7P4I

Structure of human ASCT1 transporter

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005254	molecular_function	chloride channel activity
A	0005313	molecular_function	L-glutamate transmembrane transporter activity
A	0005515	molecular_function	protein binding
A	0005813	cellular_component	centrosome
A	0005882	cellular_component	intermediate filament
A	0005886	cellular_component	plasma membrane
A	0006865	biological_process	amino acid transport
A	0006868	biological_process	glutamine transport
A	0009986	cellular_component	cell surface
A	0015171	molecular_function	amino acid transmembrane transporter activity
A	0015175	molecular_function	neutral L-amino acid transmembrane transporter activity
A	0015180	molecular_function	L-alanine transmembrane transporter activity
A	0015183	molecular_function	L-aspartate transmembrane transporter activity
A	0015184	molecular_function	L-cystine transmembrane transporter activity
A	0015186	molecular_function	L-glutamine transmembrane transporter activity
A	0015193	molecular_function	L-proline transmembrane transporter activity
A	0015194	molecular_function	L-serine transmembrane transporter activity
A	0015195	molecular_function	L-threonine transmembrane transporter activity
A	0015293	molecular_function	symporter activity
A	0015297	molecular_function	antiporter activity
A	0015808	biological_process	L-alanine transport
A	0015811	biological_process	L-cystine transport
A	0015813	biological_process	L-glutamate transmembrane transport
A	0015824	biological_process	proline transport
A	0015825	biological_process	L-serine transport
A	0015826	biological_process	threonine transport
A	0016020	cellular_component	membrane
A	0030425	cellular_component	dendrite
A	0033162	cellular_component	melanosome membrane
A	0034589	biological_process	hydroxyproline transport
A	0034590	molecular_function	L-hydroxyproline transmembrane transporter activity
A	0035249	biological_process	synaptic transmission, glutamatergic
A	0035524	biological_process	proline transmembrane transport
A	0043025	cellular_component	neuronal cell body
A	0045202	cellular_component	synapse
A	0046872	molecular_function	metal ion binding
A	0050890	biological_process	cognition
A	0070062	cellular_component	extracellular exosome
A	0098712	biological_process	L-glutamate import across plasma membrane
A	0140009	biological_process	L-aspartate import across plasma membrane
A	0150104	biological_process	transport across blood-brain barrier
A	1902476	biological_process	chloride transmembrane transport
A	1903812	biological_process	L-serine import across plasma membrane
A	1904273	biological_process	L-alanine import across plasma membrane
B	0005254	molecular_function	chloride channel activity
B	0005313	molecular_function	L-glutamate transmembrane transporter activity
B	0005515	molecular_function	protein binding
B	0005813	cellular_component	centrosome
B	0005882	cellular_component	intermediate filament
B	0005886	cellular_component	plasma membrane
B	0006865	biological_process	amino acid transport
B	0006868	biological_process	glutamine transport
B	0009986	cellular_component	cell surface
B	0015171	molecular_function	amino acid transmembrane transporter activity
B	0015175	molecular_function	neutral L-amino acid transmembrane transporter activity
B	0015180	molecular_function	L-alanine transmembrane transporter activity
B	0015183	molecular_function	L-aspartate transmembrane transporter activity
B	0015184	molecular_function	L-cystine transmembrane transporter activity
B	0015186	molecular_function	L-glutamine transmembrane transporter activity
B	0015193	molecular_function	L-proline transmembrane transporter activity
B	0015194	molecular_function	L-serine transmembrane transporter activity
B	0015195	molecular_function	L-threonine transmembrane transporter activity
B	0015293	molecular_function	symporter activity
B	0015297	molecular_function	antiporter activity
B	0015808	biological_process	L-alanine transport
B	0015811	biological_process	L-cystine transport
B	0015813	biological_process	L-glutamate transmembrane transport
B	0015824	biological_process	proline transport
B	0015825	biological_process	L-serine transport
B	0015826	biological_process	threonine transport
B	0016020	cellular_component	membrane
B	0030425	cellular_component	dendrite
B	0033162	cellular_component	melanosome membrane
B	0034589	biological_process	hydroxyproline transport
B	0034590	molecular_function	L-hydroxyproline transmembrane transporter activity
B	0035249	biological_process	synaptic transmission, glutamatergic
B	0035524	biological_process	proline transmembrane transport
B	0043025	cellular_component	neuronal cell body
B	0045202	cellular_component	synapse
B	0046872	molecular_function	metal ion binding
B	0050890	biological_process	cognition
B	0070062	cellular_component	extracellular exosome
B	0098712	biological_process	L-glutamate import across plasma membrane
B	0140009	biological_process	L-aspartate import across plasma membrane
B	0150104	biological_process	transport across blood-brain barrier
B	1902476	biological_process	chloride transmembrane transport
B	1903812	biological_process	L-serine import across plasma membrane
B	1904273	biological_process	L-alanine import across plasma membrane
C	0005254	molecular_function	chloride channel activity
C	0005313	molecular_function	L-glutamate transmembrane transporter activity
C	0005515	molecular_function	protein binding
C	0005813	cellular_component	centrosome
C	0005882	cellular_component	intermediate filament
C	0005886	cellular_component	plasma membrane
C	0006865	biological_process	amino acid transport
C	0006868	biological_process	glutamine transport
C	0009986	cellular_component	cell surface
C	0015171	molecular_function	amino acid transmembrane transporter activity
C	0015175	molecular_function	neutral L-amino acid transmembrane transporter activity
C	0015180	molecular_function	L-alanine transmembrane transporter activity
C	0015183	molecular_function	L-aspartate transmembrane transporter activity
C	0015184	molecular_function	L-cystine transmembrane transporter activity
C	0015186	molecular_function	L-glutamine transmembrane transporter activity
C	0015193	molecular_function	L-proline transmembrane transporter activity
C	0015194	molecular_function	L-serine transmembrane transporter activity
C	0015195	molecular_function	L-threonine transmembrane transporter activity
C	0015293	molecular_function	symporter activity
C	0015297	molecular_function	antiporter activity
C	0015808	biological_process	L-alanine transport
C	0015811	biological_process	L-cystine transport
C	0015813	biological_process	L-glutamate transmembrane transport
C	0015824	biological_process	proline transport
C	0015825	biological_process	L-serine transport
C	0015826	biological_process	threonine transport
C	0016020	cellular_component	membrane
C	0030425	cellular_component	dendrite
C	0033162	cellular_component	melanosome membrane
C	0034589	biological_process	hydroxyproline transport
C	0034590	molecular_function	L-hydroxyproline transmembrane transporter activity
C	0035249	biological_process	synaptic transmission, glutamatergic
C	0035524	biological_process	proline transmembrane transport
C	0043025	cellular_component	neuronal cell body
C	0045202	cellular_component	synapse
C	0046872	molecular_function	metal ion binding
C	0050890	biological_process	cognition
C	0070062	cellular_component	extracellular exosome
C	0098712	biological_process	L-glutamate import across plasma membrane
C	0140009	biological_process	L-aspartate import across plasma membrane
C	0150104	biological_process	transport across blood-brain barrier
C	1902476	biological_process	chloride transmembrane transport
C	1903812	biological_process	L-serine import across plasma membrane
C	1904273	biological_process	L-alanine import across plasma membrane

Functional Information from PROSITE/UniProt

site_id	PS00713
Number of Residues	15
Details	NA_DICARBOXYL_SYMP_1 Sodium:dicarboxylate symporter family signature 1. P.GEmLLrMLRMIIlP

Chain	Residue	Details
A	PRO78-PRO92

---

site_id	PS00714
Number of Residues	24
Details	NA_DICARBOXYL_SYMP_2 Sodium:dicarboxylate symporter family signature 2. PiGaTvNMDGAaIFqcVaaVFIAQ

Chain	Residue	Details
A	PRO372-GLN395

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	540
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---