Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0005046 | molecular_function | KDEL sequence binding |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005801 | cellular_component | cis-Golgi network |
| A | 0006621 | biological_process | protein retention in ER lumen |
| A | 0006890 | biological_process | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| A | 0015031 | biological_process | protein transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016192 | biological_process | vesicle-mediated transport |
| A | 0030663 | cellular_component | COPI-coated vesicle membrane |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0035437 | biological_process | maintenance of protein localization in endoplasmic reticulum |
| A | 0046923 | molecular_function | ER retention sequence binding |
Functional Information from PROSITE/UniProt
| site_id | PS00014 |
| Number of Residues | 4 |
| Details | ER_TARGET Endoplasmic reticulum targeting sequence. HDEL |
| Chain | Residue | Details |
| B | HIS5-LEU8 | |
| site_id | PS00951 |
| Number of Residues | 18 |
| Details | ER_LUMEN_RECEPTOR_1 ER lumen protein retaining receptor signature 1. GISgKsQlLFaLVFttRY |
| Chain | Residue | Details |
| A | GLY31-TYR48 | |
| site_id | PS00952 |
| Number of Residues | 10 |
| Details | ER_LUMEN_RECEPTOR_2 ER lumen protein retaining receptor signature 2. LESVAILPQL |
| Chain | Residue | Details |
| A | LEU126-LEU135 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"30846601","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 131 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"30846601","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"30846601","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 11 |
| Details | Region: {"description":"Interaction with the K-D-E-L motif on target proteins","evidences":[{"source":"PubMed","id":"30846601","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Region: {"description":"Important for recycling of cargo proteins with the sequence motif K-D-E-L from the Golgi to the endoplasmic reticulum","evidences":[{"source":"PubMed","id":"30846601","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Site: {"description":"Interaction with the K-D-E-L motif on target proteins","evidences":[{"source":"PubMed","id":"30846601","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for recycling of cargo proteins with the sequence motif K-D-E-L from the Golgi to the endoplasmic reticulum","evidences":[{"source":"UniProtKB","id":"P24390","evidenceCode":"ECO:0000250"}]} |
