Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7P4G

Rabbit Muscle L-lactate dehydrogenase in complex with citrate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004459	molecular_function	L-lactate dehydrogenase activity
A	0005737	cellular_component	cytoplasm
A	0006089	biological_process	lactate metabolic process
A	0006090	biological_process	pyruvate metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0019752	biological_process	carboxylic acid metabolic process
B	0003824	molecular_function	catalytic activity
B	0004459	molecular_function	L-lactate dehydrogenase activity
B	0005737	cellular_component	cytoplasm
B	0006089	biological_process	lactate metabolic process
B	0006090	biological_process	pyruvate metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0019752	biological_process	carboxylic acid metabolic process
C	0003824	molecular_function	catalytic activity
C	0004459	molecular_function	L-lactate dehydrogenase activity
C	0005737	cellular_component	cytoplasm
C	0006089	biological_process	lactate metabolic process
C	0006090	biological_process	pyruvate metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0019752	biological_process	carboxylic acid metabolic process
D	0003824	molecular_function	catalytic activity
D	0004459	molecular_function	L-lactate dehydrogenase activity
D	0005737	cellular_component	cytoplasm
D	0006089	biological_process	lactate metabolic process
D	0006090	biological_process	pyruvate metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0019752	biological_process	carboxylic acid metabolic process
E	0003824	molecular_function	catalytic activity
E	0004459	molecular_function	L-lactate dehydrogenase activity
E	0005737	cellular_component	cytoplasm
E	0006089	biological_process	lactate metabolic process
E	0006090	biological_process	pyruvate metabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E	0019752	biological_process	carboxylic acid metabolic process
F	0003824	molecular_function	catalytic activity
F	0004459	molecular_function	L-lactate dehydrogenase activity
F	0005737	cellular_component	cytoplasm
F	0006089	biological_process	lactate metabolic process
F	0006090	biological_process	pyruvate metabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F	0019752	biological_process	carboxylic acid metabolic process
G	0003824	molecular_function	catalytic activity
G	0004459	molecular_function	L-lactate dehydrogenase activity
G	0005737	cellular_component	cytoplasm
G	0006089	biological_process	lactate metabolic process
G	0006090	biological_process	pyruvate metabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
G	0019752	biological_process	carboxylic acid metabolic process
H	0003824	molecular_function	catalytic activity
H	0004459	molecular_function	L-lactate dehydrogenase activity
H	0005737	cellular_component	cytoplasm
H	0006089	biological_process	lactate metabolic process
H	0006090	biological_process	pyruvate metabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
H	0019752	biological_process	carboxylic acid metabolic process
I	0003824	molecular_function	catalytic activity
I	0004459	molecular_function	L-lactate dehydrogenase activity
I	0005737	cellular_component	cytoplasm
I	0006089	biological_process	lactate metabolic process
I	0006090	biological_process	pyruvate metabolic process
I	0016491	molecular_function	oxidoreductase activity
I	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
I	0019752	biological_process	carboxylic acid metabolic process
J	0003824	molecular_function	catalytic activity
J	0004459	molecular_function	L-lactate dehydrogenase activity
J	0005737	cellular_component	cytoplasm
J	0006089	biological_process	lactate metabolic process
J	0006090	biological_process	pyruvate metabolic process
J	0016491	molecular_function	oxidoreductase activity
J	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
J	0019752	biological_process	carboxylic acid metabolic process
K	0003824	molecular_function	catalytic activity
K	0004459	molecular_function	L-lactate dehydrogenase activity
K	0005737	cellular_component	cytoplasm
K	0006089	biological_process	lactate metabolic process
K	0006090	biological_process	pyruvate metabolic process
K	0016491	molecular_function	oxidoreductase activity
K	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
K	0019752	biological_process	carboxylic acid metabolic process
L	0003824	molecular_function	catalytic activity
L	0004459	molecular_function	L-lactate dehydrogenase activity
L	0005737	cellular_component	cytoplasm
L	0006089	biological_process	lactate metabolic process
L	0006090	biological_process	pyruvate metabolic process
L	0016491	molecular_function	oxidoreductase activity
L	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
L	0019752	biological_process	carboxylic acid metabolic process
M	0003824	molecular_function	catalytic activity
M	0004459	molecular_function	L-lactate dehydrogenase activity
M	0005737	cellular_component	cytoplasm
M	0006089	biological_process	lactate metabolic process
M	0006090	biological_process	pyruvate metabolic process
M	0016491	molecular_function	oxidoreductase activity
M	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
M	0019752	biological_process	carboxylic acid metabolic process
N	0003824	molecular_function	catalytic activity
N	0004459	molecular_function	L-lactate dehydrogenase activity
N	0005737	cellular_component	cytoplasm
N	0006089	biological_process	lactate metabolic process
N	0006090	biological_process	pyruvate metabolic process
N	0016491	molecular_function	oxidoreductase activity
N	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
N	0019752	biological_process	carboxylic acid metabolic process
O	0003824	molecular_function	catalytic activity
O	0004459	molecular_function	L-lactate dehydrogenase activity
O	0005737	cellular_component	cytoplasm
O	0006089	biological_process	lactate metabolic process
O	0006090	biological_process	pyruvate metabolic process
O	0016491	molecular_function	oxidoreductase activity
O	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
O	0019752	biological_process	carboxylic acid metabolic process
P	0003824	molecular_function	catalytic activity
P	0004459	molecular_function	L-lactate dehydrogenase activity
P	0005737	cellular_component	cytoplasm
P	0006089	biological_process	lactate metabolic process
P	0006090	biological_process	pyruvate metabolic process
P	0016491	molecular_function	oxidoreductase activity
P	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
P	0019752	biological_process	carboxylic acid metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00064
Number of Residues	7
Details	L_LDH L-lactate dehydrogenase active site. LGEHGDS

Chain	Residue	Details
A	LEU189-SER195

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	ACT_SITE: Proton acceptor => ECO:0000269\|PubMed:19715328

Chain	Residue	Details
A	HIS192
B	HIS192
C	HIS192
D	HIS192
E	HIS192
F	HIS192
G	HIS192
H	HIS192
I	HIS192
J	HIS192
K	HIS192
L	HIS192
M	HIS192
N	HIS192
O	HIS192
P	HIS192

site_id	SWS_FT_FI2
Number of Residues	96
Details	BINDING:

Chain	Residue	Details
C	ARG168
C	THR247
D	GLY28
D	ARG98
D	ARG105
D	ASN137
D	ARG168
D	THR247
E	GLY28
E	ARG98
E	ARG105
E	ASN137
E	ARG168
E	THR247
F	GLY28
F	ARG98
F	ARG105
F	ASN137
F	ARG168
F	THR247
G	GLY28
G	ARG98
G	ARG105
G	ASN137
G	ARG168
G	THR247
H	GLY28
H	ARG98
H	ARG105
H	ASN137
H	ARG168
H	THR247
I	GLY28
I	ARG98
I	ARG105
I	ASN137
I	ARG168
I	THR247
J	GLY28
J	ARG98
J	ARG105
J	ASN137
J	ARG168
J	THR247
K	GLY28
K	ARG98
K	ARG105
K	ASN137
K	ARG168
K	THR247
L	GLY28
L	ARG98
L	ARG105
L	ASN137
L	ARG168
L	THR247
M	GLY28
M	ARG98
M	ARG105
M	ASN137
M	ARG168
M	THR247
N	GLY28
N	ARG98
N	ARG105
N	ASN137
N	ARG168
N	THR247
O	GLY28
O	ARG98
O	ARG105
O	ASN137
O	ARG168
O	THR247
P	GLY28
P	ARG98
P	ARG105
P	ASN137
P	ARG168
P	THR247
A	GLY28
A	ARG98
A	ARG105
A	ASN137
A	ARG168
A	THR247
B	GLY28
B	ARG98
B	ARG105
B	ASN137
B	ARG168
B	THR247
C	GLY28
C	ARG98
C	ARG105
C	ASN137

site_id	SWS_FT_FI3
Number of Residues	16
Details	MOD_RES: N-acetylalanine => ECO:0000250\|UniProtKB:P00338

Chain	Residue	Details
A	ALA1
B	ALA1
C	ALA1
D	ALA1
E	ALA1
F	ALA1
G	ALA1
H	ALA1
I	ALA1
J	ALA1
K	ALA1
L	ALA1
M	ALA1
N	ALA1
O	ALA1
P	ALA1

site_id	SWS_FT_FI4
Number of Residues	48
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P06151

Chain	Residue	Details
A	LYS4
A	LYS117
A	LYS317
B	LYS4
B	LYS117
B	LYS317
C	LYS4
C	LYS117
C	LYS317
D	LYS4
D	LYS117
D	LYS317
E	LYS4
E	LYS117
E	LYS317
F	LYS4
F	LYS117
F	LYS317
G	LYS4
G	LYS117
G	LYS317
H	LYS4
H	LYS117
H	LYS317
I	LYS4
I	LYS117
I	LYS317
J	LYS4
J	LYS117
J	LYS317
K	LYS4
K	LYS117
K	LYS317
L	LYS4
L	LYS117
L	LYS317
M	LYS4
M	LYS117
M	LYS317
N	LYS4
N	LYS117
N	LYS317
O	LYS4
O	LYS117
O	LYS317
P	LYS4
P	LYS117
P	LYS317

site_id	SWS_FT_FI5
Number of Residues	48
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P00338

Chain	Residue	Details
F	LYS80
F	LYS125
G	LYS13
G	LYS80
G	LYS125
H	LYS13
H	LYS80
H	LYS125
I	LYS13
I	LYS80
I	LYS125
J	LYS13
J	LYS80
J	LYS125
K	LYS13
K	LYS80
K	LYS125
L	LYS13
L	LYS80
L	LYS125
M	LYS13
M	LYS80
M	LYS125
N	LYS13
N	LYS80
N	LYS125
O	LYS13
O	LYS80
O	LYS125
P	LYS13
P	LYS80
P	LYS125
A	LYS13
A	LYS80
A	LYS125
B	LYS13
B	LYS80
B	LYS125
C	LYS13
C	LYS80
C	LYS125
D	LYS13
D	LYS80
D	LYS125
E	LYS13
E	LYS80
E	LYS125
F	LYS13

site_id	SWS_FT_FI6
Number of Residues	16
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000250\|UniProtKB:P00338

Chain	Residue	Details
A	LYS56
B	LYS56
C	LYS56
D	LYS56
E	LYS56
F	LYS56
G	LYS56
H	LYS56
I	LYS56
J	LYS56
K	LYS56
L	LYS56
M	LYS56
N	LYS56
O	LYS56
P	LYS56

site_id	SWS_FT_FI7
Number of Residues	48
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P06151

Chain	Residue	Details
A	LYS223
A	LYS231
A	LYS242
B	LYS223
B	LYS231
B	LYS242
C	LYS223
C	LYS231
C	LYS242
D	LYS223
D	LYS231
D	LYS242
E	LYS223
E	LYS231
E	LYS242
F	LYS223
F	LYS231
F	LYS242
G	LYS223
G	LYS231
G	LYS242
H	LYS223
H	LYS231
H	LYS242
I	LYS223
I	LYS231
I	LYS242
J	LYS223
J	LYS231
J	LYS242
K	LYS223
K	LYS231
K	LYS242
L	LYS223
L	LYS231
L	LYS242
M	LYS223
M	LYS231
M	LYS242
N	LYS223
N	LYS231
N	LYS242
O	LYS223
O	LYS231
O	LYS242
P	LYS223
P	LYS231
P	LYS242

site_id	SWS_FT_FI8
Number of Residues	16
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:P06151

Chain	Residue	Details
A	TYR238
B	TYR238
C	TYR238
D	TYR238
E	TYR238
F	TYR238
G	TYR238
H	TYR238
I	TYR238
J	TYR238
K	TYR238
L	TYR238
M	TYR238
N	TYR238
O	TYR238
P	TYR238

site_id	SWS_FT_FI9
Number of Residues	32
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P04642

Chain	Residue	Details
A	THR308
A	THR321
B	THR308
B	THR321
C	THR308
C	THR321
D	THR308
D	THR321
E	THR308
E	THR321
F	THR308
F	THR321
G	THR308
G	THR321
H	THR308
H	THR321
I	THR308
I	THR321
J	THR308
J	THR321
K	THR308
K	THR321
L	THR308
L	THR321
M	THR308
M	THR321
N	THR308
N	THR321
O	THR308
O	THR321
P	THR308
P	THR321

site_id	SWS_FT_FI10
Number of Residues	16
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P00338

Chain	Residue	Details
A	SER309
B	SER309
C	SER309
D	SER309
E	SER309
F	SER309
G	SER309
H	SER309
I	SER309
J	SER309
K	SER309
L	SER309
M	SER309
N	SER309
O	SER309
P	SER309

site_id	SWS_FT_FI11
Number of Residues	32
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250\|UniProtKB:P00338

Chain	Residue	Details
A	LYS56
B	LYS56
C	LYS56
D	LYS56
E	LYS56
F	LYS56
G	LYS56
H	LYS56
I	LYS56
J	LYS56
K	LYS56
L	LYS56
M	LYS56
N	LYS56
O	LYS56
P	LYS56

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)