reactive oxygen species biosynthetic process
AAA	1903599	biological_process	positive regulation of autophagy of mitochondrion
AAA	1903751	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
AAA	1905259	biological_process	negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
AAA	1990381	molecular_function	ubiquitin-specific protease binding
AAA	1990422	molecular_function	glyoxalase (glycolic acid-forming) activity
AAA	2000157	biological_process	negative regulation of ubiquitin-specific protease activity
AAA	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
AAA	2000679	biological_process	positive regulation of transcription regulatory region DNA binding
AAA	2000825	biological_process	positive regulation of androgen receptor activity
AAA	2001237	biological_process	negative regulation of extrinsic apoptotic signaling pathway
AAA	2001268	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000305|PubMed:20304780, ECO:0000305|PubMed:25416785

Chain	Residue	Details
AAA	CYS106

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000305|PubMed:20304780

Chain	Residue	Details
AAA	HIS126

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by CASP6 => ECO:0000250|UniProtKB:Q99LX0

Chain	Residue	Details
AAA	ASP149

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0007744|PubMed:25944712

Chain	Residue	Details
AAA	ALA2

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455

Chain	Residue	Details
AAA	TYR67

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Cysteine sulfinic acid (-SO2H); alternate => ECO:0000269|PubMed:12939276

Chain	Residue	Details
AAA	CYS106

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site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q99LX0

Chain	Residue	Details
AAA	LYS148

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site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q99LX0

Chain	Residue	Details
AAA	LYS182

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site_id	SWS_FT_FI9
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:23847046

Chain	Residue	Details
AAA	CYS46
AAA	CYS53

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site_id	SWS_FT_FI10
Number of Residues	1
Details	LIPID: S-palmitoyl cysteine; alternate => ECO:0000269|PubMed:23847046

Chain	Residue	Details
AAA	CYS106

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site_id	SWS_FT_FI11
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:15976810

Chain	Residue	Details
AAA	LYS130

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