7P2T

Tetartohedrally twinned crystal structure of Schistosoma mansoni HDAC8 in complex with a tricyclic thieno[3,2-b]indole capped hydroxamate-based inhibitor, bromine derivative

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004407	molecular_function	histone deacetylase activity
A	0005634	cellular_component	nucleus
A	0031507	biological_process	heterochromatin formation
A	0040029	biological_process	epigenetic regulation of gene expression
A	0141221	molecular_function	histone deacetylase activity, hydrolytic mechanism
B	0004407	molecular_function	histone deacetylase activity
B	0005634	cellular_component	nucleus
B	0031507	biological_process	heterochromatin formation
B	0040029	biological_process	epigenetic regulation of gene expression
B	0141221	molecular_function	histone deacetylase activity, hydrolytic mechanism
C	0004407	molecular_function	histone deacetylase activity
C	0005634	cellular_component	nucleus
C	0031507	biological_process	heterochromatin formation
C	0040029	biological_process	epigenetic regulation of gene expression
C	0141221	molecular_function	histone deacetylase activity, hydrolytic mechanism
D	0004407	molecular_function	histone deacetylase activity
D	0005634	cellular_component	nucleus
D	0031507	biological_process	heterochromatin formation
D	0040029	biological_process	epigenetic regulation of gene expression
D	0141221	molecular_function	histone deacetylase activity, hydrolytic mechanism