7OPC

Pol II-CSB-CRL4CSA-UVSSA-SPT6-PAF (Structure 4)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0000974	cellular_component	Prp19 complex
A	0001172	biological_process	RNA-templated transcription
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003899	molecular_function	DNA-directed RNA polymerase activity
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005665	cellular_component	RNA polymerase II, core complex
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0006351	biological_process	DNA-templated transcription
A	0006366	biological_process	transcription by RNA polymerase II
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0033120	biological_process	positive regulation of RNA splicing
A	0034062	molecular_function	5'-3' RNA polymerase activity
A	0046872	molecular_function	metal ion binding
A	1990841	molecular_function	promoter-specific chromatin binding
B	0000428	cellular_component	DNA-directed RNA polymerase complex
B	0000781	cellular_component	chromosome, telomeric region
B	0001172	biological_process	RNA-templated transcription
B	0003677	molecular_function	DNA binding
B	0003682	molecular_function	chromatin binding
B	0003899	molecular_function	DNA-directed RNA polymerase activity
B	0003968	molecular_function	RNA-directed RNA polymerase activity
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005665	cellular_component	RNA polymerase II, core complex
B	0006351	biological_process	DNA-templated transcription
B	0006366	biological_process	transcription by RNA polymerase II
B	0008270	molecular_function	zinc ion binding
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0016787	molecular_function	hydrolase activity
B	0032549	molecular_function	ribonucleoside binding
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0046872	molecular_function	metal ion binding
C	0000428	cellular_component	DNA-directed RNA polymerase complex
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed RNA polymerase activity
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005665	cellular_component	RNA polymerase II, core complex
C	0005829	cellular_component	cytosol
C	0006351	biological_process	DNA-templated transcription
C	0006366	biological_process	transcription by RNA polymerase II
C	0046983	molecular_function	protein dimerization activity
D	0000166	molecular_function	nucleotide binding
D	0000428	cellular_component	DNA-directed RNA polymerase complex
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0006352	biological_process	DNA-templated transcription initiation
D	0030880	cellular_component	RNA polymerase complex
E	0000428	cellular_component	DNA-directed RNA polymerase complex
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed RNA polymerase activity
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005665	cellular_component	RNA polymerase II, core complex
E	0005666	cellular_component	RNA polymerase III complex
E	0005736	cellular_component	RNA polymerase I complex
E	0006351	biological_process	DNA-templated transcription
E	0006362	biological_process	transcription elongation by RNA polymerase I
E	0006366	biological_process	transcription by RNA polymerase II
E	0042797	biological_process	tRNA transcription by RNA polymerase III
F	0000428	cellular_component	DNA-directed RNA polymerase complex
F	0001650	cellular_component	fibrillar center
F	0003677	molecular_function	DNA binding
F	0003899	molecular_function	DNA-directed RNA polymerase activity
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005665	cellular_component	RNA polymerase II, core complex
F	0005666	cellular_component	RNA polymerase III complex
F	0005736	cellular_component	RNA polymerase I complex
F	0006351	biological_process	DNA-templated transcription
F	0006360	biological_process	transcription by RNA polymerase I
F	0006366	biological_process	transcription by RNA polymerase II
F	0042797	biological_process	tRNA transcription by RNA polymerase III
G	0003676	molecular_function	nucleic acid binding
G	0006351	biological_process	DNA-templated transcription
G	0006352	biological_process	DNA-templated transcription initiation
H	0000428	cellular_component	DNA-directed RNA polymerase complex
H	0003899	molecular_function	DNA-directed RNA polymerase activity
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005665	cellular_component	RNA polymerase II, core complex
H	0005666	cellular_component	RNA polymerase III complex
H	0005736	cellular_component	RNA polymerase I complex
H	0006351	biological_process	DNA-templated transcription
I	0000428	cellular_component	DNA-directed RNA polymerase complex
I	0001193	biological_process	maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
I	0003676	molecular_function	nucleic acid binding
I	0003899	molecular_function	DNA-directed RNA polymerase activity
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005665	cellular_component	RNA polymerase II, core complex
I	0005730	cellular_component	nucleolus
I	0006283	biological_process	transcription-coupled nucleotide-excision repair
I	0006351	biological_process	DNA-templated transcription
I	0006366	biological_process	transcription by RNA polymerase II
I	0006367	biological_process	transcription initiation at RNA polymerase II promoter
I	0008270	molecular_function	zinc ion binding
I	0046872	molecular_function	metal ion binding
J	0000428	cellular_component	DNA-directed RNA polymerase complex
J	0003677	molecular_function	DNA binding
J	0003899	molecular_function	DNA-directed RNA polymerase activity
J	0005634	cellular_component	nucleus
J	0005665	cellular_component	RNA polymerase II, core complex
J	0006351	biological_process	DNA-templated transcription
J	0008270	molecular_function	zinc ion binding
J	0046872	molecular_function	metal ion binding
K	0000428	cellular_component	DNA-directed RNA polymerase complex
K	0003677	molecular_function	DNA binding
K	0003899	molecular_function	DNA-directed RNA polymerase activity
K	0005634	cellular_component	nucleus
K	0005665	cellular_component	RNA polymerase II, core complex
K	0006351	biological_process	DNA-templated transcription
K	0006366	biological_process	transcription by RNA polymerase II
K	0046983	molecular_function	protein dimerization activity
L	0000428	cellular_component	DNA-directed RNA polymerase complex
L	0003677	molecular_function	DNA binding
L	0003899	molecular_function	DNA-directed RNA polymerase activity
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005665	cellular_component	RNA polymerase II, core complex
L	0005666	cellular_component	RNA polymerase III complex
L	0005730	cellular_component	nucleolus
L	0005736	cellular_component	RNA polymerase I complex
L	0006351	biological_process	DNA-templated transcription
L	0006366	biological_process	transcription by RNA polymerase II
L	0008270	molecular_function	zinc ion binding
L	0046872	molecular_function	metal ion binding
M	0001825	biological_process	blastocyst formation
M	0003676	molecular_function	nucleic acid binding
M	0003677	molecular_function	DNA binding
M	0003723	molecular_function	RNA binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0006139	biological_process	nucleobase-containing compound metabolic process
M	0006368	biological_process	transcription elongation by RNA polymerase II
M	0006397	biological_process	mRNA processing
M	0008023	cellular_component	transcription elongation factor complex
M	0008380	biological_process	RNA splicing
M	0031491	molecular_function	nucleosome binding
M	0034728	biological_process	nucleosome organization
M	0042393	molecular_function	histone binding
M	0045191	biological_process	regulation of isotype switching
M	0051028	biological_process	mRNA transport
M	0051147	biological_process	regulation of muscle cell differentiation
M	0140673	biological_process	transcription elongation-coupled chromatin remodeling
S	0000122	biological_process	negative regulation of transcription by RNA polymerase II
S	0000791	cellular_component	euchromatin
S	0000993	molecular_function	RNA polymerase II complex binding
S	0001711	biological_process	endodermal cell fate commitment
S	0001826	biological_process	inner cell mass cell differentiation
S	0001829	biological_process	trophectodermal cell differentiation
S	0001832	biological_process	blastocyst growth
S	0001835	biological_process	blastocyst hatching
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0006325	biological_process	chromatin organization
S	0006355	biological_process	regulation of DNA-templated transcription
S	0006357	biological_process	regulation of transcription by RNA polymerase II
S	0006368	biological_process	transcription elongation by RNA polymerase II
S	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
S	0016055	biological_process	Wnt signaling pathway
S	0016593	cellular_component	Cdc73/Paf1 complex
S	0016607	cellular_component	nuclear speck
S	0019827	biological_process	stem cell population maintenance
S	0042169	molecular_function	SH2 domain binding
S	0045638	biological_process	negative regulation of myeloid cell differentiation
S	0045814	biological_process	negative regulation of gene expression, epigenetic
S	0045944	biological_process	positive regulation of transcription by RNA polymerase II
S	0070102	biological_process	interleukin-6-mediated signaling pathway
S	0071222	biological_process	cellular response to lipopolysaccharide
U	0001650	cellular_component	fibrillar center
U	0001711	biological_process	endodermal cell fate commitment
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005813	cellular_component	centrosome
U	0006368	biological_process	transcription elongation by RNA polymerase II
U	0016055	biological_process	Wnt signaling pathway
U	0016593	cellular_component	Cdc73/Paf1 complex
U	0019827	biological_process	stem cell population maintenance
U	0031124	biological_process	mRNA 3'-end processing
U	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
U	0045638	biological_process	negative regulation of myeloid cell differentiation
U	0045944	biological_process	positive regulation of transcription by RNA polymerase II
U	1990269	molecular_function	RNA polymerase II C-terminal domain phosphoserine binding
V	0000122	biological_process	negative regulation of transcription by RNA polymerase II
V	0000993	molecular_function	RNA polymerase II complex binding
V	0001650	cellular_component	fibrillar center
V	0001711	biological_process	endodermal cell fate commitment
V	0003682	molecular_function	chromatin binding
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005737	cellular_component	cytoplasm
V	0006368	biological_process	transcription elongation by RNA polymerase II
V	0016020	cellular_component	membrane
V	0016055	biological_process	Wnt signaling pathway
V	0016593	cellular_component	Cdc73/Paf1 complex
V	0019827	biological_process	stem cell population maintenance
V	0031124	biological_process	mRNA 3'-end processing
V	0034504	biological_process	protein localization to nucleus
V	0045638	biological_process	negative regulation of myeloid cell differentiation
V	0045944	biological_process	positive regulation of transcription by RNA polymerase II
V	0071222	biological_process	cellular response to lipopolysaccharide
V	1902808	biological_process	positive regulation of cell cycle G1/S phase transition
Y	0000791	cellular_component	euchromatin
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005737	cellular_component	cytoplasm
Y	0005829	cellular_component	cytosol
Y	0006368	biological_process	transcription elongation by RNA polymerase II
Y	0016055	biological_process	Wnt signaling pathway
Y	0016593	cellular_component	Cdc73/Paf1 complex
Y	0045638	biological_process	negative regulation of myeloid cell differentiation
Y	0055087	cellular_component	Ski complex
Y	0070478	biological_process	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
Y	0072344	biological_process	rescue of stalled ribosome
Z	0000122	biological_process	negative regulation of transcription by RNA polymerase II
Z	0000781	cellular_component	chromosome, telomeric region
Z	0000993	molecular_function	RNA polymerase II complex binding
Z	0001558	biological_process	regulation of cell growth
Z	0001711	biological_process	endodermal cell fate commitment
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005829	cellular_component	cytosol
Z	0006357	biological_process	regulation of transcription by RNA polymerase II
Z	0006368	biological_process	transcription elongation by RNA polymerase II
Z	0008285	biological_process	negative regulation of cell population proliferation
Z	0016055	biological_process	Wnt signaling pathway
Z	0016593	cellular_component	Cdc73/Paf1 complex
Z	0019827	biological_process	stem cell population maintenance
Z	0030177	biological_process	positive regulation of Wnt signaling pathway
Z	0031124	biological_process	mRNA 3'-end processing
Z	0031442	biological_process	positive regulation of mRNA 3'-end processing
Z	0031648	biological_process	protein destabilization
Z	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
Z	0043066	biological_process	negative regulation of apoptotic process
Z	0045638	biological_process	negative regulation of myeloid cell differentiation
Z	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Z	0048147	biological_process	negative regulation of fibroblast proliferation
Z	0050680	biological_process	negative regulation of epithelial cell proliferation
Z	0071222	biological_process	cellular response to lipopolysaccharide
Z	1902808	biological_process	positive regulation of cell cycle G1/S phase transition
Z	2000134	biological_process	negative regulation of G1/S transition of mitotic cell cycle
a	0000012	biological_process	single strand break repair
a	0000109	cellular_component	nucleotide-excision repair complex
a	0000209	biological_process	protein polyubiquitination
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005694	cellular_component	chromosome
a	0006281	biological_process	DNA repair
a	0006283	biological_process	transcription-coupled nucleotide-excision repair
a	0006974	biological_process	DNA damage response
a	0006979	biological_process	response to oxidative stress
a	0009411	biological_process	response to UV
a	0010165	biological_process	response to X-ray
a	0010996	biological_process	response to auditory stimulus
a	0016363	cellular_component	nuclear matrix
a	0016567	biological_process	protein ubiquitination
a	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
a	0032991	cellular_component	protein-containing complex
a	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
a	0043204	cellular_component	perikaryon
a	0051865	biological_process	protein autoubiquitination
a	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
a	0090262	biological_process	regulation of transcription-coupled nucleotide-excision repair
a	0090734	cellular_component	site of DNA damage
a	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
a	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
b	0000012	biological_process	single strand break repair
b	0000077	biological_process	DNA damage checkpoint signaling
b	0000166	molecular_function	nucleotide binding
b	0000303	biological_process	response to superoxide
b	0003677	molecular_function	DNA binding
b	0003678	molecular_function	DNA helicase activity
b	0003682	molecular_function	chromatin binding
b	0004386	molecular_function	helicase activity
b	0005515	molecular_function	protein binding
b	0005524	molecular_function	ATP binding
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005694	cellular_component	chromosome
b	0005730	cellular_component	nucleolus
b	0006281	biological_process	DNA repair
b	0006283	biological_process	transcription-coupled nucleotide-excision repair
b	0006284	biological_process	base-excision repair
b	0006290	biological_process	pyrimidine dimer repair
b	0006338	biological_process	chromatin remodeling
b	0006362	biological_process	transcription elongation by RNA polymerase I
b	0006366	biological_process	transcription by RNA polymerase II
b	0006974	biological_process	DNA damage response
b	0006979	biological_process	response to oxidative stress
b	0007254	biological_process	JNK cascade
b	0007399	biological_process	nervous system development
b	0008023	cellular_component	transcription elongation factor complex
b	0008094	molecular_function	ATP-dependent activity, acting on DNA
b	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
b	0009411	biological_process	response to UV
b	0009636	biological_process	response to toxic substance
b	0010165	biological_process	response to X-ray
b	0010224	biological_process	response to UV-B
b	0010332	biological_process	response to gamma radiation
b	0016787	molecular_function	hydrolase activity
b	0016887	molecular_function	ATP hydrolysis activity
b	0022008	biological_process	neurogenesis
b	0030182	biological_process	neuron differentiation
b	0030296	molecular_function	protein tyrosine kinase activator activity
b	0031175	biological_process	neuron projection development
b	0032784	biological_process	regulation of DNA-templated transcription elongation
b	0032786	biological_process	positive regulation of DNA-templated transcription, elongation
b	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
b	0035264	biological_process	multicellular organism growth
b	0042262	biological_process	DNA protection
b	0045494	biological_process	photoreceptor cell maintenance
b	0045739	biological_process	positive regulation of DNA repair
b	0045943	biological_process	positive regulation of transcription by RNA polymerase I
b	0045944	biological_process	positive regulation of transcription by RNA polymerase II
b	0045945	biological_process	positive regulation of transcription by RNA polymerase III
b	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
b	0071168	biological_process	protein localization to chromatin
b	0090734	cellular_component	site of DNA damage
b	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
b	0110016	cellular_component	B-WICH complex
b	0140463	molecular_function	chromatin-protein adaptor activity
b	0140658	molecular_function	ATP-dependent chromatin remodeler activity
b	0140664	molecular_function	ATP-dependent DNA damage sensor activity
b	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
b	2001033	biological_process	negative regulation of double-strand break repair via nonhomologous end joining
c	0000993	molecular_function	RNA polymerase II complex binding
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005694	cellular_component	chromosome
c	0006281	biological_process	DNA repair
c	0006283	biological_process	transcription-coupled nucleotide-excision repair
c	0006325	biological_process	chromatin organization
c	0006974	biological_process	DNA damage response
c	0008270	molecular_function	zinc ion binding
c	0009411	biological_process	response to UV
c	0016567	biological_process	protein ubiquitination
c	0046872	molecular_function	metal ion binding
c	0090734	cellular_component	site of DNA damage
c	0140463	molecular_function	chromatin-protein adaptor activity
c	0140870	molecular_function	RNA polymerase inhibitor activity
d	0000781	cellular_component	chromosome, telomeric region
d	0003676	molecular_function	nucleic acid binding
d	0003677	molecular_function	DNA binding
d	0003684	molecular_function	damaged DNA binding
d	0005515	molecular_function	protein binding
d	0005615	cellular_component	extracellular space
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005730	cellular_component	nucleolus
d	0005737	cellular_component	cytoplasm
d	0006281	biological_process	DNA repair
d	0006289	biological_process	nucleotide-excision repair
d	0006511	biological_process	ubiquitin-dependent protein catabolic process
d	0006915	biological_process	apoptotic process
d	0006974	biological_process	DNA damage response
d	0007056	biological_process	spindle assembly involved in female meiosis
d	0010498	biological_process	proteasomal protein catabolic process
d	0016055	biological_process	Wnt signaling pathway
d	0016567	biological_process	protein ubiquitination
d	0019076	biological_process	viral release from host cell
d	0030674	molecular_function	protein-macromolecule adaptor activity
d	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
d	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
d	0032991	cellular_component	protein-containing complex
d	0034644	biological_process	cellular response to UV
d	0035234	biological_process	ectopic germ cell programmed cell death
d	0035861	cellular_component	site of double-strand break
d	0042752	biological_process	regulation of circadian rhythm
d	0043066	biological_process	negative regulation of apoptotic process
d	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
d	0044725	biological_process	epigenetic programming in the zygotic pronuclei
d	0044877	molecular_function	protein-containing complex binding
d	0045070	biological_process	positive regulation of viral genome replication
d	0045722	biological_process	positive regulation of gluconeogenesis
d	0045732	biological_process	positive regulation of protein catabolic process
d	0046726	biological_process	positive regulation by virus of viral protein levels in host cell
d	0048511	biological_process	rhythmic process
d	0051093	biological_process	negative regulation of developmental process
d	0051702	biological_process	biological process involved in interaction with symbiont
d	0070062	cellular_component	extracellular exosome
d	0070914	biological_process	UV-damage excision repair
d	0071987	molecular_function	WD40-repeat domain binding
d	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
d	0097225	cellular_component	sperm midpiece
d	0097228	cellular_component	sperm principal piece
d	0097229	cellular_component	sperm end piece
d	0097602	molecular_function	cullin family protein binding
d	0160072	molecular_function	ubiquitin ligase complex scaffold activity
d	1901990	biological_process	regulation of mitotic cell cycle phase transition
d	2000242	biological_process	negative regulation of reproductive process
e	0000082	biological_process	G1/S transition of mitotic cell cycle
e	0001701	biological_process	in utero embryonic development
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005737	cellular_component	cytoplasm
e	0006281	biological_process	DNA repair
e	0006511	biological_process	ubiquitin-dependent protein catabolic process
e	0006974	biological_process	DNA damage response
e	0007283	biological_process	spermatogenesis
e	0008283	biological_process	cell population proliferation
e	0008284	biological_process	positive regulation of cell population proliferation
e	0016567	biological_process	protein ubiquitination
e	0030097	biological_process	hemopoiesis
e	0030853	biological_process	negative regulation of granulocyte differentiation
e	0031461	cellular_component	cullin-RING ubiquitin ligase complex
e	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
e	0031625	molecular_function	ubiquitin protein ligase binding
e	0032502	biological_process	developmental process
e	0034644	biological_process	cellular response to UV
e	0035019	biological_process	somatic stem cell population maintenance
e	0042110	biological_process	T cell activation
e	0042254	biological_process	ribosome biogenesis
e	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
e	0045732	biological_process	positive regulation of protein catabolic process
e	0048511	biological_process	rhythmic process
e	0051246	biological_process	regulation of protein metabolic process
e	0061630	molecular_function	ubiquitin protein ligase activity
e	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
e	0097193	biological_process	intrinsic apoptotic signaling pathway
e	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
e	0160072	molecular_function	ubiquitin ligase complex scaffold activity
e	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
e	2000001	biological_process	regulation of DNA damage checkpoint
e	2000819	biological_process	regulation of nucleotide-excision repair
f	0000045	biological_process	autophagosome assembly
f	0000082	biological_process	G1/S transition of mitotic cell cycle
f	0000151	cellular_component	ubiquitin ligase complex
f	0000209	biological_process	protein polyubiquitination
f	0000423	biological_process	mitophagy
f	0001837	biological_process	epithelial to mesenchymal transition
f	0004842	molecular_function	ubiquitin-protein transferase activity
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005680	cellular_component	anaphase-promoting complex
f	0005737	cellular_component	cytoplasm
f	0005829	cellular_component	cytosol
f	0006281	biological_process	DNA repair
f	0006283	biological_process	transcription-coupled nucleotide-excision repair
f	0006366	biological_process	transcription by RNA polymerase II
f	0006368	biological_process	transcription elongation by RNA polymerase II
f	0006511	biological_process	ubiquitin-dependent protein catabolic process
f	0006513	biological_process	protein monoubiquitination
f	0006915	biological_process	apoptotic process
f	0006974	biological_process	DNA damage response
f	0006979	biological_process	response to oxidative stress
f	0007040	biological_process	lysosome organization
f	0007283	biological_process	spermatogenesis
f	0007346	biological_process	regulation of mitotic cell cycle
f	0008190	molecular_function	eukaryotic initiation factor 4E binding
f	0008270	molecular_function	zinc ion binding
f	0008286	biological_process	insulin receptor signaling pathway
f	0010507	biological_process	negative regulation of autophagy
f	0010508	biological_process	positive regulation of autophagy
f	0016567	biological_process	protein ubiquitination
f	0016740	molecular_function	transferase activity
f	0019005	cellular_component	SCF ubiquitin ligase complex
f	0030163	biological_process	protein catabolic process
f	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
f	0030891	cellular_component	VCB complex
f	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
f	0031461	cellular_component	cullin-RING ubiquitin ligase complex
f	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
f	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
f	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
f	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
f	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
f	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
f	0031625	molecular_function	ubiquitin protein ligase binding
f	0031669	biological_process	cellular response to nutrient levels
f	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
f	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
f	0032480	biological_process	negative regulation of type I interferon production
f	0032481	biological_process	positive regulation of type I interferon production
f	0032869	biological_process	cellular response to insulin stimulus
f	0034198	biological_process	cellular response to amino acid starvation
f	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
f	0034599	biological_process	cellular response to oxidative stress
f	0034644	biological_process	cellular response to UV
f	0035279	biological_process	miRNA-mediated gene silencing by mRNA destabilization
f	0038066	biological_process	p38MAPK cascade
f	0038202	biological_process	TORC1 signaling
f	0042110	biological_process	T cell activation
f	0042770	biological_process	signal transduction in response to DNA damage
f	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
f	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
f	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
f	0044877	molecular_function	protein-containing complex binding
f	0045116	biological_process	protein neddylation
f	0045727	biological_process	positive regulation of translation
f	0045732	biological_process	positive regulation of protein catabolic process
f	0045944	biological_process	positive regulation of transcription by RNA polymerase II
f	0046627	biological_process	negative regulation of insulin receptor signaling pathway
f	0046872	molecular_function	metal ion binding
f	0060090	molecular_function	molecular adaptor activity
f	0060337	biological_process	type I interferon-mediated signaling pathway
f	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
f	0061630	molecular_function	ubiquitin protein ligase activity
f	0061663	molecular_function	NEDD8 ligase activity
f	0070936	biological_process	protein K48-linked ubiquitination
f	0071230	biological_process	cellular response to amino acid stimulus
f	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
f	0090734	cellular_component	site of DNA damage
f	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
f	0097602	molecular_function	cullin family protein binding
f	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
f	0160240	biological_process	RNA polymerase II transcription initiation surveillance
f	1901797	biological_process	negative regulation of signal transduction by p53 class mediator
f	1902499	biological_process	positive regulation of protein autoubiquitination
f	1902883	biological_process	negative regulation of response to oxidative stress
f	1904037	biological_process	positive regulation of epithelial cell apoptotic process
f	1904262	biological_process	negative regulation of TORC1 signaling
f	1904263	biological_process	positive regulation of TORC1 signaling
f	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DNDPSDYVEqdDI

Chain	Residue	Details
C	ASP136-ILE148

---

site_id	PS00115
Number of Residues	7
Details	RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPA

Chain	Residue	Details
A	TYR1593-ALA1599
A	TYR1671-SER1677
A	TYR1678-SER1684
A	TYR1685-SER1691
A	TYR1692-SER1698
A	TYR1699-SER1705
A	TYR1706-SER1712
A	TYR1713-SER1719
A	TYR1720-SER1726
A	TYR1727-SER1733
A	TYR1734-SER1740
A	TYR1615-SER1621
A	TYR1741-ASN1747
A	TYR1748-ASN1754
A	TYR1755-SER1761
A	TYR1762-SER1768
A	TYR1769-ASN1775
A	TYR1776-ASN1782
A	TYR1783-SER1789
A	TYR1790-SER1796
A	TYR1797-SER1803
A	TYR1818-SER1824
A	TYR1622-SER1628
A	TYR1825-SER1831
A	TYR1832-LYS1838
A	TYR1839-SER1845
A	TYR1853-LYS1859
A	TYR1860-LYS1866
A	TYR1867-LYS1873
A	TYR1874-THR1880
A	TYR1888-THR1894
A	TYR1902-LYS1908
A	TYR1909-THR1915
A	TYR1629-ASN1635
A	TYR1916-LYS1922
A	TYR1923-THR1929
A	TYR1930-LYS1936
A	TYR1947-THR1953
A	TYR1636-SER1642
A	TYR1643-SER1649
A	TYR1650-SER1656
A	TYR1657-SER1663
A	TYR1664-SER1670

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YVCTAPH

Chain	Residue	Details
I	TYR112-HIS118

---

site_id	PS00446
Number of Residues	41
Details	RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSIRRvfiaevpiiAidwVqidaNsSvlhDEfIAhRLGLIP

Chain	Residue	Details
C	ASN32-PRO72

---

site_id	PS00466
Number of Residues	38
Details	ZF_TFIIS_1 Zinc finger TFIIS-type signature. CqkCghkeavffqSHSARaEDAmrlyyvCtaph.CghrW

Chain	Residue	Details
I	CYS86-TRP123

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. AASSslDaHIRLWDL

Chain	Residue	Details
Y	ALA79-LEU93
a	LEU202-VAL216
a	LEU260-SER274

---

site_id	PS01030
Number of Residues	27
Details	RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCQECNNMLypkedkenrillyaCrnC

Chain	Residue	Details
I	PHE16-CYS42

---

site_id	PS01110
Number of Residues	14
Details	RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPEHvvMtkEE

Chain	Residue	Details
E	HIS142-GLU155

---

site_id	PS01111
Number of Residues	15
Details	RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARvLGtRAlQ

Chain	Residue	Details
F	THR58-GLN72

---

site_id	PS01112
Number of Residues	10
Details	RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFTCG

Chain	Residue	Details
J	ILE2-GLY11

---

site_id	PS01154
Number of Residues	32
Details	RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. InkEdHTLgNiIksqLlkdpqVlfagYkvpHP

Chain	Residue	Details
K	ILE35-PRO66

---

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT

Chain	Residue	Details
B	GLY932-THR944

---

site_id	PS01256
Number of Residues	28
Details	CULLIN_1 Cullin family signature. LKkrIesLIDRdYMeRdkdnpnqYhYvA

Chain	Residue	Details
e	LEU732-ALA759

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	41
Details	Region: {"description":"Bridging helix","evidences":[{"source":"UniProtKB","id":"G3MZY8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"G3MZY8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P24928","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P04050","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P24928","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	25
Details	Zinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	42
Details	Zinc finger: {"description":"TFIIS-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00472","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10145","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00472","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	34
Details	Repeat: {"description":"TPR 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	33
Details	Repeat: {"description":"TPR 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	33
Details	Repeat: {"description":"TPR 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	33
Details	Repeat: {"description":"TPR 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	33
Details	Repeat: {"description":"TPR 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	33
Details	Repeat: {"description":"TPR 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	33
Details	Repeat: {"description":"TPR 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	32
Details	Repeat: {"description":"TPR 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	33
Details	Repeat: {"description":"TPR 9"}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	33
Details	Repeat: {"description":"TPR 10"}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	33
Details	Repeat: {"description":"TPR 11"}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	32
Details	Repeat: {"description":"TPR 12"}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	33
Details	Repeat: {"description":"TPR 13"}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	33
Details	Repeat: {"description":"TPR 14"}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	33
Details	Repeat: {"description":"TPR 15"}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	33
Details	Repeat: {"description":"TPR 16"}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	83
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	80
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	79
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	80
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI40
Number of Residues	78
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI41
Number of Residues	79
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI42
Number of Residues	38
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI43
Number of Residues	159
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI44
Number of Residues	3
Details	Motif: {"description":"DEAH box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI45
Number of Residues	12
Details	Motif: {"description":"CSA-interacting motif (CIM)","evidences":[{"source":"PubMed","id":"32355176","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI46
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI47
Number of Residues	316
Details	Region: {"description":"WD repeat beta-propeller B; Interaction with CUL4A"}

Chain

Residue

Details

---

site_id	SWS_FT_FI48
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI49
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9ESW0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI50
Number of Residues	60
Details	Domain: {"description":"Cullin neddylation","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI51
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)","evidences":[{"source":"PubMed","id":"38316879","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---