7P09

Human mitochondrial Lon protease with substrate in the ATPase domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000002	biological_process	mitochondrial genome maintenance
A	0001018	molecular_function	mitochondrial promoter sequence-specific DNA binding
A	0001666	biological_process	response to hypoxia
A	0003677	molecular_function	DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0003727	molecular_function	single-stranded RNA binding
A	0004176	molecular_function	ATP-dependent peptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005654	cellular_component	nucleoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0006508	biological_process	proteolysis
A	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
A	0007005	biological_process	mitochondrion organization
A	0008236	molecular_function	serine-type peptidase activity
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0030163	biological_process	protein catabolic process
A	0032042	biological_process	mitochondrial DNA metabolic process
A	0034599	biological_process	cellular response to oxidative stress
A	0035694	biological_process	mitochondrial protein catabolic process
A	0042645	cellular_component	mitochondrial nucleoid
A	0042731	molecular_function	PH domain binding
A	0042802	molecular_function	identical protein binding
A	0043531	molecular_function	ADP binding
A	0043560	molecular_function	insulin receptor substrate binding
A	0043565	molecular_function	sequence-specific DNA binding
A	0046627	biological_process	negative regulation of insulin receptor signaling pathway
A	0050730	biological_process	regulation of peptidyl-tyrosine phosphorylation
A	0051131	biological_process	chaperone-mediated protein complex assembly
A	0051603	biological_process	proteolysis involved in protein catabolic process
A	0051880	molecular_function	G-quadruplex DNA binding
A	0070182	molecular_function	DNA polymerase binding
A	0070407	biological_process	oxidation-dependent protein catabolic process
B	0000002	biological_process	mitochondrial genome maintenance
B	0001018	molecular_function	mitochondrial promoter sequence-specific DNA binding
B	0001666	biological_process	response to hypoxia
B	0003677	molecular_function	DNA binding
B	0003697	molecular_function	single-stranded DNA binding
B	0003727	molecular_function	single-stranded RNA binding
B	0004176	molecular_function	ATP-dependent peptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005654	cellular_component	nucleoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005829	cellular_component	cytosol
B	0006508	biological_process	proteolysis
B	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
B	0007005	biological_process	mitochondrion organization
B	0008236	molecular_function	serine-type peptidase activity
B	0016020	cellular_component	membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0030163	biological_process	protein catabolic process
B	0032042	biological_process	mitochondrial DNA metabolic process
B	0034599	biological_process	cellular response to oxidative stress
B	0035694	biological_process	mitochondrial protein catabolic process
B	0042645	cellular_component	mitochondrial nucleoid
B	0042731	molecular_function	PH domain binding
B	0042802	molecular_function	identical protein binding
B	0043531	molecular_function	ADP binding
B	0043560	molecular_function	insulin receptor substrate binding
B	0043565	molecular_function	sequence-specific DNA binding
B	0046627	biological_process	negative regulation of insulin receptor signaling pathway
B	0050730	biological_process	regulation of peptidyl-tyrosine phosphorylation
B	0051131	biological_process	chaperone-mediated protein complex assembly
B	0051603	biological_process	proteolysis involved in protein catabolic process
B	0051880	molecular_function	G-quadruplex DNA binding
B	0070182	molecular_function	DNA polymerase binding
B	0070407	biological_process	oxidation-dependent protein catabolic process
C	0000002	biological_process	mitochondrial genome maintenance
C	0001018	molecular_function	mitochondrial promoter sequence-specific DNA binding
C	0001666	biological_process	response to hypoxia
C	0003677	molecular_function	DNA binding
C	0003697	molecular_function	single-stranded DNA binding
C	0003727	molecular_function	single-stranded RNA binding
C	0004176	molecular_function	ATP-dependent peptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005654	cellular_component	nucleoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005829	cellular_component	cytosol
C	0006508	biological_process	proteolysis
C	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
C	0007005	biological_process	mitochondrion organization
C	0008236	molecular_function	serine-type peptidase activity
C	0016020	cellular_component	membrane
C	0016887	molecular_function	ATP hydrolysis activity
C	0030163	biological_process	protein catabolic process
C	0032042	biological_process	mitochondrial DNA metabolic process
C	0034599	biological_process	cellular response to oxidative stress
C	0035694	biological_process	mitochondrial protein catabolic process
C	0042645	cellular_component	mitochondrial nucleoid
C	0042731	molecular_function	PH domain binding
C	0042802	molecular_function	identical protein binding
C	0043531	molecular_function	ADP binding
C	0043560	molecular_function	insulin receptor substrate binding
C	0043565	molecular_function	sequence-specific DNA binding
C	0046627	biological_process	negative regulation of insulin receptor signaling pathway
C	0050730	biological_process	regulation of peptidyl-tyrosine phosphorylation
C	0051131	biological_process	chaperone-mediated protein complex assembly
C	0051603	biological_process	proteolysis involved in protein catabolic process
C	0051880	molecular_function	G-quadruplex DNA binding
C	0070182	molecular_function	DNA polymerase binding
C	0070407	biological_process	oxidation-dependent protein catabolic process
D	0000002	biological_process	mitochondrial genome maintenance
D	0001018	molecular_function	mitochondrial promoter sequence-specific DNA binding
D	0001666	biological_process	response to hypoxia
D	0003677	molecular_function	DNA binding
D	0003697	molecular_function	single-stranded DNA binding
D	0003727	molecular_function	single-stranded RNA binding
D	0004176	molecular_function	ATP-dependent peptidase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005654	cellular_component	nucleoplasm
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0005829	cellular_component	cytosol
D	0006508	biological_process	proteolysis
D	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
D	0007005	biological_process	mitochondrion organization
D	0008236	molecular_function	serine-type peptidase activity
D	0016020	cellular_component	membrane
D	0016887	molecular_function	ATP hydrolysis activity
D	0030163	biological_process	protein catabolic process
D	0032042	biological_process	mitochondrial DNA metabolic process
D	0034599	biological_process	cellular response to oxidative stress
D	0035694	biological_process	mitochondrial protein catabolic process
D	0042645	cellular_component	mitochondrial nucleoid
D	0042731	molecular_function	PH domain binding
D	0042802	molecular_function	identical protein binding
D	0043531	molecular_function	ADP binding
D	0043560	molecular_function	insulin receptor substrate binding
D	0043565	molecular_function	sequence-specific DNA binding
D	0046627	biological_process	negative regulation of insulin receptor signaling pathway
D	0050730	biological_process	regulation of peptidyl-tyrosine phosphorylation
D	0051131	biological_process	chaperone-mediated protein complex assembly
D	0051603	biological_process	proteolysis involved in protein catabolic process
D	0051880	molecular_function	G-quadruplex DNA binding
D	0070182	molecular_function	DNA polymerase binding
D	0070407	biological_process	oxidation-dependent protein catabolic process
E	0000002	biological_process	mitochondrial genome maintenance
E	0001018	molecular_function	mitochondrial promoter sequence-specific DNA binding
E	0001666	biological_process	response to hypoxia
E	0003677	molecular_function	DNA binding
E	0003697	molecular_function	single-stranded DNA binding
E	0003727	molecular_function	single-stranded RNA binding
E	0004176	molecular_function	ATP-dependent peptidase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005654	cellular_component	nucleoplasm
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0005829	cellular_component	cytosol
E	0006508	biological_process	proteolysis
E	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
E	0007005	biological_process	mitochondrion organization
E	0008236	molecular_function	serine-type peptidase activity
E	0016020	cellular_component	membrane
E	0016887	molecular_function	ATP hydrolysis activity
E	0030163	biological_process	protein catabolic process
E	0032042	biological_process	mitochondrial DNA metabolic process
E	0034599	biological_process	cellular response to oxidative stress
E	0035694	biological_process	mitochondrial protein catabolic process
E	0042645	cellular_component	mitochondrial nucleoid
E	0042731	molecular_function	PH domain binding
E	0042802	molecular_function	identical protein binding
E	0043531	molecular_function	ADP binding
E	0043560	molecular_function	insulin receptor substrate binding
E	0043565	molecular_function	sequence-specific DNA binding
E	0046627	biological_process	negative regulation of insulin receptor signaling pathway
E	0050730	biological_process	regulation of peptidyl-tyrosine phosphorylation
E	0051131	biological_process	chaperone-mediated protein complex assembly
E	0051603	biological_process	proteolysis involved in protein catabolic process
E	0051880	molecular_function	G-quadruplex DNA binding
E	0070182	molecular_function	DNA polymerase binding
E	0070407	biological_process	oxidation-dependent protein catabolic process
F	0000002	biological_process	mitochondrial genome maintenance
F	0001018	molecular_function	mitochondrial promoter sequence-specific DNA binding
F	0001666	biological_process	response to hypoxia
F	0003677	molecular_function	DNA binding
F	0003697	molecular_function	single-stranded DNA binding
F	0003727	molecular_function	single-stranded RNA binding
F	0004176	molecular_function	ATP-dependent peptidase activity
F	0004252	molecular_function	serine-type endopeptidase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005654	cellular_component	nucleoplasm
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0005829	cellular_component	cytosol
F	0006508	biological_process	proteolysis
F	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
F	0007005	biological_process	mitochondrion organization
F	0008236	molecular_function	serine-type peptidase activity
F	0016020	cellular_component	membrane
F	0016887	molecular_function	ATP hydrolysis activity
F	0030163	biological_process	protein catabolic process
F	0032042	biological_process	mitochondrial DNA metabolic process
F	0034599	biological_process	cellular response to oxidative stress
F	0035694	biological_process	mitochondrial protein catabolic process
F	0042645	cellular_component	mitochondrial nucleoid
F	0042731	molecular_function	PH domain binding
F	0042802	molecular_function	identical protein binding
F	0043531	molecular_function	ADP binding
F	0043560	molecular_function	insulin receptor substrate binding
F	0043565	molecular_function	sequence-specific DNA binding
F	0046627	biological_process	negative regulation of insulin receptor signaling pathway
F	0050730	biological_process	regulation of peptidyl-tyrosine phosphorylation
F	0051131	biological_process	chaperone-mediated protein complex assembly
F	0051603	biological_process	proteolysis involved in protein catabolic process
F	0051880	molecular_function	G-quadruplex DNA binding
F	0070182	molecular_function	DNA polymerase binding
F	0070407	biological_process	oxidation-dependent protein catabolic process

Functional Information from PROSITE/UniProt

site_id	PS01046
Number of Residues	9
Details	LON_SER ATP-dependent serine proteases, lon family, serine active site. DGPSAGCTI

Chain	Residue	Details
A	ASP852-ILE860

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_03120

Chain	Residue	Details
A	SER855
E	LYS898
F	SER855
F	LYS898
A	LYS898
B	SER855
B	LYS898
C	SER855
C	LYS898
D	SER855
D	LYS898
E	SER855

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site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03120

Chain	Residue	Details
A	GLY523
B	GLY523
C	GLY523
D	GLY523
E	GLY523
F	GLY523

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