7OXF
Solution structure of bee apamin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0015459 | molecular_function | potassium channel regulator activity |
| A | 0019870 | molecular_function | potassium channel inhibitor activity |
| A | 0035738 | biological_process | venom-mediated perturbation of biological process |
| A | 0070320 | molecular_function | inward rectifier potassium channel inhibitor activity |
| A | 0090729 | molecular_function | toxin activity |
| A | 0099106 | molecular_function | ion channel regulator activity |
| A | 1901017 | biological_process | negative regulation of potassium ion transmembrane transporter activity |
| A | 1901380 | biological_process | negative regulation of potassium ion transmembrane transport |
| A | 1903609 | biological_process | negative regulation of inward rectifier potassium channel activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 17 |
| Details | Peptide: {"description":"Apamin","featureId":"PRO_0000018611","evidences":[{"source":"PubMed","id":"5601655","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"1967","firstPage":"679","lastPage":"680","volume":"1967","journal":"J. Chem. Soc. Chem. Commun.","authors":["Shipolini R.","Bradbury A.F.","Callewaert G.L.","Vernon C.A."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Region: {"description":"Essential for toxin activity","evidences":[{"source":"PubMed","id":"2013287","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6122211","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Histidine amide","evidences":[{"source":"PubMed","id":"7759523","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
