7P1G

Structure of the P. aeruginosa ExoY-F-actin complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0001725	cellular_component	stress fiber
A	0003785	molecular_function	actin monomer binding
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005523	molecular_function	tropomyosin binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005865	cellular_component	striated muscle thin filament
A	0005884	cellular_component	actin filament
A	0010628	biological_process	positive regulation of gene expression
A	0016787	molecular_function	hydrolase activity
A	0019904	molecular_function	protein domain specific binding
A	0030027	cellular_component	lamellipodium
A	0030041	biological_process	actin filament polymerization
A	0030175	cellular_component	filopodium
A	0030240	biological_process	skeletal muscle thin filament assembly
A	0031013	molecular_function	troponin I binding
A	0031432	molecular_function	titin binding
A	0031941	cellular_component	filamentous actin
A	0032036	molecular_function	myosin heavy chain binding
A	0032432	cellular_component	actin filament bundle
A	0042802	molecular_function	identical protein binding
A	0044297	cellular_component	cell body
A	0048306	molecular_function	calcium-dependent protein binding
A	0048741	biological_process	skeletal muscle fiber development
A	0051017	biological_process	actin filament bundle assembly
A	0090131	biological_process	mesenchyme migration
A	0098723	cellular_component	skeletal muscle myofibril
A	0140660	molecular_function	cytoskeletal motor activator activity
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0001725	cellular_component	stress fiber
B	0003785	molecular_function	actin monomer binding
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005523	molecular_function	tropomyosin binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005865	cellular_component	striated muscle thin filament
B	0005884	cellular_component	actin filament
B	0010628	biological_process	positive regulation of gene expression
B	0016787	molecular_function	hydrolase activity
B	0019904	molecular_function	protein domain specific binding
B	0030027	cellular_component	lamellipodium
B	0030041	biological_process	actin filament polymerization
B	0030175	cellular_component	filopodium
B	0030240	biological_process	skeletal muscle thin filament assembly
B	0031013	molecular_function	troponin I binding
B	0031432	molecular_function	titin binding
B	0031941	cellular_component	filamentous actin
B	0032036	molecular_function	myosin heavy chain binding
B	0032432	cellular_component	actin filament bundle
B	0042802	molecular_function	identical protein binding
B	0044297	cellular_component	cell body
B	0048306	molecular_function	calcium-dependent protein binding
B	0048741	biological_process	skeletal muscle fiber development
B	0051017	biological_process	actin filament bundle assembly
B	0090131	biological_process	mesenchyme migration
B	0098723	cellular_component	skeletal muscle myofibril
B	0140660	molecular_function	cytoskeletal motor activator activity
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0001725	cellular_component	stress fiber
C	0003785	molecular_function	actin monomer binding
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005523	molecular_function	tropomyosin binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005865	cellular_component	striated muscle thin filament
C	0005884	cellular_component	actin filament
C	0010628	biological_process	positive regulation of gene expression
C	0016787	molecular_function	hydrolase activity
C	0019904	molecular_function	protein domain specific binding
C	0030027	cellular_component	lamellipodium
C	0030041	biological_process	actin filament polymerization
C	0030175	cellular_component	filopodium
C	0030240	biological_process	skeletal muscle thin filament assembly
C	0031013	molecular_function	troponin I binding
C	0031432	molecular_function	titin binding
C	0031941	cellular_component	filamentous actin
C	0032036	molecular_function	myosin heavy chain binding
C	0032432	cellular_component	actin filament bundle
C	0042802	molecular_function	identical protein binding
C	0044297	cellular_component	cell body
C	0048306	molecular_function	calcium-dependent protein binding
C	0048741	biological_process	skeletal muscle fiber development
C	0051017	biological_process	actin filament bundle assembly
C	0090131	biological_process	mesenchyme migration
C	0098723	cellular_component	skeletal muscle myofibril
C	0140660	molecular_function	cytoskeletal motor activator activity
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0001725	cellular_component	stress fiber
D	0003785	molecular_function	actin monomer binding
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005523	molecular_function	tropomyosin binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005865	cellular_component	striated muscle thin filament
D	0005884	cellular_component	actin filament
D	0010628	biological_process	positive regulation of gene expression
D	0016787	molecular_function	hydrolase activity
D	0019904	molecular_function	protein domain specific binding
D	0030027	cellular_component	lamellipodium
D	0030041	biological_process	actin filament polymerization
D	0030175	cellular_component	filopodium
D	0030240	biological_process	skeletal muscle thin filament assembly
D	0031013	molecular_function	troponin I binding
D	0031432	molecular_function	titin binding
D	0031941	cellular_component	filamentous actin
D	0032036	molecular_function	myosin heavy chain binding
D	0032432	cellular_component	actin filament bundle
D	0042802	molecular_function	identical protein binding
D	0044297	cellular_component	cell body
D	0048306	molecular_function	calcium-dependent protein binding
D	0048741	biological_process	skeletal muscle fiber development
D	0051017	biological_process	actin filament bundle assembly
D	0090131	biological_process	mesenchyme migration
D	0098723	cellular_component	skeletal muscle myofibril
D	0140660	molecular_function	cytoskeletal motor activator activity
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0001725	cellular_component	stress fiber
E	0003785	molecular_function	actin monomer binding
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005523	molecular_function	tropomyosin binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005856	cellular_component	cytoskeleton
E	0005865	cellular_component	striated muscle thin filament
E	0005884	cellular_component	actin filament
E	0010628	biological_process	positive regulation of gene expression
E	0016787	molecular_function	hydrolase activity
E	0019904	molecular_function	protein domain specific binding
E	0030027	cellular_component	lamellipodium
E	0030041	biological_process	actin filament polymerization
E	0030175	cellular_component	filopodium
E	0030240	biological_process	skeletal muscle thin filament assembly
E	0031013	molecular_function	troponin I binding
E	0031432	molecular_function	titin binding
E	0031941	cellular_component	filamentous actin
E	0032036	molecular_function	myosin heavy chain binding
E	0032432	cellular_component	actin filament bundle
E	0042802	molecular_function	identical protein binding
E	0044297	cellular_component	cell body
E	0048306	molecular_function	calcium-dependent protein binding
E	0048741	biological_process	skeletal muscle fiber development
E	0051017	biological_process	actin filament bundle assembly
E	0090131	biological_process	mesenchyme migration
E	0098723	cellular_component	skeletal muscle myofibril
E	0140660	molecular_function	cytoskeletal motor activator activity
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0006974	biological_process	DNA damage response
K	0008294	molecular_function	calcium- and calmodulin-responsive adenylate cyclase activity
K	0008643	biological_process	carbohydrate transport
K	0015144	molecular_function	carbohydrate transmembrane transporter activity
K	0015768	biological_process	maltose transport
K	0016020	cellular_component	membrane
K	0030288	cellular_component	outer membrane-bounded periplasmic space
K	0034219	biological_process	carbohydrate transmembrane transport
K	0034289	biological_process	detection of maltose stimulus
K	0042597	cellular_component	periplasmic space
K	0042956	biological_process	maltodextrin transmembrane transport
K	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
K	0046872	molecular_function	metal ion binding
K	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
K	0055085	biological_process	transmembrane transport
K	0060326	biological_process	cell chemotaxis
K	1901982	molecular_function	maltose binding
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0006974	biological_process	DNA damage response
L	0008294	molecular_function	calcium- and calmodulin-responsive adenylate cyclase activity
L	0008643	biological_process	carbohydrate transport
L	0015144	molecular_function	carbohydrate transmembrane transporter activity
L	0015768	biological_process	maltose transport
L	0016020	cellular_component	membrane
L	0030288	cellular_component	outer membrane-bounded periplasmic space
L	0034219	biological_process	carbohydrate transmembrane transport
L	0034289	biological_process	detection of maltose stimulus
L	0042597	cellular_component	periplasmic space
L	0042956	biological_process	maltodextrin transmembrane transport
L	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
L	0046872	molecular_function	metal ion binding
L	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
L	0055085	biological_process	transmembrane transport
L	0060326	biological_process	cell chemotaxis
L	1901982	molecular_function	maltose binding
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0006974	biological_process	DNA damage response
M	0008294	molecular_function	calcium- and calmodulin-responsive adenylate cyclase activity
M	0008643	biological_process	carbohydrate transport
M	0015144	molecular_function	carbohydrate transmembrane transporter activity
M	0015768	biological_process	maltose transport
M	0016020	cellular_component	membrane
M	0030288	cellular_component	outer membrane-bounded periplasmic space
M	0034219	biological_process	carbohydrate transmembrane transport
M	0034289	biological_process	detection of maltose stimulus
M	0042597	cellular_component	periplasmic space
M	0042956	biological_process	maltodextrin transmembrane transport
M	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
M	0046872	molecular_function	metal ion binding
M	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
M	0055085	biological_process	transmembrane transport
M	0060326	biological_process	cell chemotaxis
M	1901982	molecular_function	maltose binding
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0006974	biological_process	DNA damage response
N	0008294	molecular_function	calcium- and calmodulin-responsive adenylate cyclase activity
N	0008643	biological_process	carbohydrate transport
N	0015144	molecular_function	carbohydrate transmembrane transporter activity
N	0015768	biological_process	maltose transport
N	0016020	cellular_component	membrane
N	0030288	cellular_component	outer membrane-bounded periplasmic space
N	0034219	biological_process	carbohydrate transmembrane transport
N	0034289	biological_process	detection of maltose stimulus
N	0042597	cellular_component	periplasmic space
N	0042956	biological_process	maltodextrin transmembrane transport
N	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
N	0046872	molecular_function	metal ion binding
N	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
N	0055085	biological_process	transmembrane transport
N	0060326	biological_process	cell chemotaxis
N	1901982	molecular_function	maltose binding
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0006974	biological_process	DNA damage response
O	0008294	molecular_function	calcium- and calmodulin-responsive adenylate cyclase activity
O	0008643	biological_process	carbohydrate transport
O	0015144	molecular_function	carbohydrate transmembrane transporter activity
O	0015768	biological_process	maltose transport
O	0016020	cellular_component	membrane
O	0030288	cellular_component	outer membrane-bounded periplasmic space
O	0034219	biological_process	carbohydrate transmembrane transport
O	0034289	biological_process	detection of maltose stimulus
O	0042597	cellular_component	periplasmic space
O	0042956	biological_process	maltodextrin transmembrane transport
O	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
O	0046872	molecular_function	metal ion binding
O	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
O	0055085	biological_process	transmembrane transport
O	0060326	biological_process	cell chemotaxis
O	1901982	molecular_function	maltose binding

Functional Information from PROSITE/UniProt

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
C	TYR53-GLY63

---

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WITKqEYDE

Chain	Residue	Details
C	TRP356-GLU364

---

site_id	PS01037
Number of Residues	18
Details	SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN

Chain	Residue	Details
M	PRO-267-ASN-250

---

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
C	LEU104-ARG116

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI3
Number of Residues	125
Details	Region: {"description":"Interaction with alpha-actinin","evidences":[{"source":"PubMed","id":"8449927","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	Modified residue: {"description":"Methionine (R)-sulfoxide","evidences":[{"source":"UniProtKB","id":"P68134","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	5
Details	Modified residue: {"description":"N6-malonyllysine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	5
Details	Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"PubMed","id":"1150665","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16905096","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"213279","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2395459","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"499690","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ATN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NWK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	5
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"P68133","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	5
Details	Modified residue: {"description":"ADP-ribosylarginine; by SpvB","evidences":[{"source":"PubMed","id":"16905096","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---