7P5J

Cryo-EM structure of human TTYH1 in GDN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005225	molecular_function	volume-sensitive anion channel activity
A	0005229	molecular_function	intracellularly calcium-gated chloride channel activity
A	0005254	molecular_function	chloride channel activity
A	0005381	molecular_function	iron ion transmembrane transporter activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006821	biological_process	chloride transport
A	0006826	biological_process	iron ion transport
A	0007155	biological_process	cell adhesion
A	0015813	biological_process	L-glutamate transmembrane transport
A	0016020	cellular_component	membrane
A	0030868	cellular_component	smooth endoplasmic reticulum membrane
A	0031527	cellular_component	filopodium membrane
A	0032433	cellular_component	filopodium tip
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034707	cellular_component	chloride channel complex
A	0034755	biological_process	iron ion transmembrane transport
A	0045202	cellular_component	synapse
A	0072320	molecular_function	volume-sensitive chloride channel activity
A	1902476	biological_process	chloride transmembrane transport
B	0005225	molecular_function	volume-sensitive anion channel activity
B	0005229	molecular_function	intracellularly calcium-gated chloride channel activity
B	0005254	molecular_function	chloride channel activity
B	0005381	molecular_function	iron ion transmembrane transporter activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006821	biological_process	chloride transport
B	0006826	biological_process	iron ion transport
B	0007155	biological_process	cell adhesion
B	0015813	biological_process	L-glutamate transmembrane transport
B	0016020	cellular_component	membrane
B	0030868	cellular_component	smooth endoplasmic reticulum membrane
B	0031527	cellular_component	filopodium membrane
B	0032433	cellular_component	filopodium tip
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034707	cellular_component	chloride channel complex
B	0034755	biological_process	iron ion transmembrane transport
B	0045202	cellular_component	synapse
B	0072320	molecular_function	volume-sensitive chloride channel activity
B	1902476	biological_process	chloride transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	464
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"18260827","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"18260827","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Site: {"description":"Essential for the formation of the channel-pore","evidences":[{"source":"UniProtKB","id":"Q9D3A9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---