7OU6

Human O-GlcNAc hydrolase in complex with DNJNAc-thiazolidines

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0004415	molecular_function	hyalurononglucosaminidase activity
AAA	0005634	cellular_component	nucleus
AAA	0005737	cellular_component	cytoplasm
AAA	0005829	cellular_component	cytosol
AAA	0006044	biological_process	N-acetylglucosamine metabolic process
AAA	0006493	biological_process	protein O-linked glycosylation
AAA	0006516	biological_process	glycoprotein catabolic process
AAA	0006517	biological_process	protein deglycosylation
AAA	0009100	biological_process	glycoprotein metabolic process
AAA	0016020	cellular_component	membrane
AAA	0016231	molecular_function	beta-N-acetylglucosaminidase activity
AAA	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
AAA	0042802	molecular_function	identical protein binding
AAA	0102166	molecular_function	obsolete [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity
AAA	0102167	molecular_function	obsolete [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity
AAA	0102571	molecular_function	[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity
AAA	1901135	biological_process	carbohydrate derivative metabolic process
BBB	0004415	molecular_function	hyalurononglucosaminidase activity
BBB	0005634	cellular_component	nucleus
BBB	0005737	cellular_component	cytoplasm
BBB	0005829	cellular_component	cytosol
BBB	0006044	biological_process	N-acetylglucosamine metabolic process
BBB	0006493	biological_process	protein O-linked glycosylation
BBB	0006516	biological_process	glycoprotein catabolic process
BBB	0006517	biological_process	protein deglycosylation
BBB	0009100	biological_process	glycoprotein metabolic process
BBB	0016020	cellular_component	membrane
BBB	0016231	molecular_function	beta-N-acetylglucosaminidase activity
BBB	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
BBB	0042802	molecular_function	identical protein binding
BBB	0102166	molecular_function	obsolete [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity
BBB	0102167	molecular_function	obsolete [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity
BBB	0102571	molecular_function	[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity
BBB	1901135	biological_process	carbohydrate derivative metabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU01353, ECO:0000305|PubMed:16533067

Chain	Residue	Details
AAA	ASP175
BBB	ASP175

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site_id	SWS_FT_FI2
Number of Residues	14
Details	BINDING: BINDING => ECO:0000269|PubMed:28939839, ECO:0007744|PDB:5VVT

Chain	Residue	Details
AAA	GLY67
AAA	LYS98
BBB	ASP175
BBB	TYR219
BBB	ASP285
BBB	ASN313
AAA	ASP174
AAA	ASP175
AAA	TYR219
AAA	ASP285
AAA	ASN313
BBB	GLY67
BBB	LYS98
BBB	ASP174

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Cleavage; by caspase-3 => ECO:0000269|PubMed:18586680

Chain	Residue	Details
AAA	ASP413
BBB	ASP413

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
AAA	SER364
BBB	SER364

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